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    Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices
    23.
    发明申请
    Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices 失效

    公开(公告)号：US20050061669A1

    公开(公告)日：2005-03-24

    申请号：US10984239

    申请日：2004-11-09

    Applicant: Timothy Woudenberg ,  Zbigniew Bryning ,  Reid Kowallis

    Inventor： Timothy Woudenberg ,  Zbigniew Bryning ,  Reid Kowallis

    IPC: G01N27/30 ,  C02F1/461 ,  C02F1/469 ,  G01N27/403 ,  G01N27/447 ,  G01N27/26 ,  G01N27/27

    CPC classification number: G01N27/44704 ,  C02F1/46109 ,  C02F1/469

    Abstract: Bubble-free electrodes, electrochemical cells including bubble-free electrodes, analytical devices, and methods for preparing and using them are provided. The analytical devices each include at least one bubble-free electrode. Analytical devices that include an electrochemical cell and a sample containment device are also provided, wherein the electrochemical cell includes an anodic reservoir, a cathodic reservoir, an electrical connection between the anodic reservoir and the cathodic reservoir, and a first bubble-free electrode disposed within one of the anodic reservoir and the cathodic reservoir. A second electrode is disposed within the other reservoir and a power source is provided having a positive terminal that is normally in electrical contact with the first electrode, and a negative terminal that is normally in electrical contact with the second electrode. The analytical device further includes a power source polarity-inverting device for switching the contacts between the terminals of the power source and the first and second electrodes. The sample containment device includes a sample containment chamber having an opening for introducing a sample into the chamber and being positioned with respect to the electrochemical cell such that an electrical field generated by the electrochemical cell can influence a property of a component of a sample disposed in the sample containment chamber. Pressure-generating cells are also provided.

    Pulsed slit nozzle for generation of planar supersonic jets
    24.
    发明授权
    Pulsed slit nozzle for generation of planar supersonic jets 失效
    用于产生平面超音速喷气机的脉冲狭缝喷嘴

    公开(公告)号：US4834288A

    公开(公告)日：1989-05-30

    申请号：US452

    申请日：1987-01-05

    Applicant: Jonathan E. Kenny ,  Timothy Woudenberg

    Inventor： Jonathan E. Kenny ,  Timothy Woudenberg

    IPC: B05B1/00 ,  B05B3/02

    CPC classification number: B05B1/005 ,  B05B1/083 ,  B05B3/02 ,  Y10T137/86405

    Abstract: The present invention relates to generation of pulsed supersonic gas flow through a slit-shaped nozzle, useful in a wide range of applications, including particle separation, wind-tunnel studies, and especially spectroscopic studies of cold, gas-phase molecules. Specifically, the present invention is directed to a pulsed slit nozzle, which has a high length to width ratio, affording high sensitivity in spectroscopic applications.In addition, the present invention provides low dead volume, superior sealing properties, ease of actuation, heatability, uniform flow, ease of construction and maintenance, chemical inertness and long life.

    Abstract translation: 本发明涉及通过狭缝状喷嘴的脉冲超音速气流的产生，其可用于广泛的应用，包括颗粒分离，风洞研究，特别是冷气相分子的光谱研究。 具体地说，本发明涉及一种具有高长宽比的脉冲狭缝喷嘴，在光谱应用中提供高灵敏度。 此外，本发明提供低死体积，优异的密封性能，易于致动，可加热性，均匀的流动性，易于构造和维护，化学惰性和长寿命。

    Method and system for multiplex genetic analysis
    25.
    发明授权
    Method and system for multiplex genetic analysis 有权
    多重遗传分析方法与系统

    公开(公告)号：US09410889B2

    公开(公告)日：2016-08-09

    申请号：US11423403

    申请日：2006-06-09

    Applicant: Eric S. Nordman ,  Mark F. Oldham ,  Timothy Woudenberg

    Inventor： Eric S. Nordman ,  Mark F. Oldham ,  Timothy Woudenberg

    IPC: C12Q1/68 ,  G01N21/64

    CPC classification number: C12Q1/6874 ,  C12Q1/6869 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/648 ,  G01N21/6486 ,  G01N2021/6441 ,  C12Q2563/107

    Abstract: The present disclosure provides apparatus, systems and method for detecting separately and substantially simultaneously light emissions from a plurality of localized light-emitting analytes. A system according to exemplary embodiments of the present disclosure comprises a sample holder having structures formed thereon for spatially separating and constraining a plurality of light-emitting analytes each having a single nucleic acid molecule or a single nucleic acid polymerizing enzyme, a light source configured to illuminate the sample holder, an optical assembly configured to collect and detect separately and substantially simultaneously light emissions associated with the plurality of light emitting analytes. The system may further include a computer system configured to analyze the light emissions to determine the structures or properties of a target nucleic acid molecule associated with each analyte.

    Abstract translation: 本公开提供了用于单独和基本同时地检测来自多个局部发光分析物的光发射的装置，系统和方法。 根据本公开的示例性实施例的系统包括具有形成在其上的结构的样本保持器，用于空间分离和约束各自具有单个核酸分子或单个核酸聚合酶的多个发光分析物，光源被配置为 照亮样品架，光学组件被配置成分别收集和检测与多个发光分析物相关联的基本上同时的发光。 该系统还可以包括被配置为分析光发射以确定与每个分析物相关联的靶核酸分子的结构或性质的计算机系统。

    Method and System for Multiplex Genetic Analysis
    28.
    发明申请
    Method and System for Multiplex Genetic Analysis 审中-公开
    多重遗传分析方法与系统

    公开(公告)号：US20090305287A1

    公开(公告)日：2009-12-10

    申请号：US12482795

    申请日：2009-06-11

    Applicant: Eric S. Nordman ,  Mark F. Oldham ,  Timothy Woudenberg

    Inventor： Eric S. Nordman ,  Mark F. Oldham ,  Timothy Woudenberg

    IPC: C12Q1/68

    CPC classification number: C12Q1/6874 ,  C12Q1/6869 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/648 ,  G01N21/6486 ,  G01N2021/6441 ,  C12Q2563/107

    Abstract: A method for identifying nucleotides in a nucleic acid sequence is disclosed. A plurality of polymerization complexes are provided within a plurality of confined reaction environments. Each complex comprises a polymerase enzyme and a template nucleic acid. The plurality of complexes are contacted with a plurality of types of nucleotide analogs labeled with distinguishable fluorescent labels under conditions suitable for polymerization. Fluorescent signals associated with incorporation of a nucleotide analog are transmitted to a detector, wherein the location of the fluorescent signal on the detector is indicative of the individual confined reaction environment and the type of nucleotide incorporated. The nucleotide in a nucleic acid sequence is identified based upon the type of nucleotide incorporated and the confined reaction environment.

    Abstract translation: 公开了鉴定核酸序列中的核苷酸的方法。 在多个限制反应环境中提供多个聚合复合物。 每个复合物包含聚合酶和模板核酸。 在适于聚合的条件下，多种复合物与多种类型的可区分荧光标记的核苷酸类似物接触。 与核苷酸类似物掺入相关的荧光信号被传送到检测器，其中荧光信号在检测器上的位置指示个体限制的反应环境和掺入的核苷酸的类型。 核酸序列中的核苷酸是根据所掺入的核苷酸类型和限制性反应环境来鉴定的。

    HIGH DENSITY SEQUENCE DETECTION METHODS
    29.
    发明申请
    HIGH DENSITY SEQUENCE DETECTION METHODS 审中-公开
    高密度序列检测方法

    公开(公告)号：US20070264666A1

    公开(公告)日：2007-11-15

    申请号：US11828572

    申请日：2007-07-26

    Applicant: Timothy Woudenberg ,  Robert Jones ,  Kenneth Livak

    Inventor： Timothy Woudenberg ,  Robert Jones ,  Kenneth Livak

    IPC: C12Q1/68 ,  C07H21/00

    CPC classification number: B01L3/50851 ,  B01L3/50853 ,  B01L3/50857 ,  B01L2200/0642 ,  B01L2300/044 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2400/0409 ,  B01L2400/0487 ,  C12Q1/6837

    Abstract: A method for performing PCR on a liquid sample comprising a plurality of polynucleotide targets, wherein each polynucleotide target is present at very low concentration within the sample. The method comprises applying PCR reactants to the surface of a substrate to produce a plurality of reaction spots on the surface of the substrate; loading the liquid sample and a PCR reagent mixture onto the reaction spots; forming a sealed reaction chamber, having a volume of less than about 20 nanoliters, over each of the reaction spots; and amplifying the sample.

    Abstract translation: 在包含多个多核苷酸靶标的液体样品上进行PCR的方法，其中每个多核苷酸靶标以非常低的浓度存在于样品内。 该方法包括将PCR反应物施加到基底的表面以在基底的表面上产生多个反应点; 将液体样品和PCR试剂混合物加载到反应点上; 在每个反应点上形成体积小于约20纳升的密封反应室; 并放大样品。

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