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    Fluid processing device comprising radial channels
    11.
    发明申请
    Fluid processing device comprising radial channels 审中-公开
    流体处理装置包括径向通道

    公开(公告)号：US20070128652A1

    公开(公告)日：2007-06-07

    申请号：US11648264

    申请日：2006-12-29

    Applicant: Timothy Woudenberg ,  Reid Kowallis

    Inventor： Timothy Woudenberg ,  Reid Kowallis

    IPC: C12Q1/68 ,  C12M1/34

    CPC classification number: B01L3/502753 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502723 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0645 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2400/0409 ,  B01L2400/0421 ,  C12Q1/686 ,  G01N27/44721 ,  G01N27/44782 ,  G01N27/44791 ,  G01N35/00069 ,  C12Q2565/629

    Abstract: The present invention provides, in one aspect, an apparatus that comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i) a proximal end which is linked to the reservoir region, and (ii) a distal end, and preferably (3) for each channel, at least one chamber, and preferably three chambers, linked by a passageway in fluid communication with the distal end of that channel. Preferably, each passageway leads from each chamber in a direction that is initially away from the central reservoir region, whereby centrifugation of the substrate about a central axis that is perpendicular to the channels is effective to disperse liquid from the central reservoir region into the channels and chambers, such that any air bubbles in the chambers, channels, and passageways are forced towards the axis of rotation, when such liquid is present in the central reservoir region.

    Abstract translation: 在一个方面，本发明提供了一种装置，其包括盘形基底，其限定（1）中央储存区域，（2）多个通道，其与中央储存区域基本上径向流体连通并且基本上径向离开， 所述通道彼此共面，并且每个通道具有（i）连接到储存器区域的近端，以及（ii）用于每个通道的远端，优选（3）至少一个室，并且优选地 三个腔室通过与该通道的远端流体连通的通道连接。 优选地，每个通道从最初远离中心储存器区域的方向引导每个室，由此衬底围绕垂直于通道的中心轴的离心有效地将液体从中央储存器区域分散到通道中，并且 当这种液体存在于中央储存区域中时，腔室，通道和通道中的任何气泡被迫朝向旋转轴线。

    Microfluidic devices and methods
    15.
    发明授权
    Microfluidic devices and methods 有权
    微流体装置和方法

    公开(公告)号：US08058630B2

    公开(公告)日：2011-11-15

    申请号：US12688462

    申请日：2010-01-15

    Applicant: Martin Pieprzyk ,  Geoff Facer ,  Timothy Woudenberg ,  Brian Fowler

    Inventor： Martin Pieprzyk ,  Geoff Facer ,  Timothy Woudenberg ,  Brian Fowler

    IPC: G01N21/64

    CPC classification number: G01N1/28 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/16 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0655 ,  B33Y80/00 ,  C12Q1/686 ,  G01N21/05 ,  G01N21/6452 ,  G01N2021/0346 ,  Y10T137/7793 ,  Y10T436/2575

    Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices.

    Abstract translation: 本发明的实施例提供了改进的微流体装置和相关装置，系统和方法。 提供了减少使用微流体装置期间的混合时间的方法。 微流控装置和相关的制造方法具有提高的制造产率。 提供改进的装置和相关系统用于向微流体装置提供受控的压力。 提供了方法和相关的微流体装置，用于在使用过程中减少微流体装置的脱水。 微流控装置和相关方法提供了改进的样品与试剂混合比控制。 微流体装置和系统具有改进的抗压缩夹具压力引起的故障的阻力。 提供了使用微流体装置进行温度控制反应的方法和系统，其减少微流体装置内的冷凝水平。 提供了用于改进微流体装置的荧光成像的方法和系统。

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