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    REDUCTION OF ENTROPIC BARRIER OF POLYELECTROLYTE MOLECULES IN A NANOPORE DEVICE WITH AGAROSE GEL
    24.
    发明申请
    REDUCTION OF ENTROPIC BARRIER OF POLYELECTROLYTE MOLECULES IN A NANOPORE DEVICE WITH AGAROSE GEL 审中-公开
    在具有AGAROSE凝胶的纳米装置中减少聚电解质分子的入射阻挡层

    公开(公告)号：US20150285764A1

    公开(公告)日：2015-10-08

    申请号：US14585236

    申请日：2014-12-30

    Applicant: International Business Machines Corporation

    Inventor： Gustavo A. Stolovitzky ,  George F. Walker ,  Chao Wang ,  Deqiang Wang

    IPC: G01N27/447 ,  C12N15/10

    CPC classification number: C12Q1/6869 ,  C12N15/101 ,  G01N27/44747 ,  G01N27/44791 ,  C12Q2527/125 ,  C12Q2563/116 ,  C12Q2563/157 ,  C12Q2565/631

    Abstract: A mechanism is provided for reducing entropy of a polyelectrolyte before the polyelectrolyte moves through a nanopore. A free-standing membrane has the nanopore formed through the membrane. An agarose gel is formed onto either and/or both sides of the nanopore in the membrane. The agarose gel is a porous material. The polyelectrolyte is uncoiled by driving the polyelectrolyte through the porous material of the agarose gel via an electric field. Driving the polyelectrolyte, having been uncoiled and linearized by the agarose gel, into the nanopore is for sequencing.

    Abstract translation: 提供了一种用于在聚电解质通过纳米孔移动之前降低聚电解质的熵的机制。 独立的膜具有通过膜形成的纳米孔。 在膜中的纳米孔的两侧和/或两侧上形成琼脂糖凝胶。 琼脂糖凝胶是多孔材料。 通过电场通过琼脂糖凝胶的多孔材料驱动聚电解质来解开聚电解质。 将已经通过琼脂糖凝胶开卷并线性化的聚电解质驱入纳米孔用于测序。

    Self-formed nanometer channel at wafer scale
    29.
    发明授权
    Self-formed nanometer channel at wafer scale 有权
    硅片自制纳米通道

    公开(公告)号：US08652337B1

    公开(公告)日：2014-02-18

    申请号：US13971468

    申请日：2013-08-20

    Applicant: International Business Machines Corporation

    Inventor： Ali Afzali-Ardakani ,  Binquan Luan ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

    IPC: H01B13/00

    CPC classification number: H01B13/06 ,  B82Y40/00 ,  G01N33/48721 ,  Y10S977/70

    Abstract: A mechanism is provided for fabricating nanochannels for a nanodevice. Insulating film is deposited on a substrate. A nanowire is patterned on the film. Insulating material is deposited on the nanowire and film. A first circular hole is formed in the insulating material as an inlet, over a first tip of the nanowire to expose the first tip. A second circular hole is formed as an outlet, over a second tip of the nanowire opposite the first tip to expose the second tip. A nanochannel connects the first and second holes by etching away the nanowire via an etchant in the first and the second holes. A first reservoir is attached over the first hole in connection with the nanochannel at a previous location of the first tip. A second reservoir is attached over the second hole in connection with the nanochannel at a previous location of the second tip.

    Abstract translation: 提供了一种用于制造纳米器件的纳米通道的机制。 绝缘膜沉积在基底上。 纳米线在电影上图案化。 绝缘材料沉积在纳米线和薄膜上。 在绝缘材料中形成第一圆形孔作为入口，在纳米线的第一尖端上露出第一尖端。 在与第一尖端相对的纳米线的第二尖端上方形成第二圆形孔作为出口，以露出第二尖端。 纳米通道通过第一孔和第二孔中的蚀刻剂蚀刻掉纳米线而连接第一孔和第二孔。 在第一尖端的先前位置处，与纳通道相连接的第一孔附接第一储存器。 在第二个尖端的先前位置处，与第二孔相连接的第二个贮存器连接到纳米通道上。

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