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公开(公告)号：US09101928B2
公开(公告)日：2015-08-11
申请号：US13015242
申请日：2011-01-27
申请人： Tammy Burd Mehta , Anne R. Kopf-Sill , J. Wallace Parce , Andrea W. Chow , Luc J. Bousse , Michael R. Knapp , Theo T. Nikiforov , Steve Gallagher
发明人： Tammy Burd Mehta , Anne R. Kopf-Sill , J. Wallace Parce , Andrea W. Chow , Luc J. Bousse , Michael R. Knapp , Theo T. Nikiforov , Steve Gallagher
IPC分类号： G01N35/00 , B01L3/00 , C07H21/02 , C07H21/04 , C12Q1/68 , B01F13/00 , C40B60/14 , G01N27/447
CPC分类号： C12Q1/6874 , B01F13/0059 , B01J2219/00317 , B01J2219/00459 , B01J2219/00468 , B01L3/5027 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , C07H21/02 , C07H21/04 , C12Q1/6869 , C40B60/14 , G01N27/44756 , G01N35/0098 , G01N2035/00574 , Y10T436/143333 , C12Q2565/629 , C12Q2535/101 , C12Q2563/173 , C12Q2525/186 , C12Q2527/125
摘要： An array of transportable particle sets is used in a microfluidic device for performing chemical reactions in the microfluidic device. The microfluidic device comprises a main channel and intersecting side channels, the main channel and side channels forming a plurality of intersections. The array of particle sets is disposed in the main channel, and the side channels are coupled to reagents. As the particle sets are transported through the intersections of the main channel and the side channels, reagents are flowed through the side channels into contact with each array member (or selected array members), thereby providing a plurality of chemical reactions in the microfluidic system.
摘要翻译： 在微流体装置中使用可移动颗粒组的阵列，用于在微流体装置中执行化学反应。 微流体装置包括主通道和相交的侧通道，主通道和侧通道形成多个交叉点。 颗粒组的阵列设置在主通道中，并且侧通道与试剂偶联。 当颗粒组通过主通道和侧通道的交叉点传输时，试剂通过侧通道流动与每个阵列构件（或选定的阵列构件）接触，从而在微流体系统中提供多个化学反应。
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公开(公告)号：US20110118139A1
公开(公告)日：2011-05-19
申请号：US13015242
申请日：2011-01-27
申请人： Tammy Burd Mehta , Anne R. Kopf-Sill , J. Wallace Parce , Andrea W. Chow , Luc J. Bousse , Michael R. Knapp , Theo T. Nikiforov , Steve Gallagher
发明人： Tammy Burd Mehta , Anne R. Kopf-Sill , J. Wallace Parce , Andrea W. Chow , Luc J. Bousse , Michael R. Knapp , Theo T. Nikiforov , Steve Gallagher
CPC分类号： C12Q1/6874 , B01F13/0059 , B01J2219/00317 , B01J2219/00459 , B01J2219/00468 , B01L3/5027 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , C07H21/02 , C07H21/04 , C12Q1/6869 , C40B60/14 , G01N27/44756 , G01N35/0098 , G01N2035/00574 , Y10T436/143333 , C12Q2565/629 , C12Q2535/101 , C12Q2563/173 , C12Q2525/186 , C12Q2527/125
摘要： An array of transportable particle sets is used in a microfluidic device for performing chemical reactions in the microfluidic device. The microfluidic device comprises a main channel and intersecting side channels, the main channel and side channels forming a plurality of intersections. The array of particle sets is disposed in the main channel, and the side channels are coupled to reagents. As the particle sets are transported through the intersections of the main channel and the side channels, reagents are flowed through the side channels into contact with each array member (or selected array members), thereby providing a plurality of chemical reactions in the microfluidic system.
摘要翻译： 在微流体装置中使用可移动颗粒组的阵列，用于在微流体装置中进行化学反应。 微流体装置包括主通道和相交的侧通道，主通道和侧通道形成多个交叉点。 颗粒组的阵列设置在主通道中，并且侧通道与试剂偶联。 当颗粒组通过主通道和侧通道的交叉点传输时，试剂通过侧通道流动与每个阵列构件（或选定的阵列构件）接触，从而在微流体系统中提供多个化学反应。
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公开(公告)号：US20090137413A1
公开(公告)日：2009-05-28
申请号：US11928808
申请日：2007-10-30
申请人： Tammy Burd Mehta , Anne R. Kopf-Sill , J. Wallace Parce , Andrea W. Chow , Luc J. Bousse , Michael R. Knapp , Theo T. Nikiforov , Steve Gallagher
发明人： Tammy Burd Mehta , Anne R. Kopf-Sill , J. Wallace Parce , Andrea W. Chow , Luc J. Bousse , Michael R. Knapp , Theo T. Nikiforov , Steve Gallagher
IPC分类号： C40B30/04
CPC分类号： C12Q1/6874 , B01F13/0059 , B01J2219/00317 , B01J2219/00459 , B01J2219/00468 , B01L3/5027 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , C07H21/02 , C07H21/04 , C12Q1/6869 , C40B60/14 , G01N27/44756 , G01N35/0098 , G01N2035/00574 , Y10T436/143333 , C12Q2565/629 , C12Q2535/101 , C12Q2563/173 , C12Q2525/186 , C12Q2527/125
摘要： Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus and integrated systems comprising arrays and array members.
摘要翻译： 可流动或固定的颗粒组的数组用于微流体系统中，用于进行测定和改变流体动力学流动。 还提供了利用微流体系统内的可流动或固定的颗粒组的测定法，以及包括阵列和阵列构件的试剂盒，装置和集成系统。
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公开(公告)号：US07067263B2
公开(公告)日：2006-06-27
申请号：US10821503
申请日：2004-04-08
IPC分类号： G01N33/53
CPC分类号： G01N33/502 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00961 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0487 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/5064 , G01N33/5091 , G01N33/5097 , G01N33/5304 , G01N33/57415 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/817 , Y10S436/804 , Y10S436/805 , Y10S436/806 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/117497 , Y10T436/25
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
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公开(公告)号：US06479299B1
公开(公告)日：2002-11-12
申请号：US09132963
申请日：1998-08-12
IPC分类号： G01N33558
CPC分类号： G01N33/502 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00961 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0487 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/5064 , G01N33/5091 , G01N33/5097 , G01N33/5304 , G01N33/57415 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/817 , Y10S436/804 , Y10S436/805 , Y10S436/806 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/117497 , Y10T436/25
摘要： Microfluidic devices having predisposed assay components for increased throughput and prolonged shelf life are provided.
摘要翻译： 提供具有易于检测成分的用于增加产量和延长保质期的微流体装置。
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公开(公告)号：US6046056A
公开(公告)日：2000-04-04
申请号：US761575
申请日：1996-12-06
IPC分类号： B01J19/00 , B01L3/00 , B01L9/00 , G01N27/447 , G01N33/50 , G01N33/53 , G01N33/574 , G01N35/08 , G01N33/558 , G01N33/543
CPC分类号： G01N33/5091 , B01J19/0093 , B01L3/5025 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5044 , G01N33/5064 , G01N33/5094 , G01N33/5304 , G01N33/57415 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L9/527 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
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公开(公告)号：US07285411B1
公开(公告)日：2007-10-23
申请号：US09721508
申请日：2000-11-22
CPC分类号： B01L3/502784 , B01J19/0093 , B01L3/5025 , B01L3/502761 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2400/0415 , G01N33/5008 , G01N33/5304 , G01N33/57415 , G01N35/08
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
摘要翻译： 本发明提供了可用于进行高通量筛选测定的新型微流体装置和方法。 特别地，本发明的装置和方法可用于筛选大量不同的化合物，因为它们对多种化学品，优选生物化学体系的影响。
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公开(公告)号：US06406893B1
公开(公告)日：2002-06-18
申请号：US09718140
申请日：2000-11-20
IPC分类号： C12P1934
CPC分类号： B01L3/0262 , B01F13/0059 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0605 , B01L2200/0673 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/18 , B01L2300/1833 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , C12Q1/6869 , G01N2035/1053 , G01N2035/1058
摘要： Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.
摘要翻译： 提供了用于进行生物化学分析的综合系统，设备，软件和方法，包括DNA测序，基因组筛选，核酸和其他生物组分的纯化以及药物筛选。 提供了用于使用这些装置和系统进行各种流体操作的微流体装置，系统和方法。 这些装置和系统用于执行需要大量迭代，连续或平行流体操作的流体操作，其以微型或密封且容易自动的格式。
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公开(公告)号：US06465257B1
公开(公告)日：2002-10-15
申请号：US09308440
申请日：1999-11-15
IPC分类号： G01N110
CPC分类号： B01L3/50273 , B01L3/5025 , B01L3/502753 , B01L2300/0816 , B01L2300/0864 , B01L2400/0418 , B01L2400/0421 , G01N27/44791 , Y10T436/2575
摘要： The present invention generally provides microfluidic devices (200) and systems that utilize electrokinetic material transport systems to selectively control and direct the transport of materials through and among complex arrangements of integrated microscale channels (for example, 202 and 208+2n, where n=0, 1, . . . 8) disposed within integrated body structures.
摘要翻译： 本发明通常提供微流体装置（200）和利用电动材料输送系统来选择性地控制和指导材料通过整合微量通道（例如，202和208 + 2n，其中n = 0 ，1，...，8）。
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公开(公告)号：US06447727B1
公开(公告)日：2002-09-10
申请号：US08971854
申请日：1997-11-17
IPC分类号： B01L300
CPC分类号： B01L3/50273 , B01L3/5025 , B01L3/502753 , B01L2200/10 , B01L2300/0645 , B01L2300/0809 , B01L2300/0816 , B01L2300/0864 , B01L2400/0418 , B01L2400/0421 , B01L2400/0688 , G01N27/44791 , Y10T436/2575
摘要： The present invention generally provides microfluidic devices and systems that utilize electrokinetic material transport systems to selectively control and direct the transport of materials through and among complex arrangements of integrated, interconnected microscale channels disposed within integrated body structures.
摘要翻译： 本发明通常提供微流体装置和系统，其利用电动材料传输系统来选择性地控制和引导材料的输送通过设置在一体化身体结构内的集成的互连微通道的复杂布置。
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