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    LATERAL/VERTICAL TRANSISTOR STRUCTURES AND PROCESS OF MAKING AND USING SAME
    11.
    发明申请
    LATERAL/VERTICAL TRANSISTOR STRUCTURES AND PROCESS OF MAKING AND USING SAME 有权

    公开(公告)号：US20210129142A1

    公开(公告)日：2021-05-06

    申请号：US17063704

    申请日：2020-10-05

    Applicant: Berkeley Lights, Inc.

    Inventor： Eric D. Hobbs ,  Justin K. Valley

    IPC: B01L3/00 ,  B03C5/00 ,  B03C5/02 ,  H01L27/146

    Abstract: A microfluidic device can include a base an outer surface of which forms one or more enclosures for containing a fluidic medium. The base can include an array of individually controllable transistor structures each of which can comprise both a lateral transistor and a vertical transistor. The transistor structures can be light activated, and the lateral and vertical transistors can thus be photo transistors. Each transistor structure can be activated to create a temporary electrical connection from a region of the outer surface of the base (and thus fluidic medium in the enclosure) to a common electrical conductor. The temporary electrical connection can induce a localized electrokinetic force generally at the region, which can be sufficiently strong to move a nearby micro-object in the enclosure.

    Lateral/vertical transistor structures and process of making and using same
    13.
    发明授权
    Lateral/vertical transistor structures and process of making and using same 有权

    公开(公告)号：US10792658B2

    公开(公告)日：2020-10-06

    申请号：US16509414

    申请日：2019-07-11

    Applicant: Berkeley Lights, Inc.

    Inventor： Eric D. Hobbs ,  Justin K. Valley

    IPC: G01N15/06 ,  B01L3/00 ,  H01L21/00 ,  G01N25/18 ,  B03C5/00 ,  B03C5/02 ,  H01L27/146 ,  H01L29/732

    Abstract: A microfluidic device can include a base an outer surface of which forms one or more enclosures for containing a fluidic medium. The base can include an array of individually controllable transistor structures each of which can comprise both a lateral transistor and a vertical transistor. The transistor structures can be light activated, and the lateral and vertical transistors can thus be photo transistors. Each transistor structure can be activated to create a temporary electrical connection from a region of the outer surface of the base (and thus fluidic medium in the enclosure) to a common electrical conductor. The temporary electrical connection can induce a localized electrokinetic force generally at the region, which can be sufficiently strong to move a nearby micro-object in the enclosure.

    Microfluidic Devices Having Isolation Pens and Methods of Testing Biological Micro-Objects with Same
    14.
    发明申请
    Microfluidic Devices Having Isolation Pens and Methods of Testing Biological Micro-Objects with Same 审中-公开

    公开(公告)号：US20200230601A1

    公开(公告)日：2020-07-23

    申请号：US16683798

    申请日：2019-11-14

    Applicant: Berkeley Lights, Inc.

    Inventor： Mark P. White ,  Eric D. Hobbs ,  J. Tanner Nevill ,  Daniele Malleo ,  Steven W. Short

    IPC: B01L3/00 ,  G01N33/558

    Abstract: A microfluidic device can comprise at least one swept region that is fluidically connected to unswept regions. The fluidic connections between the swept region and the unswept regions can enable diffusion but substantially no flow of media between the swept region and the unswept regions. The capability of biological micro-objects to produce an analyte of interest can be assayed in such a microfluidic device. Biological micro-objects in sample material loaded into a microfluidic device can be selected for particular characteristics and disposed into unswept regions. The sample material can then be flowed out of the swept region and an assay material flowed into the swept region. Flows of medium in the swept region do not substantially affect the biological micro-objects in the unswept regions, but any analyte of interest produced by a biological micro-object can diffuse from an unswept region into the swept region, where the analyte can react with the assay material to produce a localized detectable reaction. Any such detected reactions can be analyzed to determine which, if any, of the biological micro-objects are producers of the analyte of interest.

    Microfluidic devices having isolation pens and methods of testing biological micro-objects with same
    15.
    发明授权
    Microfluidic devices having isolation pens and methods of testing biological micro-objects with same 有权

    公开(公告)号：US10646871B2

    公开(公告)日：2020-05-12

    申请号：US15989549

    申请日：2018-05-25

    Applicant: Berkeley Lights, Inc.

    Inventor： Mark P. White ,  Eric D. Hobbs ,  J. Tanner Nevill ,  Daniele Malleo ,  Steven W. Short

    IPC: G01N33/558 ,  B01L3/00

    Abstract: A microfluidic device can comprise at least one swept region that is fluidically connected to unswept regions. The fluidic connections between the swept region and the unswept regions can enable diffusion but substantially no flow of media between the swept region and the unswept regions. The capability of biological micro-objects to produce an analyte of interest can be assayed in such a microfluidic device. Biological micro-objects in sample material loaded into a microfluidic device can be selected for particular characteristics and disposed into unswept regions. The sample material can then be flowed out of the swept region and an assay material flowed into the swept region. Flows of medium in the swept region do not substantially affect the biological micro-objects in the unswept regions, but any analyte of interest produced by a biological micro-object can diffuse from an unswept region into the swept region, where the analyte can react with the assay material to produce a localized detectable reaction. Any such detected reactions can be analyzed to determine which, if any, of the biological micro-objects are producers of the analyte of interest.

    Isolating Microfluidic Structures and Trapping Bubbles
    17.
    发明申请
    Isolating Microfluidic Structures and Trapping Bubbles 审中-公开
    隔离微流体结构和捕获气泡

    公开(公告)号：US20150352547A1

    公开(公告)日：2015-12-10

    申请号：US14732682

    申请日：2015-06-06

    Applicant: Berkeley Lights, Inc.

    Inventor： Keith Joseph Breinlinger ,  Eric D. Hobbs ,  Dorian Liepmann ,  Joshua Tanner Nevill ,  Mark P. White ,  Maria Jimena Loureiro

    IPC: B01L3/00 ,  C12M3/06

    CPC classification number: B01L3/5027 ,  B01L2200/0647 ,  B01L2200/0684 ,  B01L2300/0864 ,  B01L2300/0883 ,  B01L2400/086 ,  C12M23/16 ,  Y10T436/2575

    Abstract: Some configurations of a microfluidic apparatus can comprise a fluidic circuit of interconnected fluidic structures into which a plurality of different media can be introduced or extracted. A variety of operations can be performed with the different media including isolating with a second medium one or more of the fluidic structures that is filled partially or fully with a first medium. Discrete volumes of a medium can be moved through the isolating second medium to deliver materials or micro-objects to or remove micro-objects or materials from a fluidic structure that is otherwise isolated by the second medium. Some configurations of a microfluidic apparatuses can isolate microfluidic structures in a microfluidic apparatus using flow rates or blocking structures, and some configurations can manage bubbles in fluidic structures.

    Abstract translation: 微流体装置的一些构造可以包括互连流体结构的流体回路，多个不同介质可以被引入或提取到流体结构中。 可以使用不同的介质进行各种操作，包括用第二介质隔离一种或多种用第一介质部分或完全填充的流体结构。 介质的离散体积可以移动通过隔离的第二介质，以将材料或微物体输送到或从其被第二介质分离的流体结构中去除微物体或材料。 微流体装置的一些构造可以使用流速或阻塞结构隔离微流体装置中的微流体结构，并且一些配置可以管理流体结构中的气泡。

    Microfluidic Devices Having Isolation Pens and Methods of Testing Biological Micro-Objects with Same
    18.
    发明申请
    Microfluidic Devices Having Isolation Pens and Methods of Testing Biological Micro-Objects with Same 有权
    具有隔离笔的微流体装置和用相同方法测试生物微物体的方法

    公开(公告)号：US20150151298A1

    公开(公告)日：2015-06-04

    申请号：US14520568

    申请日：2014-10-22

    Applicant: Berkeley Lights, Inc.

    Inventor： Eric D. Hobbs ,  Mark P. White ,  J. Tanner Nevill ,  Daniele Malleo ,  Steven W. Short

    IPC: B01L3/00 ,  G01N33/558

    CPC classification number: B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0424 ,  B01L2400/0433 ,  B01L2400/0454 ,  G01N33/558 ,  G01N2469/20

    Abstract: A microfluidic device can comprise at least one swept region that is fluidically connected to unswept regions. The fluidic connections between the swept region and the unswept regions can enable diffusion but substantially no flow of media between the swept region and the unswept regions. The capability of biological micro-objects to produce an analyte of interest can be assayed in such a microfluidic device. Biological micro-objects in sample material loaded into a microfluidic device can be selected for particular characteristics and disposed into unswept regions. The sample material can then be flowed out of the swept region and an assay material flowed into the swept region. Flows of medium in the swept region do not substantially affect the biological micro-objects in the unswept regions, but any analyte of interest produced by a biological micro-object can diffuse from an unswept region into the swept region, where the analyte can react with the assay material to produce a localized detectable reaction. Any such detected reactions can be analyzed to determine which, if any, of the biological micro-objects are producers of the analyte of interest.

    Abstract translation: 微流体装置可以包括至少一个流体连接到未被吹扫的区域的扫掠区域。 扫掠区域和未被扫描的区域之间的流体连接可以实现扩散，但是基本上不会在扫掠区域和未被扫描区域之间的介质流动。 可以在这种微流体装置中测定生物微生物产生感兴趣分析物的能力。 可以选择装载到微流体装置中的样品材料中的生物微物体用于特定特征并且被置于未被扫描的区域中。 样品材料然后可以从扫掠区域流出，并且测定材料流入扫掠区域。 扫描区域中介质的流动基本上不影响未被扫描的区域中的生物微物体，但是由生物微物体产生的任何目标分析物可以从未被扫描的区域扩散到扫描区域，其中分析物可与 测定材料以产生局部可检测的反应。 可以分析任何这样的检测到的反应，以确定生物微物体（如果有的话）是感兴趣的分析物的生产者。

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