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公开(公告)号:US12078596B2
公开(公告)日:2024-09-03
申请号:US16043651
申请日:2018-07-24
发明人: Jonathan M. Rothberg , Benjamin Cipriany , Todd Rearick , Paul E. Glenn , Faisal R. Ahmad , Todd Roswech , Brittany Lathrop , Thomas Connolly
IPC分类号: G01N21/64 , H01S5/00 , H01S5/02253 , H01S5/024 , H01S5/026
CPC分类号: G01N21/6486 , G01N21/6402 , G01N21/6408 , G01N21/6454 , H01S5/0071 , H01S5/02253 , H01S5/02461 , H01S5/0262 , G01N21/648 , G01N2021/6482 , G01N2201/0221 , G01N2201/0873
摘要: A hand-held bioanalytic instrument is described that can perform massively parallel sample analysis including single-molecule gene sequencing. The instrument includes a pulsed optical source that produces ultrashort excitation pulses and a compact beam-steering assembly. The beam-steering assembly provides automated alignment of excitation pulses to an interchangeable bio-optoelectronic chip that contains tens of thousands of reaction chambers or more. The optical source, beam-steering assembly, bio-optoelectronic chip, and coupling optics register to an alignment structure in the instrument that can form at least one wall of an enclosure and dissipate heat.
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公开(公告)号:US20240133809A1
公开(公告)日:2024-04-25
申请号:US18490713
申请日:2023-10-18
发明人: Todd Rearick , Shannon Stewman
IPC分类号: G01N21/64 , H01L27/146
CPC分类号: G01N21/64 , H01L27/14625 , H01L27/14643
摘要: Described herein are techniques for determining an illumination position on an integrated photodetector, as may be used within a fluorescence detection system. In some embodiments, such techniques may include determining an illumination position on an integrated photodetector based, at least in part, on a measurement of an amount of current output from a pixel of the integrated photodetector, the amount of current corresponding to an amount of excitation light (e.g., used for exciting fluorescence in a sample) that is received at the pixel. In some embodiments, such techniques may include measuring an amount of current output from one or more drain regions of one or more pixels of an integrated photodetector (e.g., regions used to draw away charge carriers corresponding to excitation light so as to not pollute collected charge carriers that correspond to fluorescence light to be detected).
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公开(公告)号:US20240096924A1
公开(公告)日:2024-03-21
申请号:US18520502
申请日:2023-11-27
发明人: Eric A.G. Webster , Changhoon Choi , Dajiang Yang , Xin Wang , Todd Rearick , Kyle Preston , Ali Kabiri , Gerard Schmid
IPC分类号: H01L27/146
CPC分类号: H01L27/14643 , H01L27/14683
摘要: Aspects of the technology described herein relate to improved semiconductor-based image sensor designs. In some embodiments, an integrated circuit may comprise a photodetection region and a drain region electrically coupled to the photodetection region, and the photodetection region may be configured to induce an intrinsic electric field in a direction from the photodetection region to the drain region(s). In some embodiments, a charge storage region and the drain region may be positioned on a same side of the photodetection region. In some embodiments, at least one drain layer may be configured to receive incident photons and/or charge carriers via the photodetection region. In some embodiments, an integrated circuit may comprise a plurality of pixels and a control circuit configured to control a transfer of charge carriers in the plurality of pixels.
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公开(公告)号:US11848531B2
公开(公告)日:2023-12-19
申请号:US17696755
申请日:2022-03-16
发明人: Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife , Benjamin Cipriany
IPC分类号: H01S3/0941 , H01S3/00 , H01S3/1115 , H01S3/02 , H01S3/081 , G02F1/37 , H01S3/08 , H01S3/16 , H01S3/10 , H01S3/1112 , H01S3/04 , H01S3/06 , H01S3/042
CPC分类号: H01S3/1115 , G02F1/37 , H01S3/025 , H01S3/0813 , H01S3/08072 , H01S3/09415 , H01S3/1611 , H01S3/1673 , H01S3/0092 , H01S3/042 , H01S3/0407 , H01S3/0623 , H01S3/0811 , H01S3/0941 , H01S3/10046 , H01S3/1112 , H01S3/1653
摘要: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument. The mode-locked laser can produce sub-50-ps optical pulses at a repetition rates between 200 MHz and 50 MHz, rates suitable for massively parallel data-acquisition. The optical pulses can be used to generate a reference clock signal for synchronizing data-acquisition and signal-processing electronics of the portable instrument.
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公开(公告)号:US20230349755A1
公开(公告)日:2023-11-02
申请号:US18331035
申请日:2023-06-07
IPC分类号: H01L27/146 , B01J19/00 , G01J1/44 , H01L27/148
CPC分类号: G01J1/44 , B01J19/0046 , H01L27/14683 , H01L27/14818 , H01L27/14825 , B01J2219/00504 , B01J2219/00576 , B01J2219/00587 , B01J2219/00689 , B01J2219/00698 , G01J2001/446
摘要: Described herein are techniques that improve the collection and readout of charge carriers in an integrated circuit. Some aspects of the present disclosure relate to integrated circuits having pixels with a plurality of charge storage regions. Some aspects of the present disclosure relate to integrated circuits configured to substantially simultaneously collect and read out charge carriers, at least in part. Some aspects of the present disclosure relate to integrated circuits having a plurality of pixels configured to transfer charge carriers between charge storage regions within each pixel substantially at the same time. Some aspects of the present disclosure relate to integrated circuits having three or more sequentially coupled charge storage regions. Some aspects of the present disclosure relate to integrated circuits capable of increased charge transfer rates. Some aspects of the present disclosure relate to techniques for manufacturing and operating integrated circuits according to the other techniques described herein.
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公开(公告)号:US11322906B2
公开(公告)日:2022-05-03
申请号:US16916277
申请日:2020-06-30
发明人: Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife , Benjamin Cipriany
IPC分类号: H01S3/11 , G02F1/37 , H01S3/02 , H01S3/081 , H01S3/0941 , H01S3/08 , H01S3/16 , H01S3/10 , H01S3/04 , H01S3/06 , H01S3/00 , H01S3/042
摘要: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument. The mode-locked laser can produce sub-50-ps optical pulses at a repetition rates between 200 MHz and 50 MHz, rates suitable for massively parallel data-acquisition. The optical pulses can be used to generate a reference clock signal for synchronizing data-acquisition and signal-processing electronics of the portable instrument.
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公开(公告)号:US20210277463A1
公开(公告)日:2021-09-09
申请号:US17314968
申请日:2021-05-07
发明人: Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. File
IPC分类号: C12Q1/6869 , G01N21/64 , H01L27/146 , H01S3/101 , H01S3/13 , H01S3/105 , H01S3/081 , H01S3/11 , H01S3/0941 , H01S3/10 , H01S3/00
摘要: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.
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公开(公告)号:US11072827B2
公开(公告)日:2021-07-27
申请号:US16239789
申请日:2019-01-04
发明人: Guojun Chen , Jeremy Lackey , Alexander Goryaynov , Gerard Schmid , Ali Kabiri , Jonathan M. Rothberg , Todd Rearick , Jonathan C. Schultz , Farshid Ghasemi , Keith G. Fife
IPC分类号: C12Q1/6869 , G01N21/64 , B01L3/00 , G01N30/86 , C08L1/02 , C12Q1/6806 , G01N27/447 , G01N30/88
摘要: Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.
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公开(公告)号:US20210215605A1
公开(公告)日:2021-07-15
申请号:US17149310
申请日:2021-01-14
发明人: Gerard Schmid , Dajiang Yang , Eric A.G. Webster , Xin Wang , Todd Rearick , Changhoon Choi , Ali Kabiri , Kyle Preston
IPC分类号: G01N21/64
摘要: Some aspects relate to integrated devices for obtaining timing and/or spectral information from incident light. In some embodiments, a pixel may include one or more charge storage regions configured to receive charge carriers generated responsive to incident photons from a light source, with charge carriers stored in the charge storage region(s) indicative of spectral and timing information. In some embodiments, a pixel may include regions having different depths, each configured to generate charge carriers responsive to incident photons. In some embodiments, a pixel may include multiple charge storage regions having different depths, and one or more of the charge storage regions may be configured to receive the incident photons and generate charge carriers therein. In some embodiments, a pixel may include an optical sorting element configured to direct at least some incident photons to one charge storage region and other incident photons to another charge storage region.
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公开(公告)号:US20190391010A1
公开(公告)日:2019-12-26
申请号:US16446708
申请日:2019-06-20
IPC分类号: G01J1/44
摘要: An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit includes a charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers directly into the at least one charge carrier storage region based upon times at which the charge carriers are produced.
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