公开(公告)号：US20180193451A1

公开(公告)日：2018-07-12

申请号：US15741225

申请日：2016-06-30

Applicant: OSAKA UNIVERSITY ,  CHUGAI SEIYAKU KABUSHIKI KAISHA

Inventor： Atsushi KUMANOGOH ,  Ryusuke OMIYA ,  Hiroyuki TSUNODA ,  Takeshi BABA ,  Sachiyo SUZUKI ,  Yuri TERANISHI

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/46 ,  C12N15/09

Abstract: Provided is a novel anti-Plexin-A1 agonist antibody that promotes dendritic cell contraction. Also provided is a pharmaceutical composition comprising such an antibody and a pharmaceutically acceptable carrier.

公开(公告)号：US20180178455A1

公开(公告)日：2018-06-28

申请号：US15854051

申请日：2017-12-26

Applicant: HIROTEC CORPORATION ,  OSAKA UNIVERSITY

Inventor： Kiminori Washika ,  Yousuke Kawahito

IPC: B29C65/16 ,  B29C65/00 ,  B32B15/08

Abstract: A direct bonding method of metal and resin comprises a first step where the metal material is subjected to electrolytic treatment by using a carboxylic acid to form a new surface, which is then coated with the carboxylic acid to obtain a carboxylic acid-coated metal material; a second step where the resin material and the carboxylic acid-coated metal material are laminated to form an interface to be bonded; a third step where the interface is heated to Tg of the resin material or higher by heating means to remove water from the interface, the decomposition of the resin material generates a carboxyl group, and the new surface is exposed on the surface of the carboxylic acid-coated metal material by removal of the carboxylic acid; and a fourth step where the interface is cooled below the Tg to form a bonded part by bonding the carboxyl group and the new surface.

公开(公告)号：US20180164480A1

公开(公告)日：2018-06-14

申请号：US15579158

申请日：2016-06-01

Applicant: OSAKA UNIVERSITY

Inventor： Hiroyuki YOSHIDA

IPC: G02B5/30 ,  G02B5/10 ,  G02F1/139 ,  G02B5/02 ,  F21V8/00

CPC classification number: G02B5/3016 ,  G02B5/0252 ,  G02B5/08 ,  G02B5/10 ,  G02B6/0055 ,  G02F1/137 ,  G02F1/1396 ,  G02F2001/133543

Abstract: A liquid crystal element (1) includes helical structures (7). The liquid crystal element (1) has a light incidence surface (13) on which light is incident and a reflective surface (17) which reflects the light coming through the light incidence surface (13). Each helical structure (7) includes structure units (9). Each structure unit (9) includes liquid crystal molecules (11) stacked in a twisted manner to form a helix. A second end (E2) of one structure unit (9) of structure units (9) adjacent to one another in a first direction (A1) serves as a first end (E1) of the other structure unit (9). Directions of orientation of the liquid crystal molecules (11) at the first ends (E1) included in the helical structures (7) are identical. The reflective surface (17) includes at least one of the first ends (E1) included in each helical structure (7). The reflective surface (17) is non-parallel to the light incidence surface (13).

公开(公告)号：US20180153155A1

公开(公告)日：2018-06-07

申请号：US15872157

申请日：2018-01-16

Applicant: TERUMO KABUSHIKI KAISHA ,  OSAKA UNIVERSITY

Inventor： Fumiya OHASHI ,  Shigeru MIYAGAWA ,  Yoshiki SAWA ,  Shigeo MASUDA ,  Satsuki FUKUSHIMA ,  Atsuhiro SAITO

IPC: A01N1/02 ,  G01N33/50 ,  C12N5/077 ,  A61K35/545

CPC classification number: A01N1/0215 ,  A01N1/0221 ,  A61K35/28 ,  A61K35/34 ,  A61K35/545 ,  C12N5/0653 ,  C12N5/0657 ,  C12N5/10 ,  G01N33/5073

Abstract: A method is disclosed for cryopreservation of cardiocytes derived from pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow, the method maintaining the function of the cardiocytes derived from differentiated pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow, and yet reducing the possibility for tumorigenesis of undifferentiated pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow. A method is also disclosed for cryopreservation of cardiocytes derived from pluripotent stem cells or mesenchymal stem cells (derived from adipose tissue or bone marrow, the method including dissociating cells from a cell population which has been induced to differentiate into cardiocytes from pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow.

公开(公告)号：US09974884B2

公开(公告)日：2018-05-22

申请号：US15032082

申请日：2014-10-30

Applicant: OSAKA UNIVERSITY

Inventor： Hiroshi Egusa

IPC: C12N5/00 ,  A61L27/36 ,  A61K35/32 ,  C12N5/074 ,  A61L27/54 ,  A61K38/39 ,  A61K33/06 ,  A61K35/28 ,  A61K35/545 ,  A61L27/12 ,  A61L27/24 ,  C12N5/077 ,  A61L27/38

CPC classification number: A61L27/3683 ,  A61K33/06 ,  A61K35/28 ,  A61K35/32 ,  A61K35/545 ,  A61K38/39 ,  A61L27/12 ,  A61L27/24 ,  A61L27/3633 ,  A61L27/365 ,  A61L27/3691 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/412 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/02 ,  C12N5/0654 ,  C12N5/0696 ,  C12N2500/14 ,  C12N2506/45 ,  C12N2533/54 ,  A61K2300/00

Abstract: Provided is a bone regeneration agent comprising an inactivated cell construct derived from stem cells as a source material, the inactivated cell construct at least containing a mineral and an extracellular matrix. The bone regeneration agent has osteoconductive and osteoinductive abilities, and is inexpensively producible and size-controllable. Also provided is a method comprising the steps of:(1) inducing differentiation of stem cells into mineral-producing cells in agitated culture under the condition of 0.01 to 1.00 Hz to give a cell aggregate at least containing a mineral and an extracellular matrix, or(1′) inducing differentiation of stem cells genetically engineered to overexpress a protein associated with bone formation into mineral-producing cells in agitated or static culture, to give a cell aggregate at least containing a mineral and an extracellular matrix, and (2) inactivating the cell aggregate obtained in the preceding step. The method enables easy production of the above-mentioned bone regeneration agent.

公开(公告)号：US09970003B2

公开(公告)日：2018-05-15

申请号：US14912435

申请日：2014-08-11

Applicant: OSAKA UNIVERSITY

Inventor： Toshihide Yamashita ,  Yasufumi Hayano

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/28 ,  C12N15/113 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/68 ,  A61K39/00

CPC classification number: C12N15/113 ,  A61K39/00 ,  C07K16/18 ,  C12N2310/14 ,  C12N2320/30 ,  C12Q1/68 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/15 ,  G01N33/6872 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2800/2842

Abstract: The present invention provides a screening method for pain suppressors, which method is characterized by using netrin-4 and/or a netrin-4 receptor to select a substance capable of inhibiting downstream signaling from netrin-4. According to the screening method of the present invention, pain suppressors useful as a preventive or therapeutic medicine for pain can be identified. The present invention also provides a pharmaceutical composition for prevention or treatment of pain, which composition comprises, as an active ingredient, a substance capable of inhibiting downstream signaling from netrin-4.

公开(公告)号：US09965849B2

公开(公告)日：2018-05-08

申请号：US15034302

申请日：2014-11-10

Applicant: OSAKA UNIVERSITY ,  BEAMSENSE Co., Ltd.

Inventor： Takashi Suzuki ,  Sueki Baba

IPC: G06K9/00 ,  G06T7/00 ,  G01N23/04 ,  H05K3/34

CPC classification number: G06T7/0008 ,  G01N23/04 ,  G01N2223/401 ,  G01N2223/6113 ,  G01N2223/648 ,  G06T2207/10116 ,  G06T2207/30152 ,  G06T2207/30164 ,  H05K3/3436 ,  H05K2201/10734 ,  H05K2203/162 ,  H05K2203/163 ,  Y02P70/613

Abstract: A void evaluation apparatus in a solder includes an evaluation function calculation unit for calculating a solder evaluation function by using a pixel value pi contained in the voids that is set to 1 and the pixel value pi not contained in the voids is 0 for each pixel constituting an image in the solder, and by using a weight function w(ri), which is maximum at a solder center (ri=0), and is 0 at a maximum radius (ri=r0) for a distance ri from the solder center. The apparatus further has a void evaluation unit for evaluating that the influence of voids is larger as the evaluation function is relatively larger for the each solder. ∑ i = 1 N ⁢ ⁢ w ⁡ ( r i ) ⁢ p i ∑ i = 1 N ⁢ ⁢ w ⁡ ( r i ) × 100 i: pixel number (1−N) pi: pixel value (0 or 1) w(ri): weighting function

公开(公告)号：US20180120299A1

公开(公告)日：2018-05-03

申请号：US15529936

申请日：2015-11-27

Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD. ,  OSAKA UNIVERSITY

Inventor： Takahiro NISHIBU ,  Naoko IMAWAKA ,  Ken NARUSE ,  Rikinari HANAYAMA

IPC: G01N33/50 ,  C07K1/14 ,  C07K17/02 ,  G01N33/543 ,  G01N33/68

Abstract: The invention provides a carrier and a method for obtaining, removing, or detecting extracellular membrane vesicle or virus present in a sample. In particular, the invention provides (a) a carrier (a Tim carrier) on which a protein (a Tim protein), selected from a T-cell immunoglobulin and mucin domain-containing molecule-4 (a Tim-4) protein, a Tim-3 protein, and a Tim-1 protein, is bound; (b) a method for obtaining the extracellular membrane vesicle or the virus in the sample; (c) a method for removing the extracellular membrane vesicle or the virus in the sample; (d) a method for detecting the extracellular membrane vesicle or the virus in the sample; (e) a kit for capturing the extracellular membrane vesicle or the virus, comprising the Tim carrier; and f) a kit for capturing the extracellular membrane vesicle or the virus, comprising a reagent containing the Tim protein and a reagent containing the carrier.

公开(公告)号：US09935419B2

公开(公告)日：2018-04-03

申请号：US15506248

申请日：2015-07-24

Applicant: Mitsuboshi Diamond Industrial Co., LTD. ,  OSAKA UNIVERSITY

Inventor： Masanao Murakami ,  Christian Schaefer ,  Satoshi Hattori ,  Takahisa Hayashi ,  Seiji Shimizu ,  Shigeki Tokita

IPC: H01S3/30 ,  H01S3/094 ,  H01S3/04 ,  H01S3/067 ,  H01S3/0941

CPC classification number: H01S3/094019 ,  H01S3/0405 ,  H01S3/042 ,  H01S3/067 ,  H01S3/06704 ,  H01S3/06733 ,  H01S3/07 ,  H01S3/0804 ,  H01S3/094007 ,  H01S3/094053 ,  H01S3/0941 ,  H01S3/09415 ,  H01S3/1608 ,  H01S3/173

Abstract: In an optical fiber device having a configuration in which an optical fiber is joined to a side surface of another optical fiber, a joint portion is suppressed from reaching a high temperature. The optical fiber device includes a first fluoride fiber, a second fluoride fiber, and a heat dissipation member. The first fluoride fiber guides light. The second fluoride fiber has a first end on or from which light is incident or output and a second end at which an end surface of the second fluoride fiber is obliquely joined to a side surface of the first fluoride fiber.

公开(公告)号：US20180061954A1

公开(公告)日：2018-03-01

申请号：US15687302

申请日：2017-08-25

Applicant: OSAKA UNIVERSITY

Inventor： Heiji WATANABE ,  Takahiro YAMADA ,  Mikito NOZAKI ,  Takuji HOSOI ,  Takayoshi SHIMURA

IPC: H01L29/40 ,  H01L29/20 ,  H01L21/02 ,  H01L21/285

CPC classification number: H01L29/408 ,  H01L21/02241 ,  H01L21/02389 ,  H01L21/02483 ,  H01L21/0254 ,  H01L21/28008 ,  H01L21/28575 ,  H01L29/2003 ,  H01L29/513 ,  H01L29/517

Abstract: A semiconductor device (100) includes a base layer (10), an interface layer (20), and a deposition layer (30). The base layer (10) includes a nitride semiconductor that contains gallium. The interface layer (20) is adjacent to the base layer (10). The interface layer (20) contains gallium oxide. The deposition layer (30) is adjacent to the interface layer (20). The deposition layer (30) has a wider band gap than the interface layer (20). The interface layer (20) preferably has crystallinity. The interface layer (20) preferably contains α-phase Ga2O3.