公开(公告)号：US20200256853A1

公开(公告)日：2020-08-13

申请号：US16624087

申请日：2018-06-21

Applicant: Laboratoires Expanscience

Inventor： Gaelle BELLEMERE ,  Stephanie BREDIF ,  Gaetan BOYER ,  Caroline BAUDOUIN

IPC: G01N33/50 ,  C12N5/071

Abstract: The present invention relates to models of reconstructed sensitive skin reproducing the features of sensitive skin, as well as to processes for obtaining such models. The present invention further relates to in vitro processes for testing formulations or active ingredients for the prevention or treatment of sensitive skin.

公开(公告)号：US20190234939A1

公开(公告)日：2019-08-01

申请号：US16311378

申请日：2017-06-23

Applicant: Laboratoires Expanscience

Inventor： Caroline BAUDOUIN ,  Stephanie BREDIF

IPC: G01N33/50 ,  C12N5/00 ,  C12N5/071

CPC classification number: G01N33/5064 ,  C12N5/0062 ,  C12N5/0629 ,  C12N2503/06 ,  C12N2513/00 ,  C12Q1/68 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5044 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2800/202 ,  G01N2800/38

Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is affected by atopic dermatitis. Such markers are particularly advantageous in that they allow the skin's response to atopic dermatitis to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of atopic dermatitis on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.

公开(公告)号：US10175230B2

公开(公告)日：2019-01-08

申请号：US14785212

申请日：2014-04-22

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Caroline Baudouin ,  Stephanie Bredif

IPC: G01N33/50 ,  G01N33/68

Abstract: The invention relates to a method for evaluating the effectiveness of an active ingredient selected from C7 avocado sugars, also called avocado perseose, for preventing or treating a deficiency of the skin barrier, said method comprising the determination of the level of expression and/or activation of at least one biological marker, where said biological marker is selected from epidermal maturation markers, lipid barrier markers, hydric regulation markers and stratum granulosum regulation markers.

公开(公告)号：US09952201B2

公开(公告)日：2018-04-24

申请号：US15023882

申请日：2014-09-24

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Caroline Baudouin ,  Stephanie Bredif ,  Philippe Msika

IPC: G01N33/53 ,  G01N33/50 ,  G01N33/68

CPC classification number: G01N33/5023 ,  G01N33/5044 ,  G01N33/6881 ,  G01N2333/4721 ,  G01N2333/5421 ,  G01N2333/545 ,  G01N2333/96486

Abstract: The invention relates to in vitro methods for testing formulations or active ingredients for preventing the harmful effects of UV on children's skin, in particular children aged three or less. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the harmful effects of UV on the skin of children aged three or less, using a skin model specifically capable of reproducing the characteristics of the skin of children of this age.

公开(公告)号：US20160235794A1

公开(公告)日：2016-08-18

申请号：US15023893

申请日：2014-09-25

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Sophie LECLERE-BIENFAIT ,  Stephanie BREDIF ,  Sebastien DEBROCK ,  Sebastien GARNIER

IPC: A61K36/185 ,  A61Q19/08 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/04 ,  A61K9/00 ,  C11B3/12 ,  C11B3/00 ,  C11B3/02 ,  A61K31/20 ,  A61K8/36 ,  A61K31/201 ,  A61K31/202 ,  A61K31/355 ,  A61K8/67 ,  A61K31/56 ,  A61K8/63 ,  A61K31/01 ,  A61K8/31 ,  A61K8/92

CPC classification number: A61K36/185 ,  A23D9/007 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/31 ,  A61K8/361 ,  A61K8/63 ,  A61K8/678 ,  A61K8/922 ,  A61K8/97 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/107 ,  A61K31/01 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  A61K31/355 ,  A61K31/56 ,  A61K2236/55 ,  A61K2800/592 ,  A61K2800/80 ,  A61P17/02 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/007 ,  A61Q19/04 ,  A61Q19/06 ,  A61Q19/08 ,  C11B3/001 ,  C11B3/006 ,  C11B3/02 ,  C11B3/12 ,  A61K2300/00

Abstract: The invention relates to a lipid extract of the seeds of passion fruit, Passiflora incarnata and/or Passiflora edulis, preferably P. edulis, characterised in that said lipid extract is an oil of passion fruit seeds concentrated in its unsaponifiable fraction, containing between 3 wt. % and 100 wt. % of unsaponifiable matter in relation to the total weight of the extract. The invention also relates to a method for preparing such an extract and to a composition comprising said extract, especially for the use thereof in a dermatological or pharmaceutical composition or as a food.

Abstract translation: 本发明涉及西番莲果实的种子的脂质提取物，和西番茄和/或西番莲，其特征在于，所述脂质提取物是浓缩在其不皂化部分中的含有3wt 。 ％和100wt。 关于提取物总重量的不皂化物质的百分比。 本发明还涉及制备这种提取物的方法和包含所述提取物的组合物，特别是用于皮肤病学或药物组合物或作为食物的组合物。

公开(公告)号：US09416333B2

公开(公告)日：2016-08-16

申请号：US14371057

申请日：2013-01-14

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Jacques Legrand ,  Sebastien Garnier

IPC: A01N65/00 ,  C11B1/06 ,  A23L1/30 ,  A61K36/54 ,  A23L1/212 ,  A23D9/007 ,  A23D9/02 ,  C11B1/08 ,  A61Q19/06 ,  A61Q19/08 ,  A61K8/92 ,  A23L2/52

CPC classification number: C11B1/06 ,  A23D9/007 ,  A23D9/02 ,  A23L2/52 ,  A23L19/07 ,  A23L33/105 ,  A23L33/11 ,  A23L33/115 ,  A61K8/922 ,  A61K36/54 ,  A61Q19/06 ,  A61Q19/08 ,  C11B1/08

Abstract: The present invention relates to the use of avocado seeds in order to obtain avocado oil enriched in alkyl polyols and/or acetylated derivatives thereof, said avocado seeds accounting for 10 to 50% by weight relative to the total weight of avocado used. The invention also relates to a method for obtaining avocado oil enriched in alkyl polyols or acetylated derivatives thereof from at least avocado seeds, said avocado seeds accounting for 10 to 50% by weight relative to the total weight of avocado used. The invention also relates to avocado oil enriched in alkyl polyols and/or acetylated derivatives thereof, obtainable by the present method. The invention also relates to the use of avocado oil in order to prepare an avocado oil concentrate enriched in alkyl polyols and/or acetylated derivatives thereof, or to prepare an avocado unsaponifiable enriched in alkyl polyols. Lastly, the invention relates to an avocado unsaponifiable enriched in alkyl polyols or an avocado oil concentrate enriched in alkyl polyols and/or acetylated derivatives thereof, obtainable from said avocado oil, for use as a drug, advantageously in the prevention and/or treatment of conjunctive tissue disorders such as arthrosis, articular pathologies such as rheumatism, or periodontal diseases such as gingivitis or periodontitis.

Abstract translation: 本发明涉及鳄梨种子的使用以获得富含烷基多元醇和/或其乙酰化衍生物的鳄梨油，所述鳄梨种子占所用鳄梨总重量的10至50重量％。 本发明还涉及从至少鳄梨种子获得富含烷基多元醇或其乙酰化衍生物的鳄梨油的方法，所述鳄梨种子占所用鳄梨总重量的10至50重量％。 本发明还涉及通过本方法获得的富含烷基多元醇和/或其乙酰化衍生物的鳄梨油。 本发明还涉及鳄梨油的用途，以制备富含烷基多元醇和/或其乙酰化衍生物的鳄梨油浓缩物，或制备不可皂化的富含烷基多元醇的鳄梨油。 最后，本发明涉及一种不可皂化的富含鳄梨油的富含烷基多元醇的牛油果油或富含其烷基多元醇和/或其乙酰化衍生物的鳄梨油浓缩物，其可从所述鳄梨油获得，有利地用于预防和/或治疗 结膜组织疾病如关节病，关节病变如风湿病，或牙周病如牙龈炎或牙周炎。

公开(公告)号：US20160084822A1

公开(公告)日：2016-03-24

申请号：US14785212

申请日：2014-04-22

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Caroline Baudouin ,  Stephanie Bredif

IPC: G01N33/50

CPC classification number: G01N33/5023 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/6881

Abstract: The invention relates to a method for evaluating the effectiveness of an active ingredient selected from C7 avocado sugars, also called avocado perseose, for preventing or treating a deficiency of the skin barrier, said method comprising the determination of the level of expression and/or activation of at least one biological marker, where said biological marker is selected from epidermal maturation markers, lipid barrier markers, hydric regulation markers and stratum granulosum regulation markers.

Abstract translation: 本发明涉及一种用于评估选自C7鳄梨糖（也称为鳄梨坚果）用于预防或治疗皮肤屏障缺陷的活性成分的有效性的方法，所述方法包括测定表达水平和/或激活 的至少一种生物标志物，其中所述生物标志物选自表皮成熟标志物，脂质屏障标记物，水合调节标记物和颗粒颗粒调节标记物。

公开(公告)号：US20150030550A1

公开(公告)日：2015-01-29

申请号：US14514646

申请日：2014-10-15

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Caroline BAUDOUIN ,  Philippe MSIKA

IPC: A61K8/60 ,  A61K45/06 ,  A61Q7/00 ,  A61Q5/02 ,  A61Q5/00 ,  A23L2/52 ,  A61Q5/12 ,  A61Q5/06 ,  A61K31/7004 ,  A61K36/54 ,  A23L1/164 ,  A61K8/97 ,  A61Q3/00

CPC classification number: A61K8/60 ,  A23L2/52 ,  A23L7/126 ,  A23V2002/00 ,  A61K8/97 ,  A61K9/4858 ,  A61K31/70 ,  A61K31/7004 ,  A61K36/54 ,  A61K45/06 ,  A61K2800/5922 ,  A61K2800/92 ,  A61Q3/00 ,  A61Q5/00 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q7/00 ,  A61K2300/00

Abstract: The present invention relates to a composition including at least one C7 sugar, or derivative from esterification of said sugar, and a pharmaceutically acceptable carrier for treating alopecia. The present invention also relates to a method for cosmetically treating hair and nails, said method being intended to stimulate the growth thereof and/or slow the loss thereof. According to said method, a cosmetic composition including at least one C7 sugar, or derivative from esterification of said sugar, is administered. The present invention finally relates to a method for cosmetic care of hair and/or eyelashes and/or nails.

Abstract translation: 本发明涉及包含至少一种C 7糖或所述糖的酯化衍生物和用于治疗脱发的药学上可接受的载体的组合物。 本发明还涉及一种美发头发和指甲的方法，所述方法旨在刺激其生长和/或减缓其损失。 根据所述方法，施用包含至少一种C 7糖或所述糖的酯化衍生物的化妆品组合物。 本发明最终涉及用于化妆品护理头发和/或睫毛和/或指甲的方法。

公开(公告)号：US20210236574A1

公开(公告)日：2021-08-05

申请号：US17239042

申请日：2021-04-23

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Sophie LECLERE-BIENFAIT ,  Stéphanie BREDIF

IPC: A61K36/185 ,  A61K8/49 ,  A61Q17/04 ,  A61Q19/08 ,  A61Q19/06 ,  A61Q17/00 ,  A61Q19/00 ,  A61K8/9789 ,  A61P17/16 ,  A61P29/00 ,  A61K8/368 ,  A61K31/192 ,  A61K31/353

Abstract: The invention relates to a polyphenolic extract of passion flower seeds, in particular Passiflora incarnata or Passiflora edulis seeds, comprising at least 30 percent by weight polyphenols, expressed as gallic acid equivalent, relative to the weight of the dry extract. The invention also relates to a method for preparing an extract of said type, a composition containing same, and the cosmetic, dermatological or therapeutic use thereof.

公开(公告)号：US11026880B2

公开(公告)日：2021-06-08

申请号：US14652449

申请日：2013-12-18

Applicant: Laboratoires Expanscience

Inventor： Philippe Msika ,  Sophie Leclere-Bienfait ,  Sebastien Debrock ,  Stephanie Bredif ,  Sebastien Garnier

IPC: A61K8/97 ,  A61Q19/08 ,  A61K36/185 ,  A61Q19/06 ,  A61Q17/00 ,  A61K8/60 ,  A61K8/64 ,  A61K45/06 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q7/00

Abstract: The invention relates to a composition comprising an extract of passionflower seeds, and preferentially Passiflora edulis seeds. The composition is advantageously cosmetic, pharmaceutical, dermatological or nutraceutical. The subject matter of the invention is also a process for extracting an extract of passionflower seeds and preferentially Passiflora edulis seeds, and also the extract which can be obtained by means of said process. The invention also relates to such a composition or such an extract for use in the prevention or treatment of disorders or pathological conditions of the skin, of the mucous membranes or of the skin appendages, for use in the prevention or treatment of vascular disorders, for use for combating oxidative stress, or else for use in the prevention or treatment of adipose tissue modifications. Finally, the invention relates to a cosmetic care process for the skin, the skin appendages or the mucous membranes, with a view to improving, the condition thereof or the appearance thereof, consisting in administering such a composition or such an extract.