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公开(公告)号：US09764323B2
公开(公告)日：2017-09-19
申请号：US14489855
申请日：2014-09-18
Applicant: Waters Technologies Corporation
Inventor： Bernard Bunner , Martin Gilar , Robert A. Jencks , Charles T. Murphy
CPC classification number: B01L3/502753 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2300/0681 , B01L2400/0487 , B01L2400/086 , G01N30/603 , G01N30/6095
Abstract: A system that incorporates teachings of the subject disclosure may include, for example, a process that includes obtaining a porous medium comprising a porous material having a first shape and an initial porosity profile. The porous medium is engaged with a cavity in a fluidic device, wherein the cavity is in fluid communication with a channel of the fluidic device. The first shape of the porous material can be adjusted to a second shape resulting in the initial porosity profile being adjusted to a target porosity profile. Such adjustment can be accomplished by the engaging of the porous medium with the cavity, by pre-adjusting a shape of the porous media before insertion into the cavity, or by some combination thereof. Other embodiments are disclosed.
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公开(公告)号：US09598716B2
公开(公告)日：2017-03-21
申请号：US14075637
申请日：2013-11-08
Applicant: Waters Technologies Corporation
Inventor： Edouard S. Bouvier , Bruce J. Compton , John C. Gebler , Martin Gilar , Ying Q. Yu , Peter J. Lee , Elizabeth K. Kane
CPC classification number: C12Q1/37 , C12P21/06 , G01N27/44726 , G01N27/44747 , G01N33/5306
Abstract: The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.
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公开(公告)号：US09115178B2
公开(公告)日：2015-08-25
申请号：US14034754
申请日：2013-09-24
Applicant: Waters Technologies Corporation
Inventor： Martin Gilar , Ying-Qing Yu , Jennifer Fournier , John E. O'Gara
CPC classification number: C07K1/36 , C12Q1/37 , G01N1/405 , G01N1/4055 , G01N30/34 , G01N30/6069 , G01N35/1097
Abstract: Embodiments of the present invention are directed to articles of manufacture, devices, methods and apparatus for performing liquid chromatography featuring a chromatographic sorbent having one or more pentafluorophenyl groups, wherein said one or more pentafluorophenyl groups are a bonded phase on a sorbent selected from the group comprising silica, organic polymers or hybrid organic silane material and said pentafluorophenyl groups are in a mono-, bi-, and tridentate forms.
Abstract translation: 本发明的实施方案涉及用于进行液相色谱的制品，装置，方法和装置，其特征在于具有一个或多个五氟苯基的色谱吸附剂，其中所述一个或多个五氟苯基是选自组中的吸附剂上的键合相 包括二氧化硅，有机聚合物或杂化有机硅烷材料，所述五氟苯基是单 - ，二 - 和三齿形式。
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公开(公告)号：US20140178915A1
公开(公告)日：2014-06-26
申请号：US14034754
申请日：2013-09-24
Applicant: Waters Technologies Corporation
Inventor： Martin Gilar , Ying-Qing Yu , Jennifer Fournier , John E. O'Gara
CPC classification number: C07K1/36 , C12Q1/37 , G01N1/405 , G01N1/4055 , G01N30/34 , G01N30/6069 , G01N35/1097
Abstract: Embodiments of the present invention are directed to articles of manufacture, devices, methods and apparatus for performing liquid chromatography featuring a chromatographic sorbent having one or more pentafluorophenyl groups, wherein said one or more pentafluorophenyl groups are a bonded phase on a sorbent selected from the group comprising silica, organic polymers or hybrid organic silane material and said pentafluorophenyl groups are in a mono-, bi-, and tridentate forms.
Abstract translation: 本发明的实施方案涉及用于进行液相色谱的制品，装置，方法和装置，其特征在于具有一个或多个五氟苯基的色谱吸附剂，其中所述一个或多个五氟苯基是选自组中的吸附剂上的键合相 包括二氧化硅，有机聚合物或杂化有机硅烷材料，所述五氟苯基是单 - ，二 - 和三齿形式。
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公开(公告)号：US20240361318A1
公开(公告)日：2024-10-31
申请号：US18647863
申请日：2024-04-26
Applicant: Waters Technologies Corporation
Inventor： Kevin Wyndham , Beatrice Muriithi , Martin Gilar , Yeliz Tunc Sarisozen
IPC: G01N33/569 , G01N33/53 , G01N33/543 , G01N33/74
CPC classification number: G01N33/56983 , G01N33/5308 , G01N33/54313 , G01N33/54386 , G01N33/74 , G01N2333/015 , G01N2333/62 , G01N2469/10
Abstract: The present technology is directed to methods of preparing affinity chromatographic columns using streptavidin-conjugated particles and biotinylated affinity agents (i.e., biotinylated oligonucleotides, biotinylated antibodies or biotinylated antigen-binding fragments thereof). The methods of the present technology can be utilized to perform affinity capture assays in a high-throughput, efficient manner. Further, the affinity chromatographic columns disclosed herein are customizable due to the ability to utilize any biotinylated affinity agent. The methods herein utilize an on-line loading (i.e., loading the column with biotinylated affinity agent via a liquid chromatography system).
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Patent Agency Ranking
26.发明公开公开(公告)号：US20230364585A1
公开(公告)日：2023-11-16
申请号：US18144514
申请日：2023-05-08
Applicant: Waters Technologies Corporation
Inventor： Matthew A. Lauber , Catalin Doneanu , Weibin Chen , Ying Qing Yu , Jennifer M. Nguyen , Fabrice Gritti , Martin Gilar
IPC: B01J20/288 , B01J20/32 , B01J20/10 , B01J20/28
CPC classification number: B01J20/288 , B01J20/103 , B01J20/28004 , B01J20/3204 , B01J2220/54
Abstract: The present disclosure discusses a method of separating and/or purifying polynucleotides. The method includes injecting a sample into a chromatographic column that is packed with a porous sorbent having a pore size that substantially excludes the polynucleotides from the sorbent. This restricted access to the sorbent allows separation of large polynucleotides from each other and from smaller molecular weight impurities.
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公开(公告)号：US11709085B2
公开(公告)日：2023-07-25
申请号：US16996992
申请日：2020-08-19
Applicant: Waters Technologies Corporation
Inventor： Jason F. Hill , Martin Gilar , Abhijit Tarafder , Christopher DesJardins
CPC classification number: G01F22/02 , G01N30/06 , G01N30/16 , G01N2030/027
Abstract: Described is a method for determining a dwell volume of a liquid chromatography system and a liquid chromatography system that can determined the system dwell volume. The method includes mixing a flow of a first solvent with a flow of a second solvent to form a solvent mixture. The flows of the first and second solvents are decreased and increased, respectively, to generate a gradient composition. A system pressure of the liquid chromatography system is measured to determine a pressure trace defined as the measured system pressure as a function of time. The dwell volume of the system is determined from a time delay determined between the gradient composition at the mixing location and the pressure trace. The method can be performed with a liquid chromatography system having a chromatographic column or a flow restrictor used in place of the chromatographic column.
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28.发明授权公开(公告)号：US11604174B2
公开(公告)日：2023-03-14
申请号：US16684930
申请日：2019-11-15
Applicant: Waters Technologies Corporation
Inventor： Abhijit Tarafder , Sebastien Besner , Mark Basile , Martin Gilar
Abstract: Exemplary embodiments are directed to methods and systems for controlling fluid parameters within a detector. A first and second fluid pump manager control the flow of a first and second fluid to one or more heating/cooling devices, and a mixer receives and mixes the first and second fluids. An optical detector flow cell receives the fluid mixture from the mixer, and a pressure regulator controls the pressure at the optical detector flow cell. Thus, the composition, temperature, and pressure of a fluid mixture entering an optical detector flow cell can be controlled in real time.
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公开(公告)号：US10583436B2
公开(公告)日：2020-03-10
申请号：US15702007
申请日：2017-09-12
Applicant: Waters Technologies Corporation
Inventor： Bernard Bunner , Martin Gilar , Robert A. Jencks , Charles T. Murphy
Abstract: A system that incorporates teachings of the subject disclosure may include, for example, a process that includes obtaining a porous medium comprising a porous material having a first shape and an initial porosity profile. The porous medium is engaged with a cavity in a fluidic device, wherein the cavity is in fluid communication with a channel of the fluidic device. The first shape of the porous material can be adjusted to a second shape resulting in the initial porosity profile being adjusted to a target porosity profile. Such adjustment can be accomplished by the engaging of the porous medium with the cavity, by pre-adjusting a shape of the porous media before insertion into the cavity, or by some combination thereof. Other embodiments are disclosed.
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公开(公告)号：US20200025723A1
公开(公告)日：2020-01-23
申请号：US16518388
申请日：2019-07-22
Applicant: Waters Technologies Corporation
Inventor： Martin Gilar , Fabrice Gritti , Thomas S. McDonald
IPC: G01N30/20 , G01N30/22 , B01J20/281 , G01N30/60 , G01N30/34
Abstract: A liquid chromatography system including a solvent delivery pump for delivering a mobile phase through the liquid chromatography system, an injector for injecting a sample into the mobile phase, a column for effecting a separation of components of the sample, and a dispersive element positioned between the injector and the column, the dispersive element configured to dilute a sample solvent in the mobile phase prior to entering the column is provided. Further dispersive elements, systems, and methods are also provided.
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