公开(公告)号：US08775437B2

公开(公告)日：2014-07-08

申请号：US12752149

申请日：2010-04-01

Applicant: Stefan David Weitz ,  Alexander George Gounares ,  Patrick A. Kinsel

Inventor： Stefan David Weitz ,  Alexander George Gounares ,  Patrick A. Kinsel

IPC: G06F7/00

CPC classification number: G06F17/30864

Abstract: Concepts and technologies are described herein for dynamically reranking search results based upon source authority. A search query is received and analyzed. One or more topics are identified in the search query. An authority index is searched to identify authoritative sources for content relating to the identified topic(s). Promoted results corresponding to content generated by the authoritative sources relating to the identified topics are obtained. The promoted results can be presented to an entity requesting the search, or injected into search results. Contribution dimensions associated with the promoted results can be determined, and filters based upon the contribution dimensions can be generated and used by an entity to dynamically manipulate the search results.

Abstract translation: 本文描述了基于源权限动态地重新排列搜索结果的概念和技术。 接收并分析搜索查询。 在搜索查询中标识一个或多个主题。 搜索权限索引以识别与所识别的主题相关的内容的权威来源。 获得对应于与所识别的主题相关的权威来源产生的内容的推荐结果。 推广结果可以呈现给请求搜索的实体，或者注入到搜索结果中。 可以确定与推广结果相关联的贡献维度，并且可以由实体生成和使用基于贡献维度的过滤器来动态地操纵搜索结果。

公开(公告)号：US20130157872A1

公开(公告)日：2013-06-20

申请号：US13692615

申请日：2012-12-03

Applicant: Andrew David Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

Inventor： Andrew David Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

IPC: C12P21/00

CPC classification number: B01F3/0807 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0655 ,  B01F13/0062 ,  B01F13/0071 ,  B01F13/0076 ,  B01J19/0046 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/0052 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00657 ,  B01J2219/00722 ,  B01L3/502746 ,  B01L3/502753 ,  B01L3/502776 ,  B01L3/502784 ,  B01L2200/0636 ,  B01L2200/0673 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0487 ,  C12N15/1058 ,  C12N15/1075 ,  C12P21/00 ,  C12Q1/6874 ,  G01N15/1459 ,  G01N15/1484 ,  G01N2015/149

Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.

公开(公告)号：US08260789B2

公开(公告)日：2012-09-04

申请号：US12752155

申请日：2010-04-01

Applicant: Susan T. Dumais ,  Stefan David Weitz ,  Alexander George Gounares ,  David James Gemmell ,  Paul Yiu

Inventor： Susan T. Dumais ,  Stefan David Weitz ,  Alexander George Gounares ,  David James Gemmell ,  Paul Yiu

IPC: G06F17/30

CPC classification number: G06F17/30867

Abstract: Concepts and technologies are described herein for authority ranking for real time and social search. An authority index configured to store data relating to sources is generated. Data relating to the sources, including an authority value, are generated and stored at the authority index. The authority value may be defined as a function of source, topic, and point of view (“POV”), as well as other data, if desired, and may be determined based upon one or more ranking functions. The ranking functions are determined, and data corresponding to the ranking functions is obtained. Each of the ranking functions may be weighted according to a weighting function, a confidence value or interval, one or more time functions, and/or other methods. The obtained authority value may be used for affecting ranking of search results or for other purposes.

Abstract translation: 这里描述的概念和技术用于实时和社会搜索的权限排名。 生成用于存储与源相关的数据的权限索引。 与源相关的数据（包括权限值）生成并存储在权限索引中。 如果需要，权限值可以被定义为源，主题和观点（“POV”）的函数以及其他数据，并且可以基于一个或多个排序函数来确定。 确定排序函数，并且获得与排序函数对应的数据。 可以根据加权函数，置信度值或间隔，一个或多个时间函数和/或其他方法来对每个排序函数进行加权。 获得的权限值可以用于影响搜索结果的排名或用于其他目的。

公开(公告)号：US20110116993A1

公开(公告)日：2011-05-19

申请号：US12678894

申请日：2008-09-19

Applicant: Yoon Sung Nam ,  Angela Belcher ,  Andrew Magyar ,  Daeyeon Lee ,  Jin-Woong Kim ,  David Weitz

Inventor： Yoon Sung Nam ,  Angela Belcher ,  Andrew Magyar ,  Daeyeon Lee ,  Jin-Woong Kim ,  David Weitz

IPC: B01J8/02 ,  C08K3/22 ,  H01B1/20 ,  C08L33/10 ,  B01L3/00 ,  B82Y99/00

CPC classification number: B01J13/0065 ,  B01F13/0062 ,  B01J13/14 ,  B82B3/00 ,  B82Y30/00 ,  B82Y40/00 ,  Y10S977/70 ,  Y10S977/762 ,  Y10S977/882 ,  Y10S977/902 ,  Y10S977/915 ,  Y10S977/962 ,  Y10T436/11

Abstract: Methods and apparatuses for encapsulating inorganic micro- or nanostructures within polymeric microgels are described. In various embodiments, viruses are encapsulated with microgels during microgel formation. The viruses can provide a template for in situ synthesis of the inorganic structures within the microgel. The inorganic structures can be distributed substantially homogeneously throughout the microgel, or can be distributed non-uniformly within the microgel. The inventive microgel compositions can be used for a variety of applications including electronic devices, biotechnological devices, fuel cells, display devices and optical devices.

Abstract translation: 描述了在聚合物微凝胶内封装无机微结构或纳米结构的方法和装置。 在各种实施方案中，在微凝胶形成期间，病毒用微凝胶包封。 病毒可以提供用于原位合成微凝胶内的无机结构的模板。 无机结构可以基本均匀地分布在整个微凝胶中，或者可以非均匀地分布在微凝胶内。 本发明的微凝胶组合物可用于各种应用，包括电子装置，生物技术装置，燃料电池，显示装置和光学装置。

公开(公告)号：US20090197772A1

公开(公告)日：2009-08-06

申请号：US11665099

申请日：2005-10-12

Applicant: Andrew Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

Inventor： Andrew Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

IPC: C40B30/04 ,  C40B50/00 ,  C40B30/00

CPC classification number: B01F13/0071 ,  B01F3/0807 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0655 ,  B01F13/0076 ,  B01J19/0046 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00599 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01J2219/00853 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01L3/5025 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084 ,  B82Y10/00 ,  B82Y30/00 ,  C07K1/047 ,  C40B40/06 ,  C40B40/10 ,  C40B50/08 ,  G01N2035/1034

Abstract: The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

Abstract translation: 本发明描述了一种合成化合物的方法，包括以下步骤：（a）将两组或多组初级化合物分隔成微胶囊; 使得一部分微胶囊含有两种或更多种化合物; 和（b）通过来自不同组的主要化合物之间的化学反应在微胶囊中形成次级化合物; 其中步骤（a）和（b）中的一个或两个在微流控制下进行; 优选电子微流体控制本发明进一步允许鉴定与生物化学系统的靶组分结合或调节靶的活性并且共分隔成微胶囊的化合物。

公开(公告)号：US20090005254A1

公开(公告)日：2009-01-01

申请号：US11665145

申请日：2005-10-12

Applicant: Andrew Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

Inventor： Andrew Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

IPC: C40B30/00

CPC classification number: G01N33/5432 ,  B01F3/0807 ,  B01F5/0256 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0655 ,  B01F13/0062 ,  B01F13/0071 ,  B01F13/0076 ,  B01F2003/0834 ,  B01F2003/0842 ,  B01J19/0046 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01J2219/00599 ,  B01J2219/00657 ,  B01J2219/00664 ,  B01J2219/00666 ,  B01J2219/00702 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  C12Q1/42 ,  C12Q2563/159 ,  C12Q2565/119 ,  C40B50/08 ,  G01N15/14 ,  G01N21/6428 ,  G01N33/5008 ,  G01N33/5044 ,  G01N33/573 ,  G01N2015/149 ,  G01N2021/6439 ,  G01N2333/916 ,  G01N2500/04 ,  G01N2500/10

Abstract: The invention describes a method for the identification of compounds which bind to a target component of a bio-chemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into micro-capsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

Abstract translation: 本发明描述了用于鉴定与生物化学系统的靶组分结合或调节靶的活性的化合物的方法，包括以下步骤：a）将化合物与靶一起分隔成微胶囊，如 在任何一个微胶囊中只有一个子集表现为多个拷贝; 和b）鉴定结合或调节靶标活性的化合物; 其中在微流控制下进行至少一个步骤。 本发明能够筛选可用作药物开发潜力的大分子谱系。

公开(公告)号：US20070052781A1

公开(公告)日：2007-03-08

申请号：US11221585

申请日：2005-09-08

Applicant: Seth Fraden ,  Darren Link ,  Galder Cristobal-Azkarate ,  Jung Shim ,  David Weitz

Inventor： Seth Fraden ,  Darren Link ,  Galder Cristobal-Azkarate ,  Jung Shim ,  David Weitz

IPC: B41J2/17

CPC classification number: B01L3/502784 ,  B01L3/06 ,  B01L3/502792 ,  B01L2200/0642 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2200/141 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/0487 ,  Y10T156/1093 ,  Y10T436/11 ,  Y10T436/2575

Abstract: The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including microreactors for manipulating fluids and reactions. In some embodiments, structures and methods for manipulating many (e.g., 1000) fluid samples, i.e., in the form of droplets, are described. Processes such as diffusion, evaporation, dilution, and precipitation can be controlled in each fluid sample. These methods also enable conditions within the fluid samples (e.g., concentration) to be controlled. Manipulation of fluid samples can be useful for a variety of applications, including testing for reaction conditions, e.g., in crystallization, chemical, and biological assays.

Abstract translation: 本发明一般涉及微流体结构，更具体地涉及微流体结构和方法，包括用于操纵流体和反应的微反应器。 在一些实施例中，描述了用于操纵许多（例如，1000）流体样品，即液滴形式的结构和方法。 可以在每个流体样品中控制扩散，蒸发，稀释和沉淀等过程。 这些方法还使流体样品中的条件（例如浓度）得以控制。 流体样品的操作可用于各种应用，包括测试反应条件，例如在结晶，化学和生物测定中。

公开(公告)号：US20060078888A1

公开(公告)日：2006-04-13

申请号：US10961695

申请日：2004-10-08

Applicant: Andrew Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

Inventor： Andrew Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

IPC: C12Q1/68

CPC classification number: B01F3/0807 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0655 ,  B01F13/0062 ,  B01F13/0071 ,  B01F13/0076 ,  B01J19/0046 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/0052 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00657 ,  B01J2219/00722 ,  B01L3/502746 ,  B01L3/502753 ,  B01L3/502776 ,  B01L3/502784 ,  B01L2200/0636 ,  B01L2200/0673 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0487 ,  C12N15/1058 ,  C12N15/1075 ,  C12P21/00 ,  C12Q1/6874 ,  G01N15/1459 ,  G01N15/1484 ,  G01N2015/149

Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.

Abstract translation: 本发明描述了一种用于分离编码具有所需活性的基因产物的一种或多种遗传元件的方法，包括以下步骤：（a）将遗传元件分隔成微胶囊; 和（b）分选表达具有所需活性的基因产物的遗传元件; 其中至少一个步骤处于微流控制之下。 本发明能够通过本发明方法的重复诱变和迭代应用来体外进化核酸和蛋白质。

公开(公告)号：US20050221339A1

公开(公告)日：2005-10-06

申请号：US10963044

申请日：2004-10-12

Applicant: Andrew Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

Inventor： Andrew Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

IPC: B01F3/08 ,  B01F5/02 ,  B01F5/06 ,  B01F13/00 ,  B01L3/00 ,  C12Q1/68 ,  C40B50/08 ,  G01N15/14 ,  G01N33/53 ,  G01N33/543 ,  G01N33/555

CPC classification number: G01N33/5432 ,  B01F3/0807 ,  B01F5/0256 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0655 ,  B01F13/0062 ,  B01F13/0071 ,  B01F13/0076 ,  B01F2003/0834 ,  B01F2003/0842 ,  B01J19/0046 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01J2219/00599 ,  B01J2219/00657 ,  B01J2219/00664 ,  B01J2219/00666 ,  B01J2219/00702 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  C12Q1/42 ,  C12Q2563/159 ,  C12Q2565/119 ,  C40B50/08 ,  G01N15/14 ,  G01N21/6428 ,  G01N33/5008 ,  G01N33/5044 ,  G01N33/573 ,  G01N2015/149 ,  G01N2021/6439 ,  G01N2333/916 ,  G01N2500/04 ,  G01N2500/10

Abstract: The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

Abstract translation: 本发明描述了用于鉴定与生物化学体系的靶组分结合或调节靶的活性的化合物的方法，包括以下步骤：a）将化合物与靶一起分隔成微胶囊，使得只有子集 在任何一个微胶囊中以多份拷贝表示; 和b）鉴定结合或调节靶标活性的化合物; 其中在微流控制下进行至少一个步骤。 本发明能够筛选可用作药物开发潜力的大分子谱系。

公开(公告)号：US20050172476A1

公开(公告)日：2005-08-11

申请号：US11024228

申请日：2004-12-28

Applicant: Howard Stone ,  Shelley Anna ,  Nathalie Bontoux ,  Darren Link ,  David Weitz ,  Irina Gitlin ,  Eugenia Kumacheva ,  Piotr Garstecki ,  Willow Diluzio ,  George Whitesides

Inventor： Howard Stone ,  Shelley Anna ,  Nathalie Bontoux ,  Darren Link ,  David Weitz ,  Irina Gitlin ,  Eugenia Kumacheva ,  Piotr Garstecki ,  Willow Diluzio ,  George Whitesides

IPC: B01F3/08 ,  B01F5/06 ,  B01F13/00 ,  B01L3/00 ,  B05B7/04 ,  B01D61/42

CPC classification number: B01L3/5027 ,  B01F3/0807 ,  B01F5/0682 ,  B01F5/0688 ,  B01F13/0062 ,  B01F2215/0431 ,  B01F2215/045 ,  B05B7/0408 ,  B05B7/0416 ,  B05B7/0441 ,  Y10S516/924 ,  Y10S516/927 ,  Y10T29/49002 ,  Y10T137/0324 ,  Y10T137/0329 ,  Y10T137/206 ,  Y10T137/87346 ,  Y10T436/2575

Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.

Abstract translation: 提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。 该装置可以简单地使用简单的技术从容易获得的廉价材料制造。