公开(公告)号：US11476222B2

公开(公告)日：2022-10-18

申请号：US16819806

申请日：2020-03-16

Applicant: IMMUNOLIGHT, LLC

Inventor： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr.

IPC: C09J9/02 ,  H01L23/00 ,  C09J11/02 ,  C09J163/00 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y80/00 ,  B23K26/354 ,  B22F5/04 ,  B22F7/06 ,  B23K26/34 ,  B22F12/00 ,  B22F3/10 ,  B22F10/10

Abstract: A curable resin or adhesive composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and at least one energy converting material, preferably a phosphor, capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

公开(公告)号：US11278861B2

公开(公告)日：2022-03-22

申请号：US16900091

申请日：2020-06-12

Applicant: IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

Inventor： Frederic A. Bourke, Jr. ,  Tuan Vo-Dinh

IPC: B01J19/12 ,  A23L3/26 ,  A61L2/00 ,  C02F1/30 ,  C02F1/72 ,  A23L5/30 ,  B01J19/08 ,  A61L2/08 ,  A61L2/10 ,  A61L2/16 ,  C08J3/28 ,  G21K5/00 ,  C02F1/32 ,  A61K41/00 ,  A61N5/06 ,  A61N5/10 ,  B01J23/50 ,  B01J23/52 ,  B01J31/02 ,  B01J31/22 ,  B01J35/00 ,  B01J37/00 ,  B01J37/02 ,  C09D201/00 ,  C09J5/00 ,  C09J201/00 ,  A23L2/50 ,  A23L3/28 ,  C08J3/24 ,  C08J7/18 ,  G02B5/00 ,  A61M1/36 ,  C12H1/06 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.

公开(公告)号：US10940329B2

公开(公告)日：2021-03-09

申请号：US15819130

申请日：2017-11-21

Applicant: IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

Inventor： Mark Oldham ,  Justus Adamson ,  Paul Yoon ,  Harold Walder ,  Frederic A. Bourke, Jr. ,  Zakaryae Fathi ,  Wayne F. Beyer

IPC: A61K49/00 ,  A61N5/10 ,  C09K11/59 ,  C09K11/73 ,  C09K11/02 ,  A61K31/37 ,  A61P35/00 ,  A61K41/00 ,  A61K49/04

Abstract: A phosphor-containing drug activator activatable from a Monte Carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays, wherein a distribution of the phosphors in the diseased target site is based on a Monte Carlo derived x-ray dose. A system for treating a disease in a subject in need thereof, includes the drug activator and a photoactivatable drug, one or more devices which infuse the photoactivatable drug and the activator including the pharmaceutically acceptable carrier into a diseased site in the subject; and an x-ray source which is controlled to deliver the Monte Carlo derived x-ray exposure to the subject for production of ultraviolet and visible light inside the subject to activate the photoactivatable drug.

公开(公告)号：US10441810B2

公开(公告)日：2019-10-15

申请号：US15434871

申请日：2017-02-16

Applicant: IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

Inventor： Mark Oldham ,  Zakaryae Fathi ,  Wayne F. Beyer ,  Harold Walder ,  Frederic A. Bourke, Jr. ,  Mark Dewhirst ,  Neil L. Spector ,  Paul Yoon ,  Justus Adamson ,  David Alcorta ,  Kim Lyerly ,  Leihua Liu ,  Takuya Osada

IPC: A61N5/06 ,  A61K41/00 ,  A61N5/10 ,  A61K31/352

Abstract: A system for treating a diseased site in a human or animal body. The system includes a pharmaceutical carrier including one or more phosphors which are capable of emitting light into the diseased site upon interaction, a photoactivatable drug for intercalating into DNA of cells at the diseased site, one or more devices which infuse the diseased sited with the photoactivatable drug and the pharmaceutical carrier, an x-ray or high energy electron source, and a processor programmed to control a dose of x-rays or electrons to the diseased site for production of light inside the tumor to activate the photoactivatable drug.

公开(公告)号：US10410991B2

公开(公告)日：2019-09-10

申请号：US15322928

申请日：2015-06-29

Applicant: IMMUNOLIGHT, LLC

Inventor： Zakaryae Fathi ,  Frederic A. Bourke, Jr. ,  Harold Walder

IPC: H01L23/00 ,  B32B37/12 ,  B32B38/00 ,  C09J11/06 ,  B32B7/12 ,  B32B7/06 ,  C09J133/00 ,  C09J133/06 ,  B32B5/02 ,  B32B5/18 ,  B32B5/26 ,  B32B9/02 ,  B32B9/04 ,  B32B17/00 ,  B32B18/00 ,  B32B21/04 ,  B32B25/04 ,  B32B27/08 ,  B32B27/16 ,  B32B27/30 ,  B32B27/32 ,  B32B27/34 ,  B32B27/36

Abstract: A method of and system for adhesive bonding. The method and system a) treat a surface of an element to be bonded to provide an adherent structure including one or more rubber compounds on the surface; b) place a polymerizable adhesive composition, including at least one photoinitiator and at least one energy converting material, in contact with the adherent structure and two or more components to be bonded to form an assembly, c) irradiated the assembly with radiation at a first wavelength, capable of conversion by the at least one energy converting material, to a second wavelength capable of activating the at least one photoinitiator to produce from the polymerizable adhesive composition a cured adhesive composition; and d) adhesively join the two or more components by way of the adherent structure and the cured adhesive composition.

公开(公告)号：US09993661B2

公开(公告)日：2018-06-12

申请号：US15649956

申请日：2017-07-14

Applicant: IMMUNOLIGHT, LLC.

Inventor： Frederic A. Bourke, Jr. ,  Harold Walder

IPC: A61N5/06 ,  A61N5/10 ,  A61K41/00

CPC classification number: A61N5/062 ,  A61K41/0085 ,  A61N5/0622 ,  A61N5/1077 ,  A61N2005/0661 ,  A61N2005/1091 ,  A61N2005/1098

Abstract: A system and method for light stimulation within a medium. Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

公开(公告)号：US09283275B2

公开(公告)日：2016-03-15

申请号：US14573511

申请日：2014-12-17

Applicant: Duke University ,  Immunolight, LLC

Inventor： Tuan Vo-Dinh ,  Frederic A. Bourke, Jr.

IPC: A61K41/00 ,  A61K9/14 ,  A61K47/48 ,  A61K39/00 ,  A61N5/06 ,  A61K31/37

CPC classification number: A61K41/0061 ,  A61K9/14 ,  A61K9/143 ,  A61K31/37 ,  A61K39/00 ,  A61K41/0028 ,  A61K41/0066 ,  A61K47/52 ,  A61K2039/57 ,  A61N5/06 ,  A61N5/062

Abstract: The use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes used therein.

公开(公告)号：US08791275B2

公开(公告)日：2014-07-29

申请号：US13739414

申请日：2013-01-11

Applicant: Immunolight, LLC

Inventor： Eric Toone ,  David Gooden ,  Tuan Vo-Dinh ,  Frederic A. Bourke, Jr.

IPC: C07D493/00 ,  C07D215/38 ,  C07D211/32

CPC classification number: C07D493/04 ,  A61K31/4433 ,  A61K31/453 ,  A61K31/4709 ,  A61K41/0066 ,  A61K45/06 ,  A61N5/062 ,  A61N5/10

Abstract: Psoralen compounds of Formula (I): wherein (N+ Aryl) is a member selected from the group consisting of nitrogen containing aromatic heterocycles of formulae (i)-(iii): wherein Z is a group of formula: wherein R is C1-C30 hydrocarbyl, which may be linear, branched or cyclic and contains from 1 to 15 carbon-carbon double bonds, which may be conjugated or unconjugated with one another or may include an aryl ring, and may contain one or more substituents; R1 is hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, heterocyclyl, alkenyl, alkynyl, alkene-aryl, alkene-heteroaryl, alkene-heterocyclyl, alkene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclyheteroaryl, alkylene-fused cycloalkylaryl, alkylene-fused cycloalkylheteroaryl, alkylene-fused heterocyclylaryl, alkylene-fused heterocyclyheteroaryl; n is an integer from 1 to 8 and X is a pharmaceutically acceptable counter ion; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for performing the method, and a method for causing an autovaccine effect in a subject using the method.

公开(公告)号：US12121746B2

公开(公告)日：2024-10-22

申请号：US17433890

申请日：2020-01-30

Applicant: IMMUNOLIGHT, LLC

Inventor： Frederic A. Bourke, Jr. ,  Harold Walder ,  Zakaryae Fathi ,  Wayne F. Beyer ,  Ronald A. Rudder ,  Joseph H. Simmons

IPC: A61N5/06 ,  A61K35/12 ,  A61K41/00 ,  A61N5/067 ,  C09J133/08 ,  C09K11/02 ,  C09K11/59 ,  C09K11/76 ,  C09K11/77 ,  C12N15/01 ,  F21K2/00 ,  F21S11/00 ,  F21V9/40 ,  H01J45/00 ,  H01L23/00 ,  H01L31/0352 ,  H01L31/054 ,  H01L31/06 ,  H01L31/055

CPC classification number: A61N5/0625 ,  A61K35/12 ,  A61K41/00 ,  A61K41/0057 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/067 ,  C09J133/08 ,  C09K11/025 ,  C09K11/595 ,  C09K11/76 ,  C09K11/7701 ,  C09K11/7792 ,  C12N15/01 ,  F21K2/00 ,  F21S11/007 ,  F21V9/40 ,  H01J45/00 ,  H01L24/29 ,  H01L24/83 ,  H01L31/035281 ,  H01L31/054 ,  H01L31/06 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/0663 ,  H01L31/055 ,  H01L2224/2919 ,  H01L2224/29393 ,  H01L2224/8322 ,  H01L2224/83855

Abstract: An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, particularly medical uses for treatment of cell proliferation disorders.

公开(公告)号：US11998760B2

公开(公告)日：2024-06-04

申请号：US17433827

申请日：2020-02-27

Applicant: IMMUNOLIGHT, LLC

Inventor： Frederic A. Bourke, Jr. ,  Harold Walder ,  Zakaryae Fathi ,  Wayne F. Beyer ,  Ronald A. Rudder ,  Daniel I. Becker ,  Joseph H. Simmons

IPC: H01L31/044 ,  A61K35/12 ,  A61K41/00 ,  A61N5/06 ,  A61N5/067 ,  C09J133/08 ,  C09K11/02 ,  C09K11/59 ,  C09K11/76 ,  C09K11/77 ,  C12N15/01 ,  F21K2/00 ,  F21S11/00 ,  F21V9/40 ,  H01J45/00 ,  H01L23/00 ,  H01L31/0352 ,  H01L31/054 ,  H01L31/06 ,  H01L31/055

CPC classification number: A61N5/0625 ,  A61K35/12 ,  A61K41/00 ,  A61K41/0057 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/067 ,  C09J133/08 ,  C09K11/025 ,  C09K11/595 ,  C09K11/76 ,  C09K11/7701 ,  C09K11/7792 ,  C12N15/01 ,  F21K2/00 ,  F21S11/007 ,  F21V9/40 ,  H01J45/00 ,  H01L24/29 ,  H01L24/83 ,  H01L31/035281 ,  H01L31/054 ,  H01L31/06 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/0663 ,  H01L31/055 ,  H01L2224/2919 ,  H01L2224/29393 ,  H01L2224/8322 ,  H01L2224/83855

Abstract: An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, especially in the field of solar cells and other energy conversion devices.