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    MODIFIED POROUS MATERIALS AND METHOD OF FORMING THE SAME
    23.
    发明申请
    MODIFIED POROUS MATERIALS AND METHOD OF FORMING THE SAME 有权
    改性多孔材料及其形成方法

    公开(公告)号：US20080213564A1

    公开(公告)日：2008-09-04

    申请号：US12020488

    申请日：2008-01-25

    Applicant: Peter X. Ma ,  Xiaohua Liu

    Inventor： Peter X. Ma ,  Xiaohua Liu

    IPC: B32B3/26 ,  B29C44/04 ,  C08J9/36

    CPC classification number: C08J9/36 ,  Y10T428/249953 ,  Y10T428/249957 ,  Y10T428/249965 ,  Y10T428/249975 ,  Y10T428/249978 ,  Y10T428/249979 ,  Y10T428/249986 ,  Y10T428/24999

    Abstract: Modified porous materials are disclosed having interconnected, complexly shaped three-dimensional surfaces. The modification is accomplished by crosslinking the three-dimensional surfaces or by incorporating, in situ, an inorganic material onto or into three-dimensional surfaces. The porous materials are macro structures including at least one of nano-features, micro-features, and combinations thereof. The modifying accomplishes changing surface properties of the porous materials, changing the three-dimensional surfaces, and/or rendering the porous materials substantially stable in a predetermined environment.

    Abstract translation: 公开了具有互连的，复杂形状的三维表面的改性多孔材料。 该改性是通过将三维表面交联或通过将无机材料原位并入三维表面而实现的。 多孔材料是包括纳米特征，微特征及其组合中的至少一个的宏观结构。 修饰完成了改变多孔材料的表面性质，改变三维表面和/或使多孔材料在预定环境中基本稳定。

    THREE-COMPONENT POLYANHYDRIDE COPOLYMERS AND A METHOD OF FORMING THE SAME
    24.
    发明申请
    THREE-COMPONENT POLYANHYDRIDE COPOLYMERS AND A METHOD OF FORMING THE SAME 审中-公开
    三组分聚合物共聚物及其形成方法

    公开(公告)号：US20070249536A1

    公开(公告)日：2007-10-25

    申请号：US11739757

    申请日：2007-04-25

    Applicant: Peter X. Ma ,  Sijian Hou

    Inventor： Peter X. Ma ,  Sijian Hou

    IPC: A61K38/00

    CPC classification number: A61K38/29 ,  A61K9/0024

    Abstract: A three-component polyanhydride copolymer having tunable erosion properties includes a sebacic acid anhydride precursor, a 1,3-bis(carboxyphenoxy) propane anhydride precursor, and a poly(ethylene glycol) anhydride precursor. The erosion rate of the copolymer increases with an increasing amount of the poly(ethylene glycol) precursor. A method for forming the three-component polyanhydride copolymer includes combining the sebacic acid precursor, the 1,3-bis(carboxyphenoxy) propane precursor, and the polyethylene glycol precursor to form a precursor mixture. The precursor mixture is then melt polymerized to form the three-component polyanhydride copolymer.

    Abstract translation: 具有可调腐蚀性质的三组分聚酐共聚物包括癸二酸酐前体，1,3-双（羧基苯氧基）丙烷酸酐前体和聚（乙二醇）酐前体。 共聚物的侵蚀速率随聚乙二醇前体的增加而增加。 形成三组分聚酐共聚物的方法包括将癸二酸前体，1,3-双（羧基苯氧基）丙烷前体和聚乙二醇前体组合以形成前体混合物。 然后将前体混合物熔融聚合以形成三组分聚酐共聚物。

    Non-degradable porous materials with high surface areas
    25.
    发明授权
    Non-degradable porous materials with high surface areas 失效
    具有高表面积的不可降解多孔材料

    公开(公告)号：US06979700B2

    公开(公告)日：2005-12-27

    申请号：US10271622

    申请日：2002-10-16

    Applicant: Peter X. Ma

    Inventor： Peter X. Ma

    IPC: B29C67/20 ,  C08J9/28

    CPC classification number: B29C67/20 ,  C08J9/28 ,  C08J2201/048 ,  C08J2201/054

    Abstract: A method for preparing a highly porous, high surface area non-degradable material includes the steps of mixing a non-degradable polymer with a solvent or mixture of solvents; gelling the mixture; and treating the gel under conditions whereby a substantially solvent free porous structure is created having a porosity greater than about 80%. The resultant material is mechanically strong and has an architecture including at least one of nano fibrous, micro fibrous, non fibrous, complex porous structure with nano fibrous architecture, and mixtures thereof.

    Abstract translation: 制备高度多孔，高表面积不可降解材料的方法包括将不可降解聚合物与溶剂或溶剂混合物混合的步骤; 凝胶混合物 并在条件下处理凝胶，由此产生具有大于约80％的孔隙率的基本上无溶剂的多孔结构。 所得到的材料是机械强度并且具有包括纳米纤维，微纤维，非纤维状，具有纳米纤维结构的复合多孔结构中的至少一种及其混合物的结构。

    Method of forming micro-tubular polymeric materials
    26.
    发明授权
    Method of forming micro-tubular polymeric materials 失效
    形成微管状聚合物材料的方法

    公开(公告)号：US06899873B2

    公开(公告)日：2005-05-31

    申请号：US10057287

    申请日：2002-01-25

    Applicant: Peter X. Ma ,  Ruiyan Zhang

    Inventor： Peter X. Ma ,  Ruiyan Zhang

    IPC: A61K35/12 ,  A61L27/38 ,  A61L27/50 ,  A61L27/56 ,  A61P19/00 ,  C12N5/00 ,  C12N5/077 ,  C12N5/06 ,  C12N5/08 ,  C12N11/08 ,  A61F2/00

    CPC classification number: A61L27/3878 ,  A61K35/12 ,  A61L27/3895 ,  A61L27/50 ,  A61L27/56 ,  C12N5/0075 ,  C12N5/0654 ,  C12N2500/38 ,  C12N2533/40 ,  Y10T428/29

    Abstract: The present invention discloses the design and fabrication of highly porous (up to 97%) scaffolds from biodegradable polymers with a novel phase-separation technique to generate controllable parallel array of micro-tubular architecture. The porosity, diameter of the micro-tubes, the tubular morphology and their orientation may be controlled by the polymer concentration, solvent system and temperature gradient. The mechanical properties of these scaffolds are anisotropic. Osteoblastic cells are seeded in these 3-D scaffolds and cultured in vitro. The cell distribution and the neo-tissue organization are guided by the micro-tubular architecture. The method has general applicability to a variety of polymers, therefore the degradation rate, cell-matrix interactions may be controlled by the chemical composition of the polymers and the incorporation of bioactive moieties. These micro-tubular scaffolds may be used to regenerate a variety of tissues with anisotropic architecture and properties.

    Abstract translation: 本发明公开了通过新型相分离技术设计和制造可生物降解聚合物的高度多孔（高达97％）的支架，以生成微管结构的可控并联阵列。 微管的孔隙率，直径，管状形态及其取向可以通过聚合物浓度，溶剂体系和温度梯度来控制。 这些支架的机械性能是各向异性的。 将成骨细胞接种在这些3-D支架中并在体外培养。 细胞分布和新组织结构由微管结构引导。 该方法具有对各种聚合物的普遍适用性，因此降解速率，细胞 - 基质相互作用可以通过聚合物的化学组成和生物活性部分的引入来控制。 这些微管支架可用于再生具有各向异性结构和性质的各种组织。

    Three-dimensional hydrogel/cell system
    27.
    发明授权
    Three-dimensional hydrogel/cell system 失效
    三维水凝胶/细胞系统

    公开(公告)号：US06872387B1

    公开(公告)日：2005-03-29

    申请号：US09255963

    申请日：1999-02-23

    Applicant: Peter X. Ma

    Inventor： Peter X. Ma

    IPC: A01N63/00 ,  A61F2/00 ,  A61K9/06 ,  A61K9/14 ,  A61K47/02 ,  A61K47/36 ,  C12N5/00 ,  C12N5/077 ,  C12N11/00

    CPC classification number: C12N5/0654 ,  A61K9/06 ,  A61K47/02 ,  A61K47/36 ,  C12N5/0068 ,  C12N2533/74

    Abstract: Methods and compositions are described that provide scaffolds for the support of cells. The scaffolds of the present invention have structural uniformity and desirable mechanical properties that make them suitable for a variety of uses, including uses for in vitro tissue regeneration or in vivo tissue or organ replacement. A method is described for controlling three-dimensional structure of the hydrogel/cell constructs under tissue culture environment.

    Abstract translation: 描述了提供用于支持细胞的支架的方法和组合物。 本发明的支架具有结构均匀性和期望的机械性能，使其适用于各种用途，包括用于体外组织再生或体内组织或器官置换的用途。 描述了一种在组织培养环境下控制水凝胶/细胞构建体的三维结构的方法。

    Ionically crosslinked hydrogels with adjustable gelation time
    28.
    发明授权
    Ionically crosslinked hydrogels with adjustable gelation time 失效
    具有可调凝胶时间的离子交联水凝胶

    公开(公告)号：US06497902B1

    公开(公告)日：2002-12-24

    申请号：US09452494

    申请日：1999-12-01

    Applicant: Peter X. Ma

    Inventor： Peter X. Ma

    IPC: A61K914

    CPC classification number: A61Q19/00 ,  A61K8/042 ,  A61K8/19 ,  A61K8/733 ,  A61K9/0019 ,  A61K47/32 ,  A61K47/36 ,  A61L27/52 ,  C08J3/075 ,  C08L5/04 ,  C08L5/06 ,  C08L5/08 ,  C08L5/10

    Abstract: Biocompatible hydrogels, for: scaffoldings for tissue engineering; cell encapsulation matrices; injectable bulking materials for cosmetic and functional restorations; controlled release matrices; gene delivery vehicles; immunoprotection matrices; immobilization materials; food additives; medical gels; conductive electrode gels; lubricious coatings; film forming creams; membranes; superabsorbents; hydrophilic coatings; and wound dressings. The hydrogels include: at least one water-soluble polymer/copolymer; and at least one slow and/or fast dissolving and/or releasing divalent and/or multivalent cation-containing compound. At least one of the monomers is an acid, and/or contains an acid group or a derivative thereof. Such monomer reacts with the cations to form a three-dimensional ionically crosslinked hydrogel composition. A method for preparing such a composition comprises the step of controlling a rate of gel formation by varying at least one of: solubility of the cation containing compounds; cation concentration; mixture of cation containing compounds; polymer concentration; gelation temperature.

    Abstract translation: 生物相容性水凝胶，用于：组织工程用脚手架; 细胞包封基质; 用于化妆品和功能性修复剂的可注射膨胀材料; 控制释放矩阵; 基因递送载体; 免疫保护基质; 固定材料; 食品添加剂; 医用凝胶 导电电极凝胶; 润滑涂料; 成膜霜; 膜; 超吸收剂 亲水涂料; 和伤口敷料。 水凝胶包括：至少一种水溶性聚合物/共聚物; 和至少一种缓慢和/或快速溶解和/或释放二价和/或多价阳离子的化合物。 至少一种单体是酸，和/或含有酸基或其衍生物。 这样的单体与阳离子反应形成三维离子交联的水凝胶组合物。 制备这种组合物的方法包括通过改变以下中的至少一种来控制凝胶形成速率的步骤：含阳离子化合物的溶解度; 阳离子浓度; 含阳离子化合物的混合物; 聚合物浓度; 凝胶化温度。

    Porous composite materials
    29.
    发明授权
    Porous composite materials 有权
    多孔复合材料

    公开(公告)号：US06281257B1

    公开(公告)日：2001-08-28

    申请号：US09292896

    申请日：1999-04-16

    Applicant: Peter X. Ma ,  Ruiyun Zhang

    Inventor： Peter X. Ma ,  Ruiyun Zhang

    IPC: C08J926

    CPC classification number: C08J9/28 ,  C08J2201/0482 ,  C08J2201/0484 ,  C08J2367/00 ,  C12N5/0068 ,  C12N2533/12 ,  C12N2533/18 ,  C12N2533/30 ,  C12N2533/40 ,  G01N15/14

    Abstract: Methods and compositions are described that provide three dimensional porous matrices as structural templates for cells. The porous matrices of the present invention have desirable mechanical properties suitable to a variety of applications, including platforms for in vitro cell cultivation, implants for tissue and organ engineering, and materials suitable for chromatography and filtration.

    Abstract translation: 描述了提供三维多孔基质作为细胞结构模板的方法和组合物。 本发明的多孔基质具有适合于各种应用的理想的机械性能，包括用于体外细胞培养的平台，用于组织和器官工程的植入物，以及适用于色谱和过滤的材料。

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