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11.
公开(公告)号:US09216188B2
公开(公告)日:2015-12-22
申请号:US12553800
申请日:2009-09-03
IPC分类号: A61K9/00 , A61K31/00 , A61K31/7052 , A61L27/26 , A61L27/38 , A61L27/52 , C08J3/075 , C08J3/24
CPC分类号: A61L27/26 , A61K31/00 , A61K31/7052 , A61L27/38 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/34 , C08J3/075 , C08J3/246 , C08J2305/08 , C08J2371/02 , C08L71/02
摘要: The present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation, dermal fillers, breast implants, intervertebral disks, muscle-mass). The hydrogels or compositions thereof are injected into the superficial lamina propria or phonatory epithelium to restore the phonatory mucosa of the vocal cords, thereby restoring a patient's voice. In particular, it has been discovered that hydrogels with an elastic shear modulus of approximately 25 Pa are useful in restoring the pliability of the phonatory mucosa. The invention also provides methods of preparing and using the inventive hydrogels.
摘要翻译: 本发明提供水凝胶及其组合物,用于声带修复或增强,以及其它软组织修复或增强(例如,膀胱颈增大,皮肤填充剂,乳房植入物,椎间盘,肌肉质量)。 将水凝胶或其组合物注射到表层固有层或声音上皮中以恢复声带的声音粘膜,从而恢复患者的声音。 特别地,已经发现弹性剪切模量为约25Pa的水凝胶可用于恢复发音粘膜的柔韧性。 本发明还提供了制备和使用本发明水凝胶的方法。
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公开(公告)号:US08808681B2
公开(公告)日:2014-08-19
申请号:US11758078
申请日:2007-06-05
IPC分类号: A61K47/32 , A61K35/00 , C08F2/48 , C08G73/00 , C08F299/04 , C08F290/06 , C08F283/00 , C08G73/02 , C08F299/02 , C08L79/02 , C08G63/685
CPC分类号: C08L79/02 , C08F283/00 , C08F290/06 , C08F290/061 , C08F290/065 , C08F299/024 , C08F299/0485 , C08G63/6858 , C08G73/02
摘要: Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.
摘要翻译: 丙烯酸酯封端的聚(β-氨基酯)被交联以形成用于医疗和非医学领域的材料。 将聚合起始材料与自由基引发剂,热引发剂或光引发剂组合,并且根据所使用的引发剂将用于交联的混合物加热或暴露于光。 由于聚合物骨架中的可水解的酯键导致的所得材料在生理条件下是可生物降解的。 这些交联材料特别用作药物递送载体,组织工程支架和制造微型装置。 这些材料也可以用作塑料,涂料,粘合剂,油墨等。制备的交联材料表现出广泛的降解时间,质量损失曲线和机械性能。 因此,可以调整材料的性质以达到期望的用途。 制备交联聚(β-氨基酯)文库的高通量方法允许快速筛选和设计可降解聚合物用于各种应用。
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公开(公告)号:US08637028B2
公开(公告)日:2014-01-28
申请号:US13123888
申请日:2009-10-09
申请人: Frank Alexis , Matteo Iannacone , Jinjun Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
发明人: Frank Alexis , Matteo Iannacone , Jinjun Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
IPC分类号: A61K39/40 , A61K39/395 , A61K49/04
CPC分类号: A61K9/14 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/0002 , A61K39/002 , A61K39/05 , A61K39/08 , A61K39/12 , A61K39/39 , A61K45/06
摘要: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
摘要翻译: 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供包含免疫表面和免疫刺激部分的纳米载体。 在一些实施方案中,免疫刺激部分是佐剂。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计,制造和使用本发明的纳米载体及其药物组合物的方法。
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14.
公开(公告)号:US20130302401A1
公开(公告)日:2013-11-14
申请号:US13819280
申请日:2011-08-26
IPC分类号: C08G73/02 , C09D179/02
CPC分类号: C08G73/0206 , A61K9/1273 , A61K31/7088 , A61K47/34 , A61K47/59 , A61L31/10 , C08G59/22 , C08G59/306 , C08G59/50 , C08G73/02 , C09D5/1637 , C09D179/02 , Y10T428/31725
摘要: A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.
摘要翻译: 使用组合聚合制备了一类新的聚(β-氨基醇)(PBAAs)。 本发明的PBAAs可用于生物技术和生物医学应用中,作为涂层(例如用于医疗装置或植入物的膜或多层膜的涂层),添加剂,材料,赋形剂,非生物污垢剂,微图案化剂和细胞包封剂。 当用作表面涂层时,这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。 这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。 此外,在皮下植入羧化聚苯乙烯微粒之后,这些涂层减少了炎性细胞的募集,并减少了纤维化。 这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。 本发明还可以具有许多其他生物学应用,例如抗微生物涂层,DNA或siRNA递送以及干细胞组织工程。
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公开(公告)号:US08557231B2
公开(公告)日:2013-10-15
申请号:US11099886
申请日:2005-04-06
IPC分类号: A61K31/785 , A61K31/765 , C08G69/08
CPC分类号: A61K47/34 , A61K9/5146 , A61K31/711 , A61K31/713 , A61K47/59 , A61K47/593 , A61K47/6929 , B82Y5/00 , C08G63/685 , C08G73/02 , C08G73/0273 , C08G73/06 , C08G73/0611 , C08G73/0616 , C12N15/88
摘要: Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
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公开(公告)号:US20130231412A1
公开(公告)日:2013-09-05
申请号:US13594834
申请日:2012-08-26
申请人: Robert S. Langer , Jeffrey M. Karp , Maria Jose Maio Nunes-Pereira , Ben Ouyang , Lino Da Silva Ferreira , Debanjan Sarkar
发明人: Robert S. Langer , Jeffrey M. Karp , Maria Jose Maio Nunes-Pereira , Ben Ouyang , Lino Da Silva Ferreira , Debanjan Sarkar
IPC分类号: C08G18/42
CPC分类号: C08G18/4236 , C08G18/14 , C08G18/4238 , C08G18/4283
摘要: Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B—)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.
摘要翻译: 除其他之外,本公开提供了用于弹性体交联聚酯材料的组合物和方法。 在一些实施方案中,这种弹性体交联的聚酯材料包含多个通式(-A-B-)p的聚合单元,其中p是大于1的整数; 和多个氨基甲酸酯交联体,其中每个聚合物交联部分彼此共价连接两个聚合物单元,该两个连接的聚合单元在形成交联之前各自具有至少一个游离羟基或氨基。
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公开(公告)号:US20130004522A1
公开(公告)日:2013-01-03
申请号:US13499543
申请日:2010-09-30
IPC分类号: A61K38/08 , C07K17/02 , A61K39/395
CPC分类号: A61K9/0009 , A61K9/5138 , A61K9/5146 , A61K9/5153 , A61K41/0042 , A61K47/6921 , A61K47/6935 , A61N5/0601 , A61N5/062
摘要: The present invention relates, in part, to a novel and simple particulate system that targets and binds any tissue selectively upon light illumination. The particulate system can be used for targeted delivery of substances to predefined cells or tissues in an individual.
摘要翻译: 本发明部分涉及一种新颖且简单的颗粒系统,其在光照射下靶向和结合任何组织。 颗粒系统可用于将物质定向递送到个体中预定的细胞或组织。
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公开(公告)号:US08287849B2
公开(公告)日:2012-10-16
申请号:US12507999
申请日:2009-07-23
IPC分类号: A61K31/765 , A61K9/00 , C08F26/00
CPC分类号: A61K47/34 , A61K9/5146 , A61K31/711 , A61K31/713 , A61K47/59 , A61K47/593 , A61K47/6929 , B82Y5/00 , C08G63/685 , C08G73/02 , C08G73/0273 , C08G73/06 , C08G73/0611 , C08G73/0616 , C12N15/88
摘要: Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
摘要翻译: 描述了从双(仲胺)或伯胺向双(丙烯酸酯)共轭加成制备的聚(&(bgr。 - 氨基酯))。 还提供了从市售的原料制备这些聚合物的方法。 这些含叔胺的聚合物优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。 鉴于这些聚合物的聚(胺)性质,它们特别适用于递送多核苷酸。 已经制备了含有聚合物/多核苷酸复合物的纳米颗粒。 本发明的聚合物也可以用于包封待递送的其它试剂。 考虑到缓冲其周围环境的pH值,它们特别适用于提供不稳定剂。
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19.
公开(公告)号:US08143368B2
公开(公告)日:2012-03-27
申请号:US11722655
申请日:2005-12-22
申请人: Abraham J. Domb , Robert S. Langer
发明人: Abraham J. Domb , Robert S. Langer
IPC分类号: C08G63/54
CPC分类号: A61L29/148 , Y10T428/1352 , Y10T428/2913 , Y10T428/2915 , Y10T428/31786
摘要: Hydrolytically degradable polymers in the form of biodegradable disposable medical devices for use in medicine and laboratories such as syringes, test tubes, catheters, tubing, trays, medical fabrics, and gloves are described. The devices are formed in whole or in part of a hydrolytically degradable polymer. In the preferred embodiment, the devices or structural components thereof degrade in a period of weeks to months, preferably within a year and more preferably within six months of exposure to aqueous solutions. Conventional hydrolytically degradable polymers may be utilized or these may be modified to increase mechanical or processing characteristics, for example, using a polyfunctional branching agent and/or a chain extending agent. In one embodiment, the hydrolytically degradable polymer is a member of a new class of polyesters comprising an aliphatic dicarboxylic acid, an aliphatic diol and optionally, one or more bifunctional fatty acids such as ricinoleic acid and/or castor oil. The devices are prepared using standard techniques, such as by injection molding, extrusion or melt spinning. The devices can be formed entirely of the degradable polymer, or they can be coated with a polymer coating in order to increase the compatibility of and reduce the possibility for interaction between the surface of the device and liquids that may come in contact with the device, or they may include core or other internal structural member formed of either the biodegradable or non-biodegradable material.
摘要翻译: 描述了用于药物和实验室(例如注射器,试管,导管,管道,托盘,医用织物和手套)的可生物降解的一次性医疗装置形式的水解可降解聚合物。 该装置全部或部分形成水解可降解聚合物。 在优选的实施方案中,装置或其结构组分在暴露于水溶液中的几周至数月内,优选在一年内,更优选在六个月内降解。 可以使用常规的可水解降解聚合物,或者这些聚合物可以被改性以增加机械或加工特性,例如使用多官能支化剂和/或扩链剂。 在一个实施方案中,水解可降解聚合物是包含脂族二羧酸,脂族二醇和任选的一种或多种双官能脂肪酸如蓖麻油酸和/或蓖麻油的新类聚酯的成员。 这些装置使用标准技术制备,例如通过注塑,挤出或熔融纺丝。 这些装置可以完全由可降解的聚合物形成,或者它们可以用聚合物涂层涂覆,以增加装置的表面与可能与装置接触的液体之间的相互作用的相容性并降低其相互作用的可能性, 或者它们可以包括由可生物降解或不可生物降解的材料形成的芯或其它内部结构构件。
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公开(公告)号:US20110293703A1
公开(公告)日:2011-12-01
申请号:US13128020
申请日:2009-11-06
申请人: Kerry Peter Mahon , Kevin Thomas Love , Christopher G. Levins , Kathryn Ann Whitehead , Robert S. Langer , Daniel Griffith Anderson
发明人: Kerry Peter Mahon , Kevin Thomas Love , Christopher G. Levins , Kathryn Ann Whitehead , Robert S. Langer , Daniel Griffith Anderson
IPC分类号: A61K9/127 , C07C217/42 , C07C215/18 , C07H21/00 , A61K47/18 , A61K38/02 , A61K31/7088 , A61K31/7105 , C07D295/13 , C07C215/42
CPC分类号: C07D295/13 , A61K9/107 , A61K9/1271 , A61K9/5123 , A61K31/7088 , A61K38/02 , A61K47/16 , A61K47/54 , A61K47/545 , A61K48/0025 , B01J2531/0252 , B01J2531/845 , C07C215/14 , C07C217/08 , C12N15/111 , C12N15/1137 , C12N15/88 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要: Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
摘要翻译: 氨基醇类固醇通过使胺与环氧化物封端的化合物反应来制备。 还提供了从市售的原料制备氨基醇类固醇的方法。 氨基醇类固醇可以由外消旋或立体化学纯环氧化物制备。 氨基醇类固醇或其盐形式优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。 鉴于这些氨基醇类脂质化合物的氨基部分,它们特别适用于递送多核苷酸。 已经制备了含有本发明的类脂和多核苷酸的复合物,胶束,脂质体或颗粒。 本发明的类脂质也可用于制备用于药物递送的微粒。 考虑到缓冲其周围环境的pH值,它们特别适用于提供不稳定剂。
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