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公开(公告)号：US12152980B2
公开(公告)日：2024-11-26
申请号：US18633224
申请日：2024-04-11
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kalyan Handique , Austin Payne , Vishal Sharma , Kyle Gleason , Priyadarshini Gogoi , Karthik Ganesan , Brian Boniface , Will Chow
IPC: G01N15/14 , B01L3/00 , C12M1/00 , G01N1/20 , G01N1/28 , G01N1/40 , G01N15/1433 , G01N35/00 , G01N35/10 , G06V10/141 , G06V10/145 , G06V10/147 , G06V20/69 , B01L3/02 , G01N15/01 , G01N15/10 , G01N15/149
Abstract: A system and method for isolating and analyzing single cells, including: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode.
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公开(公告)号：US12044614B2
公开(公告)日：2024-07-23
申请号：US17589507
申请日：2022-01-31
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kalyan Handique , Austin Payne , Vishal Sharma , Kyle Gleason , Priyadarshini Gogoi , Karthik Ganesan , Brian Boniface , Will Chow
IPC: G01N15/14 , B01L3/00 , B01L3/02 , C12M1/00 , G01N1/20 , G01N1/28 , G01N1/40 , G01N15/1433 , G01N35/00 , G01N35/10 , G06V10/141 , G06V10/145 , G06V10/147 , G06V20/69 , G01N15/00 , G01N15/01 , G01N15/10
CPC classification number: G01N15/1484 , B01L3/502715 , B01L3/502761 , C12M47/04 , G01N1/20 , G01N1/28 , G01N1/40 , G01N1/405 , G01N1/4077 , G01N15/1433 , G01N35/00029 , G01N35/1011 , G06V10/141 , G06V10/145 , G06V10/147 , G06V20/69 , B01L3/021 , B01L3/502746 , B01L2200/0652 , B01L2200/0668 , B01L2300/0636 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0819 , B01L2300/0848 , B01L2300/0877 , B01L2300/168 , B01L2400/086 , G01N15/01 , G01N2015/1006 , G01N2015/149 , G01N2035/00158 , G01N2035/1039
Abstract: A system and method for isolating and analyzing single cells, including: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode.
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Patent Agency Ranking
公开(公告)号：US12030051B2
公开(公告)日：2024-07-09
申请号：US16419485
申请日：2019-05-22
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kalyan Handique , Kyle Gleason , Austin Payne , Priyadarshini Gogoi , Christopher Siemer , Yi Zhou , Saedeh Javdani Sepehri
CPC classification number: B01L3/502761 , B01L3/502715 , B01L3/527 , B01L3/5635 , B01L7/00 , G01N35/0098 , B01L2200/027 , B01L2200/0647 , B01L2200/0652 , B01L2200/0684 , B01L2300/06 , B01L2300/0816 , B01L2300/0832 , B01L2300/0864 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2400/0487 , B01L2400/0683
Abstract: A system for isolating cells in at least one of single-cell format and single-cluster format, comprising a reservoir, including a reservoir inlet and a reservoir outlet, configured to receive a biological sample and to receive at least one fluid, a manifold configured to receive and deliver the biological sample and the at least one fluid from the reservoir into a biological sample substrate, the manifold comprising a broad surface comprising a central region configured to receive the biological sample substrate, a set of openings configured to enable fluid flow transmission across the biological sample substrate, a manifold inlet configured to transmit flow from the reservoir the first subset of openings, a manifold outlet configured at a downstream end of the broad surface and coupled to the second subset of openings, the manifold outlet configured to transmit waste fluid from the manifold.
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公开(公告)号：US20230015223A1
公开(公告)日：2023-01-19
申请号：US17951719
申请日：2022-09-23
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kalyan Handique , Austin Payne , Vishal Sharma , Kyle Gleason , Priyadarshini Gogoi , Karthik Ganesan , Brian Boniface , Will Chow
IPC: G01N15/14 , G01N1/20 , G01N1/40 , G01N1/28 , C12M1/00 , B01L3/00 , G01N35/10 , G01N35/00 , G06V10/141 , G06V10/145 , G06V10/147 , G06V20/69
Abstract: A system and method for isolating and analyzing single cells, including: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode.
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公开(公告)号：US11504719B2
公开(公告)日：2022-11-22
申请号：US16816817
申请日：2020-03-12
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kalyan Handique , Austin Payne
Abstract: A system and method for receiving and delivering a fluid, the system comprising: a body configured to interface with an opening of a reservoir and defining: a protrusion defining a set position of the body relative to the reservoir; a wall extending from the protrusion; a receiving surface coupled to the wall and sloping from an apex to a nadir along a first direction, the receiving surface comprising a vent; and an outlet positioned closer to the nadir than the apex of the receiving surface and displaced from the vent, the outlet comprising an extension from the body, the extension configured to contact an interior wall of the reservoir, wherein the body comprises: a bubble-mitigating operation mode in which the receiving surface receives and transmits the fluid along the receiving surface, and a fluid-transmitting operation mode in which the body directs the fluid along the interior wall of the reservoir.
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公开(公告)号：US20220152606A1
公开(公告)日：2022-05-19
申请号：US17590543
申请日：2022-02-01
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kalyan Handique , Swati Ranade , Vishal Sharma , Austin Payne , Sam Tuck
Abstract: A system and method for target material retrieval and processing, the system comprising: an adaptor configured to interface with a capture region of a capture substrate for capturing particles in single-particle format within a set of wells, wherein the adaptor comprises a first region configured to interface with the capture region, a second region, and a cavity extending from the first region to the second region; and a support structure coupled to the adaptor and providing a set of operation modes for movement of the adaptor relative to the capture substrate. The system enables methods for magnetic and/or other force-based methods of retrieval of target material (e.g., derived from single cells).
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公开(公告)号：US11273439B2
公开(公告)日：2022-03-15
申请号：US16906337
申请日：2020-06-19
Applicant: Bio-Rad Laboratories, Inc
Inventor： Kalyan Handique , Swati Ranade , Vishal Sharma , Austin Payne , Sam Tuck
Abstract: A system and method for target material retrieval and processing, the system comprising: an adaptor configured to interface with a capture region of a capture substrate for capturing particles in single-particle format within a set of wells, wherein the adaptor comprises a first region configured to interface with the capture region, a second region, and a cavity extending from the first region to the second region; and a support structure coupled to the adaptor and providing a set of operation modes for movement of the adaptor relative to the capture substrate. The system enables methods for magnetic and/or other force-based methods of retrieval of target material (e.g., derived from single cells).
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