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公开(公告)号：US06476216B1
公开(公告)日：2002-11-05
申请号：US09051610
申请日：1998-12-03
Applicant: George Just , Zhili Xin , Eric Marsault , Yi Jin , Jianchao Wang
Inventor： George Just , Zhili Xin , Eric Marsault , Yi Jin , Jianchao Wang
IPC: C07H2100
CPC classification number: C07H9/04 , C07F9/1411 , C07F9/65846 , C07H9/06 , C07H19/10 , C07H21/00
Abstract: The present invention is directed to methods for solid phase nucleotide synthesis utilizing substituted imidazole catalysts.
Abstract translation: 本发明涉及使用取代的咪唑催化剂的固相核苷酸合成方法。
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公开(公告)号：US08772507B2
公开(公告)日：2014-07-08
申请号：US13612690
申请日：2012-09-12
Applicant: Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
Inventor： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC: C07D233/64 , C07D231/12 , A61K31/415 , A61K31/4164
CPC classification number: C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
Abstract translation: 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US08163919B2
公开(公告)日：2012-04-24
申请号：US12350114
申请日：2009-01-07
Applicant: Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
Inventor： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC: C07D471/02 , A61K31/4439
CPC classification number: C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
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公开(公告)号：US07989469B2
公开(公告)日：2011-08-02
申请号：US12364394
申请日：2009-02-02
Applicant: Zhe Yang , Scott Collibee , Alex R. Muci , Jianchao Wang , Luke W. Ashcraft , Jeff Gardina , Brian Stoltz , Gustave Bergnes , Bradley P. Morgan
Inventor： Zhe Yang , Scott Collibee , Alex R. Muci , Jianchao Wang , Luke W. Ashcraft , Jeff Gardina , Brian Stoltz , Gustave Bergnes , Bradley P. Morgan
IPC: A61K31/437 , C07D471/04 , A61P25/00
CPC classification number: C07D471/04
Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of neuromuscular disorders, conditions having muscle wasting, claudication, frailty, metabolic syndrome, muscle atrophy associated with disuse, and muscle fatigue, and other indications.
Abstract translation: 提供某些化学实体以及用于调节骨骼肌球蛋白，骨骼肌动蛋白，骨骼原肌球蛋白，骨骼肌钙蛋白C，骨骼肌钙蛋白I，骨骼肌钙蛋白T和骨骼肌（包括其片段和同种型）以及骨骼肌节的使用方法， 和用于治疗神经肌肉疾病的方法，具有肌肉消瘦，跛行，虚弱，代谢综合征，与废用相关的肌肉萎缩和肌肉疲劳的症状以及其他适应症。
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公开(公告)号：US20100069453A1
公开(公告)日：2010-03-18
申请号：US12541015
申请日：2009-08-13
Applicant: Xiangping Qian , Luke W. Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley P. Morgan , David J. Morgans, JR. , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin J. Duffy , Duke Fitch , Rosanna Tedesco
Inventor： Xiangping Qian , Luke W. Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley P. Morgan , David J. Morgans, JR. , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin J. Duffy , Duke Fitch , Rosanna Tedesco
IPC: A61K31/4164 , C07D233/56 , A61P35/00
CPC classification number: C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
Abstract translation: 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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Patent Agency Ranking
公开(公告)号：US20070197481A1
公开(公告)日：2007-08-23
申请号：US11124608
申请日：2005-05-06
Applicant: Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
Inventor： Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC: A61K31/66 , A61K31/538 , A61K31/4172 , A61K31/4745 , A61K31/426 , A61K31/421
CPC classification number: C07D403/12 , A61K31/4172 , A61K31/421 , A61K31/426 , A61K31/4745 , A61K31/538 , A61K31/66 , A61K45/06 , C07C235/48 , C07C235/50 , C07C237/22 , C07C255/44 , C07C255/57 , C07C255/60 , C07C271/28 , C07C2601/14 , C07D207/273 , C07D211/76 , C07D231/12 , C07D235/18 , C07D239/22 , C07D261/08 , C07D271/06 , C07D277/42 , C07D285/12 , C07D295/15 , C07D333/38 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , A61K2300/00
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
Abstract translation: 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20070135435A1
公开(公告)日：2007-06-14
申请号：US11592016
申请日：2006-11-01
Applicant: Xiangping Qian , Jianchao Wang , Gustave Bergnes , Bradley Morgan , David Morgans , Martha Sarpong , Dashyant Dhanak , Steven Knight
Inventor： Xiangping Qian , Jianchao Wang , Gustave Bergnes , Bradley Morgan , David Morgans , Martha Sarpong , Dashyant Dhanak , Steven Knight
IPC: A61K31/5375 , C07D471/02 , A61K31/495 , A61K31/4965 , A61K31/44 , A61K31/4745 , A61K31/4152
CPC classification number: C07D211/26 , C07C229/60 , C07C311/08 , C07C311/21 , C07C2601/02 , C07C2601/14 , C07D207/14 , C07D209/14 , C07D213/40 , C07D213/75 , C07D231/12 , C07D241/12 , C07D265/30 , C07D285/135 , C07D295/13 , C07D307/38 , C07D307/68 , C07D317/58 , C07D333/20 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07F7/1804
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
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公开(公告)号：US20060264630A1
公开(公告)日：2006-11-23
申请号：US11326616
申请日：2006-01-04
Applicant: Zuchun Zhao , Xin Chen , Jianchao Wang , Hongbin Sun , Jack Liang
Inventor： Zuchun Zhao , Xin Chen , Jianchao Wang , Hongbin Sun , Jack Liang
IPC: C07D471/02 , C07D277/62 , C07D215/12 , C07D261/20 , C07D249/16
CPC classification number: C07D207/325 , C07D231/12 , C07D235/18 , C07D239/26 , C07D249/08 , C07D249/20 , C07D261/08 , C07D263/57 , C07D271/06 , C07D277/66 , C07D413/04 , C07D413/12
Abstract: Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion.
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29.发明申请Alpha(trifluoromethyl-substituted aryloxy, arylamino, arylthio or arylmethyl)-trifluoromethyl-substituted phenylacetic acids and derivatives as antidiabetic agents 失效α-（三氟甲基取代的芳氧基，芳基氨基，芳硫基或芳基甲基） - 三氟甲基取代的苯乙酸及其衍生物作为抗糖尿病药公开(公告)号：US20050222213A1
公开(公告)日：2005-10-06
申请号：US11061302
申请日：2005-02-17
Applicant: Zuchun Zhao , Xin Chen , Jianchao Wang , Hongbin Sun , Jack Liang
Inventor： Zuchun Zhao , Xin Chen , Jianchao Wang , Hongbin Sun , Jack Liang
IPC: A61K31/195 , A61K31/41 , A61K31/44 , A61K31/4415 , A61K31/4439 , C07C43/23 , C07C45/41 , C07C45/44 , C07C47/277 , C07C47/55 , C07C51/09 , C07C59/68 , C07C69/007 , C07C69/24 , C07C69/712 , C07C69/736 , C07C205/26 , C07C205/37 , C07C205/38 , C07C229/36 , C07C233/18 , C07C323/62 , C07D213/02 , C07D213/64 , C07D257/02 , C07D257/04
CPC classification number: C07C47/277 , C07B2200/07 , C07C43/23 , C07C45/41 , C07C45/44 , C07C47/55 , C07C51/09 , C07C59/68 , C07C69/007 , C07C69/736 , C07C205/26 , C07C205/37 , C07C205/38 , C07C229/36 , C07C233/18 , C07C323/62 , C07D213/64 , C07D257/04
Abstract: Compounds having a formula: or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.
Abstract translation: 提供具有式：或其药学上可接受的盐或前药的化合物，并且可用于治疗代谢性疾病。
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公开(公告)号：US06861518B2
公开(公告)日：2005-03-01
申请号：US10253981
申请日：2002-09-24
Applicant: George Just , Zhili Xin , Eric Marsault , Yi Jin , Jianchao Wang
Inventor： George Just , Zhili Xin , Eric Marsault , Yi Jin , Jianchao Wang
IPC: C07H21/04 , B01J31/02 , C07F9/141 , C07F9/6584 , C07H9/04 , C07H9/06 , C07H19/10 , C07H21/00 , C12N15/09 , C12Q1/68
CPC classification number: C07H9/04 , C07F9/1411 , C07F9/65846 , C07H9/06 , C07H19/10 , C07H21/00
Abstract: Methods and Intermediates for the Preparation of Oligomers Containing Diastereomerically Enriched Phosphorothioate Linkages are Disclosed.
Abstract translation: 公开了用于制备含有非对映异构的富含硫代磷酸酯连接的低聚物的方法和中间体。
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