公开(公告)号：US11873269B2

公开(公告)日：2024-01-16

申请号：US17537829

申请日：2021-11-30

Applicant: MITSUBISHI HEAVY INDUSTRIES, LTD.

Inventor： Shoichi Furukawa ,  Hidehiko Tajima

IPC: B01J8/02 ,  B01J7/00 ,  C07C29/151 ,  C01B3/32 ,  B01J8/00

CPC classification number: C07C29/1518 ,  B01J7/00 ,  B01J8/009 ,  B01J8/0285 ,  C01B3/32 ,  B01J2219/00905 ,  C01B2203/0211 ,  C01B2203/061 ,  C01B2203/1241 ,  C01B2203/14

Abstract: A methanol production system of the present disclosure includes: a reformer including a reaction furnace configured to reform methane in a raw material gas to produce a reformed gas containing CO and H2; a reduced-gas generator configured to reduce CO2 to produce a reduced gas containing CO; and a methanol-containing gas generator configured to produce a methanol-containing gas which contains methanol from a reformed gas produced in the reaction furnace and a reduced gas produced in the reduced-gas generator.

公开(公告)号：US20230234918A1

公开(公告)日：2023-07-27

申请号：US18042169

申请日：2021-08-24

Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

Inventor： Ajay Kumar SINGH ,  Srihari PABBARAJA ,  Deepak Kumar JAISWAL ,  Dnyaneshwar AAND ,  Abhilash RANA

IPC: C07C245/16 ,  B01J19/24 ,  B01J19/00

CPC classification number: C07C245/16 ,  B01J19/0093 ,  B01J19/2415 ,  B01J2219/00905

Abstract: A process for producing diazomethane of Formula 1 (CH2N2), with an automated apparatus is described. A stock solution of N-methyl-N-nitroso amine in an organic solvent is continuously flown and mixed with an aqueous inorganic base at a T-mixer to form a mixture. Then it is passed through a capillary micro reactor at a temperature in a range of 20 to 30° C. to form diazomethane. The mixture is separated into an aqueous layer and an organic layer using a continuous flow micro-separator. The organic layer has 0.1-0.4 M diazomethane. The organic layer is reacted with a carboxylic acid, phenol, an alkyne, an anhydride, a carboxyl metal organic framework (MOF), or MOF coated cotton to form a corresponding ester, a pyrazole, an ether, a diazo ketone, a stable carboxyl MOF or a stable MOF coated cotton fiber.

公开(公告)号：US20180264473A1

公开(公告)日：2018-09-20

申请号：US15983815

申请日：2018-05-18

Applicant: University Of Cincinnati

Inventor： Ian Papautsky ,  Jian Zhou

IPC: B01L3/00 ,  B07B7/00 ,  B03B5/62 ,  B01J19/00

CPC classification number: B01L3/502761 ,  B01J19/0093 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00984 ,  B01L3/502753 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B03B5/62 ,  B07B7/00 ,  Y10T137/0318

Abstract: A method of separating a plurality of particles (14) from a portion of fluid, comprising directing the plurality of particles (14) into a microchannel (12). A first portion (16) of particles (14) is focused into an equilibrium position in the microchannel (12). The focused first portion (16) is directed into a first outlet (18) aligned with the equilibrium position. A portion of the fluid is directed into one or more outlets (20, 22). A microfluidic device (10) for separating a plurality of particles (14) from a portion of fluid, comprising a microchannel (12) having a first aspect ratio and a length L, thereby focusing the particles (14) directed therein into an equilibrium position in the microchannel, wherein at least a first portion (16) of the particles (14) focuses at distance X from a beginning of the microchannel (12). A first outlet (18) disposed after distance X and aligned with the equilibrium position to receive at least the first portion (16) of the particles (14) after the first portion (16) focuses into an equilibrium position in the microchannel (12). At least a second outlet (20) for receiving a second portion of the particles (14) before the second portion focuses into an equilibrium position.

公开(公告)号：US09751057B2

公开(公告)日：2017-09-05

申请号：US15167712

申请日：2016-05-27

Applicant: The University Court of the University of Glasgow

Inventor： Rab Wilson ,  Jonathan M. Cooper ,  Julien Reboud

IPC: B01F13/00 ,  B01F11/02 ,  B01J19/00 ,  B01L3/00 ,  C12N13/00 ,  G01N33/48

CPC classification number: B01F13/0071 ,  B01F11/0266 ,  B01F2215/0073 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00932 ,  B01J2219/00952 ,  B01L3/502792 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/089 ,  B01L2400/0436 ,  B01L2400/0439 ,  B01L2400/0496 ,  C12N13/00 ,  G01N33/48 ,  Y10T436/25125

Abstract: A method of using a fluidics apparatus for lysing a cell. In the method, the cell is placed in a fluid sample contacting a substrate surface. The method further includes providing surface acoustic waves (SAWs) at the substrate surface, causing cell lyses.

公开(公告)号：US09375690B2

公开(公告)日：2016-06-28

申请号：US13391762

申请日：2010-08-24

Applicant: Rab Wilson ,  Jonathan M. Cooper ,  Julien Reboud

Inventor： Rab Wilson ,  Jonathan M. Cooper ,  Julien Reboud

IPC: G01N1/00 ,  B06B1/00 ,  B01F13/00 ,  B01F11/02 ,  B01J19/00 ,  B01L3/00

CPC classification number: B01F13/0071 ,  B01F11/0266 ,  B01F2215/0073 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00932 ,  B01J2219/00952 ,  B01L3/502792 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/089 ,  B01L2400/0436 ,  B01L2400/0439 ,  B01L2400/0496 ,  C12N13/00 ,  G01N33/48 ,  Y10T436/25125

Abstract: A fluidics apparatus is disclosed for manipulation of at least one fluid sample, typically in the form of a droplet. The apparatus has a substrate surface with a sample manipulation zone for location of the fluid sample. A transducer arrangement such as an interdigitated electrode structure on a piezoelectric body provides surface acoustic waves at the substrate surface for manipulation of the fluid sample. The substrate surface has an arrangement of surface acoustic wave scattering elements forming a phononic crystal structure for affecting the transmission, distribution and/or behavior of surface acoustic waves at the substrate surface. Also disclosed is a method for lysing a cell. In this method, the cell is comprised in a fluid sample contacting a substrate surface, the method comprising providing surface acoustic waves at the substrate surface, such that the cell lyses.

Abstract translation: 公开了用于操纵至少一种流体样品的流体装置，通常为液滴的形式。 该设备具有一个具有用于定位流体样品的样品操作区的基底表面。 诸如压电体之间的交错电极结构的换能器装置在衬底表面上提供表面声波，用于操纵流体样品。 衬底表面具有形成声子晶体结构的表面声波散射元件的布置，用于影响衬底表面处表面声波的透射，分布和/或行为。 还公开了一种裂解细胞的方法。 在该方法中，电池被包含在与衬底表面接触的流体样品中，该方法包括在衬底表面提供表面声波，使得细胞裂解。

公开(公告)号：US09283536B2

公开(公告)日：2016-03-15

申请号：US14288765

申请日：2014-05-28

Applicant: GTLpetrol LLC

Inventor： Rodney J. Allam

IPC: B01J19/00 ,  C01B3/38 ,  C07C29/151 ,  C01B3/36 ,  C01B13/02

CPC classification number: C07C29/1518 ,  B01J19/0053 ,  B01J19/245 ,  B01J2219/00051 ,  B01J2219/00873 ,  B01J2219/00905 ,  B01J2219/0875 ,  B01J2219/24 ,  C01B3/36 ,  C01B3/382 ,  C01B3/384 ,  C01B13/0248 ,  C01B2203/0233 ,  C01B2203/0244 ,  C01B2203/025 ,  C01B2203/04 ,  C01B2203/0495 ,  C01B2203/061 ,  C01B2203/0844 ,  C01B2203/0894 ,  C01B2210/0046 ,  Y02P20/123 ,  Y02P20/124 ,  Y02P20/129 ,  C07C31/04

Abstract: In various implementations, methanol is produced using a (CO+H2) containing synthesis gas produced from a combined POX plus EHTR or a combined ATR plus EHTR at a pressure of 70 bar to 100 bar at the correct stoichiometric composition for methanol synthesis so that no feed gas compressor is required for the feed to the methanol synthesis reactor loop.

Abstract translation: 在各种实施方案中，使用由组合的POX加EHTR或组合的ATR加EHTR产生的（CO + H 2）的合成气在70巴至100巴的压力下以合适的化学计量组成用于甲醇合成来生产甲醇，因此不存在 进料气压缩机是进料到甲醇合成反应器回路所必需的。

公开(公告)号：US20150336074A1

公开(公告)日：2015-11-26

申请号：US14788876

申请日：2015-07-01

Applicant: Velocys, Inc.

Inventor： Anna Lee Tonkovich ,  Kai Tod Paul Jarosch ,  Jeffrey Dale Marco ,  Bin Yang ,  Sean Patrick Fitzgerald ,  Steven T. Perry ,  Thomas Yuschak ,  Francis P. Daly ,  Haibiao Chen

IPC: B01J19/00 ,  C01B3/38 ,  C07C45/38 ,  C07C5/48

CPC classification number: B01F5/0646 ,  B01F5/0475 ,  B01F5/061 ,  B01F5/0655 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00835 ,  B01J2219/00844 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00918 ,  C01B3/38 ,  C01B2203/0233 ,  C01B2203/0833 ,  C01B2203/1041 ,  C01B2203/1082 ,  C01B2203/1241 ,  C07C5/48 ,  C07C45/38 ,  C07C2521/08 ,  C07C2523/28 ,  F28F3/048 ,  F28F13/003 ,  F28F2260/02 ,  Y02P20/582

Abstract: The disclosed technology relates to an apparatus, comprising: at least one microchannel, the microchannel comprising at least one heat transfer wall; a porous thermally conductive support in the microchannel in contact with the heat transfer wall; a catalyst or a sorption medium supported by the porous support; and a heat source and/or heat sink in thermal contact with the heat transfer wall.

Abstract translation: 所公开的技术涉及一种装置，包括：至少一个微通道，所述微通道包括至少一个传热壁; 在与所述传热壁接触的所述微通道中的多孔导热支撑件; 由多孔载体支撑的催化剂或吸附介质; 以及与传热壁热接触的热源和/或散热器。

公开(公告)号：US09169284B2

公开(公告)日：2015-10-27

申请号：US14253049

申请日：2014-04-15

Applicant: HAMMERSMITH IMANET LIMITED

Inventor： Frank Brady ,  Sajinder Kaur Luthra ,  James Millar Gillies ,  Nicholas Toby Jeffrey

IPC: B01J19/00 ,  C07H5/02 ,  C07B59/00 ,  C07C211/48 ,  C07C229/36 ,  C07D223/16 ,  C07D401/04 ,  B01L3/00

CPC classification number: C07H5/02 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00952 ,  B01L3/5027 ,  B01L3/502715 ,  C07B59/00 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07C211/48 ,  C07C229/36 ,  C07D223/16 ,  C07D401/04

Abstract: This invention relates to the miniaturization of radiosyntheses onto microfabricated devices, and in particular to use of microfabricated devices for radiosynthesis, isolation, and analysis of radiotracers for use in Positron Emission Tomography (PET).

Abstract translation: 本发明涉及在微加工装置上放射合成的小型化，特别是涉及使用微加工装置进行放射性合成，分离和分析用于正电子发射断层扫描（PET）的放射性示踪剂。

公开(公告)号：US20150160171A1

公开(公告)日：2015-06-11

申请号：US14618772

申请日：2015-02-10

Applicant: ABT Molecular Imaging, Inc.

Inventor： Atilio Anzellotti ,  Aaron McFarland ,  Clive Brown-Proctor ,  Daniel Hillesheim ,  Mark Khachaturian

IPC: G01N30/74

CPC classification number: G01N30/74 ,  A61K51/0491 ,  B01D15/08 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00905 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/77 ,  G01N2030/8872

Abstract: An automated HPLC-based quality control system to perform quality control testing on a radiopharmaceutical solution shortly after synthesis. An automated HPLC-based quality control system makes efficient use of sample volume and is compatible with a variety of radioisotopes and radiopharmaceutical compounds. In several embodiments, the automated nature of an automated HPLC-based quality control system allows for quality control tests to be conducted quickly and with minimal impact on user workflow. When used as part of an integrated PET biomarker radiopharmaceutical production system, the present general inventive concept permits a manufacturer to produce product and conduct quality control tests with lower per dose costs and shorter testing times.

Abstract translation: 一种基于HPLC的自动化质量控制系统，可在合成后不久就对放射性药物溶液进行质量控制测试。 基于HPLC的自动化质量控制系统有效利用样品体积，并与各种放射性同位素和放射性药物化合物相容。 在几个实施例中，基于HPLC的自动化质量控制系统的自动化性质允许快速进行质量控制测试并且对用户工作流程的影响最小。 当作为PET生物标志物整合放射性药物生产系统的一部分使用时，本发明的总体构思允许制造商生产产品并以较低的每剂量成本和较短的测试时间进行质量控制测试。

公开(公告)号：US08435454B2

公开(公告)日：2013-05-07

申请号：US12986323

申请日：2011-01-07

Applicant: Arkadij M. Elizarov ,  Carroll Edward Ball ,  Jianzhong Zhang ,  Hartmuth C. Kolb ,  Reza Miraghaie ,  Todd L. Graves ,  Artem Lebedev ,  Keith E. Schleiffer

Inventor： Arkadij M. Elizarov ,  Carroll Edward Ball ,  Jianzhong Zhang ,  Hartmuth C. Kolb ,  Reza Miraghaie ,  Todd L. Graves ,  Artem Lebedev ,  Keith E. Schleiffer

IPC: G21C1/00 ,  B01J19/00

CPC classification number: B01J19/0093 ,  B01J2219/0081 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00936

Abstract: Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.

Abstract translation: 宏观和微流体装置及相关技术以及使用这种装置的化学过程。 更具体地，这些装置可以用于以有效，紧凑和安全的操作者方式全面自动化合成用于成像的放射性化合物，例如通过正电子发射断层摄影（PET）。 特别地，本发明的实施例涉及一种用于多步合成放射性药物的自动化，多运行微流控仪器，例如PET探针，其包括含有辐射递送部件的远程屏蔽微型电池。