Abstract:
Novel spiro benzocyclane acetic acid compounds of the formula
WHEREIN R is selected from the group consisting of hydrogen and linear and branched alkyl of one to four carbon atoms, R1 is selected from the group consisting of hydrogen, chlorine, trifluoromethyl and lower alkoxy, Y is selected from the group consisting of methylene, oxygen and sulfur, n is 2, 3 or 4 and R2 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl of one to six carbon atoms and cation of nontoxic, pharmaceutically acceptable mineral and organic bases, processes for their preparation and novel intermediates. The compounds of formula I have analgesic and anti-inflammatory properties.
Abstract:
1-Oxa-13 Beta -R1-17 Alpha -methyl-A-nor- Delta 3(5),9gonadienes of the formula
WHEREIN R1 is alkyl of one to three carbon atoms and R2 is acyl of an aliphatic carboxylic acid of two to four carbon atoms having antiandrogenic activity and their preparation and intermediates formed therein.
(ANDROSTA-1,4-DIENE-17,4''-(1,3)DIOXANE) WITH X IN
POSITION 11
WHEREIN X:CO OR CH2 OR CHOH-Y:H OR F-Z:H OR CH3-P:H OR ALKYL OR ALKYIDENE-N: O OR 1-R:H OR HALOGEN OR ALKYL-R1:H OR ALKYL OR CARBOXYL OR ALKOXYCARBONYL-BROKEN LINE IN THE RING A: OPTIONAL PRESENCE OF A DOUBLE BOND. THESE PRODUCTS ARE VERY USEFUL SUBSTANCES IN HUMAN AND ANIMAL THERAPY, ESPECIALLY OWING TO THEIR REMARKABLE ANTI-INFLAMMATORY ACTION. THE PRODUCTS ARE PREPARED BY ACTION OF A DIALKYL ACETAL ON A PREGNANE DERIVATIVE HAVING HYDROXYL RADICALS IN ITS 17 AND 21 POSITIONS, IN THE PRESENCE OF AN ACID CATALYST.
Abstract:
A PROCESS FOR THE RECOVERY OF D-TRANS-CHRYSANTHEMIC ACID FROM A MIXTURE OF DL-TRANS-CIS-CHRYSANTHEMIC ACID WITH D(-)-THREO-1-P-NITROPHENYL-2-DIMETHYLAMINO-PROPANE1,3-DIOL.
WHERIN X AND X'' MAY BE DIFFERENT AND ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALOGEN, ALKYL, ALKOXY, TRIHALOMETHYL AND NITRO, R IS SELECTED FROM THE GROUP CONSISTING OF -COOH, -COOR'', AND
-CO-N(-A)-B
R'' IS SELECTED FROM THE GROUP CONSISTING OF ALIPHATIC AND HHDROXYLATED RESIDUE OF A GLYCOL, A AND B ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND OPTIONALLY SUBSTITUTED ALIPHATIC AND R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALIPHATIC HDROCARBON, UNSUBSTITUTED AND POLYSUBSTITUTED ARYL, ARYLALIPHATIC, A THIENYL, A B-PYRIDYL AND A FURYL WITH THE PROVISO THAT WHEN R1 IS PHENYL, X'' AND X ARE OTHER THAN HALOGEN, ALKOXY AND TRIFLUROMETHYL WHICH COMPOUNDS POSSESS ANTI-INFLAMMATORY AND ANTIVIRAL ACTIVITY AND A NOVEL PROCESS FOR THEIR PREPARATION.
Abstract:
3-AMINO-4,4-DIHALO-5-PYRAZOLONES OF THE FORMULA
1-Y,3-(R-N(-R1)-),4-X,4-X'',5-(O=)-2-PYRAZOLINE
WHEREIN X AND X'' ARE SELECTED FRO THE GROUP CONSISTING OF CHLORINE AND BROMINE, Y IS SELECTED FROM THE GROUP CONSISTING OF ALKYL, CYCLOALKYL, AND ARYL WHICH MAY BE SUBSTITUTED AND R AND R1 ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ALKYL, ARYL, CYCLOALKYL AND ARALKYL WHICH POSSES; FUNGICIDAL ACTIVITY AND THEIR PREPARATION.
Abstract:
OPTICALLY ACTIVE 1-HYDROXYCYCLOALKANE-3-ONES, SELECTED FROM THE GROUP CONSISTING OF LEVOROTATORY 1B-HYDROXY-2BMETHYL-2A-(3''-OXO-6''-CARBOMETHOXY-HEXYL)-CYCLOPENTANE-3-ONE, DEXTROROTATORY 1-B-HYDROXY-2A-METHYL-2B(3'' - OXO - 6'' - CARBOMETHOXYHEXYL) - CYCLOPENTANE - 3ONE AND LEVOROTATORY 3-METHOXY-8,14-SECO-$**1,3,5(10),9(11). ESTRATETRAENE-17-OL-14-ONE OF THE NATURAL SERIES. THE COMPOUNDS ARE OPTICALLY ACTIVE INTERMEDIATGES IN THE TOTAL SYNTHESIS OF STEROIDS.
Abstract:
WHEREIN R" IS LOWER ALKYL AND R"'' IS SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYLENE AND SUBSTITUTED LOWER ALKYLENE; AND A IS SELECTED FROM THE GROUP CONSISTING OF TWO HYDROGENS AND A DOUBLE BOND THESE COMPOUNDS ARE USEFUL AS INTERMEDIATES IN THE TOTAL SYNTHESIS OF STEROIDS, PARTICULARLY THOSE HAVING SUBSTITUENTS ON THE 17 CARBON ATOM.
=C(-O-R")2 AND =C WHREIN R'' REPRESENTS AN ALKYL HAVING FROM 1 TO 4 CARBON ATOMS; X REPRESENTS A MEMBER SELECTED FROM THE GROUP CONSISTING OF
X AND THE 9,11-POSITION IS A
3-(X=),13-R''-GON-4-EN-17-ONE WHERE C-4 IS REPLACED BY
THE PRESENT INVENTON RELATES TO 3,5-DIKETALS OF 4,5SECO-GONANE-3,517-TRIONES OF THE FORMULA