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公开(公告)号：US11307196B2
公开(公告)日：2022-04-19
申请号：US16098893
申请日：2017-05-11
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Joseph Joel Pollak , Sarah Levy Schreier , Yochay Shlomo Eshel , Amir Zait , Sharon Pecker , Trevor Ruggiero
Abstract: Apparatus and methods are described for determining a property of a biological sample. A sample carrier (22) includes one or more sample chambers (40) that define at least a first region (42) and a second region (44), the height of the one or more sample chambers varying between the first and second regions in a predefined manner. A computer processor (28) receives data relating to a first optical measurement that is performed upon a portion of the sample that is disposed within the first region, receives data relating to a second optical measurement that is performed upon a portion of the sample that is disposed within the second region, and determines the property of the sample by using a relationship between the first optical measurement, the second optical measurement, and the predefined variation in height between the regions. Other applications are also described.
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公开(公告)号：US20210072226A1
公开(公告)日：2021-03-11
申请号：US17082483
申请日：2020-10-28
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Joseph Joel Pollak , Sarah Levy Schreier , Yochay Shlomo Eshel , Amir Zait , Sharon Pecker , Trevor Ruggiero
Abstract: Apparatus and methods are described including placing a sample into a sample carrier that comprises a plurality of regions having upper and lower surfaces, having respective heights that are different from each other, and being configured such that cells form a monolayer, the monolayer within respective regions of the sample carrier having respective, different densities from each other, due to the respective regions of the sample carrier having respective heights that are different from each other. Microscopic images are acquired of each of the plurality of regions. Measurements are performed upon cell types that have a relatively high density upon microscopic images of a region of the sample chamber having a relatively low height, and measurements are performed upon cell types that have a relatively low density upon microscopic images of a region of the sample chamber having a relatively great height. Other applications are also described.
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公开(公告)号：US20200249458A1
公开(公告)日：2020-08-06
申请号：US16851410
申请日：2020-04-17
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Natalie Lezmy , Dan Gluck , Arnon Houri Yafin , Joseph Joel Pollak
Abstract: Apparatus and methods are described including acquiring microscopic images of a blood sample, and identifying deformed red blood cells within the microscopic images. A degree of red blood cell deformity within the sample is determined, at least partially based upon the identified deformed red blood cells. A sample-informative parameter that is indicative of a characteristic of the blood sample as a whole is determined, at least partially based upon the degree of red blood cell deformity within the sample. Other applications are also described.
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公开(公告)号：US20200034967A1
公开(公告)日：2020-01-30
申请号：US16592335
申请日：2019-10-03
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam Yorav-Raphael , Uri Wolfovitz , Joseph Joel Pollak
Abstract: Apparatus and methods are described for use with a digital microscope unit that includes a digital microscope. A biological cell sample disposed within a sample carrier, is received into the digital microscope unit. For at least one imaging field of the biological cell sample, it is determined that, within the imaging field, there is a variation in the focal depth of the biological sample with respect to the microscope. At least one image of the imaging field is captured. A characteristic of the biological sample is determined by analyzing the captured image of the imaging field, the analyzing including, in response to determining that there is a variation in the focal depth of the biological sample with respect to the microscope, accounting for the variation in the focal depth of the biological sample with respect to the microscope. Other applications are also described.
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公开(公告)号：US10482595B2
公开(公告)日：2019-11-19
申请号：US15506997
申请日：2015-08-27
Applicant: S.D. Sight Diagnostics Ltd
Inventor： Noam Yorav-Raphael , Uri Wolfovitz , Joseph Joel Pollak
Abstract: A digital microscopy method, comprising: obtaining data representative of a series of images of at least a portion of a cell sample, the images being captured by performing a depth scan using a digital microscope, the series of images being associated with a series of depth levels of the cell sample, wherein the portion encompasses a mapping field, and the mapping field comprises a plurality of focus analysis regions; and calculating, using the images, a focus configuration for at least two of the focus analysis regions within the mapping field, giving rise to data indicative of focus variations within the mapping field.
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Patent Agency Ranking
公开(公告)号：US20240293812A1
公开(公告)日：2024-09-05
申请号：US18654698
申请日：2024-05-03
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Ido BACHELET , Joseph Joel Pollak , Daniel Levner , Yanatan Bilu , Noam Yorav-Raphael
CPC classification number: B01L3/502715 , G01N15/1433 , G01N21/23 , G01N21/5907 , G01N21/6458 , B01L2300/0816 , B01L2300/0864 , G01N2015/016 , G01N2015/1006 , G01N2021/5957 , G01N2021/6419 , G01N2021/6421 , G06V2201/03 , G06V2201/04
Abstract: Apparatus and methods are described including a digital camera, and a computer processor configured to drive the digital camera to acquire, for each of a plurality of imaging fields of a stained bodily sample, three or more digital images. At least one of the images is a brightfield image and at least two of the images are fluorescent images, each of the fluorescent images being acquired using respective first and second filters, which are different from each other. The computer processor performs image processing on the digital images, by extracting visual classification features from each of the three or more digital images, and identifies one or more entities that are contained within the bodily sample, based upon the image processing. Other applications are also described.
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公开(公告)号：US11808758B2
公开(公告)日：2023-11-07
申请号：US17082483
申请日：2020-10-28
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Joseph Joel Pollak , Sarah Levy Schreier , Yochay Shlomo Eshel , Amir Zait , Sharon Pecker , Trevor Ruggiero
CPC classification number: G01N33/50 , G01N21/0303 , G01N21/31 , G01N21/59 , G01N21/64 , G01N2201/0662
Abstract: Apparatus and methods are described including placing a sample into a sample carrier that comprises a plurality of regions having upper and lower surfaces, having respective heights that are different from each other, and being configured such that cells form a monolayer, the monolayer within respective regions of the sample carrier having respective, different densities from each other, due to the respective regions of the sample carrier having respective heights that are different from each other. Microscopic images are acquired of each of the plurality of regions. Measurements are performed upon cell types that have a relatively high density upon microscopic images of a region of the sample chamber having a relatively low height, and measurements are performed upon cell types that have a relatively low density upon microscopic images of a region of the sample chamber having a relatively great height. Other applications are also described.
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公开(公告)号：US11733150B2
公开(公告)日：2023-08-22
申请号：US16088321
申请日：2017-03-23
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo Eshel , Arnon Houri Yafin , Joseph Joel Pollak , Neta Bachar , Annael Marciano , Sarah Levy Schreier
CPC classification number: G01N15/1475 , G01N1/30 , G01N33/49 , G02B21/367 , G01N2015/1006 , G06V20/698
Abstract: Apparatus and methods are described for use with an output device (34), and a blood sample (12) that was drawn from a subject. A microscope system (10) acquires first and second images of the blood sample at respective times. A computer processor (28) determines whether, between acquisitions of the first and second images, there was relative motion between at least one erythrocyte within the sample and at least one entity within the sample, by comparing the first and second images to one another. At least partially in response thereto, the computer processor determines whether the entity is an extra-erythrocytic or an intra-erythrocytic entity, and generates an output on the output device, at least partially in response thereto. Other applications are also described.
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公开(公告)号：US11434515B2
公开(公告)日：2022-09-06
申请号：US16106085
申请日：2018-08-21
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Joseph Joel Pollak , Arnon Houri Yafin , Seth J. Salpeter
Abstract: Apparatus and methods are described including introducing a cell suspension comprising red blood cells into a carrier that is a closed cavity that includes a base surface, via an inlet defined by the carrier. The cells in the cell suspension are allowed to settle on the base surface of the carrier to form a monolayer of cells on the base surface of the carrier. At least one microscope image of at least a portion of the monolayer of cells is acquired. Other applications are also described.
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公开(公告)号：US11295440B2
公开(公告)日：2022-04-05
申请号：US16706159
申请日：2019-12-06
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yuval Greenfield , Yonatan Bilu , Joseph Joel Pollak , Noam Yorav-Raphael
Abstract: Apparatus and methods are described for use with a sample that includes a plurality of red blood cells. A series of images associated with a series of depth levels of the sample are acquired, by performing a depth scan of the sample with a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the sample using the microscope, by identifying that a drop in image contrast occurs at the identified depth level. The sample is imaged using the microscope, by focusing the microscope at an investigative depth level that is based on the identified depth level. Other applications are also described.
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