公开(公告)号：US09562919B2

公开(公告)日：2017-02-07

申请号：US14294197

申请日：2014-06-03

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Tom Lorenzen ,  Reto Andrin Meier

IPC: B65G65/32 ,  G01N35/04

CPC classification number: G01N35/04 ,  G01N2035/0406 ,  G01N2035/0462 ,  G01N2035/0465

Abstract: An apparatus for handling sample tubes is presented. The apparatus comprises a sample tube tray, a sample tube individualizer, a first conveyor, a second conveyor, a sample tube buffer, and a sample tube rack inserter. The sample tube tray stores sample tubes in bulk commodity. The sample tube individualizer sequentially unloads single sample tubes from the sample tube tray and sequentially provides the unloaded sample tubes to the first conveyor. The first conveyor conveys the sample tubes to the sample tube buffer. The sample tube buffer buffers the sample tubes provided by the first conveyor and provides buffered sample tubes to the second conveyor with a predeterminable, constant, sample tube rate. The second conveyor conveys the sample tubes to the sample tube rack inserter. The sample tube rack inserter inserts the sample tubes into a sample tube rack.

Abstract translation: 提出了一种处理样品管的设备。 该装置包括样品管托盘，样品管分离器，第一输送器，第二输送器，样品管缓冲器和样品管架插入器。 样品管托盘以大宗商品存储样品管。 样品管分离器顺序地从样品管盘中卸载单个样品管，并且将未加载的样品管依次提供给第一输送机。 第一个输送机将样品管传送到样品管缓冲液。 样品管缓冲液缓冲由第一输送机提供的样品管，并以可预定的，恒定的样品管速度将缓冲的样品管提供给第二输送机。 第二个输送器将样品管传送到样品管架插入器。 样品管架插入器将样品管插入样品管架。

公开(公告)号：US20170010283A1

公开(公告)日：2017-01-12

申请号：US15274533

申请日：2016-09-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Johann Karl ,  Ursula-Henrike Wienhues-Thelen ,  Dirk Block ,  Christian Zaugg ,  Hans-Peter Brunner ,  James Januzzi ,  Andre Ziegler ,  Julian Braz ,  Thomas Dieterle ,  Edelgard Kaiser

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/6887 ,  G01N2333/47 ,  G01N2800/325

Abstract: The present invention relates to a method for diagnosing and/or grading diastolic dysfunction or at least one structural or functional abnormality associated with diastolic dysfunction. The method comprises measuring the level of IGFBP7 (Insulin like growth factor binding protein 7) and, optionally, the level of at least one further marker in a patient suffering from heart failure, and comparing the level to a reference level. Further envisaged is a method of monitoring diastolic function in a patient suffering from heart failure. Also encompassed by the present invention are kits and devices adapted to carry out the method of the present invention.

Abstract translation: 本发明涉及一种用于诊断和/或分级舒张功能障碍或与舒张功能障碍相关的至少一种结构或功能异常的方法。 该方法包括测量患有心力衰竭的患者中IGFBP7（胰岛素样生长因子结合蛋白7）的水平和任选地至少一个其他标记物的水平，并将该水平与参考水平进行比较。 进一步设想的是监测患有心力衰竭的患者的舒张功能的方法。 本发明还包括适用于实施本发明方法的试剂盒和装置。

公开(公告)号：US20170000396A9

公开(公告)日：2017-01-05

申请号：US13958404

申请日：2013-08-02

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Arnulf Staib ,  Reinhold Mischler ,  Martin Hajnsek ,  Harvey Buck ,  Walter Jernigan

IPC: A61B5/1486

CPC classification number: A61B5/14865 ,  A61B5/14532

Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.

Abstract translation: 提供体内电流传感器用于测量体液中分析物的浓度。 传感器包括对电极和工作电极，并且工作电极包括通常为水可渗透并且布置在与接触垫相邻的支撑构件上的感测层。 感测层包含能够在分析物存在下催化作用以产生电信号的固定化酶。 感测层具有面向体液的上表面和背离体液的下表面，并且固定化酶分布在感测层内，使得上下表面中间的酶浓度为 至少与感测层的上表面一样高。

公开(公告)号：US09535073B2

公开(公告)日：2017-01-03

申请号：US13713719

申请日：2012-12-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Georg Hess ,  Andrea Horsch ,  Dietmar Zdunek

IPC: G01N33/68 ,  G01N33/74

CPC classification number: G01N33/6893 ,  G01N33/6872 ,  G01N33/74 ,  G01N2333/47 ,  G01N2333/475 ,  G01N2800/347 ,  G01N2800/56

Abstract: Systems, kits, and methods for predicting the risk of an adverse event related to acute kidney injury AKI as a consequence of a surgical intervention in a subject. Embodiments of the system and methods include means and steps for determining an amount of liver-type fatty acid binding protein (L-FABP) in a sample, such as a urine-sample of a subject; comparing the amounts of the L-FABP with a reference amount, and predicting the risk of an adverse event related to acute kidney injury as a consequence of surgical intervention in the subject.

Abstract translation: 用于预测与受试者的外科手术相关的急性肾损伤AKI有关的不良事件风险的系统，试剂盒和方法。 该系统和方法的实施方案包括用于测定样品（例如受试者的尿液样品）中肝型脂肪酸结合蛋白（L-FABP）的量的方法和步骤; 将L-FABP的量与参考量进行比较，并且预测与受试者的外科手术相关的与急性肾损伤有关的不良事件的风险。

公开(公告)号：US09534951B2

公开(公告)日：2017-01-03

申请号：US14426590

申请日：2013-09-05

Applicant: JENOPTIK Polymer Systems GmbH ,  Roche Diagnostics Operations, Inc.

Inventor： Jan Buchwald ,  Susanne Gaumitz ,  Stefan Kalveram ,  Sebastian Trick

IPC: H01L25/16 ,  G01J1/04 ,  G01N21/47 ,  G02B5/20 ,  H01L31/167 ,  C23C14/22 ,  G01J1/42

CPC classification number: G01J1/0411 ,  C23C14/22 ,  C23C14/221 ,  G01J1/42 ,  G01N21/474 ,  G01N2201/0633 ,  G02B5/20 ,  H01L25/167 ,  H01L31/167 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A measuring module for remission photometric analysis of one or a plurality of specimens is provided with the following features: a transmitter with a transmission channel for transmitting a measuring radiation to location of the specimen; a first focusing device for focusing the measuring radiation on the specimen; a receiver with a receiving channel to receive the radiation reflected by the specimen; a second focusing device made of plastic for focusing the measuring radiation reflected by the specimen onto the receiver, whereby the second focusing device further comprises a filter which is designed to filter a fluorescence radiation from the specimen excited by the measuring radiation.

Abstract translation: 一个或多个样本的光度测量分析测量模块具有以下特征：具有传输通道的发射器，用于将测量辐射传输到试样的位置; 用于将测量辐射聚焦在样本上的第一聚焦装置; 接收器，具有用于接收由样本反射的辐射的接收通道; 由塑料制成的第二聚焦装置，用于将由样品反射的测量辐射聚焦到接收器上，由此第二聚焦装置还包括被设计成过滤来自由测量辐射激发的样品的荧光辐射的滤光器。

公开(公告)号：US09534885B2

公开(公告)日：2017-01-03

申请号：US14175141

申请日：2014-02-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Darko Klinec ,  Michael Koehler

IPC: G01B11/14 ,  G01B11/02 ,  G01N33/48 ,  G01N21/13 ,  G01N15/04 ,  G01N15/05 ,  G01F23/292

CPC classification number: G01B11/028 ,  G01F23/2921 ,  G01N15/042 ,  G01N15/05 ,  G01N21/13 ,  G01N33/48 ,  G01N2015/045 ,  G01N2035/0493 ,  G01N2035/1025

Abstract: An apparatus for determining a vertical position of an interface between a first component and a second component comprising different layers in a sample container comprises a first unit comprising a first emitting light, a first optics, and a first detector; a second unit vertically spaced from the first unit comprising a second emitting light, a second optics, and a second detector; a driving unit to move the first unit and the second unit relative to the sample container; a position sensing unit to output a position sensing signal indicative of a vertical position of the sample container; and a vertical position determining unit to calculate the vertical position of the interface.

Abstract translation: 一种用于确定在样品容器中包括不同层的第一部件和第二部件之间的界面的垂直位置的装置包括：第一单元，包括第一发射光，第一光学器件和第一检测器; 与第一单元垂直间隔开的第二单元包括第二发光，第二光学器件和第二检测器; 驱动单元，用于相对于样品容器移动第一单元和第二单元; 位置检测单元，输出表示样品容器的垂直位置的位置感测信号; 以及垂直位置确定单元，用于计算界面的垂直位置。

公开(公告)号：US20160370391A1

公开(公告)日：2016-12-22

申请号：US15249565

申请日：2016-08-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Thomas Meyer ,  Gottlieb Schacher ,  Rolf Sigrist ,  Christian Guzek

IPC: G01N35/00 ,  G01N35/10 ,  G01N35/02 ,  G01N33/86

CPC classification number: G01N35/0092 ,  G01N33/86 ,  G01N35/026 ,  G01N35/1002 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0094 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/115831 ,  Y10T436/2575

Abstract: A method and system for automatic in-vitro diagnostic analysis are described. The method comprises adding a first reagent type and a second reagent type to a first test liquid during a first and second cycle times respectively. The addition of the first reagent type to the first test liquid comprises parallel addition of a second reagent type to a second test liquid during the first cycle time. The addition of the second reagent type to the first test liquid comprises parallel addition of a first reagent type to a third test liquid during the second cycle time, respectively.

公开(公告)号：US20160356795A1

公开(公告)日：2016-12-08

申请号：US15243187

申请日：2016-08-22

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Sascha Antoni ,  Christian Vogl

IPC: G01N33/82

CPC classification number: G01N33/82 ,  G01N2440/00 ,  Y10T436/203332

Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition and the reagent mixture obtained in this manner. The use of the disclosed reagent composition to release vitamin D compounds as well as a kit for detecting a vitamin D compound which contains the reagent composition for releasing vitamin D compounds in addition to common detecting reagents.

公开(公告)号：US09506918B2

公开(公告)日：2016-11-29

申请号：US14673049

申请日：2015-03-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Thomas Fischer ,  Thomas Froehlich ,  Dieter Hendl

IPC: G01N33/543 ,  G01N33/50 ,  C12Q1/68

CPC classification number: G01N33/54306 ,  C12Q1/6823 ,  C12Q1/6834 ,  G01N33/5005 ,  G01N2800/00 ,  C12Q2521/301 ,  C12Q2525/131 ,  C12Q2565/518

Abstract: The present invention relates to a method of specifically releasing a one or more members of a sub-group of objects from an entity, a method of detecting a subject's disease by detecting one or more members of a sub-group of biological entities indicative of the disease and a method of isolating one or more members of a sub-group of objects from a group of objects.

Abstract translation: 本发明涉及一种从实体特异性地释放物体子组的一个或多个成员的方法，通过检测生物实体子组的一个或多个成员来检测受试者的疾病的方法， 疾病和从一组对象中分离对象子组的一个或多个成员的方法。

公开(公告)号：US20160341750A1

公开(公告)日：2016-11-24

申请号：US15153888

申请日：2016-05-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Achim Sinz ,  Namitha Mallikarjunaiah ,  Christoph Pedain

IPC: G01N35/00 ,  G01N35/04

CPC classification number: G01N35/0092 ,  B65G1/137 ,  B65G43/08 ,  G01N35/00584 ,  G01N35/00603 ,  G01N35/026 ,  G01N35/04 ,  G01N2035/0401 ,  G01N2035/0406 ,  G01N2035/0462 ,  G01N2035/0477 ,  G01N2035/0491

Abstract: A method of operating a laboratory automation system is presented. The laboratory automation system comprises a plurality of laboratory stations and a plurality of sample container carriers. The sample container carriers carry one or more sample containers. The sample containers comprise samples to be analyzed by the laboratory stations. The system also comprises a transport plane. The transport plane supports the sample container carriers. The system also comprises a drive. The drive moves the sample container carriers on the transport plane. The method comprises, during an initialization of the laboratory automation system, logically reserving at least one buffer area on the transport plane and, after the initialization of the laboratory automation system, buffering in the at least one buffer area sample container carriers carrying sample containers comprising samples waiting for a result of an analysis. Depending on the result of the analysis, the samples are further processed.

Abstract translation: 提出了一种操作实验室自动化系统的方法。 实验室自动化系统包括多个实验室和多个样品容器载体。 样品容器载体携带一个或多个样品容器。 样品容器包括由实验室进行分析的样品。 该系统还包括运输平面。 运输平面支持样品容器载体。 该系统还包括一个驱动器。 驱动器将样品容器载体移动到运输平面上。 该方法包括在实验室自动化系统的初始化过程中逻辑地保留运输平面上的至少一个缓冲区域，并且在实验室自动化系统初始化之后，缓冲至少一个缓冲区域携带样本容器的样品容器载体， 样品等待分析结果。 根据分析结果，进一步处理样品。