公开(公告)号：US20060206147A1

公开(公告)日：2006-09-14

申请号：US11418541

申请日：2006-05-03

申请人： Lauri DeVore ,  Richard Shea ,  John Wang ,  Hugo Gonzales ,  Steven Springmeyer

发明人： Lauri DeVore ,  Richard Shea ,  John Wang ,  Hugo Gonzales ,  Steven Springmeyer

IPC分类号： A61B17/08

CPC分类号： A61M31/00 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/1204 ,  A61B17/12104 ,  A61B17/12159 ,  A61B17/12172 ,  A61B2017/1205 ,  A61B2017/22051 ,  A61B2017/22067 ,  A61B2017/242 ,  A61B2217/005 ,  A61F2002/043 ,  A61M1/0023 ,  A61M25/04 ,  A61M2025/0076 ,  A61M2210/1035 ,  A61N5/1027 ,  A61N2005/1021

摘要： An intra-bronchial device provides a medicant intra-bronchially. The medicant may be used for controlling biological interaction of an intra-bronchial obstruction device with the patient, to treat a disease or condition of the lungs such as pneumonia or lung cancer, or to treat a systemic disease or condition. The medicant is provided by associating a medicant with the intra-bronchial device, either before, at the time of placement, or after placement. The medicant may overlie at least a portion of the intra-bronchial device, be absorbed into at least a portion of the intra-bronchial device, or be carried in a chamber. The intra-bronchial device may further include an absorptive member, and the medicant is absorbed by the absorptive member.

摘要翻译： 支气管内装置在支气管内提供药物。 药物可以用于控制支气管阻塞装置与患者的生物相互作用，以治疗肺的疾病或病症如肺炎或肺癌，或治疗全身性疾病或病症。 该药物通过将药物与支气管内装置相关联，在放置之前，放置之后或放置后提供。 药物可以覆盖支气管内装置的至少一部分，被吸收到支气管内装置的至少一部分中，或者被携带在腔室中。 支气管内装置还可以包括吸收构件，并且药物被吸收构件吸收。

公开(公告)号：US20030158515A1

公开(公告)日：2003-08-21

申请号：US10317667

申请日：2002-12-11

申请人： Spiration, Inc.

发明人： Hugo X. Gonzalez ,  Steven Chase Springmeyer ,  Richard O. Shea ,  John H. Wang ,  Lauri J. DeVore

IPC分类号： A61M031/00

CPC分类号： A61M31/002 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/1204 ,  A61B17/12104 ,  A61B17/12159 ,  A61B17/12172 ,  A61B2017/1205 ,  A61B2017/22051 ,  A61B2017/22067 ,  A61B2017/242 ,  A61B2217/005 ,  A61F2002/043 ,  A61M1/0023 ,  A61M25/04 ,  A61M31/00 ,  A61M2025/0076 ,  A61M2210/1035 ,  A61N5/1027 ,  A61N2005/1021

摘要： The present invention includes an intra-bronchial device, system, and method for providing a therapeutic agent to a patient. A device includes a flow control member for placement in an air passageway communicating with a lung portion, and when deployed in the air passageway inhibits a therapeutic agent distal of the control member from moving proximal of the control member, and includes the therapeutic agent associated with the flow control member. The control member may inhibit movement of the therapeutic agent by limiting airflow, and may include a one-way valve limiting exhalation of air from the lung portion. The control member may include a flexible membrane impervious to air flow, or a separator arranged to inhibit the movement of the therapeutic agent. The control member may include at least one anchor, and the anchor may be releasable from the air passageway for removal of the intra-bronchial device.

摘要翻译： 本发明包括用于向患者提供治疗剂的支气管内装置，系统和方法。 一种装置包括用于放置在与肺部连通的空气通道中的流量控制构件，并且当部署在空气通道中时，阻止控制构件远侧的治疗剂移动到控制构件的近侧，并且包括与 流量控制构件。 控制构件可以通过限制气流来抑制治疗剂的移动，并且可以包括限制从肺部呼出空气的单向阀。 控制构件可以包括不透气体的柔性膜，或者设置成抑制治疗剂运动的隔膜。 控制构件可以包括至少一个锚固件，并且锚固件可以从空气通道释放以去除支气管内装置。

公开(公告)号：US11690507B2

公开(公告)日：2023-07-04

申请号：US16001102

申请日：2018-06-06

申请人： Thoracent, Inc.

发明人： Wissam Abouzgheib

IPC分类号： A61B1/267 ,  A61B1/015 ,  A61M39/10 ,  A61M5/20 ,  A61M16/20 ,  A61M16/00 ,  A61B1/018 ,  A61B1/00 ,  A61M39/22

CPC分类号： A61B1/2676 ,  A61B1/015 ,  A61M5/20 ,  A61M16/201 ,  A61M39/10 ,  A61B1/00068 ,  A61B1/018 ,  A61M16/0096 ,  A61M16/20 ,  A61M39/223 ,  A61M2039/226 ,  A61M2202/0208 ,  A61M2210/1035 ,  A61M2210/1039 ,  A61M2202/0208 ,  A61M2202/0007

摘要： A system and method for performing a bronchoscopy. The system may include a bronchoscope, a multi-fluid conduit apparatus, and a switching apparatus. The bronchoscope may include an insertion tube having a distal end, a control section, and a working channel. The multi-fluid conduit apparatus may include a first conduit section operably coupled to a vacuum source, a second conduit section operably coupled to an oxygen source, and a third conduit section operably coupled to the working channel, each of the first and second conduit sections being fluidly coupled to the third conduit section. The switching apparatus may include a valve apparatus operably coupled to each of the first and second conduit sections and an actuator apparatus operably coupled to the valve apparatus. The actuator apparatus may alter the valve apparatus between: (1) a suction supply state; and (2) an oxygen supply state.

公开(公告)号：US20180272089A1

公开(公告)日：2018-09-27

申请号：US15934249

申请日：2018-03-23

申请人： Luiz Maracaja

发明人： Luiz Maracaja

IPC分类号： A61M16/04 ,  A61B1/00 ,  A61B1/267 ,  A61M16/10 ,  A61B1/018 ,  A61B1/07 ,  A61B1/04

CPC分类号： A61M16/0404 ,  A61B1/00082 ,  A61B1/00098 ,  A61B1/00135 ,  A61B1/00154 ,  A61B1/015 ,  A61B1/018 ,  A61B1/042 ,  A61B1/07 ,  A61B1/126 ,  A61B1/2676 ,  A61M16/0431 ,  A61M16/0434 ,  A61M16/0459 ,  A61M16/0463 ,  A61M16/0833 ,  A61M16/105 ,  A61M2210/1035

摘要： Embodiments are directed to an endotracheal intubation system that provides for differential ventilation of lungs and lung lobes.

公开(公告)号：US20170189644A1

公开(公告)日：2017-07-06

申请号：US15208809

申请日：2016-07-13

申请人： Cook Regentec LLC

发明人： Frank J. Fischer, JR. ,  Michael P. DeBruyne

IPC分类号： A61M25/00 ,  A61M25/10 ,  A61M11/00 ,  A61M31/00 ,  A61M25/01

CPC分类号： A61M25/0026 ,  A61B1/018 ,  A61B1/2676 ,  A61M11/00 ,  A61M25/0068 ,  A61M25/0102 ,  A61M25/0136 ,  A61M25/0147 ,  A61M25/10 ,  A61M31/00 ,  A61M2025/0073 ,  A61M2025/1052 ,  A61M2210/1032 ,  A61M2210/1035 ,  A61M2210/1039

摘要： A device for introducing a material into a body cavity is shown. The device includes a catheter with a distal tip. A first lumen extends through the catheter. The catheter is configured to form a mist from liquid passed through the first lumen, for example including a misting nozzle in fluid communication with the first lumen and configured to provide a mist from a flow of liquid through the first lumen. An inflatable balloon may be included on the catheter to allow the user to isolate the portion of the body in which the material is introduced. Additional described features can provide for controlled deflection of a distal region of the catheter, guidewire or guide loop tool lumens, first and second misting nozzles on the catheter, and delivery apparatuses including the catheter devices coupled or that can be coupled to endoscopes such as bronchoscopes. Methods of use of the catheter devices and delivery apparatuses are also described.

公开(公告)号：US20160243333A1

公开(公告)日：2016-08-25

申请号：US15142794

申请日：2016-04-29

申请人： MERCATOR MEDSYSTEMS, INC.

发明人： Kirk Patrick SEWARD

IPC分类号： A61M25/00 ,  A61L29/16 ,  A61L29/08 ,  A61M25/10

CPC分类号： A61M25/0084 ,  A61B5/489 ,  A61B5/6852 ,  A61K31/337 ,  A61L27/52 ,  A61L29/14 ,  A61L2300/416 ,  A61M25/003 ,  A61M25/0108 ,  A61M25/10 ,  A61M25/1029 ,  A61M2025/0087 ,  A61M2025/0092 ,  A61M2025/0093 ,  A61M2025/0183 ,  A61M2025/105 ,  A61M2025/1059 ,  A61M2025/1086 ,  A61M2210/1032 ,  A61M2210/1035 ,  A61N1/0529

摘要： Systems, devices, and methods for maintaining patency in a bronchus of a patient are presented. A catheter is positioned within the bronchus. A target region of one or more of a bronchial wall, submucosa, media, and adventitia is punctured with an injection needle disposed on a distal end of the catheter. Such puncturing is achieved by expanding a balloon disposed on the distal end of the catheter. The balloon may be comprised of at least two materials of different elastic modulus, which allows for a flexible but relatively non-distensible, unfolding component of the balloon as well as an elastomeric, inflatable component of the balloon. Through the injection needle, an amount of one or more crosslinking agents is delivered to the target region. The delivered amount is effective to provide structural support for the bronchial wall, substituting for the bronchial cartilage thereby treating bronchomalacia.

摘要翻译： 提出了用于维持患者支气管通畅的系统，装置和方法。 导管位于支气管内。 支气管壁，粘膜下层，介质和外膜中的一个或多个的靶区域用设置在导管的远端上的注射针刺穿。 通过使设置在导管的远端上的气囊膨胀来实现这种穿刺。 球囊可以由至少两种不同弹性模量的材料组成，其允许球囊的柔性但相对不扩张的展开部件以及气囊的弹性的，可充气的部件。 通过注射针，将一定量的一种或多种交联剂输送到目标区域。 输送量有效地为支气管壁提供结构支撑，代替支气管软骨，从而治疗支气管扩张。

公开(公告)号：US20160101246A1

公开(公告)日：2016-04-14

申请号：US14877032

申请日：2015-10-07

申请人： Solaeromed Inc.

发明人： John H. Dennis ,  Ian G. Mcaffer ,  Stefan Dalberg ,  Francis Green ,  Andy Clark

IPC分类号： A61M11/02 ,  A61M11/04 ,  A61M15/00 ,  A61K31/02 ,  A61M11/00

CPC分类号： A61M11/02 ,  A61K31/02 ,  A61M11/003 ,  A61M11/04 ,  A61M15/0025 ,  A61M15/009 ,  A61M2202/0476 ,  A61M2205/7536 ,  A61M2205/8225 ,  A61M2210/1035

摘要： Disclosed are apparatus and methods for producing and delivering vapour medicament. An exemplary apparatus disclosed comprises: a gas inlet for receiving a gas from a source of pressurized gas; a chamber for receiving a liquid medicament therein, the chamber being in communication with the gas inlet for permitting entrance and expansion of the gas in the chamber in the presence of the liquid medicament to produce the vapour medicament; and a vapour outlet in communication with the chamber for delivering the vapour medicament.

摘要翻译： 公开了用于生产和递送蒸气药物的装置和方法。 公开的示例性装置包括：用于从加压气体源接收气体的气体入口; 用于在其中接收液体药物的腔室，所述腔室与所述气体入口连通，用于在所述液体药物的存在下允许所述腔室中的气体进入和膨胀以产生所述蒸汽药物; 以及与腔室连通以输送蒸气药剂的蒸气出口。

公开(公告)号：US20150165136A1

公开(公告)日：2015-06-18

申请号：US14566173

申请日：2014-12-10

申请人： STELA Medical, LLC

发明人： Richard Edward Galgon ,  Katherine Lorraine Baldwin ,  James French Dorrance ,  Terah Michelle Hennick ,  Alyssa Ruth Mitchell ,  Mitchell Eugene Tyler

IPC分类号： A61M11/00 ,  A61M19/00

CPC分类号： A61M19/00 ,  A61M11/007 ,  A61M25/0032 ,  A61M25/007 ,  A61M39/223 ,  A61M2039/082 ,  A61M2039/229 ,  A61M2202/048 ,  A61M2210/0618 ,  A61M2210/0625 ,  A61M2210/065 ,  A61M2210/1028 ,  A61M2210/1032 ,  A61M2210/1035 ,  A61M2210/1039 ,  B05B1/1636 ,  B05B1/1672 ,  B05B1/205 ,  B05B1/3415

摘要： Provided herein are medicament delivery systems for selectively providing radial, distal, or a combination radial and distal delivery spray patterns of a medicament, and a method of their use to treat a patient's airway. Generally, a medicament delivery system comprises an elongate shaft, a medicament source, and a means for controlling the delivery spray pattern of the elongate shaft. In use, the medicament delivery system is inserted into a patient's airway during a laryngoscopy procedure to deliver a topical anesthetic to the airway. The medicament delivery device can be used with both direct and indirect view laryngoscopy procedures.

摘要翻译： 本文提供了用于选择性地提供药物的径向，远端或组合的径向和远端递送喷雾图案的药物递送系统及其用于治疗患者气道的方法。 通常，药物输送系统包括细长轴，药物源和用于控制细长轴的输送喷雾图案的装置。 在使用中，药物输送系统在喉镜检查过程中插入患者的气道中以将局部麻醉剂递送至气道。 药物输送装置可以用于直接和间接观察喉镜检查程序。

公开(公告)号：US20140277060A1

公开(公告)日：2014-09-18

申请号：US13795910

申请日：2013-03-12

申请人： ACCLARENT, INC.

发明人： Shrirang V. Ranade

IPC分类号： A61M29/02

CPC分类号： A61M29/02 ,  A61M25/0102 ,  A61M25/10184 ,  A61M2025/0002 ,  A61M2025/0008 ,  A61M2025/1093 ,  A61M2205/18 ,  A61M2205/332 ,  A61M2205/3344 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2210/1028 ,  A61M2210/1032 ,  A61M2210/1035

摘要： An apparatus comprises a balloon catheter, an inflatable balloon, and a force sensor. The balloon catheter is operable to communicate fluid to the balloon. The balloon is disposed on the distal end of the balloon catheter. The balloon is positionable within an airway or other anatomical passageway of a patient. The force sensor is positioned along the balloon catheter or in the balloon and is able to detect a physical change within the balloon catheter or balloon. A control logic may trigger a response based on readings by the force measuring device. For instance, the control logic may trigger an alert when a force related parameter exceeds a threshold; or when a rate of change in the parameter exceeds a threshold. In addition or in the alternative, the control logic may trigger a feature that is operable to reduce fluid pressure in the balloon in response to such conditions.

摘要翻译： 一种装置包括球囊导管，可膨胀球囊和力传感器。 气囊导管可操作以将流体传送到气囊。 气囊设置在气囊导管的远端。 气囊可定位在患者的气道或其他解剖通道内。 力传感器沿着气囊导管或气球定位，并且能够检测球囊导管或球囊内的物理变化。 控制逻辑可以基于力测量装置的读数触发响应。 例如，当力相关参数超过阈值时，控制逻辑可以触发警报; 或当参数的变化率超过阈值时。 另外或在替代方案中，控制逻辑可以触发可操作以响应于这种状况来减小气囊中的流体压力的特征。

公开(公告)号：US20130296696A1

公开(公告)日：2013-11-07

申请号：US13938025

申请日：2013-07-09

申请人： Pulmonx Corporation

发明人： Nikolai Aljuri ,  Rodney C. Perkins ,  Niyazi Beyhan

IPC分类号： A61M16/04 ,  A61M16/20 ,  A61B6/03

CPC分类号： A61B17/12104 ,  A61B5/055 ,  A61B5/08 ,  A61B5/0813 ,  A61B5/085 ,  A61B5/6853 ,  A61B6/03 ,  A61B6/032 ,  A61B17/1204 ,  A61B17/12136 ,  A61B2017/00022 ,  A61M16/0434 ,  A61M16/208 ,  A61M25/10 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M2025/1052 ,  A61M2205/3303 ,  A61M2205/3334 ,  A61M2205/3344 ,  A61M2210/1035 ,  A61M2230/46

摘要： The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment.

摘要翻译： 通过在进入肺隔室的气道中密封导管的远端来减少超膨胀的肺隔室的体积。 当患者呼气时，空气通过导管中的通道从肺隔间通过。 与导管相关联的单向流动元件防止空气在患者吸入时再次进入肺隔室。 随着时间的推移，随着空气体积的减小，肺室周围的区域压力会使其崩溃。 残余体积减少有效地导致功能性肺容积扩张。 任选地，肺隔室可以被密封以便永久地防止空气重新进入肺隔室。