公开(公告)号：US20170160299A1

公开(公告)日：2017-06-08

申请号：US15436051

申请日：2017-02-17

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans Schneider ,  Christian Riether

IPC: G01N35/04 ,  B65G54/02

CPC classification number: G01N35/04 ,  B65G54/02 ,  G01N2035/0477 ,  H01F5/04 ,  H01F7/206 ,  H05K3/325 ,  H05K2201/1003 ,  H05K2201/10189 ,  H05K2201/10424 ,  H05K2201/10962

Abstract: A laboratory sample distribution system and to a laboratory automation system comprising a printed circuit board arrangement and a coil are presented. The printed circuit board arrangement and the coil are configured such that assembly and maintenance of the laboratory automation system are greatly simplified.

公开(公告)号：US20170145047A1

公开(公告)日：2017-05-25

申请号：US15425329

申请日：2017-02-06

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus-Peter Stengele

IPC: C07H19/20 ,  C07D207/16 ,  C07D231/12 ,  C07K1/04 ,  C07H19/10 ,  C07H19/16 ,  C07K7/08 ,  C07C323/19 ,  C07H19/06

CPC classification number: C07H19/20 ,  C07C319/14 ,  C07C323/19 ,  C07C323/32 ,  C07D207/16 ,  C07D213/70 ,  C07D231/12 ,  C07D235/28 ,  C07H1/00 ,  C07H19/02 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07K1/04 ,  C07K7/08 ,  Y02P20/55

Abstract: The present disclosure relates to photoactivable protecting groups containing a diarylsulfide chromophore, a method for the synthesis thereof and their use as photoactivable protecting groups using maskless photolithography based array synthesis.

公开(公告)号：US09623440B2

公开(公告)日：2017-04-18

申请号：US13747667

申请日：2013-01-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Wolfgang Hofmann ,  Taghi Noormofidi ,  Doris Zahrl

IPC: B05D5/00 ,  B01L3/00 ,  G01N33/543

CPC classification number: B05D5/00 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0627 ,  B01L2300/161 ,  G01N33/54393

Abstract: A method for at least partially applying a hydrophilic polymer to a measurement channel of a sensor cartridge is provided, which sensor cartridge can be replaceably inserted in an analyzer. The measurement channel comprises at least one sensor element. The method comprises inserting the sensor cartridge into the analyzer, introducing an aqueous solution containing chitosan or a chitosan derivative into the measurement channel of the sensor cartridge, and following a residence time replacing the aqueous chitosan solution with a gaseous or liquid medium, wherein residues of the chitosan or chitosan derivatives remain on the inside surface of the measurement channel and hydrophilize the surface.

公开(公告)号：US20170101272A1

公开(公告)日：2017-04-13

申请号：US15276148

申请日：2016-09-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudio Cherubini ,  Andreas Drechsler ,  Reto Huesser ,  Nenad Milicevic ,  Gottlieb Schacher

IPC: B65G33/04 ,  B65G33/06

CPC classification number: B65G33/04 ,  B65G33/06 ,  B65G2201/0261 ,  G01N35/04 ,  G01N2035/0406 ,  G01N2035/0465 ,  G01N2035/0487

Abstract: A conveyor device for conveying test tube holders in a laboratory distribution system is presented. The conveyor device is a screw conveyor device comprising a helical track having a helix axis and a drive shaft having an axis of rotation parallel or coaxial to the helix axis, which drive shaft is adapted to be driven to rotate about the axis of rotation for causing a movement of one test tube holder or a plurality of test tube holders contacting the helical track between an entry region and an exit region. The entry region and the exit region are spaced in a direction of the helix axis. A laboratory distribution system for conveying test tube holders and a laboratory automation system comprising a laboratory distribution system are also presented.

公开(公告)号：US20170096307A1

公开(公告)日：2017-04-06

申请号：US15272792

申请日：2016-09-22

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Mohammadreza Mahmudimanesh ,  Achim Sinz

IPC: B65G54/02 ,  B65G43/00 ,  B65G19/02

CPC classification number: B65G54/02 ,  B65G19/02 ,  B65G43/00 ,  G01N35/04 ,  G01N2035/0465 ,  G01N2035/0477 ,  G01N2035/0491 ,  G01N2035/0493

Abstract: A method of configuring a laboratory automation system is presented. The position of a laboratory station is detected automatically. A laboratory sample distribution system and a laboratory automation system adapted to perform such a method are also presented.

公开(公告)号：US20170095811A1

公开(公告)日：2017-04-06

申请号：US15352672

申请日：2016-11-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke

IPC: B01L3/00 ,  G01N35/10 ,  G01N1/38 ,  G01N35/00

CPC classification number: B01L3/50273 ,  B01L3/502723 ,  B01L3/502738 ,  B01L2200/04 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  B01L2400/0694 ,  G01N1/38 ,  G01N35/00069 ,  G01N35/1016 ,  G01N2035/00247 ,  G01N2035/00257 ,  G01N2035/1032 ,  G01N2035/1034

Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.

公开(公告)号：US20170082639A1

公开(公告)日：2017-03-23

申请号：US15358779

申请日：2016-11-22

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Georg Hess ,  Andrea Horsch ,  Dietmar Zdunek

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/6872 ,  G01N33/74 ,  G01N2333/47 ,  G01N2333/475 ,  G01N2800/347 ,  G01N2800/56

Abstract: Systems, kits, and methods for predicting the risk of an adverse event related to acute kidney injury AKI as a consequence of a surgical intervention in a subject. Embodiments of the system and methods include means and steps for determining an amount of liver-type fatty acid binding protein (L-FABP) in a sample, such as a urine-sample of a subject; comparing the amounts of the L-FABP with a reference amount, and predicting the risk of an adverse event related to acute kidney injury as a consequence of surgical intervention in the subject.

公开(公告)号：US20170082578A1

公开(公告)日：2017-03-23

申请号：US15366695

申请日：2016-12-01

Applicant: Roche Diagnostics Operations, Inc. ,  Owlstone Medical Limited

Inventor： Uwe Kobold ,  Roland Thiele ,  Noah Weiss ,  Lauren Brown

IPC: G01N27/62 ,  H01J49/00 ,  G01N33/487

CPC classification number: G01N27/624 ,  G01N33/487 ,  G01N33/82 ,  H01J49/0031

Abstract: A method of quantifying the amount of at least two analytes A1 and A2 involving (a) adding at least one salt (S) to at least a portion (P1) of the sample comprising the at least two analytes A1 and A2, (b) ionizing at least a portion of the sample according to (a) thereby forming an analyte flow comprising the analytes A1 and A2 in ionized form, (c) separating the ionized analytes A1 and A2 from each other by using at least one ion mobility separator (124), wherein the analyte flow according to (b) at least partially passes through the ion mobility separator (124), and (d) quantifying the amount of the separated ionized analytes obtained according to (c), wherein A1 is a pharmaceutically active compound C or derivative thereof and A2 is a metabolite or stereoisomer of C.

公开(公告)号：US20170074892A1

公开(公告)日：2017-03-16

申请号：US15359674

申请日：2016-11-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dirk Block ,  Roberto Latini ,  Serge Masson ,  Ursula-Henrike Wienhues-Thelen ,  Christian Zaugg ,  Andre Ziegler

IPC: G01N33/68

CPC classification number: G01N33/6887 ,  G01N33/6869 ,  G01N33/6893 ,  G01N2333/4712 ,  G01N2333/4737 ,  G01N2333/4745 ,  G01N2333/5412 ,  G01N2333/58 ,  G01N2800/326 ,  G01N2800/52

Abstract: The present invention relates to a method for diagnosing a recent paroxysmal atrial fibrillation. The method is based on the determination of the at least one marker selected from the group consisting of a cardiac Troponin, NT-proBNP (N-terminal prohormone of brain natriuretic peptide), hsCRP, IL-6 (Interleukin-6) and IGFBP7 (Insulin like growth factor binding protein 7) in a sample from the subject, and on the comparison of the, thus, determined amount(s) with a reference amount (reference amounts). Further, the present invention relates to a method for identifying a subject being treatable with anticoagulation therapy. Further envisaged are systems, reagents and kits used in performing the methods disclosed herein.

Abstract translation: 本发明涉及一种诊断近期阵发性房颤的方法。 该方法基于选自心肌肌钙蛋白，NT-proBNP（脑钠尿肽的N-末端激素原），hsCRP，IL-6（白细胞介素-6）和IGFBP7（ 来自受试者的样品中的胰岛素样生长因子结合蛋白7），以及由此确定的量与参考量（参考量）的比较。 此外，本发明涉及用抗凝治疗来鉴别受治疗者的方法。 进一步设想的是用于执行本文公开的方法的系统，试剂和试剂盒。

公开(公告)号：US20170067926A1

公开(公告)日：2017-03-09

申请号：US15254105

申请日：2016-09-01

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Meyberg

IPC: G01N35/00 ,  B01L3/00

CPC classification number: G01N35/00722 ,  B01L3/0237 ,  B01L9/54 ,  B01L9/56 ,  G01N35/00623 ,  G01N35/1002 ,  G01N35/1011 ,  G01N35/1016 ,  G01N2035/009 ,  G01N2035/0091

Abstract: A laboratory analyzer for manually handling a plurality of reagents is disclosed. The laboratory analyzer comprises a computing device comprising a display for displaying a workflow of a pipetting process comprising a plurality of method steps to an operator, a pipette for pipetting reagents connected to the computing device, a plurality of compartments for receiving a plurality of reagents vessels including reagents to be pipetted by the pipette, and a camera connected to the computing device. The camera is adapted to acquire data from a vision analysis of at least the plurality of compartments during manually carrying out a pipetting process by the operator according to the workflow. The computing device is adapted to compare the data to target data correlated to the plurality of method steps of the workflow. Further, a method for operating a laboratory analyzer for manually handling a plurality of reagents is disclosed.

Abstract translation: 公开了用于手动处理多种试剂的实验室分析仪。 实验室分析仪包括计算装置，该计算装置包括用于显示移液过程的工作流程的显示器，其包括向操作者提供的多个方法步骤，用于移液器的移液器，用于连接到计算装置的试剂，多个隔室，用于容纳多个试剂容器 包括由移液管吸移的试剂和连接到计算装置的照相机。 在根据工作流程手动执行操作者的移液过程期间，照相机适于从至少多个隔室的视觉分析中获取数据。 计算设备适于将数据与与工作流程的多个方法步骤相关的目标数据进行比较。 此外，公开了一种操作用于手动处理多种试剂的实验室分析仪的方法。