公开(公告)号：US20250150692A1

公开(公告)日：2025-05-08

申请号：US18915106

申请日：2024-10-14

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi ,  Jun Tian ,  Wei Dong

IPC: H04N23/51 ,  G01N21/84 ,  H04N23/55 ,  H04N23/56 ,  H04N23/57

Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of an image-based assay. One aspect of the present invention is to sandwich a sample between two plates and add reference marks in the sample areas of the plates, with at least one of the geometric and/optical properties of the reference marks being predetermined and known, and taking images of the sample with the reference marks, and applying a machine learning model in the analysis of the image-based assay.

公开(公告)号：US20250116593A1

公开(公告)日：2025-04-10

申请号：US18739128

申请日：2024-06-10

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wu CHOU ,  Xing LI ,  Hongbing LI ,  Yuecheng Zhang ,  Mingquan WU ,  Wei DING ,  Jun TIAN

IPC: G01N15/1433 ,  G06N20/00 ,  G06T7/00 ,  G06T7/10 ,  G06T7/40 ,  G06T7/62

Abstract: The present invention is related to, among other things, the devices and methods that improve the accuracy and reliability of an assay, even when the assay device and/or the operation of the assay device has certain errors, and in some embodiments the errors are random.

公开(公告)号：US12248533B2

公开(公告)日：2025-03-11

申请号：US18101109

申请日：2023-01-24

Applicant: Essenlix Corporation

Inventor： Xing Li ,  Wu Chou ,  Stephen Y. Chou ,  Wei Ding ,  Ji Qi

IPC: G06F18/214 ,  G06N3/042 ,  G06N3/045 ,  G06N3/08 ,  G06T5/50 ,  G06T7/00 ,  G06T7/11 ,  G06T7/70 ,  G06V10/22

Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of image-based assay, that uses imaging system having uncertainties or deviations (imperfection) compared with an ideal imaging system. One aspect of the present invention is to add the monitoring marks on the sample holder, with at least one of their geometric and/optical properties of the monitoring marks under predetermined and known, and taking images of the sample with the monitoring marks, and train a machine learning model using the images with the monitoring mark.

公开(公告)号：US20240410885A1

公开(公告)日：2024-12-12

申请号：US18809047

申请日：2024-08-19

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi

IPC: G01N33/543 ,  G01N1/40 ,  G01N21/64 ,  G01N21/65 ,  G01N21/69 ,  G01N21/76 ,  G01N33/558

Abstract: The present invention provides, among other things, QMAX card based assays in different forms for various analytes, offering simpler, fast, more sensitive assaying.

公开(公告)号：US20240361247A1

公开(公告)日：2024-10-31

申请号：US18598299

申请日：2024-03-07

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi ,  Ji Li

IPC: G01N21/65 ,  G01N21/64 ,  G01N21/66 ,  G01N33/543 ,  G01N33/58

CPC classification number: G01N21/65 ,  G01N21/64 ,  G01N21/66 ,  G01N33/54366 ,  G01N33/582 ,  G01N2201/06113

Abstract: A homogeneous assay method that employs a device is provided. In some embodiments, the device contains a pair of plates that can be opened and closed. The sample is placed between two plates. In some embodiments, the thickness of the sample in a closed configuration, the concentration of labels, and amplification factor of the amplification surface are configured to make the label(s) bound on the amplification surface visible without washing away of the unbound labels.

公开(公告)号：US12066434B2

公开(公告)日：2024-08-20

申请号：US16484678

申请日：2018-02-08

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi

IPC: G01N33/543 ,  G01N1/40 ,  G01N21/64 ,  G01N21/65 ,  G01N21/69 ,  G01N21/76 ,  G01N33/558

CPC classification number: G01N33/54366 ,  G01N1/405 ,  G01N21/648 ,  G01N21/65 ,  G01N21/69 ,  G01N21/76 ,  G01N33/558

Abstract: The present invention provides, among other things, QMAX card based assays in different forms for various analytes, offering simpler, fast, more sensitive assaying.

公开(公告)号：US12044603B2

公开(公告)日：2024-07-23

申请号：US17752823

申请日：2022-05-24

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding

IPC: G01N1/28 ,  B01L3/00 ,  G01N1/30 ,  G01N15/01 ,  G01N15/14 ,  G01N21/64 ,  G01N21/65 ,  G01N21/69 ,  G01N21/76 ,  G01N33/487 ,  G01N33/49 ,  G01N33/543 ,  G01N35/00

CPC classification number: G01N1/2813 ,  B01L3/5055 ,  G01N1/30 ,  G01N15/1484 ,  G01N21/6452 ,  G01N21/69 ,  G01N21/76 ,  G01N33/487 ,  G01N33/49 ,  G01N33/543 ,  G01N33/54366 ,  G01N35/00029 ,  G01N35/00871 ,  B01L2300/0809 ,  B01L2300/123 ,  B01L2400/0481 ,  G01N2015/012 ,  G01N2015/016 ,  G01N2015/018 ,  G01N2015/1486 ,  G01N2021/6482 ,  G01N21/658

Abstract: The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g. 0.5 uL or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them.

公开(公告)号：US12007315B2

公开(公告)日：2024-06-11

申请号：US17060020

申请日：2020-09-30

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi

IPC: G01N1/28

CPC classification number: G01N1/2813 ,  G01N1/286

Abstract: The present invention provides, among other things, devices, methods and applications of collecting, preserving, transporting, and analyzing tiny body fluids which have targeted biomarkers.

公开(公告)号：US20240125705A1

公开(公告)日：2024-04-18

申请号：US18389758

申请日：2023-12-19

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING ,  Ji LI ,  Shengjian Cai ,  Yufan Zhang ,  Jia Peng

IPC: G01N21/64 ,  G01N1/30 ,  G01N21/76 ,  G01N33/543

CPC classification number: G01N21/6458 ,  G01N1/30 ,  G01N21/76 ,  G01N33/54373

Abstract: The present invention provides, among other things, devices, kits, apparatus, and methods for rapid homogenous cell staining and imaging. Particularly, in some embodiments, the present invention can immunochemically stain a cell or a tissue in less than 60 seconds without washing. In some embodiments, the present invention stains and observes analyte (protein or nucleic acid) inside a cell in 60 seconds without washing.

公开(公告)号：US11846582B2

公开(公告)日：2023-12-19

申请号：US17858931

申请日：2022-07-06

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Jun Tian ,  Wu Chou

IPC: G01N21/03 ,  G01N1/28 ,  G01N21/25 ,  G01N21/64 ,  G01N33/49

CPC classification number: G01N21/0303 ,  G01N1/2813 ,  G01N21/25 ,  G01N21/6458 ,  G01N33/49 ,  G01N2021/035 ,  G01N2021/6439 ,  G01N2201/0221

Abstract: Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.