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    APPARATUS AND METHOD FOR RANGING AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS
    11.
    发明申请
    APPARATUS AND METHOD FOR RANGING AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS 有权
    通过平行检测光谱仪的低相干干涉LCI和光学相干TOMOGRAPHY OCT信号的范围和噪声降低的装置和方法

    公开(公告)号：US20080152353A1

    公开(公告)日：2008-06-26

    申请号：US11955986

    申请日：2007-12-13

    申请人： Johannes F. de Boer ,  Guillermo J. Tearney ,  Brett E. Bouma

    发明人： Johannes F. de Boer ,  Guillermo J. Tearney ,  Brett E. Bouma

    IPC分类号： G01B9/02

    CPC分类号： G01B9/02007 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02008 ,  G01B9/0201 ,  G01B9/02032 ,  G01B9/02044 ,  G01B9/02045 ,  G01B9/02079 ,  G01B9/0209 ,  G01B9/02091 ,  G01B2290/45 ,  G01N21/4795

    摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.

    摘要翻译： 通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。 对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。 结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。 信号保持不变。 喷射噪声的降低增加了系统的动态范围和灵敏度。

    Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
    12.
    发明授权
    Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging 有权
    用于提供用于高速多普勒光学频域成像的束扫描图案的系统和方法

    公开(公告)号：US09375158B2

    公开(公告)日：2016-06-28

    申请号：US12183630

    申请日：2008-07-31

    申请人： Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

    发明人： Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

    IPC分类号： A61B5/05 ,  A61B5/026 ,  A61B5/00

    CPC分类号： A61B5/0261 ,  A61B5/0066 ,  A61B5/0073

    摘要： An exemplary apparatus and/or an exemplary method can be provided using which, it is possible (e.g., with at least one first arrangement) to measure an amplitude and/or a phase of at least one electromagnetic radiation provided from a particular portion of a sample. Further, it is possible (e.g., using at least one second arrangement) to scan a location of the particular portion along a path from a first point of the sample to a second point of the sample. In addition, it is possible to control the scan (e.g., with the second arrangement) such that the scan may comprise at least one first segment having a positive velocity and at least one segment having a negative velocity. A first distance of the first segment and/or the second segment can be smaller than a second distance between the first and second points.

    摘要翻译： 可以提供示例性的装置和/或示例性方法，其可以（例如，利用至少一个第一布置）来测量从特定部分提供的至少一个电磁辐射的幅度和/或相位 样品。 此外，可以（例如，使用至少一个第二布置）沿着从样品的第一点到样品的第二点的路径扫描特定部分的位置。 此外，可以控制扫描（例如，利用第二布置），使得扫描可以包括具有正速度的至少一个第一段和至少一个具有负速度的段。 第一段和/或第二段的第一距离可以小于第一和第二点之间的第二距离。

    Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling
    13.
    发明授权
    Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling 有权
    通过光学子采样扩展光学相干断层扫描成像深度范围的系统和方法

    公开(公告)号：US08937724B2

    公开(公告)日：2015-01-20

    申请号：US12635435

    申请日：2009-12-10

    申请人： Benjamin J. Vakoc ,  Wang Y. Oh ,  Guillermo J. Tearney ,  Brett E. Bouma

    发明人： Benjamin J. Vakoc ,  Wang Y. Oh ,  Guillermo J. Tearney ,  Brett E. Bouma

    IPC分类号： G01B11/02 ,  A61B5/00

    CPC分类号： A61B5/6852 ,  A61B5/0066

    摘要： Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one sample. For example, using at least one first arrangement, it is possible to forward at least one first radiation to the sample(s) so as to cause at least one second radiation to be provided from the sample(s) that can be based on the first radiation(s). In addition, using at least one second arrangement, it is possible to receive the second radiation from the sample(s), generate a plurality of distinct measurements regarding at least one portion of the sample(s) based the second radiation(s), and characterize the portion(s) over a plurality of continuous resolvable depth points thereof which are associated with the distinct measurements. Further, the characterization of the at least one portion can be resolved and distinctly characterized at a number of the depth points which is greater than a number of the distinct measurements.

    摘要翻译： 可以提供可以生成与至少一个样本相关联的数据的系统和方法的示例性实施例。 例如，使用至少一个第一布置，可以将至少一个第一辐射转发到样品，以便使得至少一个第二辐射从可以基于该样品的样品提供 第一次辐射。 另外，使用至少一个第二布置，可以从样品接收第二辐射，基于第二辐射产生关于样品的至少一部分的多个不同的测量结果， 并且通过与不同测量相关联的多个连续可分辨深度点来表征部分。 此外，可以在多个不同的测量值的多个深度点上解析和明确地表征至少一个部分的表征。

    APPARATUS AND METHOD FOR UTILIZATION OF A HIGH-SPEED OPTICAL WAVELENGTH TUNING SOURCE
    19.
    发明申请
    APPARATUS AND METHOD FOR UTILIZATION OF A HIGH-SPEED OPTICAL WAVELENGTH TUNING SOURCE 有权
    高速光波导调谐源的利用方法及方法

    公开(公告)号：US20100254415A1

    公开(公告)日：2010-10-07

    申请号：US12700552

    申请日：2010-02-04

    申请人： Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

    发明人： Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

    IPC分类号： H01S3/10 ,  G21G4/00

    CPC分类号： H01S3/08009 ,  G01J3/10 ,  H01S3/08013 ,  H01S3/08059 ,  H01S3/0813 ,  H01S3/083 ,  H01S3/105 ,  H01S5/005 ,  H01S5/06216 ,  H01S5/141

    摘要： Exemplary embodiments of apparatus, source arrangement and method for, e.g., providing high-speed wavelength tuning can be provided. According to one exemplary embodiment, at least one arrangement can be provided which is configured to emit an electromagnetic radiation that (i) has a spectrum whose mean frequency changes at an absolute rate that is greater than about 6000 (or 2000) terahertz per millisecond, (ii) whose mean frequency changes over a range that is greater than about 10 terahertz, and/or (iii) has an instantaneous line width that is less than about 15 gigahertz. According to another exemplary embodiment, at least one arrangement can be provided configured to, periodically and as a function of time, select at least one first electro-magnetic radiation based on a mean frequency of the at least one first electro-magnetic radiation, with the periodic selection being performed at a first characteristic period. The mean frequency can vary linearly over time, wherein the apparatus can emit at least one second electromagnetic radiation that has a spectrum whose mean frequency changes periodically as a function of time with a second characteristic period. Further, the first characteristic period can be greater than the second characteristic period.

    摘要翻译： 可以提供用于例如提供高速波长调谐的装置，源装置和方法的示例性实施例。 根据一个示例性实施例，可以提供至少一种布置，其被配置为发射电磁辐射，其中（i）具有平均频率以大于每毫秒大约6000（或2000）太赫兹的绝对速率变化的频谱， （ii）其平均频率在大于约10太赫兹的范围内变化，和/或（iii）具有小于约15千兆赫兹的瞬时线宽。 根据另一示例性实施例，可以提供至少一种布置，其被配置为周期性地和作为时间的函数，基于所述至少一个第一电磁辐射的平均频率选择至少一个第一电磁辐射， 在第一特征周期执行周期性选择。 平均频率可以随时间线性变化，其中该装置可以发射至少一个第二电磁辐射，其具有在第二特征周期内平均频率作为时间的函数周期性地改变的频谱。 此外，第一特征周期可以大于第二特征周期。

    System and method for identifying tissue using low-coherence interferometry
    20.
    发明授权
    System and method for identifying tissue using low-coherence interferometry 有权
    使用低相干干涉法识别组织的系统和方法

    公开(公告)号：US07761139B2

    公开(公告)日：2010-07-20

    申请号：US10765430

    申请日：2004-01-26

    申请人： Guillermo J. Tearney ,  Milen Stefanov Shishkov ,  Nicusor V. Iftimia ,  Brett E. Bouma ,  Martha Pitman

    发明人： Guillermo J. Tearney ,  Milen Stefanov Shishkov ,  Nicusor V. Iftimia ,  Brett E. Bouma ,  Martha Pitman

    IPC分类号： A61B5/00

    CPC分类号： A61B5/6852 ,  A61B5/0066 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/6848

    摘要： An apparatus for needle biopsy with real time tissue differentiation using one dimensional interferometric ranging imaging, comprising a biopsy device having a barrel and a needle, an optical fiber inserted in the needle, and a fiber optic imaging system connected to the optical fiber. The imaging system obtains images and compares the optical properties and patterns to a database of normalized tissue sample images to determine different tissue types. The physician performing the biopsy obtains feedback via a feedback unit associated with the biopsy device and which is connected to the imaging system. The feedback unit can provide visual, audible or vibratory feedback as to tissue type encountered when the needle is inserted toward the target tissue. The feedback unit can be programmed for different biopsy procedures so that the user can actuate a button to select a display or other feedback mechanism for the desired procedure and anticipated tissue to be encountered.

    摘要翻译： 一种使用一维干涉测量成像的实时组织分化的针活检装置，包括具有镜筒和针的活检装置，插入针中的光纤以及连接到光纤的光纤成像系统。 成像系统获得图像并将光学性质和图案与标准化组织样本图像的数据库进行比较，以确定不同的组织类型。 执行活组织检查的医师通过与活检装置相关联的反馈单元获得反馈，并且连接到成像系统。 反馈单元可以提供关于当针朝向目标组织插入时遇到的组织类型的视觉，听觉或振动反馈。 反馈单元可以被编程用于不同的活检程序，使得用户可以致动按钮以选择用于期望的程序和所期望的组织的显示器或其他反馈机构。