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    CALIBRATION METHOD FOR PHOTOMETRY
    16.
    发明申请
    CALIBRATION METHOD FOR PHOTOMETRY 有权
    用于光度测定的校准方法

    公开(公告)号：US20160097785A1

    公开(公告)日：2016-04-07

    申请号：US14966804

    申请日：2015-12-11

    申请人： Roche Diagnostics Operations, Inc.

    发明人： Martin Horstmann ,  Fridl Lang

    IPC分类号： G01N33/96 ,  G01N21/75 ,  G01J1/02 ,  G01N35/00

    CPC分类号： G01N33/96 ,  G01J1/0295 ,  G01N21/274 ,  G01N21/75 ,  G01N33/487 ,  G01N35/00693 ,  G01N2201/12746 ,  G01N2496/00

    摘要： A method for determining a physical property of a biological sample. The method comprises the steps of: acquiring a set of preliminary calibration signals of a first lot of a reagent using an automatic analyzer with a first photometry module; acquiring a reference set of signals of the first lot of the reagent using a calibration analyzer with a second photometry module; determining a set of module specific components by subtracting the reference set of signals from the preliminary calibration signals; acquiring a lot specific set of signals of a second lot of the reagent using the second photometry module; determining a lot calibration for the first photometry module using the set of module specific components and the lot specific set of signals; acquiring a measurement signal of the biological sample using the first photometry module and the second lot of the reagent; and determining a physical property of the biological sample using the measurement signal and the lot calibration.

    摘要翻译： 一种用于确定生物样品的物理性质的方法。 该方法包括以下步骤：使用具有第一测光模块的自动分析仪获取试剂的第一批次的一组初步校准信号; 使用具有第二测光模块的校准分析仪获取所述第一批试剂的参考信号集; 通过从所述初步校准信号中减去所述参考信号组来确定一组模块特定组件; 使用第二测光模块获取第二批试剂的许多特定信号集合; 使用所述一组模块特定组件和所述特定的信号集来确定所述第一测光模块的批量校准; 使用第一测光模块和第二批试剂获取生物样品的测量信号; 以及使用测量信号和批次校准来确定生物样品的物理性质。

    OXIDIZABLE SPECIES AS AN INTERNAL REFERENCE IN CONTROL SOLUTIONS FOR BIOSENSORS
    17.
    发明申请
    OXIDIZABLE SPECIES AS AN INTERNAL REFERENCE IN CONTROL SOLUTIONS FOR BIOSENSORS 有权
    可氧化物种作为生物传感器控制解决方案的内部参考

    公开(公告)号：US20160091454A1

    公开(公告)日：2016-03-31

    申请号：US14964827

    申请日：2015-12-10

    申请人： Bayer HealthCare LLC

    发明人： Greg P. Beer ,  Huan-Ping Wu

    IPC分类号： G01N27/327 ,  G01N33/487 ,  G01N33/49

    CPC分类号： G01N27/3274 ,  C12Q1/004 ,  G01N33/48707 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  Y10T436/104998

    摘要： Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample.

    摘要翻译： 用于测量生物样品中特别是葡萄糖的分析物存在的电化学仪表的性能的测试包括引入含有预定量的分析物和预定量的内部参考化合物的对照溶液。 选择内部参考化合物使得其以比用于氧化分析物的电位大的电位被氧化，从而使得可以将对照溶液与生物样品区分开。

    MULTIFUNCTIONAL PROTEIN MOLECULAR WEIGHT LADDERS
    18.
    发明申请
    MULTIFUNCTIONAL PROTEIN MOLECULAR WEIGHT LADDERS 有权
    多功能蛋白分子量子梯

    公开(公告)号：US20160084860A1

    公开(公告)日：2016-03-24

    申请号：US14857661

    申请日：2015-09-17

    申请人： LI-COR, INC.

    发明人： NISHA PADHYE ,  Rose Skopp ,  Ying Wang

    IPC分类号： G01N33/96 ,  G01N33/58 ,  C07K7/06

    CPC分类号： G01N33/96 ,  C07K7/06 ,  C07K14/795 ,  C12Q1/28 ,  G01N33/581 ,  G01N33/582 ,  G01N2333/908 ,  G01N2550/00

    摘要： Multifunctional molecular weight protein ladders and methods of making thereof are disclosed herein that are useful for determining the molecular weight of a test protein and/or the relative mass or amount of the test protein in a protein separation assay, such as gel electrophoresis or western blotting. Also included are compounds of Formula I (e.g., mono acetylated MP-11 NHS ester) that may be used to label purified proteins of the protein ladder. The MP-11 label protein ladder can be detected on a blotting membrane by exposing the microperoxidase to a suitable substrate, such as a chromogenic substrate or a chemiluminescent substrate.

    摘要翻译： 本文公开了多功能分子量蛋白质梯子及其制备方法，其可用于测定蛋白质分离测定（例如凝胶电泳或western印迹法）中测试蛋白质的分子量和/或测试蛋白质的相对质量或量 。 还包括可用于标记蛋白质梯度蛋白的式I化合物（例如，单乙酰化MP-11NNS酯）。 通过将微过氧化物酶暴露于合适的底物例如显色底​​物或化学发光底物，可以在印迹膜上检测MP-11标记蛋白梯度。

    Stimulated cell standards
    20.
    发明授权
    Stimulated cell standards 有权
    刺激电池标准

    公开(公告)号：US09267956B2

    公开(公告)日：2016-02-23

    申请号：US13003661

    申请日：2009-07-09

    申请人： Richard John Stebbings

    发明人： Richard John Stebbings

    IPC分类号： G01N33/96

    CPC分类号： G01N33/96

    摘要： Methods for producing stimulated, positive and negative control reference standard for monitoring intracellular cytokine levels and cytokine release in test samples by stimulating cells to produce cytokines in the presence of a cytokine release inhibitor, fixing the stimulated cells with a fixative such as paraformaldehyde, washing to remove excess fixatives and freeze-drying the stimulated, fixed cells. Methods for producing labeled reference standards for cell proliferation assays are also disclosed, in which proliferation-competent mammalian cells, isolated from a human or animal body are labeled with a label, such as a dye, that is divided between daughter cells during cell proliferation (e.g., carboxyfluorescein succinimidyl ester), the cells are stimulated to proliferate, the proliferated cells are fixed by addition of a fixative and then preserved by freeze drying or cryopreservation.

    摘要翻译： 用于产生用于通过刺激细胞在细胞因子释放抑制剂存在下产生细胞因子的细胞内细胞因子水平和细胞因子释放来监测细胞内细胞因子水平和细胞因子释放的方法，用固定剂如多聚甲醛固定刺激的细胞，洗涤至 去除多余的固定剂并冷冻干燥受刺激的固定细胞。 还公开了用于产生细胞增殖测定的标记参考标准的方法，其中从人或动物体分离的增殖能力的哺乳动物细胞用细胞增殖期间在子细胞之间划分的标记（例如染料）进行标记（ 例如羧基荧光素琥珀酰亚胺酯），刺激细胞增殖，通过加入固定剂固定增殖的细胞，然后通过冷冻干燥或冷冻保存来保存细胞。