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    Methods and compositions to diagnose disease using concatenated oligopeptide standard
    31.
    发明申请
    Methods and compositions to diagnose disease using concatenated oligopeptide standard 审中-公开
    使用连接寡肽标准诊断疾病的方法和组合物

    公开(公告)号：US20060211077A1

    公开(公告)日：2006-09-21

    申请号：US11082348

    申请日：2005-03-17

    申请人： Kenneth Abel ,  Andreas Braun ,  Johanna Whitacre ,  Kai Tang

    发明人： Kenneth Abel ,  Andreas Braun ,  Johanna Whitacre ,  Kai Tang

    IPC分类号： C12Q1/37 ,  G01N33/00

    CPC分类号： C12Q1/37

    摘要： The present invention is a method to quantitate proteins associated with a disease or disease state comprising the steps of isolating at least two target proteins from a test sample, combining the target proteins with a known concentration of a concatenated oligopeptide standard and a proteinase to form peptide fragments and standard peptide fragments. The concatenated oligopeptide standard comprising at least one peptide having an amino acid sequence substantially similar to a unique amino acid sequence of a peptide fragment of the two target proteins. The peptides for each of the target proteins are joined by proteinase cleavage sites to form the concatenated oligopeptide. Quantitation of the target proteins is determined by comparison of the peptide fragments to the standard peptide fragments using mass spectroscopy.

    摘要翻译： 本发明是一种定量与疾病或疾病状态相关的蛋白质的方法，包括以下步骤：从测试样品中分离出至少两种靶蛋白，将目标蛋白质与已知浓度的连接寡肽标准品和蛋白酶组合以形成肽 片段和标准肽片段。 连接的寡肽标准品包含至少一种具有与两种靶蛋白的肽片段的独特氨基酸序列基本相似的氨基酸序列的肽。 用于每种靶蛋白的肽通过蛋白酶切割位点连接以形成连接的寡肽。 通过使用质谱法将肽片段与标准肽片段进行比较来确定靶蛋白质的定量。

    Hydropneumatic suspension system
    34.
    发明授权
    Hydropneumatic suspension system 失效
    液压气动悬挂系统

    公开(公告)号：US06669216B1

    公开(公告)日：2003-12-30

    申请号：US09806388

    申请日：2001-07-02

    申请人： Dieter Elser ,  Andreas Braun ,  Manfred Heintschel ,  Wolfgang Zeitz

    发明人： Dieter Elser ,  Andreas Braun ,  Manfred Heintschel ,  Wolfgang Zeitz

    IPC分类号： B60G1126

    CPC分类号： B60G17/0432 ,  B60G17/056 ,  B60G21/067 ,  B60G21/073 ,  B60G2202/154

    摘要： A hydropneumatic suspension system for motor vehicles, having at least one hydropneumatic support aggregate and one automatic level control system cooperating with the aggregate, the automatic level control system, as a function of the lift position of the wheels, sending hydraulic fluid from the hydropneumatic pressure reservoir into the hydropneumatic suspension cylinders, or drawing hydraulic fluid from the hydropneumatic suspension cylinders into the pressure reservoirs, and the functions of suspension, roll stabilization, and automatic level control being able to be performed using the hydropneumatic suspension cylinders.

    摘要翻译： 一种用于机动车辆的液压气动悬挂系统，具有至少一个液压气动支撑骨架和与骨料配合的一个自动液位控制系统，自动液位控制系统作为车轮的提升位置的函数，从液压气动压力 液压气动悬架液压缸，或将液压油缸从液压气动悬架滚筒拉入压力储存器，并且能够使用液压气动悬架气缸进行悬架，滚动稳定和自动液位控制的功能。

    DNA diagnostics based on mass spectrometry
    35.
    发明授权
    DNA diagnostics based on mass spectrometry 失效
    基于质谱的DNA诊断

    公开(公告)号：US06602662B1

    公开(公告)日：2003-08-05

    申请号：US09724877

    申请日：2000-11-28

    申请人： Hubert Köster ,  Daniel P. Little ,  Andreas Braun

    发明人： Hubert Köster ,  Daniel P. Little ,  Andreas Braun

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6872 ,  C12Q1/6816 ,  C12Q1/6827 ,  C12Q1/6837 ,  C12Q1/6858 ,  C12Q1/686 ,  C12Q1/6862 ,  C12Q1/6883 ,  C12Q1/706 ,  G01N35/1067 ,  H01J49/00 ,  Y10T436/143333 ,  Y10T436/24 ,  C12Q2565/627 ,  C12Q2537/113 ,  C12Q2535/113 ,  C12Q2521/325 ,  C12Q2535/131 ,  C12Q2525/107 ,  C12Q2523/107 ,  C12Q2523/319 ,  C12Q2565/625 ,  C12Q2535/125

    摘要： Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogen, or for determining identity or heredity. One aspect provides a process for determining whether a target nucleotide is present in a nucleic acid molecule including hybridizing a nucleic acid molecule with a primer oligonucleotide; contacting the hybridized primer with deoxyribonucleoside triphosphates, chain terminating nucleotides and a DNA polymerase, whereby the hybridized primer is extended until a chain terminating nucleotide is incorporated, producing an extended primer, and determining the molecular mass of the extended primer, thereby determining whether the target nucleotide is present in a nucleic acid molecule.

    摘要翻译： 提供了用于检测分子中特定核酸分子和序列的基于质谱的快速和高精度的方法。 根据待检测的序列，例如，该过程可用于诊断遗传疾病或染色体异常，疾病或病症的易感性或病原体的感染，或用于确定身份或遗传。 一方面提供了确定靶核苷酸是否存在于核酸分子中的方法，包括将核酸分子与引物寡核苷酸杂交; 使杂交引物与脱氧核糖核苷三磷酸，链终止核苷酸和DNA聚合酶接触，由此将杂交引物延伸直到引入链终止核苷酸，产生延伸引物，并测定延伸引物的分子量，由此确定靶 核苷酸存在于核酸分子中。

    Bonding agent composition for polymer substrates
    39.
    发明授权
    Bonding agent composition for polymer substrates 有权
    聚合物基材的粘合剂组合物

    公开(公告)号：US08318311B2

    公开(公告)日：2012-11-27

    申请号：US12448752

    申请日：2008-01-17

    申请人： Andreas Braun

    发明人： Andreas Braun

    IPC分类号： B32B27/40 ,  B32B37/12 ,  C08L75/06 ,  B05D3/00

    CPC分类号： C08G18/7664 ,  C08G18/10 ,  C08G18/4208 ,  C08G18/7671 ,  C08G18/776 ,  C08G18/7831 ,  C08G18/792 ,  C08G2190/00 ,  C09J5/02 ,  C09J175/06 ,  Y10T428/31551 ,  Y10T428/3158 ,  Y10T428/31583 ,  Y10T428/31587 ,  Y10T428/31601 ,  C08G18/307

    摘要： Adhesion promoter compositions which include at least one binder having isocyanate groups. This specific binder is prepared from a mixture of a polyester resin A, at least one monomeric diphenylmethane diisocyanate, and at least one polyisocyanate B, where the proportion of monomeric diphenylmethane diisocyanate (MDI) is ≦2% by weight of the overall composition. Such adhesion promoter compositions are particularly suitable for new generation automotive paint systems and are very desirable from an ecological and toxicological point of view owing to their low content of MDI.

    摘要翻译： 粘合促进剂组合物，其包含至少一种具有异氰酸酯基团的粘合剂。 该特定粘合剂由聚酯树脂A，至少一种单体二苯基甲烷二异氰酸酯和至少一种多异氰酸酯B的混合物制备，其中单体二苯基甲烷二异氰酸酯（MDI）的比例为总组成的2重量％。 这种粘合促进剂组合物特别适用于新一代汽车涂料体系，并且由于其低含量的MDI，从生态和毒理学的观点来看是非常理想的。