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162 条记录 (耗时 0.028 秒)

    Method of delivering drugs to a tissue using drug-coated medical devices
    21.
    发明申请
    Method of delivering drugs to a tissue using drug-coated medical devices 审中-公开
    使用药物包被的医疗装置将药物递送到组织的方法

    公开(公告)号：US20030064965A1

    公开(公告)日：2003-04-03

    申请号：US10076723

    申请日：2002-02-14

    发明人： Jacob Richter

    IPC分类号： A61K031/675 ,  A61K031/66 ,  A61K009/127

    CPC分类号： A61K31/675 ,  A61K9/127 ,  A61K31/66 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/622 ,  A61L2300/624 ,  A61L2300/626

    摘要： The present invention relates to a method of delivering drugs having anti-proliferative activity in the cardiovascular system to a tissue or circulation using a drug-coated medical device. The drug-coated medical device is brought into contact with the target tissue or circulation and the drugs are quickly released into the area surrounding the device in a short time after the contact step. The release times may include 30 seconds, 1 minute or 3 minutes. Once the therapeutic drugs are released, they are quickly and effectively absorbed by the surrounding cells or circulation. The therapeutic drug may have sustained anti-proliferative activity and thus a prolonged effect. The therapeutic drug, which inhibits proliferative activity in the cardiovascular system, may be preferably encapsulated in a controlled release carrier. In a preferred embodiment, the controlled release carrier may be a liposome, drug aggregate, microparticle or nanoparticle and the therapeutic agent may be a bisphosphonate.

    摘要翻译： 本发明涉及使用药物包被的医疗装置将在心血管系统中具有抗增殖活性的药物递送至组织或循环的方法。 药物涂覆的医疗装置与目标组织或循环接触，并且药物在接触步骤之后的短时间内快速释放到装置周围的区域中。 释放时间可能包括30秒，1分钟或3分钟。 一旦治疗药物被释放，它们被周围细胞或循环迅速有效地吸收。 治疗药物可能具有持续的抗增殖活性，从而延长效果。 抑制心血管系统增殖活性的治疗药物可优选包封在控释载体中。 在优选的实施方案中，控释载体可以是脂质体，药物聚集体，微粒或纳米颗粒，并且治疗剂可以是双膦酸盐。

    Drug delivery via therapeutic hydrogels
    23.
    发明授权
    Drug delivery via therapeutic hydrogels 失效
    通过治疗性水凝胶进行药物输送

    公开(公告)号：US06228393B1

    公开(公告)日：2001-05-08

    申请号：US09412584

    申请日：1999-10-05

    申请人： Frank DiCosmo ,  Valerio DiTizio

    发明人： Frank DiCosmo ,  Valerio DiTizio

    IPC分类号： A61K9127

    CPC分类号： A61L27/52 ,  A61K9/127 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/145 ,  A61L29/16 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/436 ,  A61L2300/626

    摘要： The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to the surface of substrates such as in-dwelling medical devices, such as implants, catheters, and the like. The present invention is particularly useful in the treatment and prevention of biofilm mediated infection often associated with the use of in-dwelling medical devices.

    摘要翻译： 本发明涉及一种用于从固体基质进行药物递送的载体。 装载有脂质体治疗剂如抗生素的水凝胶共价结合到诸如植入物，导管等的诸如住院医疗装置的底物表面。 本发明特别可用于治疗和预防通常与使用住院医疗器械有关的生物膜介导的感染。

    Biocompatible surfaces
    24.
    发明授权
    Biocompatible surfaces 失效
    生物相容表面

    公开(公告)号：US4348329A

    公开(公告)日：1982-09-07

    申请号：US218556

    申请日：1980-12-22

    申请人： Dennis Chapman

    发明人： Dennis Chapman

    IPC分类号： A61K9/127 ,  A61L15/44 ,  A61L27/16 ,  A61L29/08 ,  A61L33/00 ,  A61L33/06 ,  B01D67/00 ,  C07C51/353 ,  C07C57/18 ,  C07F9/10 ,  C08F38/00 ,  C07F9/02 ,  A23J7/00

    CPC分类号： B01D67/0088 ,  A61K9/1273 ,  A61L15/44 ,  A61L27/16 ,  A61L29/085 ,  A61L33/00 ,  A61L33/064 ,  B01D67/0093 ,  C07C51/353 ,  C07C57/18 ,  C07F9/10 ,  C08F38/00 ,  A61L2300/626 ,  B01D2323/30 ,  B01D2323/34 ,  Y10S623/92

    摘要： New phospholipids containing a conjugated di-yne system have the formula: ##STR1## wherein at least one of B.sub.1 and B.sub.2 is a group of the formula--(CO).sub.p --X.sub.1 --C.tbd.C--C.tbd.C--Y.sub.1wherein p is 0 or 1, X.sub.1 is a direct bond or a divalent aliphatic or cycloaliphatic group, Y.sub.1 is H or a monovalent aliphatic or cycloaliphatic group, the total number of carbon atoms in X.sub.1 and Y.sub.1 in each of B.sub.1 and/or B.sub.2 being 8 to 26; and the other of B.sub.1 and B.sub.2 is either (a) the same or a different group of the formula:--(CO).sub.p --X.sub.1 --C.tbd.C--C.tbd.C--Y.sub.1where X.sub.1, Y.sub.1 or p are as defined above;or (b) is an aliphatic or cycloaliphatic group containing at least 8 carbon atoms; n is 0 or 1, m is 2, 3 or 4 and each R independently represents an alkyl group containing 1 to 4 carbon atoms, and are prepared by esterification and/or etherification of glycerol by conventional techniques. The conjugated di-yne systems can be cross-linked by actinic radiation to give intermolecular and, in certain cases, also intramolecular cross-linking. Thin layers of the phospholipids can be coated onto substrates subsequently to be brought into contact with blood or other body fluids and then cross-linked to give polymer coated surfaces which have a reduced tendency to initiate blood coagulation, for example, compared to untreated surfaces. Artificial lenses for the human eye treated in this way have a reduced tendency to cause endothelial damage. The phospholipids of the invention can also be formed into liposomes and the conjugated di-yne system then cross-linked. Physiologically active materials such as drugs, enzymes or antigens can be incorporated into the liposomes which can then be used as prolonged release formulations.

    摘要翻译： 含有共轭二烯体系的新型磷脂具有下式：其中B1和B2中的至少一个是式 - （CO）p-X1-C 3BOND CC 3BOND C-Y1的基团，其中p为0或 1，X1是直接键或二价脂族或脂环族基团，Y1是H或一价脂族或脂环族基团，B1和/或B2各自的X1和Y1中的碳原子总数为8-26; B1和B2中的另一个是（a）相同或不同的下式： - （CO）p-X1-C 3BOND C-C 3BOND C-Y1，其中X1，Y1或p如上定义; 或（b）是含有至少8个碳原子的脂族或脂环族基团; n为0或1，m为2,3或4，各R独立地表示含有1至4个碳原子的烷基，并且通过常规技术酯化和/或醚化甘油来制备。 共轭二烯系统可以通过光化辐射交联以产生分子间，在某些情况下也是分子内的交联。 磷脂的薄层可以涂覆在基底上，随后与血液或其他体液接触，然后交联以得到例如与未处理的表面相比具有降低的凝血发生倾向的聚合物涂覆的表面。 以这种方式处理的人眼的人造镜片具有降低的引起内皮损伤的倾向。 本发明的磷脂也可以形成脂质体，然后共轭二烯系统交联。 可以将生理活性物质如药物，酶或抗原掺入脂质体中，然后将其用作延长释放制剂。