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21.发明授权Cysteine and serine protease inhibitors containing D-amino acid at the P2 position, methods of making same, and methods of using same 失效在P2位置含有D-氨基酸的半胱氨酸和丝氨酸蛋白酶抑制剂，其制备方法及其使用方法
公开(公告)号：US5852007A
公开(公告)日：1998-12-22
申请号：US795546
申请日：1997-02-06
申请人： Sankar Chatterjee
发明人： Sankar Chatterjee
IPC分类号： C07D295/22 , A61K31/165 , A61K31/18 , A61K31/381 , A61K31/39 , A61K31/40 , A61K31/4035 , A61K31/405 , A61K31/415 , A61K31/416 , A61K31/42 , A61K31/47 , A61K31/472 , A61K31/5375 , A61K31/55 , A61P1/18 , A61P3/14 , A61P7/02 , A61P9/10 , A61P11/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P43/00 , C07C237/22 , C07C271/22 , C07C307/06 , C07C311/06 , C07C311/13 , C07C311/18 , C07C311/19 , C07C311/46 , C07C317/48 , C07C323/60 , C07D207/16 , C07D207/48 , C07D209/20 , C07D209/48 , C07D215/36 , C07D217/04 , C07D217/08 , C07D223/10 , C07D231/18 , C07D233/02 , C07D233/84 , C07D261/10 , C07D295/26 , C07D327/04 , C07D333/24 , C07D333/34 , C07D409/12 , A61K31/27 , A61K31/16 , A61K31/195 , A61K31/395 , A61K31/445 , C07D205/04 , C07D333/16 , C07D401/06 , C07D401/12 , C07D401/14
CPC分类号： C07D209/48 , C07C237/22 , C07C307/06 , C07C311/06 , C07C311/18 , C07C311/19 , C07C311/46 , C07C317/48 , C07C323/60 , C07D207/16 , C07D209/20 , C07D215/36 , C07D217/08 , C07D231/18 , C07D233/02 , C07D233/84 , C07D261/10 , C07D295/26 , C07D333/24 , C07D333/34 , C07D409/12
摘要： The present invention is directed to (D)-amino acid containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
摘要翻译： 本发明涉及含有（D） - 氨基酸的半胱氨酸或丝氨酸蛋白酶抑制剂。 还描述了使用蛋白酶抑制剂的方法。
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22.发明申请SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS 审中-公开作为HISTAMINE-3（H3）受体配体的取代的羟基丙烯酰胺衍生物公开(公告)号：US20140296212A1
公开(公告)日：2014-10-02
申请号：US14177046
申请日：2014-02-10
申请人： Edward R. Bacon , Thomas R. Bailey , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Allison L. Zulli , Brigitte Lesur , Babu G. Sundar , Christophe Yue
发明人： Edward R. Bacon , Thomas R. Bailey , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Allison L. Zulli , Brigitte Lesur , Babu G. Sundar , Christophe Yue
IPC分类号： C07D403/12 , C07C217/54 , C07D211/22 , C07D209/44 , C07D215/02 , C07D207/08 , C07D217/04
CPC分类号： C07D403/12 , C07C217/54 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/27 , C07D209/44 , C07D211/14 , C07D211/22 , C07D211/38 , C07D211/46 , C07D215/02 , C07D215/06 , C07D217/04 , C07D241/08 , C07D295/108 , C07D295/185 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula I: their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.
摘要翻译： 本发明提供式I化合物：它们用作H3拮抗剂/反向激动剂，其制备方法及其药物组合物。
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公开(公告)号：US07122679B2
公开(公告)日：2006-10-17
申请号：US09850858
申请日：2001-05-08
申请人： Mark A. Ator , Ron Bihovsky , Sankar Chatterjee , Derek Dunn , Robert L. Hudkins
发明人： Mark A. Ator , Ron Bihovsky , Sankar Chatterjee , Derek Dunn , Robert L. Hudkins
IPC分类号： C07D209/56 , A61K31/46
CPC分类号： C07D491/04 , C07D471/14 , C07D487/04 , C07D491/14 , C07D495/04
摘要： The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.
摘要翻译： 本发明涉及介导酶活性的新型多环分子。 特别地，所述化合物可有效治疗与PARP，VEGFR2和MLK3酶的活性相关的疾病或疾病状态，包括例如神经变性疾病，炎症，局部缺血和癌症。
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公开(公告)号：US06703368B2
公开(公告)日：2004-03-09
申请号：US09879336
申请日：2001-06-12
IPC分类号： A61K3805
CPC分类号： C07D207/08 , C07C311/06 , C07C311/46 , C07C311/48 , C07D207/20 , C07D207/48 , C07D211/76 , C07D211/96 , C07D213/70 , C07D213/74 , C07D235/06 , C07D239/42 , C07D275/06 , C07D277/40 , C07D277/54 , C07D333/34 , C07D333/62 , C07D409/04 , C07D409/14 , C07D413/04 , C07K5/0202 , C07K5/06069
摘要： This invention relates to peptide-containing &agr;-ketoamide inhibitors of cysteine and serine proteases, methods for making these compounds, and methods for using the same.
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公开(公告)号：US06670358B2
公开(公告)日：2003-12-30
申请号：US10014645
申请日：2001-10-26
申请人： Edward R. Bacon , Sankar Chatterjee , Derek Dunn , John P. Mallamo , Matthew S. Miller , Rabindranath Tripathy , Jeffry L. Vaught
发明人： Edward R. Bacon , Sankar Chatterjee , Derek Dunn , John P. Mallamo , Matthew S. Miller , Rabindranath Tripathy , Jeffry L. Vaught
IPC分类号： C07D21302
CPC分类号： C07D263/34 , C07C317/44 , C07C323/60 , C07C323/63 , C07C2603/18 , C07C2603/32 , C07D207/16 , C07D207/273 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04
摘要： The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
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公开(公告)号：US06492396B2
公开(公告)日：2002-12-10
申请号：US09855228
申请日：2001-05-15
申请人： Edward R. Bacon , Sankar Chatterjee , Derek Dunn , John P. Mallamo , Jeffry L. Vaught , Matthew S. Miller
发明人： Edward R. Bacon , Sankar Chatterjee , Derek Dunn , John P. Mallamo , Jeffry L. Vaught , Matthew S. Miller
IPC分类号： C07D40102
CPC分类号： C07D495/04 , C07C317/44 , C07C323/60 , C07C2603/18 , C07D207/16 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D263/34 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06
摘要： The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
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27.发明授权Peptidyl-containing .alpha.-ketoamide cysteine and serine protease inhibitors 失效含肽基的α-酮酰胺半胱氨酸和丝氨酸蛋白酶抑制剂
公开(公告)号：US6150378A
公开(公告)日：2000-11-21
申请号：US166808
申请日：1998-10-06
IPC分类号： C07D295/18 , A61K31/422 , A61K31/4406 , A61K31/4433 , A61K31/4436 , A61K31/497 , A61K31/5375 , A61K31/5377 , A61K38/00 , A61P1/18 , A61P7/02 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P19/02 , A61P25/08 , A61P25/16 , A61P25/28 , A61P43/00 , C07C311/06 , C07C311/46 , C07C311/48 , C07D207/08 , C07D207/20 , C07D207/48 , C07D211/76 , C07D211/96 , C07D213/70 , C07D213/71 , C07D213/74 , C07D233/54 , C07D235/06 , C07D239/42 , C07D275/06 , C07D277/40 , C07D277/54 , C07D333/34 , C07D333/62 , C07D409/04 , C07D409/14 , C07D413/04 , C07K5/062 , C07K5/065 , C07K5/078 , A61K31/44 , C07D333/02
CPC分类号： C07D207/08 , C07C311/06 , C07C311/46 , C07C311/48 , C07D207/20 , C07D207/48 , C07D211/76 , C07D211/96 , C07D213/70 , C07D213/74 , C07D235/06 , C07D239/42 , C07D275/06 , C07D277/40 , C07D277/54 , C07D333/34 , C07D333/62 , C07D409/04 , C07D409/14 , C07D413/04 , C07K5/0202 , C07K5/06069
摘要： This invention relates to peptide-containing .alpha.-ketoamide inhibitors of cysteine and serine proteases, methods for making these compounds, and methods for using the same.
摘要翻译： 本发明涉及半胱氨酸和丝氨酸蛋白酶的含肽α-酮酰胺抑制剂，制备这些化合物的方法及其使用方法。
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28.发明授权Quinoline-containing .alpha.-ketoamide cysteine and serine protease inhibitors 失效含喹啉的α-酮酰胺半胱氨酸和丝氨酸蛋白酶抑制剂
公开(公告)号：US6083944A
公开(公告)日：2000-07-04
申请号：US167193
申请日：1998-10-06
申请人： Sankar Chatterjee , John P. Mallamo , Derek Douglas Dunn , Kurt Allen Josef , Zi-Qiang Gu , Robert A. Daines , William Dennis Kingsbury , Israel Pendrak , Kelvin C. Sham
发明人： Sankar Chatterjee , John P. Mallamo , Derek Douglas Dunn , Kurt Allen Josef , Zi-Qiang Gu , Robert A. Daines , William Dennis Kingsbury , Israel Pendrak , Kelvin C. Sham
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/517 , A61K31/5377 , A61K31/55 , A61P1/18 , A61P7/02 , A61P9/10 , A61P9/12 , A61P11/06 , A61P19/02 , A61P21/04 , A61P25/28 , A61P29/00 , A61P35/04 , A61P43/00 , C07D215/40 , C07D215/50 , C07D239/74 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , A61K31/445 , C07D215/12 , C07D215/14 , C07D215/20
CPC分类号： C07D401/12 , C07D215/40 , C07D215/50 , C07D239/74 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention is directed to quinoline-containing .alpha.-ketoamide inhibitors of cysteine and serine proteases are disclosed. Methods for making these compounds, and methods for using the same are also disclosed.
摘要翻译： 本发明涉及含有喹啉的α-酮酰胺半胱氨酸抑制剂和丝氨酸蛋白酶。 还公开了制备这些化合物的方法及其使用方法。
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公开(公告)号：US5990083A
公开(公告)日：1999-11-23
申请号：US816510
申请日：1997-03-13
IPC分类号： A61K31/18 , A61K31/216 , A61K31/22 , A61K31/275 , A61K31/277 , A61K31/353 , A61K31/4035 , A61K31/69 , A61K38/00 , A61K38/55 , A61K45/00 , A61P19/00 , A61P21/00 , A61P43/00 , C07C279/14 , C07C279/34 , C07C279/36 , C07C311/01 , C07C311/06 , C07C311/09 , C07C311/47 , C07C311/64 , C07C337/06 , C07C337/08 , C07D209/48 , C07D311/70 , C07F5/02 , C07K5/02 , C07K5/023 , C07K5/072 , C07C231/00 , C07C235/00 , C07C255/00
CPC分类号： C07D209/48 , A61K31/18 , A61K31/216 , A61K31/22 , A61K31/277 , A61K31/353 , A61K31/4035 , C07C279/36 , C07C311/09 , C07C311/47 , C07C311/64 , C07C337/08 , C07D311/70 , C07F5/025 , C07K5/0207 , C07K5/06095 , A61K38/00 , C07C2101/08
摘要： Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.
摘要翻译： 本文公开了由以下通式表示的多分析蛋白酶的抑制剂：本文公开了组成成分和优选的组成成分。 制备和使用所公开的化合物的方法也在本文中阐述。
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公开(公告)号：US5827877A
公开(公告)日：1998-10-27
申请号：US646071
申请日：1996-05-07
申请人： Sankar Chatterjee
发明人： Sankar Chatterjee
IPC分类号： C07C235/74 , C07C237/22 , C07C271/20 , C07D217/06 , C07D295/185 , C07D311/90 , A01N43/16 , C07D311/82
CPC分类号： C07D295/185 , C07C235/74 , C07C237/22 , C07C271/20 , C07D217/06 , C07D311/90
摘要： The present invention is directed to novel ketomethylene group-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
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