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    Droplet actuator devices and methods employing magnetic beads
    12.
    发明授权
    Droplet actuator devices and methods employing magnetic beads 有权

    公开(公告)号：US10379112B2

    公开(公告)日：2019-08-13

    申请号：US14719731

    申请日：2015-05-22

    Applicant: Advanced Liquid Logic, Inc. ,  Duke University

    Inventor： Ramakrishna Sista ,  Vamsee K. Pamula ,  Michael G. Pollack ,  Vijay Srinivasan ,  Allen E. Eckhardt ,  Richard B. Fair

    IPC: B01L3/00 ,  G01N27/447 ,  G01N33/543 ,  C12M1/12 ,  G01N35/10 ,  G01N35/00

    Abstract: A method of providing a droplet in contact with a magnetically responsive bead and having a reduced quantity of a substance. The method generally includes the steps of (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged for conducting droplet operations on a surface; (ii) a starting droplet comprising: (1) one or more magnetically responsive beads; (2) a starting quantity of the substance; and (3) a starting volume; (b) magnetically immobilizing the one or more magnetically responsive beads at a location which is at a distance from a target droplet splitting zone; (c) conducting one or more droplet operations comprising droplet dividing operations selected to divide the combined droplet to yield a set of droplets comprising: (i) a droplet comprising substantially all of the one or more magnetically responsive beads and having a decreased quantity of the substance relative to the starting concentration; and (ii) a droplet substantially lacking the magnetically responsive beads.

    Droplet manipulation device
    13.
    发明授权
    Droplet manipulation device 有权

    公开(公告)号：US10022719B2

    公开(公告)日：2018-07-17

    申请号：US14935823

    申请日：2015-11-09

    Applicant: Duke University

    Inventor： Michael G. Pollack ,  Vamsee K. Pamula ,  Richard B. Fair

    IPC: G01N27/447 ,  B01L3/00 ,  B01F11/00 ,  B01F13/00 ,  G02B26/00 ,  C25B9/00 ,  B41J2/14

    Abstract: Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements, wherein the droplet is disposed on a first one of the electrodes, and the droplet at least partially overlaps a second one of the electrodes and an intervening one of the reference elements disposed between the first and second electrodes. The methods further include activating the first and second electrodes to spread at least a portion of the droplet across the second electrode and deactivating the first electrode to move the droplet from the first electrode to the second electrode.

    Droplet-Based Nucleic Acid Amplification Method and Apparatus
    19.
    发明申请
    Droplet-Based Nucleic Acid Amplification Method and Apparatus 审中-公开
    基于液滴的核酸扩增方法和装置

    公开(公告)号：US20160016172A1

    公开(公告)日：2016-01-21

    申请号：US14837133

    申请日：2015-08-27

    Applicant: ADVANCED LIQUID LOGIC, INC. ,  DUKE UNIVERSITY

    Inventor： Michael G. Pollack ,  Philip Paik ,  Vamsee K. Pamula

    IPC: B01L7/00 ,  G01N27/447

    CPC classification number: C12Q1/68 ,  B01L7/52 ,  B01L2300/0645 ,  B01L2300/1822 ,  B01L2300/1894 ,  B01L2400/0424 ,  B01L2400/0427 ,  C12Q1/6869 ,  G01N27/44791 ,  Y10T436/25 ,  C12Q2565/629 ,  C12Q2565/301 ,  C12Q2563/149

    Abstract: Aspects of embodiments of the invention relate to a simulator including a visual display capable of outputting to a user a display one or more effects of a command series selected and a system including a droplet microactuator electronically coupled to and controlled by a processor capable of executing instructions, the droplet microactuator including a substrate comprising electrodes for conducting droplet operations. Further aspects of embodiments of the invention relate to a droplet operations troubleshooting apparatus. Other aspects of embodiments of the invention relate to a computer implemented method of displaying simulated microactuator droplets.

    Abstract translation: 本发明的实施例的方面涉及一种模拟器，其包括能够向用户输出显示所选择的命令序列的一个或多个效果的视觉显示器，以及包括电子耦合到能够执行指令的处理器并由其控制的液滴微致动器的系统 液滴微致动器包括包括用于进行液滴操作的电极的基板。 本发明的实施例的其它方面涉及一种液滴操作故障排除装置。 本发明的实施例的其他方面涉及一种显示模拟微致动器液滴的计算机实现的方法。

    Droplet-based nucleic acid amplification method and apparatus
    20.
    发明授权
    Droplet-based nucleic acid amplification method and apparatus 有权
    基于液滴的核酸扩增方法和装置

    公开(公告)号：US09139865B2

    公开(公告)日：2015-09-22

    申请号：US13680979

    申请日：2012-11-19

    Applicant: Advanced Liquid Logic, Inc. ,  Duke University

    Inventor： Michael G. Pollack ,  Philip Paik ,  Vamsee K. Pamula

    IPC: G05D5/06 ,  C12Q1/68 ,  G01N27/447

    CPC classification number: C12Q1/68 ,  B01L7/52 ,  B01L2300/0645 ,  B01L2300/1822 ,  B01L2300/1894 ,  B01L2400/0424 ,  B01L2400/0427 ,  C12Q1/6869 ,  G01N27/44791 ,  Y10T436/25 ,  C12Q2565/629 ,  C12Q2565/301 ,  C12Q2563/149

    Abstract: Aspects of embodiments of the invention relate to a simulator including a visual display capable of outputting to a user a display one or more effects of a command series selected and a system including a droplet microactuator electronically coupled to and controlled by a processor capable of executing instructions, the droplet microactuator including a substrate comprising electrodes for conducting droplet operations. Further aspects of embodiments of the invention relate to a droplet operations troubleshooting apparatus. Other aspects of embodiments of the invention relate to a computer implemented method of displaying simulated microactuator droplets.

    Abstract translation: 本发明的实施例的方面涉及一种模拟器，其包括能够向用户输出显示所选择的命令序列的一个或多个效果的视觉显示器，以及包括电子耦合到能够执行指令的处理器并由控制器执行指令的液滴微致动器的系统 液滴微致动器包括包括用于进行液滴操作的电极的基板。 本发明的实施例的其它方面涉及一种液滴操作故障排除装置。 本发明的实施例的其他方面涉及一种显示模拟微致动器液滴的计算机实现的方法。

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