Crosslinked, degradable polymers and uses thereof
    12.
    发明授权
    Crosslinked, degradable polymers and uses thereof 有权
    交联的可降解聚合物及其用途

    公开(公告)号:US08808681B2

    公开(公告)日:2014-08-19

    申请号:US11758078

    申请日:2007-06-05

    摘要: Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.

    摘要翻译: 丙烯酸酯封端的聚(β-氨基酯)被交联以形成用于医疗和非医学领域的材料。 将聚合起始材料与自由基引发剂,热引发剂或光引发剂组合,并且根据所使用的引发剂将用于交联的混合物加热或暴露于光。 由于聚合物骨架中的可水解的酯键导致的所得材料在生理条件下是可生物降解的。 这些交联材料特别用作药物递送载体,组织工程支架和制造微型装置。 这些材料也可以用作塑料,涂料,粘合剂,油墨等。制备的交联材料表现出广泛的降解时间,质量损失曲线和机械性能。 因此,可以调整材料的性质以达到期望的用途。 制备交联聚(β-氨基酯)文库的高通量方法允许快速筛选和设计可降解聚合物用于各种应用。

    POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF
    14.
    发明申请
    POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF 有权
    聚(氨基 - 氨基醇),其制备及其用途

    公开(公告)号:US20130302401A1

    公开(公告)日:2013-11-14

    申请号:US13819280

    申请日:2011-08-26

    IPC分类号: C08G73/02 C09D179/02

    摘要: A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.

    摘要翻译: 使用组合聚合制备了一类新的聚(β-氨基醇)(PBAAs)。 本发明的PBAAs可用于生物技术和生物医学应用中,作为涂层(例如用于医疗装置或植入物的膜或多层膜的涂层),添加剂,材料,赋形剂,非生物污垢剂,微图案化剂和细胞包封剂。 当用作表面涂层时,这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。 这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。 此外,在皮下植入羧化聚苯乙烯微粒之后,这些涂层减少了炎性细胞的募集,并减少了纤维化。 这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。 本发明还可以具有许多其他生物学应用,例如抗微生物涂层,DNA或siRNA递送以及干细胞组织工程。

    Biodegradable poly(beta-amino esters) and uses thereof
    18.
    发明授权
    Biodegradable poly(beta-amino esters) and uses thereof 有权
    可生物降解的聚(β-氨基酯)及其用途

    公开(公告)号:US08287849B2

    公开(公告)日:2012-10-16

    申请号:US12507999

    申请日:2009-07-23

    IPC分类号: A61K31/765 A61K9/00 C08F26/00

    摘要: Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

    摘要翻译: 描述了从双(仲胺)或伯胺向双(丙烯酸酯)共轭加成制备的聚(&(bgr。 - 氨基酯))。 还提供了从市售的原料制备这些聚合物的方法。 这些含叔胺的聚合物优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。 鉴于这些聚合物的聚(胺)性质,它们特别适用于递送多核苷酸。 已经制备了含有聚合物/多核苷酸复合物的纳米颗粒。 本发明的聚合物也可以用于包封待递送的其它试剂。 考虑到缓冲其周围环境的pH值,它们特别适用于提供不稳定剂。

    Disposable medical supplies from hydrolytically biodegradable plastics
    19.
    发明授权
    Disposable medical supplies from hydrolytically biodegradable plastics 有权
    水解生物降解塑料的一次性医疗用品

    公开(公告)号:US08143368B2

    公开(公告)日:2012-03-27

    申请号:US11722655

    申请日:2005-12-22

    IPC分类号: C08G63/54

    摘要: Hydrolytically degradable polymers in the form of biodegradable disposable medical devices for use in medicine and laboratories such as syringes, test tubes, catheters, tubing, trays, medical fabrics, and gloves are described. The devices are formed in whole or in part of a hydrolytically degradable polymer. In the preferred embodiment, the devices or structural components thereof degrade in a period of weeks to months, preferably within a year and more preferably within six months of exposure to aqueous solutions. Conventional hydrolytically degradable polymers may be utilized or these may be modified to increase mechanical or processing characteristics, for example, using a polyfunctional branching agent and/or a chain extending agent. In one embodiment, the hydrolytically degradable polymer is a member of a new class of polyesters comprising an aliphatic dicarboxylic acid, an aliphatic diol and optionally, one or more bifunctional fatty acids such as ricinoleic acid and/or castor oil. The devices are prepared using standard techniques, such as by injection molding, extrusion or melt spinning. The devices can be formed entirely of the degradable polymer, or they can be coated with a polymer coating in order to increase the compatibility of and reduce the possibility for interaction between the surface of the device and liquids that may come in contact with the device, or they may include core or other internal structural member formed of either the biodegradable or non-biodegradable material.

    摘要翻译: 描述了用于药物和实验室(例如注射器,试管,导管,管道,托盘,医用织物和手套)的可生物降解的一次性医疗装置形式的水解可降解聚合物。 该装置全部或部分形成水解可降解聚合物。 在优选的实施方案中,装置或其结构组分在暴露于水溶液中的几周至数月内,优选在一年内,更优选在六个月内降解。 可以使用常规的可水解降解聚合物,或者这些聚合物可以被改性以增加机械或加工特性,例如使用多官能支化剂和/或扩链剂。 在一个实施方案中,水解可降解聚合物是包含脂族二羧酸,脂族二醇和任选的一种或多种双官能脂肪酸如蓖麻油酸和/或蓖麻油的新类聚酯的成员。 这些装置使用标准技术制备,例如通过注塑,挤出或熔融纺丝。 这些装置可以完全由可降解的聚合物形成,或者它们可以用聚合物涂层涂覆,以增加装置的表面与可能与装置接触的液体之间的相互作用的相容性并降低其相互作用的可能性, 或者它们可以包括由可生物降解或不可生物降解的材料形成的芯或其它内部结构构件。