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    BIODEGRADABLE THERMORESPONSIVE 3-ARM POLYETHYLENE GLYCOL POLY(LACTIDE-CO-GLYCOLIDE) COPOLYMER FOR GINSENG ADMINISTRATION
    11.
    发明申请
    BIODEGRADABLE THERMORESPONSIVE 3-ARM POLYETHYLENE GLYCOL POLY(LACTIDE-CO-GLYCOLIDE) COPOLYMER FOR GINSENG ADMINISTRATION 审中-公开
    可生物降解的三聚氰胺聚酰胺（LACTIDE-CO-GLYCOLIDE）三羟甲基丙烷三羟甲基丙烷共聚物

    公开(公告)号：US20110070320A1

    公开(公告)日：2011-03-24

    申请号：US12779026

    申请日：2010-05-12

    申请人： Soonkap Hahn ,  Weijian Zhang ,  Jae Young Yang ,  Younjung Yuk

    发明人： Soonkap Hahn ,  Weijian Zhang ,  Jae Young Yang ,  Younjung Yuk

    IPC分类号： A61K36/258 ,  A61P1/04

    CPC分类号： A61K36/258 ,  A61K9/0043 ,  A61K9/006

    摘要： The present invention discloses a composition comprising a ginseng product, a mucoadhesive and a mucosa penetration enhancer in an aqueous biodegradable block copolymer solution consisting of a 3-arm polyethylene glycol (PEG) and 3 polyesters chains, each of which extends on each of the arm of the 3-arm PEG. The invention also provides a method for transmucosal delivery of pharmaceuticals and nutraceutical such as ginsenosides with improved absorption and bioavailability.

    摘要翻译： 本发明公开了一种组合物，其包含由3-臂聚乙二醇（PEG）和3个聚酯链组成的水性生物可降解嵌段共聚物溶液中的人参制品，粘膜粘附剂和粘膜渗透促进剂，其中每一个在每个臂上延伸 的3臂PEG。 本发明还提供了具有改善的吸收和生物利用度的药物和营养药物如人参皂苷的经粘膜递送的方法。

    Method of making biochips and the biochips resulting therefrom
    19.
    发明授权
    Method of making biochips and the biochips resulting therefrom 失效
    制作生物芯片的方法及由此产生的生物芯片

    公开(公告)号：US06174683B1

    公开(公告)日：2001-01-16

    申请号：US09299831

    申请日：1999-04-26

    申请人： Soonkap Hahn ,  Roberto Fagnani

    发明人： Soonkap Hahn ,  Roberto Fagnani

    IPC分类号： C12Q168

    CPC分类号： G01N33/54353 ,  G01N33/545

    摘要： Methods for preparing a biochip are provided herein wherein the biomolecular probe to be used with the biochip is alternatively bound to a hydrogel prepolymer prior to or simultaneously with polymerization of the prepolymer. In particularly preferred embodiments, a polyurethane-based hydrogel prepolymer is derivatized with an organic solvent soluble biomolecule, such as a peptide nucleic acid probe in aprotic, organic solvent. Following derivatization of the prepolymer, an aqueous solution, for example sodium bicarbonate, preferably buffered to a pH of about 7.2 to about 9.5, is added to the derivatized prepolymer solution to initiate polymerization of the hydrogel. Alternatively, a water soluble biomolecule, such as DNA or other oligonucleotide, is prepared in an aqueous solution and added to the polyurethane-based hydrogel prepolymer such that derivatization and polymerization occur, essentially, simultaneously. While the hydrogel is polymerizing, it is microspotted onto a solid substrate, preferably a silanated glass substrate, to which the hydrogel microdroplet becomes covalently bound. Most preferably the hydrogel microdroplets are at least about 30 &mgr;m thick, for example about 50 &mgr;m to about 100 &mgr;m thick. The resulting biochips are particularly useful for gene discovery, gene characterization, functional gene analysis and related studies.

    摘要翻译： 本文提供了制备生物芯片的方法，其中与生物芯片一起使用的生物分子探针在预聚物聚合之前或同时与水凝胶预聚物交替结合。 在特别优选的实施方案中，聚氨酯基水凝胶预聚物用有机溶剂可溶性生物分子衍生，例如非质子有机溶剂中的肽核酸探针。 在预聚物衍生化之后，向衍生化的预聚物溶液中加入优选缓冲至pH约7.2至约9.5的碳酸氢钠水溶液以引发水凝胶的聚合。 或者，在水溶液中制备水溶性生物分子，例如DNA或其它寡核苷酸，并加入到基于聚氨酯的水凝胶预聚物中，使得衍生化和聚合基本上同时发生。 当水凝胶聚合时，将其微滴在固体基质上，优选硅烷化的玻璃底物，水凝胶微滴变成共价键。 最优选地，水凝胶微滴至少约30μm厚，例如约50μm至约100μm厚。 所得到的生物芯片对于基因发现，基因表征，功能基因分析和相关研究特别有用。

    Child-birth assisting system
    20.
    发明授权
    Child-birth assisting system 失效
    育儿辅助系统

    公开(公告)号：US5405356A

    公开(公告)日：1995-04-11

    申请号：US86099

    申请日：1993-06-30

    申请人： Soonkap Hahn ,  Wei Pan ,  Ron Yamamoto ,  Peter M. Lloyd ,  Mingying Gai

    发明人： Soonkap Hahn ,  Wei Pan ,  Ron Yamamoto ,  Peter M. Lloyd ,  Mingying Gai

    IPC分类号： A61B5/00 ,  A61B17/135 ,  A61B17/42

    CPC分类号： A61B17/42 ,  A61B17/1355

    摘要： The childbirth-assisting device uses an automatically synchronized expandable pneumatic girdle-to externally augment the secondary force of labor. The pneumatic girdle is fitted around the abdomen of the woman and the girdle is inflated to create a downward pressure on the abdomen when a contraction occurs. The synchronization of the girdle's inflation and the contractions is provided by an electronic controller which receives a signal from an intra-uterine monitor indicating a contraction and causes the girdle to inflate at a certain rate until a preset intra-uterine pressure is attained. Once the intra-uterine pressure reaches the pre-set pressure, the girdle pressure is maintained until the offset of the contraction is detected, at which time the girdle is deflated.

    摘要翻译： 分娩辅助装置使用自动同步的可膨胀气动腰带 - 以外部增强第二劳动力。 气动腰带安装在女人的腹部周围，腰带充气，当收缩发生时，腹部产生向下的压力。 腰带充气和收缩的同步由电子控制器提供，该电子控制器接收来自子宫内监视器的指示收缩的信号，并使腰带以一定的速率膨胀，直到达到预设的子宫内压力。 一旦子宫内压力达到预设压力，则保持腰带压力，直到检测到收缩的偏移，此时腰围放气。