公开(公告)号：US08352205B2

公开(公告)日：2013-01-08

申请号：US12528101

申请日：2008-02-25

Applicant: Michael L. Myrick ,  Luisa Profeta

Inventor： Michael L. Myrick ,  Luisa Profeta

IPC: G01D18/00 ,  G01N21/00 ,  G06F19/00 ,  G06F17/40

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0232 ,  G01J3/12 ,  G01N21/274 ,  G01N21/31 ,  G01N2201/12769

Abstract: The present subject matter is direct to methodologies for calibrating data obtained from an optical analysis system. An initial calibration matrix of sampled analyte concentrations is modified using mean-centering techniques and selection of low and high analyte concentration spectra to produce a two-point calibration. A modified calibration matrix is produced by generating a non-linear calibration matrix by multiplying the initial calibration matrix by the two-point calibration. In an alternate embodiment, an initial multivariate optical element design is modified by iteratively adjusting the design based on standard error of calibration determination based on non-linerly fitted functions.

Abstract translation: 本主题直接涉及用于校准从光学分析系统获得的数据的方法。 使用平均定心技术和低分辨率和高分析物浓度光谱的选择来修改采样分析物浓度的初始校准矩阵，以产生两点校准。 通过将初始校准矩阵乘以两点校准来生成非线性校准矩阵来产生修改的校准矩阵。 在替代实施例中，通过基于非线性拟合函数的校准确定的标准误差迭代地调整设计来修改初始多变量光学元件设计。

公开(公告)号：US08119066B2

公开(公告)日：2012-02-21

申请号：US11351181

申请日：2006-02-08

Applicant: Daniel M. Stock ,  Josef J. Atzler

Inventor： Daniel M. Stock ,  Josef J. Atzler

IPC: G01N21/00

CPC classification number: G01N21/645 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/763 ,  G01N2021/1738 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/0618 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0692 ,  G01N2201/0696

Abstract: A cartridge and cartridge system for use in an apparatus for analyzing a sample are provided. The cartridge has one or more light sources and/or optical systems and other components that are specific for a certain type of application such as fluorescence, absorbance, or luminescence. The light source, optical systems, and other components for a specific application are housed in a single cartridge. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with the apparatus in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed.

Abstract translation: 提供了用于分析样品的装置中的盒和盒系统。 盒具有一个或多个光源和/或光学系统以及其它特定于某种类型的应用，如荧光，吸光度或发光的组件。 用于特定应用的光源，光学系统和其他部件容纳在单个盒中。 该系统具有用于多模仪器的不同应用的多个盒。 盒可以以“插入”格式可移除地与设备接合，使得一个盒可以从设备移除，并且另一个盒可以容易地安装。

公开(公告)号：US20120026484A1

公开(公告)日：2012-02-02

申请号：US13196802

申请日：2011-08-02

Applicant: Michael L. Myrick ,  Robert P. Freese ,  William Soltmann ,  David L. Perkins

Inventor： Michael L. Myrick ,  Robert P. Freese ,  William Soltmann ,  David L. Perkins

IPC: G01N21/01

CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0286 ,  G01J3/08 ,  G01J3/28 ,  G01J3/42 ,  G01J2003/1213 ,  G01N2201/1293

Abstract: The present subject matter relates to methods of high-speed analysis of product samples during production of the product. Light is directed to a portion of a product under analysis and reflected from or transmitted through the product toward optical detectors. Signals from the optical detectors are compared to determine characteristics of the product under analysis. Temperature within the monitoring system may be monitored in order to provide compensation for the signals produced by the optical detectors. The products under analysis may be stationary, moved by an inspection point by conveyor or other means, or may be contained within a container, the container including a window portion through which the product illuminating light may pass.

Abstract translation: 本主题涉及产品生产过程中产品样品的高速分析方法。 光被引导到被分析产品的一部分，从产品反射或透射到光学检测器。 将来自光学检测器的信号进行比较，以确定正在分析的产品的特性。 可以监视监视系统内的温度，以便为由光学检测器产生的信号提供补偿。 被分析的产品可以是固定的，由检查点通过输送机或其他方式移动，或者可以容纳在容器内，该容器包括产品照明光通过的窗口部分。

公开(公告)号：US08054453B2

公开(公告)日：2011-11-08

申请号：US12876242

申请日：2010-09-07

Applicant: Dale A. Harrison

Inventor： Dale A. Harrison

IPC: G01J3/00

CPC classification number: G01J3/2803 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/027 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/08 ,  G01J3/10 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/36 ,  G01J3/42 ,  G01J3/4531 ,  G01N21/211 ,  G01N21/274 ,  G01N21/33 ,  G01N21/47 ,  G01N21/55 ,  G01N21/9501 ,  G01N2021/335

Abstract: A spectroscopy system is provided which is optimized for operation in the VUV region and capable of performing well in the DUV-NIR region. Additionally, the system incorporates an optical module which presents selectable sources and detectors optimized for use in the VUV and DUV-NIR. As well, the optical module provides common delivery and collection optics to enable measurements in both spectral regions to be collected using similar spot properties. The module also provides a means of quickly referencing measured data so as to ensure that highly repeatable results are achieved. The module further provides a controlled environment between the VUV source, sample chamber and VUV detector which acts to limit in a repeatable manner the absorption of VUV photons. The use of broad band data sets which encompass VUV wavelengths, in addition to the DUV-NIR wavelengths enables a greater variety of materials to be meaningfully characterized. Array based detection instrumentation may be exploited to permit the simultaneous collection of larger wavelength regions.

Abstract translation: 提供了一种光谱系统，其被优化用于在VUV区域中的操作并且能够在DUV-NIR区域中表现良好。 此外，该系统还包含一个光学模块，该模块提供可用于VUV和DUV-NIR中优化的可选择的源和检测器。 同样，光学模块提供通用的传送和收集光学器件，以使得能够使用类似的光点特性来收集两个光谱区域中的测量。 该模块还提供了快速参考测量数据的方法，以确保实现高度可重复的结果。 该模块还在VUV源，样品室和VUV检测器之间提供受控的环境，其作用是以可重复的方式限制VUV光子的吸收。 除了DUV-NIR波长之外，使用包含VUV波长的宽带数据集使得可以有意义地表征更多种类的材料。 可以利用基于阵列的检测仪器来允许同时收集更大的波长区域。

公开(公告)号：US08049881B2

公开(公告)日：2011-11-01

申请号：US12094469

申请日：2006-11-27

Applicant: Michael L. Myrick ,  Robert P. Freese ,  John C. Blackburn ,  Ryan J. Priore

Inventor： Michael L. Myrick ,  Robert P. Freese ,  John C. Blackburn ,  Ryan J. Priore

IPC: G01J3/40

CPC classification number: G01J3/08 ,  A61K8/046 ,  A61K8/25 ,  A61K8/26 ,  A61K8/44 ,  A61Q11/00 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/0291 ,  G01J3/28 ,  G01N21/274 ,  G01N21/31

Abstract: A method of arranging and utilizing a multivariate optical computing and analysis system includes transmitting light from a light source; reflecting the light from the sample; directing a portion of the light reflected from the sample with a beamsplitter; and arranging an optical filter mechanism in a normal incidence orientation to receive the light reflected from the sample, the optical filter mechanism configured to filter and measure data carried by the light reflected from the sample.

Abstract translation: 一种布置和利用多变量光学计算和分析系统的方法，包括从光源发射光; 反映样品的光; 用分束器引导从样品反射的一部分光; 以及将法兰入射方向的滤光器机构布置成接收从样品反射的光，所述滤光器机构被配置为过滤和测量由样品反射的光携带的数据。

公开(公告)号：US20110178581A1

公开(公告)日：2011-07-21

申请号：US13079639

申请日：2011-04-04

Applicant: Constance Haber ,  Allan Gardiner

Inventor： Constance Haber ,  Allan Gardiner

IPC: A61N5/06

CPC classification number: G01J3/10 ,  A61B5/0488 ,  A61B5/0531 ,  A61B5/726 ,  A61N5/0619 ,  A61N2005/0663 ,  G01J1/0488 ,  G01J1/08 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/0235 ,  G01J2003/1213

Abstract: This invention provides methods for treating a variety of disorders using localized electromagnetic radiation directed at excitable tissues, including nerves, muscles and blood vessels. By controlling the wavelength, the wavelength bandpass, pulse duration, intensity, pulse frequency, and/or variations of those characteristics over time, and by selecting sites of exposure to electromagnetic radiation, improvements in the function of different tissues and organs can be provided. By monitoring physiological variables such as muscle tone and activity, temperature gradients, surface electromyography, blood flow and others, the practitioner can optimize a therapeutic regimen suited for the individual patient.

Abstract translation: 本发明提供了使用针对可兴奋组织（包括神经，肌肉和血管）的局部电磁辐射来治疗多种疾病的方法。 通过控制波长，波长带通，脉冲持续时间，强度，脉冲频率和/或这些特性随时间的变化，并且通过选择暴露于电磁辐射的部位，可以提供不同组织和器官的功能的改善。 通过监测诸如肌肉紧张度和活动，温度梯度，表面肌电描记术，血流量等生理变量，医师可以优化适合于个体患者的治疗方案。

公开(公告)号：US20100328648A1

公开(公告)日：2010-12-30

申请号：US12876242

申请日：2010-09-07

Applicant: Dale A. Harrison

Inventor： Dale A. Harrison

IPC: G01N21/55 ,  G01J3/00

CPC classification number: G01J3/2803 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/027 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/08 ,  G01J3/10 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/36 ,  G01J3/42 ,  G01J3/4531 ,  G01N21/211 ,  G01N21/274 ,  G01N21/33 ,  G01N21/47 ,  G01N21/55 ,  G01N21/9501 ,  G01N2021/335

Abstract: A spectroscopy system is provided which is optimized for operation in the VUV region and capable of performing well in the DUV-NIR region. Additionally, the system incorporates an optical module which presents selectable sources and detectors optimized for use in the VUV and DUV-NIR. As well, the optical module provides common delivery and collection optics to enable measurements in both spectral regions to be collected using similar spot properties. The module also provides a means of quickly referencing measured data so as to ensure that highly repeatable results are achieved. The module further provides a controlled environment between the VUV source, sample chamber and VUV detector which acts to limit in a repeatable manner the absorption of VUV photons. The use of broad band data sets which encompass VUV wavelengths, in addition to the DUV-NIR wavelengths enables a greater variety of materials to be meaningfully characterized. Array based detection instrumentation may be exploited to permit the simultaneous collection of larger wavelength regions.

Abstract translation: 提供了一种光谱系统，其被优化用于在VUV区域中的操作并且能够在DUV-NIR区域中表现良好。 此外，该系统还包含一个光学模块，该模块提供可用于VUV和DUV-NIR中优化的可选择的源和检测器。 同样，光学模块提供通用的传送和收集光学器件，以使得能够使用类似的光点特性来收集两个光谱区域中的测量。 该模块还提供了快速参考测量数据的方法，以确保实现高度可重复的结果。 该模块还在VUV源，样品室和VUV检测器之间提供受控的环境，其作用是以可重复的方式限制VUV光子的吸收。 除了DUV-NIR波长之外，使用包含VUV波长的宽带数据集使得可以有意义地表征更多种类的材料。 可以利用基于阵列的检测仪器来允许同时收集更大的波长区域。

公开(公告)号：US20100321687A1

公开(公告)日：2010-12-23

申请号：US12486747

申请日：2009-06-17

Applicant: Carles Flotats VILLAGRASA ,  Jordi Ferran CASES ,  Oscar Martinez BAILAC ,  David A. CHAMPION ,  Stephan R. CLARK

Inventor： Carles Flotats VILLAGRASA ,  Jordi Ferran CASES ,  Oscar Martinez BAILAC ,  David A. CHAMPION ,  Stephan R. CLARK

IPC: G01J3/42 ,  G02B26/02

CPC classification number: G01J3/02 ,  G01J1/04 ,  G01J1/044 ,  G01J3/0232 ,  G01J3/0267 ,  G01J3/524 ,  G01J2001/0276

Abstract: A shuttering and sealing device is disclosed. In one embodiment, the device includes an aperture through which light may pass to an optical sensor, a seal surrounding the aperture, and a shutter movable between an open position in which the shutter does not cover the aperture and a closed position in which the shutter covers the aperture and the seal seals the shutter around the aperture.

Abstract translation: 公开了一种遮蔽和密封装置。 在一个实施例中，该装置包括孔，光可以通过该光圈传递到光学传感器，围绕孔的密封件以及可在打开位置之间移动的挡板，在该打开位置中挡板不覆盖孔，在该位置中挡板 覆盖光圈并且密封件围绕光圈密封快门。

公开(公告)号：US20100315629A1

公开(公告)日：2010-12-16

申请号：US12724192

申请日：2010-03-15

Applicant: Kevin J. Knopp ,  Robert L. Green ,  Brendon D. Tower ,  Christopher D. Brown ,  Gregory H. Vander Rhodes

Inventor： Kevin J. Knopp ,  Robert L. Green ,  Brendon D. Tower ,  Christopher D. Brown ,  Gregory H. Vander Rhodes

IPC: G01J3/44 ,  G01J3/00 ,  G01N21/62 ,  G01N21/55 ,  G01N21/47 ,  G01N21/59

CPC classification number: G01N21/17 ,  G01J3/02 ,  G01J3/0232 ,  G01J3/0262 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/42 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/47 ,  G01N21/4738 ,  G01N21/55 ,  G01N21/59 ,  G01N21/65 ,  G01N2021/3595 ,  G01N2201/0221 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/105 ,  G01N2201/125

Abstract: Disclosed are apparatus, kits, methods, and systems that include a radiation source configured to direct radiation to a sample; a detector configured to measure radiation from the sample; an electronic processor configured to determine infotmation about the sample based on the measured radiation; a housing enclosing the source, the detector, and the electronic processor, the housing having a hand-held form factor; an arm configured to maintain a separation between the sample and the housing, the arm including a first end configured to connect to the housing and a second end configured to contact the sample; and a layer positioned on the second end of the arm, the layer being configured to contact the sample and to transmit at least a portion of the radiation from the sample to the detector.

Abstract translation: 公开了包括被配置为将辐射引导到样品的辐射源的装置，试剂盒，方法和系统; 检测器，被配置为测量来自样品的辐射; 配置为基于所测量的辐射来确定关于样本的信息的电子处理器; 包围所述源，所述检测器和所述电子处理器的外壳，所述外壳具有手持外形尺寸; 臂被配置为保持样品和壳体之间的分离，所述臂包括构造成连接到壳体的第一端和被配置为接触样品的第二端; 以及位于所述臂的第二端上的层，所述层被配置为接触所述样品并将所述辐射的至少一部分从所述样品透射到所述检测器。

公开(公告)号：US20100302539A1

公开(公告)日：2010-12-02

申请号：US12530265

申请日：2008-03-27

Applicant: Michael L. Myrick ,  Robert P. Freese ,  David L. Perkins ,  Terrell Teague ,  William Soltmann ,  Leonard Zheleznyak

Inventor： Michael L. Myrick ,  Robert P. Freese ,  David L. Perkins ,  Terrell Teague ,  William Soltmann ,  Leonard Zheleznyak

IPC: G01J3/28

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0216 ,  G01J3/0232 ,  G01J3/0237 ,  G01J3/0294 ,  G01J3/10 ,  G01J3/28 ,  G01J3/32 ,  G01J3/36 ,  G01N21/31 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/8806 ,  G01N21/9508 ,  G01N33/02 ,  G01N2201/1293

Abstract: The present subject matter relates to methods of high-speed analysis of product samples. Light is directed to a portion of a product under analysis and reflected from or transmitted through the product toward a plurality of optical detectors. Signals from the detectors are compared with a reference signal based on a portion of the illuminating light passing through a reference element to determine characteristics of the product under analysis. The products under analysis may be stationary, moved by an inspection point by conveyor or other means, or may be contained within a container, the container including a window portion through which the product illuminating light may pass.

Abstract translation: 本主题涉及产品样品的高速分析方法。 光被引导到被分析产品的一部分，从产品反射或透过产品朝向多个光学检测器。 将来自检测器的信号与基于通过参考元件的照明光的一部分的参考信号进行比较，以确定正在分析的产品的特性。 被分析的产品可以是固定的，由检查点通过输送机或其他方式移动，或者可以容纳在容器内，该容器包括产品照明光通过的窗口部分。