公开(公告)号：US10241124B2

公开(公告)日：2019-03-26

申请号：US15092806

申请日：2016-04-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Manfred Augstein ,  Nadine Losleben ,  Thorsten Brueckner ,  Christoph Boehm ,  Juergen Spinke

IPC: C12M1/00 ,  G01N35/10 ,  B01L3/02 ,  G01F11/08 ,  B01L3/00 ,  G01N35/00

Abstract: A method of performing a measurement of an analyte in a sample using an automatic analyzer is provided. The automatic analyzer comprises: a cartridge for dispensing a fluid, a measurement unit for performing the measurement, a sample holder for receiving the sample, and a pump for pumping the fluid out of the cartridge and into the sample holder. The cartridge comprises: a rigid portion, a flexible bladder, and an outlet. The rigid portion comprises an opening, which is connected to an inner cavity. The flexible bladder seals the opening to form a fluid chamber from the inner cavity. The fluid chamber is at least partially filled with the fluid. The pump is connected to the outlet. The method comprises: placing the sample into the sample holder, controlling the pumping of the fluid from the cartridge into the sample holder, and performing the measurement of the analyte using the measurement unit.

公开(公告)号：US20180221872A1

公开(公告)日：2018-08-09

申请号：US15943093

申请日：2018-04-02

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke

IPC: B01L3/00 ,  G01N35/00 ,  G01N35/10 ,  G01N1/38

CPC classification number: B01L3/50273 ,  B01L3/502723 ,  B01L3/502738 ,  B01L2200/04 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  B01L2400/0694 ,  G01N1/38 ,  G01N35/00069 ,  G01N35/1016 ,  G01N2035/00247 ,  G01N2035/00257 ,  G01N2035/1032 ,  G01N2035/1034

Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.

公开(公告)号：US10018644B2

公开(公告)日：2018-07-10

申请号：US15006476

申请日：2016-01-26

Applicant: Roche Diagnostics Operations, Inc. ,  Hitachi High-Technologies Corporation

Inventor： Thorsten Brueckner ,  Christoph Boehm ,  Juergen Spinke ,  Terumi Tamura ,  Taku Sakazume ,  Kyoko Imai

IPC: B01L3/00 ,  G01N35/10 ,  B01L3/02

CPC classification number: G01N35/1002 ,  B01L3/0268 ,  B01L3/0286 ,  B01L2200/04 ,  B01L2200/0684 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/082 ,  G01N35/1009

Abstract: A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid. The reservoir chamber has a fluid outlet. The cartridge further comprises a controllable dispenser component for dispensing a dispensing volume of the fluid from the reservoir chamber. The dispenser component is connected to the fluid outlet of the reservoir. The cartridge further comprises a single compressible fluid pump with a single elastic pumping element and a conduit extending from the fluid pump towards the fluid outlet. The fluid pump discharges a mixing volume of the fluid from the conduit into the reservoir chamber upon compression of the elastic pumping element. The mixing volume depends on the degree of compression of the elastic pumping element. The fluid pump sucks in the mixing volume from the reservoir into the conduit upon decompression of the elastic pumping element.

公开(公告)号：US20200038858A1

公开(公告)日：2020-02-06

申请号：US16599673

申请日：2019-10-11

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke

IPC: B01L3/00 ,  G01N35/10 ,  G01N35/00 ,  G01N1/38

Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.

公开(公告)号：US10345322B2

公开(公告)日：2019-07-09

申请号：US15138474

申请日：2016-04-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Thorsten Brueckner ,  Christoph Boehm ,  Juergen Spinke

IPC: G01N35/10 ,  B01F7/00 ,  B01F7/16 ,  B01F13/10 ,  B01F15/02 ,  B01L3/00 ,  B01F15/00

Abstract: A cartridge for dispensing a fluid is provided, the cartridge comprising: a reservoir chamber configured for receiving the fluid, the reservoir chamber having a fluid outlet and a cover with a first bearing; and a stirring assembly comprising a stirrer located inside the reservoir chamber, the stirring assembly comprising a shaft connected to the stirrer. The stirring assembly can be moved between first and second positions, wherein in the first position the stirring assembly can seal the fluid outlet, the stirring assembly in the first position being configured to form a second bearing with the reservoir chamber or the fluid outlet such that the stirrer can be rotated about an axis defined by the first and second bearing, and wherein if the stirring assembly is in the second position the fluid can pass through the fluid outlet, the shaft being configured to transmit rotational power to the stirrer.

公开(公告)号：US20180093267A1

公开(公告)日：2018-04-05

申请号：US15833476

申请日：2017-12-06

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke

IPC: B01L3/00

CPC classification number: B01L3/50273 ,  B01L3/5027 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  B01L2400/0694 ,  G01N1/38 ,  G01N35/00069 ,  G01N35/1016 ,  G01N2035/00257 ,  G01N2035/1032

Abstract: An automatic analyzer cartridge, spinnable around a rotational axis, has aliquoting and metering chambers, a connecting duct there between, and a vent connected to the metering chamber and nearer to the rotational axis than the metering chamber. The metering chamber has side walls that taper away from a central region. Capillary action next to the side walls is greater than in the central region. A circular arc about the rotational axis passes through a duct entrance in the aliquoting chamber and a duct exit in the metering chamber. The cartridge has a downstream fluidic element which is part of a fluidic structure for processing a biological sample into the processed biological sample. A valve connects the metering chamber to the fluidic element, which is fluidically connected to the fluidic structure. The fluidic structure receives the biological sample and has a measurement structure for enabling measurement of the processed biological sample.

公开(公告)号：US20170095814A1

公开(公告)日：2017-04-06

申请号：US15352698

申请日：2016-11-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke ,  Thorsten Brueckner

IPC: B01L3/00 ,  G01N21/07 ,  G01N21/64 ,  G01N35/00

CPC classification number: B01L3/50273 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/023 ,  B01L2300/045 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0644 ,  B01L2400/0688 ,  G01N21/07 ,  G01N21/64 ,  G01N21/6428 ,  G01N35/00 ,  G01N35/00069 ,  G01N35/00584 ,  G01N35/00871 ,  G01N2015/045 ,  G01N2021/0325 ,  G01N2035/00257 ,  G01N2035/00881 ,  G01N2035/0449

Abstract: An automatic analyzer cartridge, spinnable around a rotational axis, has a support structure with a front face perpendicular to the rotational axis, a fluidic structure for processing a biological sample into the processed biological sample, a measurement structure with at least one detection zone on the front face, and a rotatable lid covering the front face. The rotatable lid is rotatable about the rotational axis relative to the support structure from a first position relative to the support structure to a second position relative to the support structure. The rotatable lid has a sample inlet opening and a detection zone opening. In the first position, a sample inlet is aligned with the sample inlet opening and the measurement structure is covered by the rotatable lid. In the second position, the sample inlet is covered by the rotatable lid and the measurement structure is aligned with the detection zone opening.

公开(公告)号：US20160252540A1

公开(公告)日：2016-09-01

申请号：US15138474

申请日：2016-04-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Thorsten Brueckner ,  Christoph Boehm ,  Juergen Spinke

IPC: G01N35/10 ,  B01F15/02 ,  B01F15/00 ,  B01L3/00 ,  B01F7/16

CPC classification number: G01N35/1016 ,  B01F7/00141 ,  B01F7/161 ,  B01F7/1695 ,  B01F13/1072 ,  B01F15/00993 ,  B01F15/027 ,  B01F15/0292 ,  B01F2015/00103 ,  B01F2015/0011 ,  B01L3/502 ,  B01L2300/04 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2300/0832 ,  B01L2300/0851 ,  B01L2400/0475 ,  B01L2400/0633 ,  G01N2035/1058

Abstract: A cartridge for dispensing a fluid is provided, the cartridge comprising: a reservoir chamber configured for receiving the fluid, the reservoir chamber having a fluid outlet and a cover with a first bearing; and a stirring assembly comprising a stirrer located inside the reservoir chamber, the stirring assembly comprising a shaft connected to the stirrer. The stirring assembly can be moved between first and second positions, wherein in the first position the stirring assembly can seal the fluid outlet, the stirring assembly in the first position being configured to form a second bearing with the reservoir chamber or the fluid outlet such that the stirrer can be rotated about an axis defined by the first and second bearing, and wherein if the stirring assembly is in the second position the fluid can pass through the fluid outlet, the shaft being configured to transmit rotational power to the stirrer.

Abstract translation: 提供了用于分配流体的盒，所述盒包括：构造成用于接收流体的储存室，所述储存室具有流体出口和具有第一轴承的盖; 以及包括位于储存室内的搅拌器的搅拌组件，搅拌组件包括连接到搅拌器的轴。 搅拌组件可以在第一和第二位置之间移动，其中在第一位置中，搅拌组件可以密封流体出口，第一位置中的搅拌组件构造成与储存室或流体出口形成第二轴承，使得 搅拌器可以围绕由第一和第二轴承限定的轴线旋转，并且其中如果搅拌组件处于第二位置，则流体可以通过流体出口，该轴构造成将旋转动力传递到搅拌器。

公开(公告)号：US20160231344A1

公开(公告)日：2016-08-11

申请号：US15132915

申请日：2016-04-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Peter Kupser ,  Norbert Oranth ,  Juergen Spinke ,  Thorsten Brueckner ,  Timo Klein

IPC: G01N35/10 ,  B01L3/00 ,  G01N35/00

CPC classification number: G01N35/1002 ,  A61M5/14216 ,  A61M5/16809 ,  B01L3/0217 ,  B01L3/0224 ,  B01L3/502 ,  B01L2200/025 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0627 ,  B01L2300/0681 ,  B01L2400/0478 ,  B01L2400/0644 ,  B01L2400/065 ,  G01F11/021 ,  G01N35/00871 ,  G01N35/1016 ,  G01N35/1097 ,  G01N2035/1025 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.

公开(公告)号：US20160139164A1

公开(公告)日：2016-05-19

申请号：US15006476

申请日：2016-01-26

Applicant: Roche Diagnostics Operations, Inc. ,  Hitachi High-Technologies Corporation

Inventor： Thorsten Brueckner ,  Christoph Boehm ,  Juergen Spinke ,  Terumi Tamura ,  Taku Sakazume ,  Kyoko Imai

IPC: G01N35/10 ,  B01L3/02

CPC classification number: G01N35/1002 ,  B01L3/0268 ,  B01L3/0286 ,  B01L2200/04 ,  B01L2200/0684 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/082 ,  G01N35/1009

Abstract: A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid. The reservoir chamber has a fluid outlet. The cartridge further comprises a controllable dispenser component for dispensing a dispensing volume of the fluid from the reservoir chamber. The dispenser component is connected to the fluid outlet of the reservoir. The cartridge further comprises a single compressible fluid pump with a single elastic pumping element and a conduit extending from the fluid pump towards the fluid outlet. The fluid pump discharges a mixing volume of the fluid from the conduit into the reservoir chamber upon compression of the elastic pumping element. The mixing volume depends on the degree of compression of the elastic pumping element. The fluid pump sucks in the mixing volume from the reservoir into the conduit upon decompression of the elastic pumping element.

Abstract translation: 呈现用于分配流体的盒。 墨盒包括用于接收流体的储存室。 储存室具有流体出口。 墨盒还包括可控分配器部件，用于从储存室分配流体的分配体积。 分配器部件连接到储存器的流体出口。 墨盒还包括具有单个弹性抽吸元件的单个可压缩流体泵和从流体泵朝向流体出口延伸的导管。 当压缩弹性抽吸元件时，流体泵将流体的混合体积从管道排出到储存室中。 混合体积取决于弹性泵送元件的压缩程度。 当弹性抽吸元件减压时，流体泵从储存器吸入混合容积。