公开(公告)号：US20240216042A1

公开(公告)日：2024-07-04

申请号：US18408513

申请日：2024-01-09

Applicant: CILAG GMBH INTERNATIONAL

Inventor： David C. Yates ,  Jeffrey D. Messerly ,  Cameron D. McLain ,  Peter K. Shires ,  Frederick L. Estera ,  Cameron R. Nott ,  Foster B. Stulen ,  Christopher A. Papa

IPC: A61B18/14 ,  A61B17/00 ,  A61B17/28 ,  A61B17/285 ,  A61B17/29 ,  A61B17/295 ,  A61B17/32 ,  A61B18/00 ,  A61B18/12 ,  A61B18/16 ,  A61N1/04 ,  A61N1/05 ,  A61N1/36

CPC classification number: A61B18/1442 ,  A61B17/2812 ,  A61B17/285 ,  A61B17/29 ,  A61B17/295 ,  A61B17/320068 ,  A61B17/320092 ,  A61N1/0551 ,  A61N1/3605 ,  A61N1/36057 ,  A61N1/36146 ,  A61B2017/00017 ,  A61B2017/2945 ,  A61B2017/320093 ,  A61B2017/320094 ,  A61B2017/320095 ,  A61B2018/00083 ,  A61B2018/00434 ,  A61B2018/00601 ,  A61B2018/00607 ,  A61B2018/0063 ,  A61B2018/00958 ,  A61B2018/00994 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/162 ,  A61N1/04

Abstract: Aspects of the present disclosure are presented for a single surgical instrument configured to grasp, seal, and/or cut tissue through application of therapeutic energy, and also detect nerves through application of non-therapeutic electrical energy. A medical device may include two jaws at an end effector, used to apply therapeutic energy and to perform surgical procedures. The therapeutic energy may be in the form of ultrasonic vibrations or higher voltage electrosurgical energy. One of the jaws may be configured to cut tissue through application of the blade. In addition, one or both of the two jaws may be configured to apply nontherapeutic energy for nerve stimulation probing. The application of therapeutic energy may be disabled while the nontherapeutic nerve stimulation energy is applied, and vice versa. The nontherapeutic nerve stimulation energy may be applied to the use of one or more probes positioned near one or both of the jaws.

公开(公告)号：US12023493B2

公开(公告)日：2024-07-02

申请号：US17606427

申请日：2020-01-09

Applicant: SOOCHOW UNIVERSITY

Inventor： Yaobo Liu ,  Dan Yang ,  Wei Yang ,  Kai Zhou ,  Wei Wei ,  Hui Zhang

IPC: A61N1/05 ,  A61B5/00 ,  A61B5/389 ,  A61N1/36

CPC classification number: A61N1/36003 ,  A61B5/389 ,  A61B5/4848 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/36062 ,  A61N1/36153 ,  A61N1/36171 ,  A61B2503/40 ,  A61B2503/42

Abstract: A closed-loop spinal cord electrical stimulation system includes a spinal epidural electrical stimulation electrode, a low limb electrical stimulation electrode, a closed-loop electrical stimulator and a controller. The spinal epidural electrical stimulation electrode, the low limb electrical stimulation electrode and the controller are electrically connected to the closed-loop electrical stimulator respectively. The spinal epidural electrical stimulation electrode is used for applying a first electrical stimulation to the spinal epidural site, and the low limb electrical stimulation electrode is used for applying a second electrical stimulation to a low limb. The voltage of the first electric stimulation is 400-600 mV, the voltage of the second electric stimulation is 1 V-1.5 V, and the stimulation frequency of the both is 10-20 Hz. The stimulation system can send electrophysiological signals similar to sensorimotor neural circuitry to the subject with spinal cord injury, and can activate and remodel the neural circuit.

公开(公告)号：US20240198101A1

公开(公告)日：2024-06-20

申请号：US18286987

申请日：2022-04-13

Applicant: Gate Science, Inc.

Inventor： Sanjay SINHA

IPC: A61N1/36 ,  A61M5/142 ,  A61M25/00 ,  A61N1/05

CPC classification number: A61N1/36021 ,  A61M5/14244 ,  A61M25/0082 ,  A61N1/0551 ,  A61M2025/0095 ,  A61M2202/048 ,  A61M2205/04 ,  A61M2205/054 ,  A61M2210/1003 ,  A61N1/36034

Abstract: Embodiments of the present disclosure relate to, among other things, systems, devices, and related methods for operating the same, to treat or provide pain control via multimodal control of pain. Specifically, embodiments of the present disclosure are directed to by both the delivery of pulsed electrical current to and/or around a nerve trunk, and delivery of one or more substances to and/or around the nerve trunk.

公开(公告)号：US20240198089A1

公开(公告)日：2024-06-20

申请号：US18465043

申请日：2023-09-11

Applicant: Presidio Medical, Inc.

Inventor： Douglas Michael Ackermann ,  Kenneth Wu ,  Aaron Hardinger

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/40

CPC classification number: A61N1/0534 ,  A61N1/0551 ,  A61N1/36062 ,  A61N1/36071 ,  A61N1/36157 ,  A61N1/40

Abstract: Disclosed herein are systems and methods for nerve conduction block. The systems and methods can utilize at least one rechargeable electrode. The methods can include delivering a first direct current with a first polarity to an electrode proximate nervous tissue sufficient to at least partially block conduction in the nervous tissue.

公开(公告)号：US12011597B2

公开(公告)日：2024-06-18

申请号：US17850843

申请日：2022-06-27

Applicant: Neuros Medical, Inc.

Inventor： Zi-Ping Fang ,  Nemath Syed Shah

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/36071 ,  A61N1/0551 ,  A61N1/36021 ,  A61N1/3616 ,  A61N1/36171 ,  A61N1/0556

Abstract: A durable nerve cuff electrode for achieving block of an action potential in a large diameter nerve.

公开(公告)号：US12011212B2

公开(公告)日：2024-06-18

申请号：US16706468

申请日：2019-12-06

Applicant: Medtronic Ireland Manufacturing Unlimited Company

Inventor： Bobak Robert Azamian ,  Jonathan Allen Coe ,  Scott Bradley Vafai

IPC: A61B18/14 ,  A61N1/05 ,  A61N1/36 ,  A61B18/00 ,  A61B90/00 ,  A61M25/01 ,  A61M25/10

CPC classification number: A61B18/1492 ,  A61N1/0551 ,  A61N1/3605 ,  A61B2018/00029 ,  A61B2018/00214 ,  A61B2018/00279 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00529 ,  A61B2018/00577 ,  A61B2018/1467 ,  A61B2090/064 ,  A61M25/0138 ,  A61M25/0141 ,  A61M25/0147 ,  A61M2025/1052

Abstract: According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) are provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves within a wall of (e.g., within adventitia surrounding a lumen of) an artery or other blood vessel, such as the common hepatic artery.

公开(公告)号：US20240181260A1

公开(公告)日：2024-06-06

申请号：US18491267

申请日：2023-10-20

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： Michael Fortner

IPC: A61N1/36 ,  A61N1/02 ,  A61N1/05 ,  A61N1/06

CPC classification number: A61N1/36139 ,  A61N1/025 ,  A61N1/0551 ,  A61N1/06 ,  A61N1/36062 ,  A61N1/36071 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36178

Abstract: An implantable medical device (IMD) configured to sense biosignals of a patient. The IMD comprises one or more power components for powering the IPG and sensing circuitry for sensing one or more biosignals of the patient, wherein the sensing circuitry comprises a hybrid circuit having a BJT portion and a CMOS FET portion, the BJT portion configured to amplify low voltage signals with low equivalent noise and the CMOS FET portion forming a power-optimized output stage.

公开(公告)号：US11998743B2

公开(公告)日：2024-06-04

申请号：US17137133

申请日：2020-12-29

Applicant: Boston Scientific Neuromodulation Corporation

Inventor： Rosana Esteller ,  Tianhe Zhang ,  Qi An ,  Gezheng Wen

IPC: A61N1/36 ,  A61N1/05 ,  G16H20/40

CPC classification number: A61N1/36062 ,  A61N1/0551 ,  A61N1/36132 ,  A61N1/36139 ,  G16H20/40

Abstract: Methods and systems for providing closed loop control of stimulation provided by an implantable stimulator device are disclosed herein. The disclosed methods and systems use a neural feature prediction model to predict a neural feature, which is used as a feedback control variable for adjusting stimulation. The predicted neural feature is determined based on one or more stimulation artifact features. The disclosed methods and systems can be used to provide closed loop feedback in situations, such as sub-perception therapy, when neural features cannot be readily directly measured.

公开(公告)号：US20240173062A1

公开(公告)日：2024-05-30

申请号：US18399851

申请日：2023-12-29

Applicant: Medtronic Ireland Manufacturing Unlimited Company

Inventor： Bobak Robert Azamian ,  Jonathan Allen Coe ,  Scott Bradley Vafai

IPC: A61B18/02 ,  A61B17/00 ,  A61B17/32 ,  A61B18/00 ,  A61B18/04 ,  A61B18/06 ,  A61B18/14 ,  A61B18/18 ,  A61B18/20 ,  A61B18/24 ,  A61K9/00 ,  A61K31/045 ,  A61K31/05 ,  A61K31/395 ,  A61K33/30 ,  A61K45/06 ,  A61M5/14 ,  A61N1/05 ,  A61N5/00 ,  A61N7/00 ,  A61N7/02

CPC classification number: A61B18/02 ,  A61B17/00 ,  A61B17/00234 ,  A61B17/32 ,  A61B18/04 ,  A61B18/06 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/24 ,  A61K9/0019 ,  A61K31/045 ,  A61K31/05 ,  A61K31/395 ,  A61K33/30 ,  A61K45/06 ,  A61M5/14 ,  A61N1/0551 ,  A61N5/00 ,  A61N7/00 ,  A61B2017/00318 ,  A61B2017/320069 ,  A61B2017/32007 ,  A61B2018/00023 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00529 ,  A61B2018/00577 ,  A61B2018/00732 ,  A61B2018/00791 ,  A61B2018/00839 ,  A61B2018/00994 ,  A61B2018/0212 ,  A61B2018/048 ,  A61B2018/1861 ,  A61N7/022

Abstract: According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

公开(公告)号：US11992319B2

公开(公告)日：2024-05-28

申请号：US16664329

申请日：2019-10-25

Applicant: The Board of Regents of The University of Texas System

Inventor： Paul Yoonsu Choi ,  Bong Kyun Kim ,  Bernardo Garza

IPC: A61B5/24 ,  A61B5/00 ,  A61F2/72 ,  A61N1/05 ,  H01B17/60

CPC classification number: A61B5/24 ,  A61B5/6877 ,  A61F2/72 ,  A61N1/0551 ,  H01B17/60 ,  A61B2562/0209 ,  A61B2562/028 ,  A61B2562/12

Abstract: Neural interfaces with the peripheral nervous system have been developed to provide a direct communication pathway between peripheral nerves and prosthetic limbs. Described herein is a method of making a microchannel integrated neural interface device comprising a plurality of hollow cylindrical electrodes in a PDMS scaffold, which can control the reinnervated muscles and interpret neurological signals. The acquired bioelectrical signals can be used for the interpretation of mind and create a neural map.