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公开(公告)号：US08697137B2
公开(公告)日：2014-04-15
申请号：US10220982
申请日：2001-03-23
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
IPC: A61K9/50
CPC classification number: A61K9/1635 , A61K31/715 , A61K45/06 , A61L2430/36 , Y10T428/2982
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
Abstract translation: 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地输送用于栓塞药物治疗的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于治疗血管生成和非血管生成依赖性疾病的方法。
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公开(公告)号：US20120309644A1
公开(公告)日：2012-12-06
申请号：US13552356
申请日：2012-07-18
Applicant: Lee O. Lomas , Jian Ding , Egisto Boschetti
Inventor： Lee O. Lomas , Jian Ding , Egisto Boschetti
IPC: C40B30/04 , G01N27/447 , B01D15/42 , F17D1/00
CPC classification number: G01N30/461 , B01D15/325 , B01D15/362 , B01D15/363 , B01L3/5025 , B01L3/50255 , B01L3/563 , B01L2200/026 , B01L2200/028 , B01L2300/0681 , B01L2300/0829 , B01L2300/087 , B01L2400/0487 , C07K1/34 , G01N27/44704 , G01N27/44795 , G01N30/466 , G01N30/468 , Y10T137/2224 , Y10T137/794 , Y10T137/86187 , Y10T436/255
Abstract: The present invention contemplates various devices that are configured to separate a sample, which contains more than one unique species, into any desired number of sub-samples by passing the sample across a like number of separation media configured for a first separation protocol. Each of the sub-samples may be further separated by an additional separation protocol, thereby creating a plurality of mini-samples, each of which may be further separated and/or analyzed. The invention also contemplates using a simple method of using conduits to form a fluid path that passes through a plurality of separation media, each of which media is configured to isolate a particular sub-sample. After various sub-samples of the sample are isolated by the various separation media, the conduits may be removed, thereby enabling each of the isolated sub-samples to be further separated and/or analyzed independent of any other sub-sample.
Abstract translation: 本发明考虑了通过将样品穿过配置用于第一分离方案的相似数量的分离介质，将被配置成将含有多于一种独特物种的样品分离成任何所需数量的子样品的各种装置。 每个子样品可以通过另外的分离方案进一步分离，从而产生多个微型样品，每个小样品可进一步分离和/或分析。 本发明还考虑使用简单的方法来使用导管来形成通过多个分离介质的流体路径，其中每个介质被配置为隔离特定的子样品。 在通过各种分离介质分离样品的各种亚样品之后，可以去除导管，从而使每个分离的子样品能够独立于任何其它亚样品进一步分离和/或分析。
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公开(公告)号：US20080023630A1
公开(公告)日：2008-01-31
申请号：US11557286
申请日：2006-11-07
Applicant: Egisto Boschetti , Lee O. Lomas
Inventor： Egisto Boschetti , Lee O. Lomas
IPC: H01J49/00
CPC classification number: H01J49/0418
Abstract: A mass spectrometer probe is formed of a nonconductive polymer that is doped with conductive material. The probe may be used as, or as part of, a repeller plate in a parallel laser ion desorption/ionization time-of-flight mass spectrometer. Transparent locations on the probe enable a sample placed thereon to be visualized before or during mass spectrometry. The conductive nature of the probe maintains the consistency of the electromagnetic field applied to the sample. The probe also displays low outgassing and high mechanical and chemical stability, thereby enabling it to be used repetitively.
Abstract translation: 质谱仪探针由掺杂有导电材料的非导电聚合物形成。 探针可以用作平行激光离子解吸/电离飞行时间质谱仪中的或作为排斥板的一部分。 在探针之前或期间，探针上的透明位置使其上放置的样品可视化。 探头的导电性质保持了施加到样品的电磁场的一致性。 该探头还显示出低的除气和高的机械和化学稳定性，从而使其能够重复使用。
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公开(公告)号：US20070254378A1
公开(公告)日：2007-11-01
申请号：US11682655
申请日：2007-03-06
Applicant: Hongmin Zhang , Egisto Boschetti , Lee Lomas , Pil-Je Um
Inventor： Hongmin Zhang , Egisto Boschetti , Lee Lomas , Pil-Je Um
CPC classification number: C08F220/36 , B01D71/28 , C02F1/683 , C02F2101/20 , C08F220/30 , C08F222/1006 , Y10T436/24
Abstract: This invention provides chelating moieties that comprise an aryl group. Monomers that include the chelating moieties can be polymerized into chelating polymers. Chelating polymers are useful to chelate metals. Chelating polymers in the form of metal chelates are useful for binding analytes, such as polypeptides that comprise histidine residues. Chelating polymers can be includes in articles such as chips and chromatographic materials.
Abstract translation: 本发明提供了包含芳基的螯合部分。 包含螯合部分的单体可以聚合成螯合聚合物。 螯合聚合物可用于螯合金属。 金属螯合物形式的螯合聚合物可用于结合分析物，例如包含组氨酸残基的多肽。 螯合聚合物可以包括在诸如芯片和色谱材料的制品中。
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公开(公告)号：US20060063732A1
公开(公告)日：2006-03-23
申请号：US11253435
申请日：2005-10-18
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
CPC classification number: A61K9/0019 , A61K9/1635 , A61K48/00 , A61K48/0008 , A61K48/0041
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) physically linked to a transfection agent for use in embolization gene therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions., using the injectable compositions.
Abstract translation: 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地递送与用于栓塞基因治疗的转染剂物理连接的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于使用可注射组合物治疗血管生成和非血管生成依赖性疾病的方法。
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Patent Agency Ranking
公开(公告)号：US06790456B2
公开(公告)日：2004-09-14
申请号：US10222819
申请日：2002-08-19
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
IPC: A61F1300
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.
Abstract translation: 本发明涉及可注射组合物，其包含生物相容性，可溶胀，亲水，无毒和基本上为球形的微球微球和用于皮肤增生的生物相容性载体。 本发明还涉及使用可注射组合物的皮肤增强方法，特别是用于治疗皮肤轮廓缺陷的方法。
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37.发明授权Hydrophilic copolymers based on N-[tris(hydroxymethyl)methyl]-acrylamide, processes for their preparation, aqueous gels of said copolymers and their use as ion exchangers 失效基于N- [三（羟甲基）甲基] - 丙烯酰胺的亲水性共聚物，其制备方法，所述共聚物的水凝胶及其作为离子交换剂的用途
公开(公告)号：US4452916A
公开(公告)日：1984-06-05
申请号：US415961
申请日：1982-09-08
Applicant: Egisto Boschetti
Inventor： Egisto Boschetti
IPC: C08F20/00 , B01J20/281 , B01J20/285 , B01J39/20 , B01J41/14 , C08F12/00 , C08F16/14 , C08F16/38 , C08F20/38 , C08F20/52 , C08F26/00 , C08F28/00 , C08F212/14 , C08F216/12 , C08F216/36 , C08F220/38 , C08F220/58 , C08F220/60 , C08F226/02 , C08F228/02 , G01N30/88 , B01D15/00 , C08L5/00 , C08L89/00
CPC classification number: C08F220/58
Abstract: Tridimensional cross-linked random copolymers, insoluble in water, containing in copolymerized form: (a) 25% to 98% by weight of N-[tris(hydroxymethyl)methyl]acrylamide or N-[tris(hydroxymethyl)methyl]methacrylamide, or a mixture of these two compounds. (b) 2% to 50% by weight of one or more monomers containing two or several polymerizable ethylenic double bonds and free from anionic or cationic functional groups, and (c) 0.1% to 50% by weight of one or more monomers containing a polymerizable ethylenic double bond and one or more mono- or di-substituted amino, pyrimidinyl, guanidyl, purinyl, quaternary ammonium, SO.sub.3 H or SO.sub.3 M groups, M being an alkali metal. These copolymers are utilizable, in the form of aqueous gels, as ion exchangers.
Abstract translation: 含有共聚形式的三维交联无规共聚物（a）25％至98％重量的N- [三（羟甲基）甲基]丙烯酰胺或N- [三（羟甲基）甲基]甲基丙烯酰胺，或 这两种化合物的混合物。 （b）2重量％至50重量％的一种或多种含有两个或几个可聚合的烯属双键并且不含阴离子或阳离子官能团的单体，和（c）0.1重量％至50重量％的一种或多种含有 可聚合的烯属双键和一个或多个单取代或二取代的氨基，嘧啶基，胍基，嘌呤基，季铵，SO 3 H或SO 3 M基团，M为碱金属。 这些共聚物可以以水凝胶的形式用作离子交换剂。
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38.发明授权Hydrophilic copolymers, their preparation and their use in separation techniques 失效亲水共聚物，它们的制备及其在分离技术中的应用
公开(公告)号：US4192784A
公开(公告)日：1980-03-11
申请号：US873026
申请日：1978-01-27
Applicant: Eric Brown , Egisto Boschetti , Monique M. Corgier , Joel Touet
Inventor： Eric Brown , Egisto Boschetti , Monique M. Corgier , Joel Touet
IPC: C08F20/00 , B01D15/08 , C08F20/52 , C08F220/58 , C08L33/24 , C08L33/26 , C12N11/08 , C08L89/00 , C08F20/54 , C08L3/00
CPC classification number: C08F220/58 , C12N11/08 , Y10S524/916 , Y10S526/909 , Y10T428/2998
Abstract: Water-insoluble, tridimensional cross-linked random copolymers, which contain in copolymerized form:(a) 25% to 98% by weight of N-[tris(hydroxymethyl)methyl]acrylamide or N-[tris(hydroxymethyl)methyl]methacrylamide or a mixture of these two compounds;(b) 2% to 50% by weight of one or more monomers having several polymerizable ethylenic double bonds and one or more hydroxy groups, and free from NH.sub.2 or COOH groups; and(c) 0% to 50% by weight of one or more monomers having a polymerizable ethylenic double bond and one or more amino or carboxy groups. These copolymers may be used, in the form of aqueous gels, as supports in techniques of separation such as gell permeation chromatography and in techniques of immobilization of natural substances.
Abstract translation: 含有共聚形式的水不溶性三维交联无规共聚物：（a）25-98重量％的N- [三（羟甲基）甲基]丙烯酰胺或N- [三（羟甲基）甲基]甲基丙烯酰胺或 这两种化合物的混合物; （b）2重量％至50重量％的一种或多种具有几个可聚合的烯属双键和一个或多个羟基并且不含NH 2或COOH基团的单体; 和（c）0重量％至50重量％的一种或多种具有可聚合烯键式双键和一个或多个氨基或羧基的单体。 这些共聚物可以水凝胶的形式用作分离技术中的载体，例如凝胶渗透色谱法和固定天然物质的技术。
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39.发明授权Process for obtaining gels of N-methylol-acrylamide copolymers and application of said gels for the stepped gradient separation of seric lipoproteins 失效获得N-羟甲基丙烯酰胺共聚物凝胶的方法和用于梯度梯度分离线性脂蛋白的所述凝胶的应用
公开(公告)号：US4189370A
公开(公告)日：1980-02-19
申请号：US917549
申请日：1978-06-21
Applicant: Egisto Boschetti
Inventor： Egisto Boschetti
IPC: G01N27/447 , G01N27/26 , G01N27/28
CPC classification number: G01N27/44747
Abstract: A process for preparing plates of a new gel polymer, said plates being adapted to the electrophoresis separation of the seric or plasmatic lipoproteins under a stepped gradient. The gel polymers are prepared by radical polymerization of N-methylol-acrylamide and of a bifunctional allylic or acrylic compound causing cross-linking to yield a tridimensional configuration polymer. The polymerization may optionally be catalyzed by peroxides and/or ultraviolet radiation. Anionic polysaccharides containing only COOH groups may be added to assist migration of lipoproteins in the gel.
Abstract translation: 一种制备新凝胶聚合物的平板的方法，所述板适于在梯度梯度下电泳分离浆液或血浆脂蛋白。 凝胶聚合物通过N-羟甲基丙烯酰胺和双官能烯丙基或丙烯酸化合物的自由基聚合制备，引起交联以产生三维构型聚合物。 聚合可以任选地被过氧化物和/或紫外线辐射催化。 可以加入仅含有COOH基团的阴离子多糖以辅助凝胶中脂蛋白的迁移。
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公开(公告)号：US09803184B2
公开(公告)日：2017-10-31
申请号：US13976557
申请日：2011-12-30
Applicant: Egisto Boschetti , Gérald Perret
Inventor： Egisto Boschetti , Gérald Perret
CPC classification number: C12N9/6437 , B01J20/289 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J20/3278 , C07H21/02 , C07H21/04 , C07K1/22
Abstract: The invention relates to a method for immobilizing nucleic ligands including at least one reactive amine function, by grafting on an activated solid substrate, including a step of coupling said nucleic acids on said activated solid substrate having a pH of less than 6.
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