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公开(公告)号：US07731907B2
公开(公告)日：2010-06-08
申请号：US11279030
申请日：2006-04-07
申请人： Ilse Ballhorn , Gert Blankenstein , Ralf-Peter Peters , Birgit Mueller-Chorus , Michael Schlueter
发明人： Ilse Ballhorn , Gert Blankenstein , Ralf-Peter Peters , Birgit Mueller-Chorus , Michael Schlueter
IPC分类号： B01L3/02
CPC分类号： B01F13/0059 , B01L3/5025 , B01L3/50273 , B01L2200/0605 , B01L2200/0621 , B01L2300/0806 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , Y10T436/25375 , Y10T436/2575
摘要： A device and a process for testing a sample liquid in which especially the ELISA process can be carried out very easily, rapidly and with high precision. To do this, a sample liquid and a dilution liquid are each supplied to several metering chambers of different volumes, so that the sample liquid can be diluted into assigned reaction chambers in one dilution step in different dilution ratios. Different liquids can be supplied in succession to the reaction chambers by means of a common receiving chamber. The liquids are transferred from the reaction chambers into the assigned test chambers to stop the detection reaction.
摘要翻译： 用于测试样品液体的装置和方法，其中特别是可以非常容易，快速和高精度地进行ELISA过程。 为此，将样品液体和稀释液分别供给到不同体积的多个计量室，使得样品液体可以以不同稀释比在一个稀释步骤中稀释成指定的反应室。 可以通过公共接收室连续地向反应室提供不同的液体。 液体从反应室转移到指定的测试室中以停止检测反应。
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公开(公告)号：US07655189B2
公开(公告)日：2010-02-02
申请号：US11279917
申请日：2006-04-17
申请人： Thomas Willms , Gert Blankenstein
发明人： Thomas Willms , Gert Blankenstein
IPC分类号： B01L3/02
CPC分类号： B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2300/0825 , B01L2300/0887 , B01L2300/089 , B01L2400/0406 , B01L2400/0421 , B01L2400/0424 , B01L2400/0622 , B01L2400/0633 , B01L2400/0644 , B01L2400/065 , B01L2400/0688
摘要： A device and a process for manipulation of a liquid, the ability of a liquid to flow from a first channel section in a second channel section being temporarily stopped by means of a capillary stop before it flows from the first channel section into the second channel section. Control which is accurate in time is easily enabled by the two channel sections being moved relative to one another for bridging or cancelling the capillary stop, especially being brought into contact.
摘要翻译： 一种用于操纵液体的装置和方法，液体从第二通道部分中的第一通道部分流出的能力在从第一通道部分流入第二通道部分之前通过毛细管停止暂时停止 。 通过两个通道部分相对于彼此移动以便桥接或取消毛细管停止部分，特别是与之接触，容易实现时间准确的控制。
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13.发明申请Device for Collecting Blood and Separating Blood Constituents, Method for Separating Blood Constituents and Use of Said Device 有权用于收集血液和分离血液成分的装置，分离血液成分的方法和所述装置的使用公开(公告)号：US20070269893A1
公开(公告)日：2007-11-22
申请号：US11569999
申请日：2005-06-03
CPC分类号： B01L3/502723 , B01L3/502746 , B01L3/502753 , B01L2200/0621 , B01L2200/0684 , B01L2300/0654 , B01L2300/0681 , B01L2300/0825 , B01L2300/0864 , B01L2300/089 , B01L2300/161 , B01L2400/0406 , B01L2400/084 , B01L2400/086 , B01L2400/088 , Y10T436/25375
摘要： The invention relates to a device and a method for collecting blood and separating blood plasma as a liquid sample, by means of a canal that absorbs the liquid sample by capillary forces. The aim of the invention is to obtain a uniform filling of the canal with the liquid sample and an effective separation. To achieve this, deaeration takes place in a transverse direction to the main filling direction or to the longitudinal direction of the canal, immediately downstream of a separation device in an inlet region of the canal.
摘要翻译： 本发明涉及一种用于收集血液并分离作为液体样品的血浆的装置和方法，借助于通过毛细管力吸收液体样品的管道。 本发明的目的是获得用液体样品均匀填充管道并进行有效分离。 为了实现这一点，在运河入口区域的分离装置的紧下游处，沿着主填充方向或管道的纵向在横向上进行脱气。
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公开(公告)号：US20070207548A1
公开(公告)日：2007-09-06
申请号：US11560824
申请日：2006-11-16
申请人： Gert Blankenstein
发明人： Gert Blankenstein
IPC分类号： G01N33/48
CPC分类号： B03C5/028 , B01D57/02 , B01J19/0093 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0647 , B01L2200/0652 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0421 , B01L2400/0424 , B01L2400/043 , B01L2400/0487 , B01L2400/084 , B03C1/035 , B03C5/026 , G01N15/1031 , G01N15/1056 , G01N15/1484 , G01N33/56966 , G01N2015/1006 , G01N2015/1081 , G01N2015/149
摘要： A micro flow system is provided for separating particles, comprising a microfabricated member having a flow channel (5) defined therein for guiding a flow of a fluid containing the particles through the flow channel, first inlet means (2) positioned at one end of the flow channel for entering the fluid into the flow channel, first outlet means (7) positioned at the other end of the flow channel for discharging the fluid from the flow channel, the flow of the fluid containing the particles being controlled in such a way that one particle at the time passes a cross section of the flow channel, the member being positioned in a field that is substantially perpendicular to a longitudinal axis of the flow channel so that particles residing in the flow channel and being susceptible to the field across the flow channel are deflected in the direction of the field. Further, a micro flow system is provided for analyzing components of a fluid comprising a microfabricated member having a flow channel defined therein for guiding a flow of a fluid through the flow channel, first inlet means for entering particles into the flow channel, first outlet means for discharging of fluid from the flow channel and a plurality of assay sites located in the flow channel and comprising immobilized reagents whereby the fluid may be analyzed for a plurality of components while residing in the flow channel.
摘要翻译： 提供微流量系统用于分离颗粒，包括微型构件，其具有限定在其中的流动通道（5），用于引导包含颗粒的流体通过流动通道，第一入口装置（2）位于 用于将流体进入流动通道的流动通道，位于流动通道的另一端的第一出口装置（7），用于从流动通道排出流体，包含颗粒的流体的流动被控制为使得 一个颗粒此时通过流动通道的横截面，该构件定位在基本上垂直于流动通道的纵向轴线的场中，使得位于流动通道中的颗粒易于流过流动的场 通道沿场的方向偏转。 此外，提供了一种微流量系统，用于分析流体的部件，该流体包括具有限定在其中的流动通道的微型构件，用于引导流体流过流动通道，用于将颗粒进入流动通道的第一入口装置，第一出口装置 用于从流动通道排放流体和位于流动通道中的多个测定位点，并且包括固定的试剂，由此可以在流体在流动通道中同时分析多种组分。
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15.发明申请Microstructured separation device, and method for separating liquid components from a liquid containing particles 审中-公开微结构分离装置以及从含有颗粒的液体中分离液体组分的方法公开(公告)号：US20050106756A1
公开(公告)日：2005-05-19
申请号：US10983096
申请日：2004-11-08
申请人： Gert Blankenstein , Claus Marquordt
发明人： Gert Blankenstein , Claus Marquordt
IPC分类号： G01N33/48 , B01F5/06 , B01F13/00 , B01L3/00 , G01N1/28 , G01N33/483 , G01N33/49 , G01N33/543
CPC分类号： G01N1/4077 , B01F13/0059 , B01F2005/0621 , B01F2005/0625 , B01L3/502753 , B01L2200/0668 , B01L2200/10 , B01L2300/0681 , B01L2300/18 , B01L2400/0406 , B01L2400/086
摘要： A microstructured separation device for separating parts of a liquid which comprises liquid components and at least one type of particle and/or at least one complex of interconnected particles of at least one type, with the following features: the device has an inlet for the liquid, a collection section, and a transport path from the inlet to the collection section; the transport path includes, situated one after the other in the direction of transport, a resuspension section, an incubation section, a first separation section for holding back at least some of the complexes and/or for slowing down the movement of at least some of the complexes and/or at least some of the particles, and a second separation section for holding back at least some of the complexes and/or at least some of the particles and/or for slowing down the movement of the particles; and the first separation section and second separation section have a microstructure with one or more microstructure elements.
摘要翻译： 一种用于分离液体部分的微结构分离装置，其包括液体组分和至少一种类型的颗粒和/或至少一种至少一种类型的互连颗粒的复合物，具有以下特征：该装置具有用于液体的入口 ，收集部分和从入口到收集部分的输送路径; 运输路径包括在运输方向上一个接一个地安置重悬部分，孵育部分，用于阻止至少一些复合物的第一分离部和/或用于减缓至少一些复合物的运动 复合物和/或至少一些颗粒，以及用于阻止至少一些复合物和/或至少一些颗粒和/或减缓颗粒运动的第二分离部分; 并且第一分离部分和第二分离部分具有具有一个或多个微结构元素的微结构。
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16.发明授权公开(公告)号：US08916110B2
公开(公告)日：2014-12-23
申请号：US13811729
申请日：2011-07-05
CPC分类号： B01D61/38 , B01L3/502715 , B01L3/502753 , B01L2200/027 , B01L2200/0621 , B01L2300/043 , B01L2300/047 , B01L2300/0681 , B01L2300/0887 , B01L2400/0406 , B01L2400/0633 , B01L2400/0688 , B01L2400/086 , G01N33/491 , G01N33/5302 , G01N33/86 , G01N2021/0346
摘要： A device and a process are proposed for separating constituents of a sample fluid, wherein the sample fluid is supplied by capillary force to a receiving region (7) for metering, stopping or delaying the sample fluid and the sample fluid is pre-treated with a soluble chemical (13) in the receiving region (7) before the sample fluid is supplied to a separating device (5) for separating off constituents of the sample fluid.
摘要翻译： 提出了一种用于分离样品流体的组分的装置和方法，其中样品流体通过毛细管力供应到用于计量，停止或延迟样品流体的接收区域（7），并且样品流体用 在样品流体被供应到分离装置（5）之前，在接收区域（7）中的可溶解化学物质（13），以分离样品流体的组分。
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17.发明授权公开(公告)号：US08580072B2
公开(公告)日：2013-11-12
申请号：US12519293
申请日：2007-12-07
CPC分类号： B81C1/00119 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/0636 , B01L2200/12 , B01L2300/0681 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0406 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B81B2201/058 , Y10T137/8593 , Y10T156/10
摘要： A device for the intake or manipulation of a fluid, in particular, a liquid, and a method for the production of a device of this type in which a flat, non-preformed covering film is laminated onto a carrier, a three-dimensionally shaped or convex chamber wall being formed solely by means of the laminating process. The chamber wall which forms a boundary of a chamber for the fluid is partially deformable. The device is simple to produce and can be used universally.
摘要翻译： 用于吸入或操纵流体，特别是液体的装置，以及用于制造这种类型的装置的方法，其中平坦的未预成型的覆盖膜层压在载体上，三维形状 或凸室壁仅通过层压工艺形成。 形成用于流体的室的边界的室壁是部分可变形的。 该设备生产简单，可以普遍使用。
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公开(公告)号：US20130236985A1
公开(公告)日：2013-09-12
申请号：US13698111
申请日：2011-05-26
申请人： Gert Blankenstein , Dirk Kurowski
发明人： Gert Blankenstein , Dirk Kurowski
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/168 , B82Y15/00 , G01N33/54346 , G01N33/54366 , G01N33/588
摘要： A method and a device for the optical examination of a surface region are proposed. Fluorescence measurement is used to determine the amount of a substance bound to the surface region. Light interference is shut out thanks to the surface region being covered with an optically active liquid which filters, reflects, scatters and/or absorbs light with a wavelength at least substantially corresponding to the light radiated in and/or out.
摘要翻译： 提出了一种用于光学检测表面区域的方法和装置。 使用荧光测量来确定与表面区域结合的物质的量。 由于表面区域被光学活性液体覆盖，所以光干涉被遮挡，该光学活性液体以至少基本对应于辐射入和/或输出的光的波长进行过滤，反射，散射和/或吸收光。
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19.发明申请公开(公告)号：US20130209331A1
公开(公告)日：2013-08-15
申请号：US13811729
申请日：2011-07-05
IPC分类号： B01D61/38
CPC分类号： B01D61/38 , B01L3/502715 , B01L3/502753 , B01L2200/027 , B01L2200/0621 , B01L2300/043 , B01L2300/047 , B01L2300/0681 , B01L2300/0887 , B01L2400/0406 , B01L2400/0633 , B01L2400/0688 , B01L2400/086 , G01N33/491 , G01N33/5302 , G01N33/86 , G01N2021/0346
摘要： A device and a process are proposed for separating constituents of a sample fluid, wherein the sample fluid is supplied by capillary force to a receiving region (7) for metering, stopping or delaying the sample fluid and the sample fluid is pre-treated with a soluble chemical (13) in the receiving region (7) before the sample fluid is supplied to a separating device (5) for separating off constituents of the sample fluid.
摘要翻译： 提出了一种用于分离样品流体的组分的装置和方法，其中样品流体通过毛细管力供应到用于计量，停止或延迟样品流体的接收区域（7），并且样品流体用 在样品流体被供应到分离装置（5）之前，在接收区域（7）中的可溶解化学物质（13），以分离样品流体的组分。
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公开(公告)号：US20130156643A1
公开(公告)日：2013-06-20
申请号：US13583788
申请日：2011-03-14
IPC分类号： G01N33/53
CPC分类号： F16K99/0017 , B01L3/5027 , B01L3/50273 , B01L3/502769 , B01L2200/0647 , B01L2300/0636 , B01L2400/043 , B01L2400/0475 , B01L2400/0688 , G01N33/5304 , G01N33/54326 , G01N33/54366 , Y10T137/2202 , Y10T137/2218 , Y10T137/2224
摘要： A device and a method for manipulating or analysing a liquid sample in a microfluidic channel are proposed. In order to implement an immunoassay, a movable substrate having a binding region is inserted in the channel. The substrate is embodied as a plate-like plastic part and is microstructured in the binding region. It is magnetically movable in the channel and for optical detection can be moved into a gas space.
摘要翻译： 提出了一种用于操纵或分析微流体通道中的液体样品的装置和方法。 为了实现免疫测定，具有结合区域的可移动基板插入通道中。 基板被实施为板状塑料部件，并且在结合区域中被微结构化。 它在通道中是磁性可移动的，并且光学检测可以移动到气体空间中。
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