公开(公告)号：US11898998B2

公开(公告)日：2024-02-13

申请号：US17186623

申请日：2021-02-26

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Joshua A. Burnett

IPC: G01N30/32 ,  G01N30/20 ,  G01N30/02

CPC classification number: G01N30/32 ,  G01N30/20 ,  G01N2030/027 ,  G01N2030/324

Abstract: A method for injecting a sample into a flow of a liquid chromatography system includes providing a flow of a mobile phase, and injecting a volume of a sample into the flow of the mobile phase such that the concentration of the sample within the mobile phase varies with a triangular profile over the course of the injecting.

公开(公告)号：US11821881B2

公开(公告)日：2023-11-21

申请号：US17104874

申请日：2020-11-25

Applicant: Waters Technologies Corporation

Inventor： Timothy M. Raymond ,  Christopher Walden ,  Sean Anderson

IPC: G01N30/32 ,  B01D15/16 ,  G01N30/34 ,  G01N30/20 ,  B01F25/00 ,  G01N30/02

CPC classification number: G01N30/32 ,  B01D15/163 ,  B01D15/166 ,  B01F25/1051 ,  G01N30/20 ,  G01N30/34 ,  G01N2030/027 ,  G01N2030/205 ,  G01N2030/322 ,  G01N2030/328 ,  G01N2030/347

Abstract: Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of fluid conduits internal to the manifold, each of the plurality of fluid conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of fluid conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of fluid conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and a passive fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold where at least one of the plurality of fluid conduits is compliant.

公开(公告)号：US11821530B2

公开(公告)日：2023-11-21

申请号：US17569744

申请日：2022-01-06

Applicant: Waters Technologies Corporation

Inventor： Sean Eric Anderson ,  Wade P. Leveille

IPC: F16K31/06 ,  F16K15/18

CPC classification number: F16K15/1843 ,  F16K31/0665

Abstract: Described is an active check valve that uses electro-magnetic actuation for operation. The valve includes a plunger assembly having a magnet in a sealed internal volume. The plunger assembly further includes a plunger tip that extends from either a plunger assembly housing or a sealing member. Although the plunger assembly is disposed in the solvent flow, the magnet is not exposed to the solvent. When the valve is actuated, the plunger tip moves the sealing member to open or close the valve. Optionally, an arming force may be applied to the sealing member in advance of opening or closing to reduce the subsequent additional force necessary to move the sealing member during opening or closing, thereby improving the accuracy of the solvent composition in liquid chromatography system applications.

公开(公告)号：US11819781B2

公开(公告)日：2023-11-21

申请号：US17500460

申请日：2021-10-13

Applicant: Waters Technologies Corporation

Inventor： Pamela C. Iraneta ,  Xin Zhang ,  Frank John Marszalkowski, Jr.

IPC: B01D15/38 ,  B01J20/28 ,  B01J20/32 ,  G01N30/50 ,  G01N30/72 ,  B01J20/287 ,  B01J20/288 ,  G01N30/00 ,  G01N1/40

CPC classification number: B01D15/3847 ,  B01J20/287 ,  B01J20/288 ,  B01J20/28052 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  G01N30/50 ,  G01N30/72 ,  G01N2001/4061 ,  G01N2030/009

Abstract: Disclosed is a device for a solid phase extraction comprising two or more of the sorbents to remove phospholipids and salts from a sample, to thereby eliminate matrix effects during mass spectrometry analysis. In particular, the sorbents includes at least one sorbent which is water-wettable and contains at least one hydrophobic component and at least one hydrophilic component and at least one of sorbent having a specific affinity for a matrix interference like phospholipids. Further disclosed is a method using the device of the present invention.

公开(公告)号：US20230364585A1

公开(公告)日：2023-11-16

申请号：US18144514

申请日：2023-05-08

Applicant: Waters Technologies Corporation

Inventor： Matthew A. Lauber ,  Catalin Doneanu ,  Weibin Chen ,  Ying Qing Yu ,  Jennifer M. Nguyen ,  Fabrice Gritti ,  Martin Gilar

IPC: B01J20/288 ,  B01J20/32 ,  B01J20/10 ,  B01J20/28

CPC classification number: B01J20/288 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/3204 ,  B01J2220/54

Abstract: The present disclosure discusses a method of separating and/or purifying polynucleotides. The method includes injecting a sample into a chromatographic column that is packed with a porous sorbent having a pore size that substantially excludes the polynucleotides from the sorbent. This restricted access to the sorbent allows separation of large polynucleotides from each other and from smaller molecular weight impurities.

公开(公告)号：US11796399B2

公开(公告)日：2023-10-24

申请号：US17523667

申请日：2021-11-10

Applicant: Waters Technologies Corporation

Inventor： Robert L. Danley

IPC: G01K17/00 ,  G01K19/00 ,  G01K7/02

CPC classification number: G01K17/00 ,  G01K7/02 ,  G01K19/00

Abstract: A heat flow rate measurement method for use with a differential scanning calorimeter sensor is provided. The method includes calculating a heat exchange between a plurality of sample containers and a reference container placed on a plurality of sample calorimeter units and a reference calorimeter unit, respectively, and determining a heat flow rate of samples within the sample containers using the calculated heat exchange between the plurality of sample containers and the reference container. A multiple sample differential scanning calorimeter sensor and calorimeter system are also provided.

公开(公告)号：US11774415B2

公开(公告)日：2023-10-03

申请号：US17212329

申请日：2021-03-25

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Burnett ,  Rose Solow ,  David A. Simpson ,  Peter Osswald ,  John M. Auclair ,  Michael LeBeau

IPC: G01N30/28 ,  G01N30/02 ,  G01N30/32

CPC classification number: G01N30/28 ,  G01N2030/027 ,  G01N2030/326 ,  G01N2030/328

Abstract: Described is a metering pump that may be used to meter volumes of sample in a chromatography system. The metering pump has a modular configuration that allows for separation of a head pod from a drive assembly for easy serviceability. The head pod includes a pump head, cartridge housing, seal wash housing and plunger. The drive assembly can be implemented in an inline drive configuration. Alternatively, the drive assembly can be implemented in an offset drive configuration in which a stepper motor is displaced laterally from other drive assembly components but is coupled through a belt and pulley system.

公开(公告)号：US11761932B2

公开(公告)日：2023-09-19

申请号：US16893537

申请日：2020-06-05

Applicant: Waters Technologies Corporation

Inventor： Robert Birdsall ,  Ying Qing Yu ,  Jacob Kellett

IPC: G01N33/68 ,  G01N33/15 ,  C12Q1/37 ,  G01N1/40 ,  G01N30/08 ,  G01N30/72 ,  G01N30/74

CPC classification number: G01N30/08 ,  C12Q1/37 ,  G01N1/405 ,  G01N1/4044 ,  G01N30/7233 ,  G01N30/74 ,  G01N33/15 ,  G01N33/6848

Abstract: The present technology relates to a method of analyzing a sample including an analyte. The method includes injecting the sample including the analyte into a mobile phase. The mobile phase includes a metal chelator additive having a concentration between about 1 ppm to about 10 ppm. The method also includes separating the analyte using liquid chromatography and analyzing the analyte using a mass spectrometer, an ultra-violet detector, or a combination thereof.

公开(公告)号：US20230251230A1

公开(公告)日：2023-08-10

申请号：US18304470

申请日：2023-04-21

Applicant: Waters Technologies Corporation

Inventor： Theodore A. Dourdeville

IPC: G01N30/60 ,  B23K20/02 ,  B23K20/233 ,  B23K20/24 ,  G01N30/20

CPC classification number: G01N30/606 ,  B23K20/023 ,  B23K20/233 ,  B23K20/24 ,  G01N30/20 ,  B23K2101/14

Abstract: A liquid chromatography apparatus includes a diffusion-bonded separation column comprising a lower substrate comprising titanium, an upper substrate comprising titanium, and a titanium patterned foil disposed between the lower substrate and the upper substrate. The lower substrate, titanium patterned foil, and upper substrate are diffusion bonded together to form a fluid path extending from an inlet port to an outlet port, wherein walls defining the fluid path within the diffusion-bonded separation column include a titanium surface coating.

公开(公告)号：US11709085B2

公开(公告)日：2023-07-25

申请号：US16996992

申请日：2020-08-19

Applicant: Waters Technologies Corporation

Inventor： Jason F. Hill ,  Martin Gilar ,  Abhijit Tarafder ,  Christopher DesJardins

IPC: G01F22/02 ,  G01N30/06 ,  G01N30/16 ,  G01N30/02

CPC classification number: G01F22/02 ,  G01N30/06 ,  G01N30/16 ,  G01N2030/027

Abstract: Described is a method for determining a dwell volume of a liquid chromatography system and a liquid chromatography system that can determined the system dwell volume. The method includes mixing a flow of a first solvent with a flow of a second solvent to form a solvent mixture. The flows of the first and second solvents are decreased and increased, respectively, to generate a gradient composition. A system pressure of the liquid chromatography system is measured to determine a pressure trace defined as the measured system pressure as a function of time. The dwell volume of the system is determined from a time delay determined between the gradient composition at the mixing location and the pressure trace. The method can be performed with a liquid chromatography system having a chromatographic column or a flow restrictor used in place of the chromatographic column.