公开(公告)号：US10191020B2

公开(公告)日：2019-01-29

申请号：US14713439

申请日：2015-05-15

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

IPC: G01N30/68 ,  F23D14/00 ,  B01D15/40

Abstract: Burner assemblies are configured to deliver decompressed mobile phase of supercritical fluid chromatography systems to the flame of a flame-based detector while providing for improved optimization of analyte response as well as enhanced flame stability during operation.

公开(公告)号：US10151733B2

公开(公告)日：2018-12-11

申请号：US14484350

申请日：2014-09-12

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

IPC: G01N30/84 ,  G01N30/68 ,  G01N27/62

Abstract: The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used.

公开(公告)号：US20180326324A1

公开(公告)日：2018-11-15

申请号：US15948666

申请日：2018-04-09

Applicant: Waters Technologies Corporation

Inventor： Jason F. Hill ,  Michael O. Fogwill ,  Joseph D. Michienzi ,  Joshua A. Shreve ,  Abhijit Tarafder

IPC: B01D15/40 ,  G01N30/60 ,  G01N30/32 ,  B01D15/16

CPC classification number: B01D15/40 ,  B01D15/163 ,  G01N30/32 ,  G01N30/60 ,  G01N30/6039 ,  G01N30/8658 ,  G01N30/8668 ,  G01N30/8672 ,  G01N30/8693 ,  G01N2030/027 ,  G01N2030/8648

Abstract: Methods for transferring a separation procedure from a first chromatographic system to a second one are disclosed that involve substantially matching a pressure profile. In some such methods, a length, an area, and a particle size of a first column in the first system and a flow rate in the first separation procedure are identifiable. Some such methods also involve selecting a combination of a length, an area, and a particle size of a second column in the second system and a flow rate for the second separation procedure. These methods may involve calculating a target length, a target area, or a target particle size for the second column in the second system or a target flow rate for the second separation procedure.

公开(公告)号：US09625428B2

公开(公告)日：2017-04-18

申请号：US14507310

申请日：2014-10-06

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

IPC: G01N7/00 ,  G01N30/38 ,  G01F1/76 ,  G01N1/28 ,  G01N33/00 ,  G01N30/68 ,  G01N1/00 ,  G01N30/32

CPC classification number: G01N30/38 ,  G01F1/76 ,  G01N1/28 ,  G01N30/68 ,  G01N33/0016 ,  G01N2001/002 ,  G01N2030/324 ,  Y02E20/328

Abstract: Methods and apparatus for the modulation of flame gas stoichiometry to a flame-based detector for use in chromatographic separations are presented. As the total mass flow rate of mobile phase entering the flame-based detector changes (e.g., as a result of density programming in the separation), the mass flow rate of combustion gases to the detector are altered in proportion to the amount of mobile phase entering the detector. As a result, flame stability and sensitivity of the detector can be maintained by the methods and apparatus of the present disclosure.

公开(公告)号：US09242192B2

公开(公告)日：2016-01-26

申请号：US14273040

申请日：2014-05-08

Applicant: Waters Technologies Corporation

Inventor： David P. Prentice ,  Russell L. Keene ,  Stanislaw Koziol ,  Joseph D. Michienzi ,  Paul E. Linderson

IPC: B01D15/10 ,  B05B1/02 ,  B01L3/00 ,  G01N30/60 ,  G01N30/72 ,  H01J49/16 ,  G01N27/447 ,  B05B1/00

CPC classification number: B01D15/10 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502753 ,  B01L3/563 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0883 ,  B05B1/00 ,  B05B1/02 ,  G01N27/44791 ,  G01N30/6095 ,  G01N30/72 ,  G01N30/7233 ,  G01N30/724 ,  G01N30/7266 ,  H01J49/167 ,  Y10T137/598 ,  Y10T436/24

Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal.

Abstract translation: 一种用于化学分离的装置包括具有用于输出样品洗脱液的出口孔的微流体衬底，具有用于接收洗脱液的入口的喷雾单元和用于喷射洗脱液的出口以及施力单元。 喷射单元具有限定入口的可变形部分，并且具有低于微流体衬底的弹性模量的弹性模量。 力施加单元（例如弹簧）被设置成推动与基底接触的可变形部分以形成基本上流体密封的密封。

公开(公告)号：US20150122988A1

公开(公告)日：2015-05-07

申请号：US14594644

申请日：2015-01-12

Applicant: Waters Technologies Corporation

Inventor： Joseph D. Michienzi ,  James P. Murphy ,  Dennis DellaRovere

IPC: G01N30/60 ,  B01D15/22 ,  G01N30/72 ,  B01D15/42

CPC classification number: G01N30/6095 ,  B01D15/22 ,  B01D15/424 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0816 ,  B01L2400/0487 ,  G01N30/461 ,  G01N30/606 ,  G01N30/6091 ,  G01N30/7233 ,  G01N30/7266 ,  G01N2030/027 ,  G01N2030/085 ,  G01N2030/8881 ,  Y10T29/49826

Abstract: An apparatus for chemical separations includes a first substantially rigid microfluidic substrate defining a first fluidic port; a second substantially rigid microfluidic substrate defining second fluidic port; and a coupler disposed between the first and second substrates, the coupler defining a fluidic path in fluidic alignment with the ports of the first and second substrates. The coupler includes a material that is deformable relative to a material of the first substrate and a material of the second substrate. The substrates are clamped together to compress the coupler between the substrates and form a fluid-tight seal.

Abstract translation: 一种用于化学分离的装置包括限定第一流体端口的第一基本上刚性的微流体衬底; 限定第二流体端口的第二基本上刚性的微流体衬底; 以及耦合器，设置在所述第一和第二基板之间，所述耦合器限定与所述第一和第二基板的端口流体对准的流体路径。 耦合器包括相对于第一基板的材料和第二基板的材料可变形的材料。 将基板夹在一起以压缩基板之间的耦合器并形成流体密封。

公开(公告)号：US12163934B2

公开(公告)日：2024-12-10

申请号：US17354234

申请日：2021-06-22

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Martin Gilar ,  Joseph D. Michienzi ,  Wade P. Leveille ,  Geoff C. Gerhardt ,  Jeffrey Musacchio ,  Jason F. Hill ,  Sylvain G. Cormier

IPC: G01N30/46 ,  G01N30/02 ,  G01N30/30 ,  G01N30/32 ,  G01N30/72 ,  G01N30/74

Abstract: The exemplary embodiments may provide a collective insulating sleeve for a plurality of chromatography columns or may provide separate insulating sleeve for each of the chromatography columns in a plurality. As a result, column ovens are not needed, and pre-heaters may not be required for each chromatography column in some exemplary embodiments. Thus, parallel column arrangements in the exemplary embodiments may be more compact than conventional arrangements.

公开(公告)号：US12051582B2

公开(公告)日：2024-07-30

申请号：US18468380

申请日：2023-09-15

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  Sylvain Gilles Cormier

IPC: H01J49/00 ,  G01N30/72 ,  H01J49/04 ,  H01J49/16

CPC classification number: H01J49/0495 ,  G01N30/7206 ,  G01N30/7233 ,  H01J49/0009 ,  H01J49/165

Abstract: Exemplary embodiments may deploy a valve that introduces a sample of a calibrant coaxially with flow exiting a source of a mobile phase flow, such as a liquid chromatography (LC) column, on a path to an ion source for the mass spectrometer (MS). The valve may be positioned remotely on a branch that has a junction with the path leading form the source of the mobile phase flow to the ion source. Alternatively, the valve may be positioned in line on the flow path from the source of the mobile phase flow to the ion source of the MS. A novel five port valve design may be employed. With this valve design, a first position of the valve allows a sample loop for the calibrant to be filled. In a second position, the calibrant is added coaxially to the flow from the source of the mobile phase to the MS. In a third position of the valve, diversion of or infusion to a post-source flow is enabled.

公开(公告)号：US20240044852A1

公开(公告)日：2024-02-08

申请号：US18491132

申请日：2023-10-20

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Joseph D. Antocci ,  Jeffrey Musacchio

IPC: G01N30/60

CPC classification number: G01N30/6026 ,  G01N30/6047

Abstract: A clamp assembly includes a rail extending along the length and configured to receive a first fluidic assembly, and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly, the carriage including an actuator and a stop mechanism. The stop mechanism is configured to selectively prevent and allow movement of the carriage relative to the rail. The stop mechanism is configured to be independently operable from the actuator assembly, and the actuator is configured: to move a chromatography column received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column and the first fluidic assembly, and move the second fluidic assembly relative to the carriage body to create a second fluid tight seal between the second fluidic assembly and the chromatography column.

公开(公告)号：US11796516B2

公开(公告)日：2023-10-24

申请号：US17239813

申请日：2021-04-26

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Joseph D. Antocci ,  Jeffrey Musacchio

IPC: G01N30/60

CPC classification number: G01N30/6026 ,  G01N30/6047

Abstract: A clamp assembly includes a rail extending along the length and configured to receive a first fluidic assembly, and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly, the carriage including an actuator and a stop mechanism. The stop mechanism is configured to selectively prevent and allow movement of the carriage relative to the rail. The stop mechanism is configured to be independently operable from the actuator assembly, and the actuator is configured: to move a chromatography column received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column and the first fluidic assembly, and move the second fluidic assembly relative to the carriage body to create a second fluid tight seal between the second fluidic assembly and the chromatography column.