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公开(公告)号：US20150038717A1
公开(公告)日：2015-02-05
申请号：US14516655
申请日：2014-10-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07D471/04
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A method for making the compound is set forth utilizing the starting material
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公开(公告)号：US20150038711A1
公开(公告)日：2015-02-05
申请号：US14516669
申请日：2014-10-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07F9/09
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A method for making the compound is set forth utilizing the starting material
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公开(公告)号：US20150038709A1
公开(公告)日：2015-02-05
申请号：US14516636
申请日：2014-10-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07F9/6561
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A method for making the compound is set forth utilizing the starting material
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公开(公告)号：US12018097B2
公开(公告)日：2024-06-25
申请号：US17943532
申请日：2022-09-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gardner S. Creech , Mahboubeh Kheirabadi , Martin D. Eastgate , David S. Nirschl , Percy H Carter
IPC: C07C309/73 , C07C309/07 , C07C309/75 , C07C309/77 , C07D225/02 , C07D225/08 , C07K1/04 , C07K1/107 , C07K7/64 , C07K17/08
CPC classification number: C07K7/64 , C07C309/07 , C07C309/73 , C07C309/75 , C07D225/08 , C07K1/042 , C07K1/1077 , C07K17/08
Abstract: The disclosure is directed to the synthesis and improved methods for purifying macrocyclic peptides produced by solid phase peptide synthesis. The synthesized peptide is capped with an alkyne-functionalized or azide-functionalized compound of formula (I):
prior to cleavage of the peptide from the solid phase support.-
![PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE](/abs-image/US/2022/06/09/US20220177482A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220177482A1
公开(公告)日：2022-06-09
申请号：US17677312
申请日：2022-02-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C.D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu
IPC: C07D487/04
Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
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Patent Agency Ranking
公开(公告)号：US20210395200A1
公开(公告)日：2021-12-23
申请号：US17292123
申请日：2019-11-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Adrian Ortiz , Alina Borovika , Sergei Kolotuchin , Michael R. Luzung , Jeffrey A. Nye , Yichen Tan , Serge Zaretsky , Jason J. Zhu , Martin D. Eastgate
IPC: C07D207/273
Abstract: Highly efficient processes are provided for preparing key intermediates in the synthesis of compounds (I). The process are broadly applicable and can provide selected components having a variety of substituents. Some intermediates are claimed.
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![PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE](/abs-image/US/2020/07/16/US20200223852A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200223852A1
公开(公告)日：2020-07-16
申请号：US16631915
申请日：2018-07-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C.D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu
IPC: C07D487/04
Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolodin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
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![Process for the preparation of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide](/abs-image/US/2016/12/13/US09518058B2/abs.jpg.150x150.jpg)
28.发明授权Process for the preparation of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide 有权制备N，N-二环丙基-4-（1,5-二甲基-1H-吡唑-3-基氨基）-6-乙基-1-甲基-1,6-二氢咪唑并[4,5-d]吡咯的方法 [2,3-b]吡啶-7-甲酰胺公开(公告)号：US09518058B2
公开(公告)日：2016-12-13
申请号：US14914330
申请日：2014-08-28
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Martin D. Eastgate , Gregory L. Beutner , Benjamin Cohen , Nicolas Cuniere , Lopa V. Desai , Monica Fitzgerald , Qi Gao , Michael Bryan Hay , Michael Joseph Lawler , Paul C. Lobben , Christopher S. Regens , Thorsten Rosner , Neil Strotman , Carolyn S. Wei , Yi Xiao , Bin Zheng , Keming Zhu
IPC: C07D471/14 , C07D207/42 , C07D403/04 , C07D231/16
CPC classification number: C07D471/14 , C07D207/42 , C07D231/16 , C07D403/04
Abstract: The invention relates to an improved process for synthesizing N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide of the formula: (I) Compound (I) is currently in clinical trials for the treatment of myeloproliferative disorders, such as polycythaemia vera, thrombocythaemia and primary myelofibrosis.
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29.发明授权Methods for the Preparation of HIV attachment inhibitor piperazine prodrug compound 有权制备HIV附着抑制剂哌嗪前药化合物的方法公开(公告)号：US09255113B2
公开(公告)日：2016-02-09
申请号：US14516655
申请日：2014-10-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07D471/04 , C07F9/09 , C07F9/6561 , C07C213/08 , C07F1/02 , C07D207/333 , C07D405/04
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A method for making the compound is set forth utilizing the starting material wherein R7═—H, alkyl, aryl, —SO2R, —C(O)OR, and —C(O)NR2; where R═—H, C1-C6 alkyl, -aryl, and —CH2Aryl.
Abstract translation: 使用其中R 7 = -H，烷基，芳基，-SO 2 R，-C（O）OR和-C（O）NR 2的起始物质来阐述制备该化合物的方法。 其中R = -H，C 1 -C 6烷基， - 芳基和-CH 2芳基。
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30.发明申请PROCESS FOR PREPARING DIASTEREOMERICALLY ENRICHED PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS 审中-公开制备用于治疗病毒感染的核苷类化合物的二异氰酸酯衍生物的方法公开(公告)号：US20150183818A1
公开(公告)日：2015-07-02
申请号：US14409523
申请日：2013-07-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kristy Tran , Martin D. Eastgate , Jacob Janey , Ke Chen , Victor W. Rosso
CPC classification number: C07H19/20 , C07D471/08 , C07F9/2458 , C07F9/26 , C07F9/65586 , C07F9/65616 , C07H19/10 , C07H19/16
Abstract: The present invention is directed to a process for preparing diastereomerically enriched nucleoside phosphoramidates having the formula I:
Abstract translation: 本发明涉及一种制备具有式I的非对映体富集的核苷氨基磷酸酯的方法：
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