公开(公告)号：US08721591B2

公开(公告)日：2014-05-13

申请号：US13355758

申请日：2012-01-23

申请人： John Y. Chang ,  Joshua Makower ,  Julia D. Vrany ,  Amrish Jayprakash Walke

发明人： John Y. Chang ,  Joshua Makower ,  Julia D. Vrany ,  Amrish Jayprakash Walke

IPC分类号： A61M29/00

CPC分类号： A61M29/02 ,  A61B5/6852 ,  A61B17/24 ,  A61B17/32002 ,  A61B17/3403 ,  A61B17/3421 ,  A61B18/1492 ,  A61B2017/22039 ,  A61B2017/22051 ,  A61B2017/22061 ,  A61B2018/00327 ,  A61B2018/00595 ,  A61B2034/2051 ,  A61F2/186 ,  A61F2/82 ,  A61F2/90 ,  A61F2/95 ,  A61F2/958 ,  A61M25/0026 ,  A61M25/005 ,  A61M25/0082 ,  A61M25/0102 ,  A61M25/0138 ,  A61M25/0147 ,  A61M25/09 ,  A61M25/10 ,  A61M25/1006 ,  A61M25/1011 ,  A61M2025/0177 ,  A61M2025/1072 ,  A61M2025/1079 ,  A61M2025/109 ,  A61M2029/025 ,  A61M2210/0681 ,  A61M2210/1028

摘要： Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat.

摘要翻译： 使用具有柔性或刚性器械的微创方法诊断和/或治疗鼻窦炎和其他耳朵，鼻子和喉咙疾病。 各种方法和装置用于重建或改变耳朵，鼻子或喉咙中的窦口或导管或其他解剖结构的形状，尺寸或构型; 植入装置，细胞或组织; 从耳朵，鼻子或喉咙去除物质; 提供诊断或治疗物质或执行其他诊断或治疗程序。 可以使用引入装置（例如，引导导管，管，导线，细长探针，其它细长构件）来促进工作装置（例如，导管例如球囊导管，导线，组织切割或重塑装置，用于植入元件如支架的装置， 电外科装置，能量发射装置，用于递送诊断或治疗剂，物质输送植入物，范围等的装置）到耳鼻窦或耳朵，鼻子或喉咙中的其他结构中。

公开(公告)号：US20100152730A1

公开(公告)日：2010-06-17

申请号：US12643788

申请日：2009-12-21

申请人： Joshua Makower ,  John Y. Chang ,  Ketan P. Muni ,  Wenda Carlyle ,  Howard Levine ,  William M. Facteau

发明人： Joshua Makower ,  John Y. Chang ,  Ketan P. Muni ,  Wenda Carlyle ,  Howard Levine ,  William M. Facteau

IPC分类号： A61F13/02 ,  A61B18/18

CPC分类号： A61L26/0023 ,  A61F13/00017 ,  A61F2013/00357 ,  A61K9/006 ,  A61L15/42 ,  A61L15/44 ,  A61L15/58 ,  A61L15/64 ,  A61L26/0061 ,  A61L26/0066 ,  A61L26/009 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/608 ,  Y10T156/10

摘要： A method and apparatus for reducing or eliminating pain after surgical procedures related to mucosal tissue, including tonsillectomy, adenoidectomy, or other pharyngeal operations. Certain embodiments provide a biodegradable film or covering that serves as a mechanical barrier to reduce pain caused, for example, by friction between solid food and healing tissue in the first few days after surgery. Some embodiments include a method for increasing the adhesion between tissue and the film or covering.

摘要翻译： 用于减少或消除与粘膜组织相关的外科手术后疼痛的方法和装置，包括扁桃体切除术，腺样体切除术或其他咽部手术。 某些实施方案提供用作机械屏障的可生物降解的膜或覆盖物，以减少例如在手术后的头几天固体食物与愈合组织之间的摩擦所引起的疼痛。 一些实施例包括用于增加组织和膜或覆盖物之间的粘附的方法。

公开(公告)号：US07654997B2

公开(公告)日：2010-02-02

申请号：US10829917

申请日：2004-04-21

申请人： Joshua Makower ,  John Y. Chang

发明人： Joshua Makower ,  John Y. Chang

IPC分类号： A61M31/00

CPC分类号： A61B17/24 ,  A61B1/233 ,  A61B1/313 ,  A61B10/0233 ,  A61B10/06 ,  A61B17/0218 ,  A61B17/1688 ,  A61B17/29 ,  A61B17/3201 ,  A61B17/32053 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/320758 ,  A61B17/320783 ,  A61B17/3478 ,  A61B18/02 ,  A61B18/042 ,  A61B18/12 ,  A61B18/18 ,  A61B2017/00477 ,  A61B2017/22061 ,  A61B2017/320052 ,  A61B2017/320064 ,  A61B2018/00327 ,  A61B2018/00595 ,  A61B2018/0212 ,  A61B2018/1405 ,  A61B2217/005 ,  A61B2217/007 ,  A61F2/18 ,  A61F2/186 ,  A61F2/82 ,  A61F11/004 ,  A61F13/2005 ,  A61F2250/0039 ,  A61M16/0434 ,  A61M25/10 ,  A61M29/02 ,  A61M31/00 ,  A61M31/005 ,  A61N1/0541

摘要： Sinusitis, enlarged nasal turbinates, tumors, infections, hearing disorders, allergic conditions, facial fractures and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies, endoscopic studies and transillumination studies. Access and occluder devices may be used to establish fluid tight seals in the anterior or posterior nasal cavities/nasopharynx and to facilitate insertion of working devices (e.g., scopes, guidewires, catheters, tissue cutting or remodeling devices, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting devices, substance delivery implants, etc.

摘要翻译： 使用微创方法诊断和/或治疗鼻窦炎，扩大的鼻甲，肿瘤，感染，听力障碍，过敏症状，面部骨折和其他疾病，并且在许多情况下，柔性导管与仪器相反 具有刚性轴。 使用各种诊断程序和装置进行成像研究，粘液流研究，空气/气体流动研究，解剖维度研究，内镜研究和透照研究。 可以使用进入和闭塞器装置在前鼻/鼻后鼻/鼻咽中建立流体密封，并且便于插入工作装置（例如，示波器，导丝，导管，组织切割或重塑装置，电外科装置，能量发射装置， 用于注射诊断或治疗剂的装置，用于植入装置如支架，物质洗脱装置，物质输送植入物等的装置

公开(公告)号：US07641644B2

公开(公告)日：2010-01-05

申请号：US11926377

申请日：2007-10-29

申请人： John Y. Chang ,  Joshua Makower ,  Julia D. Vrany

发明人： John Y. Chang ,  Joshua Makower ,  Julia D. Vrany

IPC分类号： A61M31/00

CPC分类号： A61F11/002 ,  A61B5/065 ,  A61B10/06 ,  A61B17/1204 ,  A61B17/12045 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/1604 ,  A61B17/1608 ,  A61B17/1679 ,  A61B17/1688 ,  A61B17/24 ,  A61B17/32002 ,  A61B17/32075 ,  A61B17/3478 ,  A61B34/20 ,  A61B50/13 ,  A61B50/15 ,  A61B50/20 ,  A61B90/16 ,  A61B90/361 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2017/320004 ,  A61B2017/3486 ,  A61B2017/3488 ,  A61B2018/00392 ,  A61B2034/2051 ,  A61F2/958 ,  A61F2250/0067 ,  A61M25/007 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1052

摘要： Sinusitis, mucocysts, tumors, infections, hearing disorders, choanal atresia, fractures and other disorders of the paranasal sinuses, Eustachian tubes, Lachrymal ducts and other ear, nose, throat and mouth structures are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies and endoscopic studies. Access and occluding devices may be used to facilitate insertion of working devices such asendoscopes, wires, probes, needles, catheters, balloon catheters, dilation catheters, dilators, balloons, tissue cutting or remodeling devices, suction or irrigation devices, imaging devices, sizing devices, biopsy devices, image-guided devices containing sensors or transmitters, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting or delivering devices and implants, etc.

公开(公告)号：US20080287908A1

公开(公告)日：2008-11-20

申请号：US12100361

申请日：2008-04-09

申请人： Ketan P. Muni ,  Hung V. Ha ,  John Y. Chang ,  Randy S. Chan ,  Nga K. Van ,  Joshua Makower ,  William M. Facteau ,  Howard L. Levine

发明人： Ketan P. Muni ,  Hung V. Ha ,  John Y. Chang ,  Randy S. Chan ,  Nga K. Van ,  Joshua Makower ,  William M. Facteau ,  Howard L. Levine

IPC分类号： A61M31/00

CPC分类号： A61M25/10 ,  A61B17/24 ,  A61B17/3415 ,  A61B17/3417 ,  A61B17/3421 ,  A61B2090/062 ,  A61F11/004 ,  A61M25/0075 ,  A61M25/0084 ,  A61M25/04 ,  A61M29/02 ,  A61M31/00 ,  A61M2025/0681 ,  A61M2025/105

摘要： Substance delivering spacer devices may comprise expandable reservoirs that are implantable in paranasal sinuses and other cavities, openings and passageways of the body to maintain patency and to provide sustained local delivery of a therapeutic or diagnostic substance. Also provided are sinus penetrator devices and systems for performing ethmoidotomy procedures or for creating other openings in the walls of paranasal sinuses or other anatomical structures.

摘要翻译： 输送间隔物的物质可以包括可植入鼻旁窦和身体的其它空腔，开口和通道的可扩张的储存器，以维持通畅并提供治疗或诊断物质的持续的局部递送。 还提供了用于执行筛管手术或用于在鼻旁窦或其他解剖结构的壁中产生其他开口的窦穿刺装置和系统。

公开(公告)号：US20080262468A1

公开(公告)日：2008-10-23

申请号：US11749733

申请日：2007-05-16

申请人： Anton Clifford ,  Greg Liu ,  John Morriss ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

发明人： Anton Clifford ,  Greg Liu ,  John Morriss ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

IPC分类号： A61M31/00

CPC分类号： A61M31/00 ,  A61B5/0077 ,  A61B2017/00787 ,  A61F11/002 ,  A61F2230/0039 ,  A61F2230/0052 ,  A61F2250/0039 ,  A61M2210/0662 ,  A61N1/30 ,  A61N1/306

摘要： Systems and methods for treating a patient having a head with a first ear and a second ear, function by mounting a support structure to the head of the patient; aligning the support structure with a target tissue in an ear canal of the first ear; stabilizing the support structure relative to the target tissue by injecting a material into the canal and hardening the material; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear.

摘要翻译： 用于治疗患有具有第一耳朵和第二耳朵的头部的患者的系统和方法通过将支撑结构安装到患者的头部而起作用; 将支撑结构与第一耳的耳道中的目标组织对准; 通过将材料注入到管道中并使材料硬化来相对于目标组织稳定支撑结构; 以及当所述装置由所述支撑系统支撑时启动装置，使得所述装置治疗性地改造所述第一耳朵的目标组织。

公开(公告)号：US20080154250A1

公开(公告)日：2008-06-26

申请号：US12042221

申请日：2008-03-04

申请人： Joshua Makower ,  John Y. Chang

发明人： Joshua Makower ,  John Y. Chang

IPC分类号： A61B1/06

CPC分类号： A61B17/24 ,  A61B1/233 ,  A61B1/313 ,  A61B10/0233 ,  A61B10/06 ,  A61B17/0218 ,  A61B17/1688 ,  A61B17/29 ,  A61B17/3201 ,  A61B17/32053 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/320758 ,  A61B17/320783 ,  A61B17/3478 ,  A61B18/02 ,  A61B18/042 ,  A61B18/12 ,  A61B18/18 ,  A61B2017/00477 ,  A61B2017/22061 ,  A61B2017/320052 ,  A61B2017/320064 ,  A61B2018/00327 ,  A61B2018/00595 ,  A61B2018/0212 ,  A61B2018/1405 ,  A61B2217/005 ,  A61B2217/007 ,  A61F2/18 ,  A61F2/186 ,  A61F2/82 ,  A61F11/004 ,  A61F13/2005 ,  A61F2250/0039 ,  A61M16/0434 ,  A61M25/10 ,  A61M29/02 ,  A61M31/00 ,  A61M31/005 ,  A61N1/0541

摘要： Sinusitis, enlarged nasal turbinates, tumors, infections, hearing disorders, allergic conditions, facial fractures and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies, endoscopic studies and transillumination studies. Access and occluder devices may be used to establish fluid tight seals in the anterior or posterior nasal cavities/nasopharynx and to facilitate insertion of working devices (e.g., scopes, guidewires, catheters, tissue cutting or remodeling devices, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting devices, substance delivery implants, etc.

摘要翻译： 使用微创方法诊断和/或治疗鼻窦炎，扩大的鼻甲，肿瘤，感染，听力障碍，过敏症状，面部骨折和其他疾病，并且在许多情况下，柔性导管与仪器相反 具有刚性轴。 使用各种诊断程序和装置进行成像研究，粘液流研究，空气/气体流动研究，解剖维度研究，内镜研究和透照研究。 可以使用进入和闭塞器装置在前鼻/鼻后鼻/鼻咽中建立流体密封，并且便于插入工作装置（例如，示波器，导丝，导管，组织切割或重塑装置，电外科装置，能量发射装置， 用于注射诊断或治疗剂的装置，用于植入装置如支架，物质洗脱装置，物质输送植入物等的装置

公开(公告)号：US09814379B2

公开(公告)日：2017-11-14

申请号：US11929667

申请日：2007-10-30

申请人： Joshua Makower ,  John Y. Chang ,  Ketan P. Muni ,  John H. Morriss ,  Hung V. Ha ,  Isaac J. Kim ,  Julia D. Vrany

发明人： Joshua Makower ,  John Y. Chang ,  Ketan P. Muni ,  John H. Morriss ,  Hung V. Ha ,  Isaac J. Kim ,  Julia D. Vrany

IPC分类号： A61B17/24 ,  A61B1/233 ,  A61B1/00 ,  A61B1/018 ,  A61B1/267 ,  A61B17/28 ,  A61B17/34 ,  A61M29/02 ,  A61B90/50 ,  A61B1/005 ,  A61B90/00 ,  A61B34/20

CPC分类号： A61B1/233 ,  A61B1/00135 ,  A61B1/0051 ,  A61B1/018 ,  A61B1/267 ,  A61B17/24 ,  A61B17/2804 ,  A61B17/282 ,  A61B17/3421 ,  A61B34/20 ,  A61B90/361 ,  A61B90/50 ,  A61B2017/3445 ,  A61B2017/3447 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2034/2065 ,  A61B2090/063 ,  A61B2090/0811 ,  A61B2090/376 ,  A61B2090/3941 ,  A61B2090/3954 ,  A61M29/02 ,  A61M2029/025 ,  A61M2210/0681

摘要： Methods and apparatus for treating disorders of the ear, nose, throat or paranasal sinuses, including methods and apparatus for dilating ostia, passageways and other anatomical structures, endoscopic methods and apparatus for endoscopic visualization of structures within the ear, nose, throat or paranasal sinuses, navigation devices for use in conjunction with image guidance or navigation system and hand held devices having pistol type grips and other handpieces.

公开(公告)号：US08727988B2

公开(公告)日：2014-05-20

申请号：US13114987

申请日：2011-05-24

申请人： Christopher J. Flaherty ,  Jason B. Whitt ,  John Y. Chang ,  David R. Tholfsen ,  Philip C. Evard ,  Joshua Makower

发明人： Christopher J. Flaherty ,  Jason B. Whitt ,  John Y. Chang ,  David R. Tholfsen ,  Philip C. Evard ,  Joshua Makower

IPC分类号： A61B8/00 ,  A61B8/14 ,  A61M25/098

CPC分类号： A61B17/3403 ,  A61B1/3137 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4488 ,  A61B17/11 ,  A61B17/12109 ,  A61B17/12172 ,  A61B17/3207 ,  A61B17/320725 ,  A61B17/3417 ,  A61B17/3496 ,  A61B18/00 ,  A61B18/1445 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/24 ,  A61B90/361 ,  A61B90/39 ,  A61B90/40 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/003 ,  A61B2017/00455 ,  A61B2017/00504 ,  A61B2017/1107 ,  A61B2017/1139 ,  A61B2017/12127 ,  A61B2017/22038 ,  A61B2017/22069 ,  A61B2017/22072 ,  A61B2017/22077 ,  A61B2017/306 ,  A61B2017/347 ,  A61B2017/3488 ,  A61B2018/00392 ,  A61B2018/00869 ,  A61B2018/1425 ,  A61B2090/378 ,  A61B2090/3784 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3958 ,  A61F2/07 ,  A61F2/2493 ,  A61F2/90 ,  A61F2/95 ,  A61F2002/30079 ,  A61F2002/8486 ,  A61F2210/009 ,  A61K31/195 ,  A61M25/0133 ,  A61M25/0152 ,  A61M29/00 ,  A61M29/02 ,  A61M2025/0076 ,  A61M2025/018 ,  A61M2025/1052

摘要： Devices and methods for penetrating from a vessel lumen in which a catheter device is positioned to a target location outside of that vessel lumen. A tissue penetrator advances from a catheter positioned within the vessel lumen to the target location when properly aimed. An imaging transducer fixedly mounted on or within the catheter body provides an imaging signal from which an image of the target location can be obtained. An imageable marker may be present on the catheter to form on the image obtainable from the imaging signal to predict the path that will be followed by the tissue penetrator when the tissue penetrator exits from the catheter. Alternatively, or addition thereto, the imaging transducer may comprise a plurality of imaging elements which are located so that the penetrator path indication can be obtained electronically without use of an imageable marker on the catheter.

摘要翻译： 用于从其中导管装置定位到血管腔外的目标位置的血管腔穿透的装置和方法。 当适当瞄准时，组织穿透器从位于血管腔内的导管前进到目标位置。 固定地安装在导管主体上或内部的成像传感器提供成像信号，从该成像信号可以获得目标位置的图像。 可以在导管上存在可成像的标记物以形成从成像信号获得的图像上，以便当组织穿透器从导管离开时预测组织穿透器将遵循的路径。 或者，或者除此之外，成像换能器可以包括多个成像元件，其被定位成使得可以电子地获得穿透器路径指示，而不使用导管上的可成像标记。

公开(公告)号：US08715169B2

公开(公告)日：2014-05-06

申请号：US11928097

申请日：2007-10-30

申请人： John Y. Chang ,  Joshua Makower ,  Julia D. Vrany ,  John H. Morriss ,  Ketan P. Muni ,  Isaac J. Kim ,  Hung Ha ,  William M. Facteau ,  Amrish Jayprakash Walke

发明人： John Y. Chang ,  Joshua Makower ,  Julia D. Vrany ,  John H. Morriss ,  Ketan P. Muni ,  Isaac J. Kim ,  Hung Ha ,  William M. Facteau ,  Amrish Jayprakash Walke

IPC分类号： A61B1/04 ,  A61B1/00

CPC分类号： A61M29/00 ,  A61B1/233 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/1657 ,  A61B17/1688 ,  A61B17/24 ,  A61B17/320016 ,  A61B17/320725 ,  A61B34/20 ,  A61B2017/00292 ,  A61B2017/246 ,  A61B2034/2051 ,  A61B2090/3764 ,  A61B2503/40 ,  A61M25/0041 ,  A61M25/0054 ,  A61M25/0662 ,  A61M25/09 ,  A61M25/1002 ,  A61M29/02 ,  A61M2025/0008 ,  A61M2025/1079 ,  A61M2029/025 ,  A61M2210/0618 ,  A61M2210/1028

摘要： Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat. Specific devices (e.g., tubular guides, guidewires, balloon catheters, tubular sheaths) are provided as are methods for manufacturing and using such devices to treat disorders of the ear, nose or throat.