公开(公告)号：US06632532B1

公开(公告)日：2003-10-14

申请号：US09693892

申请日：2000-10-23

Applicant: Yukio Yamada ,  Toshiyuki Matsumoto

Inventor： Yukio Yamada ,  Toshiyuki Matsumoto

IPC: B32B516

CPC classification number: H01L23/4828 ,  B03C5/026 ,  C08K9/08 ,  C09J9/02 ,  H01B1/22 ,  H01L23/49883 ,  H01L24/29 ,  H01L24/83 ,  H01L2224/29101 ,  H01L2224/2919 ,  H01L2224/29399 ,  H01L2224/8319 ,  H01L2224/838 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01033 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/014 ,  H01L2924/0665 ,  H01L2924/07802 ,  H01L2924/0781 ,  H01R4/04 ,  H01R13/03 ,  H05K3/323 ,  H05K2201/0224 ,  Y10T428/2991 ,  Y10T428/2998 ,  H01L2924/00 ,  H01L2924/3512

Abstract: A particle material for anisotropic conductive connection, is comprised of a conductive particle and an insulating resin layer covering the surface thereof, wherein the insulating resin layer includes an insulating gelled resin with a gel proportion of at least 90%. The particle material can be manufactured by fixing an insulating gelled resin powder with a gel proportion of at least 90% to the surface of the conductive particle by a physical/mechanical method to form the insulating resin layer.

Abstract translation: 用于各向异性导电连接的颗粒材料由导电颗粒和覆盖其​​表面的绝缘树脂层组成，其中绝缘树脂层包括具有至少90％的凝胶比例的绝缘凝胶树脂。 可以通过物理/机械方法将具有至少90％的凝胶比例的绝缘胶凝树脂粉末固定到导电颗粒的表面上以形成绝缘树脂层来制造颗粒材料。

公开(公告)号：US06472544B1

公开(公告)日：2002-10-29

申请号：US09509998

申请日：2000-08-16

Applicant: Noriyuki Kizaki ,  Yukio Yamada ,  Yoshihiko Yasohara ,  Akira Nishiyama ,  Makoto Miyazaki ,  Masaru Mitsuda ,  Takeshi Kondo ,  Noboru Ueyama ,  Kenji Inoue

Inventor： Noriyuki Kizaki ,  Yukio Yamada ,  Yoshihiko Yasohara ,  Akira Nishiyama ,  Makoto Miyazaki ,  Masaru Mitsuda ,  Takeshi Kondo ,  Noboru Ueyama ,  Kenji Inoue

IPC: C07D31906

CPC classification number: C07D319/06 ,  C07B2200/07 ,  C07C67/343 ,  C07C253/30 ,  C12P7/62 ,  C07C69/716 ,  C07C255/21

Abstract: This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as that required for super-low temperature reactions. A process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives which comprises reacting an acetic acid derivative at a temperature of not less than −30° C. with an enolate prepared by permitting either a base or a metal having a valency of 0 to act on the derivative to produce a hydroxyoxohexanoic acid derivative, reducing this compound with the aid of a strain of microorganism to provide a halomethyldioxanylacetic acid derivative, treating this compound with an acetalizing agent in the presence of an acid catalyst to provide a halomethyldioxanylacetic acid derivative, reacted with an acyloxylating agent to provide a acyloxymethyldioxanylacetic acid derivative, and subjecting this compound to solvolysis in the presence of a base.

Abstract translation: 本发明提供了从廉价起始原料生产具有价值作为药物中间体的光学活性的2- [6-（羟甲基）-1,3-二恶烷-4-基]乙酸衍生物的方法，而不使用任何特殊设备 例如超低温反应所需的方法。一种制备光学活性的2- [6-（羟甲基）-1,3-二恶烷-4-基]乙酸衍生物的方法，其包括在不是的温度下使乙酸衍生物反应 小于-30℃，通过使碱金属或化合价为0的金属作用于衍生物以制备羟基氧代己酸衍生物而制备的烯醇化物，借助于微生物菌株还原该化合物以提供 卤甲基二恶烷基乙酸衍生物，在酸催化剂存在下用缩醛化剂处理该化合物，得到卤代甲基二恶烷基乙酸衍生物，与酰氧基化剂反应，得到酰氧基甲基二恶烷基乙酸 在碱的存在下，将该化合物施用于溶剂分解。

公开(公告)号：US06349872B1

公开(公告)日：2002-02-26

申请号：US09549204

申请日：2000-04-13

Applicant: Yukio Yamada ,  Hiroyuki Fujihira ,  Motohide Takeichi

Inventor： Yukio Yamada ,  Hiroyuki Fujihira ,  Motohide Takeichi

IPC: B23K3102

CPC classification number: H01L21/563 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/73203 ,  H01L2224/73204 ,  H01L2224/75251 ,  H01L2224/75252 ,  H01L2924/00014 ,  H01L2924/01019 ,  H01L2924/09701 ,  H01L2924/3511 ,  Y10T156/10 ,  H01L2924/00 ,  H01L2224/0401

Abstract: Substrate warpage is eliminated without adversely affecting connection reliability when an IC chip or other packaging component is mounted on a substrate by thermocompression bonding with an interposed thermosetting adhesive. In a packaging method for the thermocompression bonding of a substrate and an IC chip or other packaging component between a stage and a head by means of an interposed thermosetting adhesive, the temperature of the stage during thermocompression bonding is set above the temperature corresponding to the inflection point of the elastic modulus in the relationship between the elastic modulus and the temperature of the cured adhesive.

Abstract translation: 当将IC芯片或其它包装部件通过热压接合与中间的热固性粘合剂安装在基板上时，消除基板翘曲而不会不利地影响连接可靠性。 在通过插入的热固性粘合剂将基板和IC芯片或其他包装部件热压接合在台架和头部之间的封装方法中，将热压接合期间的台阶的温度设定为高于对应于拐点的温度 弹性模量与固化粘合剂的温度之间的关系的弹性模量的点。

公开(公告)号：US06344156B1

公开(公告)日：2002-02-05

申请号：US09460389

申请日：1999-12-13

Applicant: Yukio Yamada ,  Mikio Sakairi ,  Yasushi Akutsu ,  Tomoyuki Ishimatsu

Inventor： Yukio Yamada ,  Mikio Sakairi ,  Yasushi Akutsu ,  Tomoyuki Ishimatsu

IPC: H01B122

CPC classification number: H01L24/83 ,  C09J7/10 ,  C09J9/02 ,  C09J2201/602 ,  H01B1/22 ,  H01L24/29 ,  H01L2224/16 ,  H01L2224/2919 ,  H01L2224/29399 ,  H01L2224/73204 ,  H01L2224/8319 ,  H01L2224/838 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01019 ,  H01L2924/01023 ,  H01L2924/01024 ,  H01L2924/01027 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/01075 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/0665 ,  H01L2924/07802 ,  H01L2924/0781 ,  H01L2924/07811 ,  H01L2924/14 ,  H05K3/323 ,  H05K2201/0221 ,  H05K2201/0233 ,  H05K2203/0307 ,  Y10T428/2991 ,  Y10T428/2998 ,  H01L2924/00

Abstract: An anisotropic conductive adhesive film capable of maintaining a high connection reliability on connection electrodes with a fine pitch on which an oxide film is formed. The anisotropic conductive adhesive film 1 comprises conductive particles 7 dispersed in an insulating binder 6. Each conductive particle 7 consists of a styrene resin particle 71 and a thin metal film 72 formed on the surface thereof by gold-plating, etc. Projections 72a are formed on the surface of the thin metal film 72 of the conductive particle 7.

Abstract translation: 一种各向异性导电粘合膜，其能够在形成有氧化膜的细间距的连接电极上保持高的连接可靠性。各向异性导电粘合膜1包括分散在绝缘粘合剂6中的导电粒子7.每个导电粒子7由 通过镀金等形成在其表面上的苯乙烯树脂颗粒71和薄金属膜72.在导电颗粒7的薄金属膜72的表面上形成有突起72a。

公开(公告)号：US5728531A

公开(公告)日：1998-03-17

申请号：US624116

申请日：1996-03-29

Applicant: Yukio Yamada ,  Osamu Asami ,  Hiroko Uchiyama ,  Hidehiko Sugiyama ,  Satoshi Fujita ,  Takekazu Yamamoto ,  Naoto Kagiyama ,  Masayoshi Momiyama ,  Yasumitsu Kondoh

Inventor： Yukio Yamada ,  Osamu Asami ,  Hiroko Uchiyama ,  Hidehiko Sugiyama ,  Satoshi Fujita ,  Takekazu Yamamoto ,  Naoto Kagiyama ,  Masayoshi Momiyama ,  Yasumitsu Kondoh

IPC: G01N33/58 ,  C07H19/10 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/53 ,  G01N37/00 ,  C07H21/04 ,  C12N15/00

CPC classification number: C12Q1/6804 ,  C07H19/10 ,  C12Q1/6834

Abstract: A method of detecting nucleic acid utilizes hybridization between the nucleic acid to be detected which is present on an immobilizing support and a DNA probe which is complementary to at least a portion of the desired nucleotide sequence of the nucleic acid. The present DNA probe includes a hapten attached via a linker which a hapten is gibberellin or a gibberellin derivative. After hybridization by reaction between the nucleic acid to be detected and the DNA probe, the unreacted DNA probe is removed, and then labelled anti-hapten antibody is allowed to bind with the DNA probe of the hybrid and the labelling is used to detect the nucleic acid. Accordingly, stable detecting sensitivity may be achieved regardless of the label mixing ratio or labelling ratio, and thus regardless of the nucleotide sequence composition of the nucleic acid being tested.

Abstract translation: 检测核酸的方法利用存在于固定化载体上的待检测核酸与与核酸的所需核苷酸序列的至少一部分互补的DNA探针之间的杂交。 本DNA探针包括通过接头连接的半抗原，半抗原是赤霉素或赤霉素衍生物。 在待检测核酸与DNA探针之间的反应杂交后，除去未反应的DNA探针，然后标记抗半抗原抗体与杂交体的DNA探针结合，并用标记物检测核酸 酸。 因此，无论标记混合比或标记比例如何，均可实现稳定的检测灵敏度，因此与所测核酸的核苷酸序列组成无关。

公开(公告)号：US5714346A

公开(公告)日：1998-02-03

申请号：US507313

申请日：1995-08-22

Applicant: Shigezo Udaka ,  Tsutomu Kajino ,  Yoko Saito ,  Masana Hirai ,  Yukio Yamada ,  Fumihiko Hoshino

Inventor： Shigezo Udaka ,  Tsutomu Kajino ,  Yoko Saito ,  Masana Hirai ,  Yukio Yamada ,  Fumihiko Hoshino

IPC: C07K14/61 ,  C12N1/21 ,  C12N15/75 ,  C12P21/06 ,  C07H21/04 ,  C12N1/20

CPC classification number: C07K14/61 ,  C12N15/75 ,  C07K2319/02

Abstract: A host-vector system suitable for production of human growth hormone (hGH) and a process for production of hGH using the same are provided. As an hGH expression plasmid, a recombinant DNA wherein a DNA coding for hGH is linked to the 3'-terminal of a DNA containing a promoter region derived from Bacillus brevis is provided, and as a host, especially a mutant Bacillus brevis substantially not exhibiting protease activity to hGH is provided. A microorganism obtained by transforming said host with said hGH expression plasmid efficiently produces hGH when it is cultured.

Abstract translation: PCT No.PCT / JP94 / 00269 Sec。 371日期：1995年8月22日 102（e）日期1995年8月22日PCT 1994年2月22日PCT PCT。 WO94 / 19474 PCT公开号 日期1995年9月1日提供适用于生产人生长激素（hGH）的宿主载体系统和使用其的生产hGH的方法。 作为hGH表达质粒，提供了重组DNA，其中编码hGH的DNA与含有源自短芽孢杆菌的启动子区的DNA的3'-末端连接，作为宿主，特别是基本上不显示的突变体短芽孢杆菌 提供了对hGH的蛋白酶活性。 通过用所述hGH表达质粒转化所述宿主获得的微生物在培养时有效地产生hGH。

公开(公告)号：US5695968A

公开(公告)日：1997-12-09

申请号：US479638

申请日：1995-06-07

Applicant: Hirokazu Nanba ,  Yukio Yamada ,  Masayuki Takano ,  Yasuhiro Ikenaka ,  Satomi Takahashi ,  Kazuyoshi Yajima

Inventor： Hirokazu Nanba ,  Yukio Yamada ,  Masayuki Takano ,  Yasuhiro Ikenaka ,  Satomi Takahashi ,  Kazuyoshi Yajima

IPC: C12N1/21 ,  C12N9/80 ,  C12N15/55 ,  C12P13/04 ,  C12P41/00 ,  C07H19/00 ,  C12N1/20 ,  C12P21/06

CPC classification number: C12P41/009 ,  C12N9/80 ,  C12P13/04

Abstract: The present invention is directed to a gene which is related to a D-N-carbamoyl-.alpha.-amino acid amidohydrolase which is an enzyme capable of converting D-N-carbamoyl-.alpha.-amino acids into D-.alpha.-amino acids; a recombinant plasmid in which a DNA fragment containing the gene is incorporated into a vector; a microorganism belonging to the genus Escherichia, Pseudomonas, Flavobacterium, Bacillus, Serratia, Corynebacterium, or Brevibacterium, which is transformed by incorporating the recombinant plasmid thereinto; a process for the production of D-N-carbamoyl-.alpha.-amino acid amidohydrolases, comprising the steps of cultivating the transformed microorganism and collecting the desired product therefrom; a D-N-carbamoyl-.alpha.-amino acid amidohydrolase obtained by the method; and a process for the production of D-.alpha.-amino acids with the aid of an action of the enzyme. The D-N-carbamoyl-.alpha.-amino acid amidohydrolase can be fixed on a support for immobilization and used as an immobilized enzyme.

Abstract translation: 本发明涉及与D-N-氨基甲酰基-α-氨基酸酰胺水解酶相关的基因，其是能够将D-N-氨基甲酰基-α-氨基酸转化为D-α-氨基酸的酶; 将含有该基因的DNA片段并入载体的重组质粒; 通过将重组质粒并入而转化的属于埃希氏杆菌属，假单胞菌属，黄杆菌属，芽孢杆菌属，沙雷氏菌属，棒状杆菌属或短杆菌属的微生物; 制备D-N-氨基甲酰基-α-氨基酸酰胺水解酶的方法，包括培养转化的微生物并从其中收集所需产物的步骤; 通过该方法获得的D-N-氨基甲酰基-α-氨基酸酰胺水解酶; 以及借助于酶的作用生产D-氨基酸的方法。 D-N-氨基甲酰基-α-氨基酸酰胺水解酶可以固定在用于固定的载体上并用作固定化酶。

公开(公告)号：US5496719A

公开(公告)日：1996-03-05

申请号：US68395

申请日：1993-05-27

Applicant: Yukio Yamada ,  Osamu Asami ,  Hidehiko Sugiyama ,  Chie Idekoba ,  Fumihiko Hoshino ,  Masana Hirai ,  Tsutomu Kajino ,  Takao Imaeda ,  Kiyoko Sarai

Inventor： Yukio Yamada ,  Osamu Asami ,  Hidehiko Sugiyama ,  Chie Idekoba ,  Fumihiko Hoshino ,  Masana Hirai ,  Tsutomu Kajino ,  Takao Imaeda ,  Kiyoko Sarai

IPC: C12N9/90 ,  A61K38/00 ,  C07K1/00 ,  C12N9/00

CPC classification number: C12N9/90

Abstract: A highly thermostable polypeptide possessing protein disulfide isomerase (PDI) activity, a gene coding for the polypeptide and a process for producing the polypeptide are provided. The polypeptide possessing PDI activity is characterized by A) having a capability of catalyzing a disulfide exchange in proteins, B) recognizing mainly ribonuclease A as a substrate, C) having a suitable active temperature of 20.degree. to 70.degree. C., D) being stable at a pH value of 6 to 9, and E) having a molecular weight of about 60,000 to 62,000. Since it has a higher thermostability and exhibits a stable activity in a wider dithiothreitol concentration range as compared with the conventional PDI, it is possible to provide a novel enzyme active protein which can be advantageously used for a refolding reaction of certain proteins. Further, a process which enables the polypeptide possessing PDI activity to be efficiently produced using Humicola insolens or a transformant transformed with an expression vector containing the above-described gene is also provided.

Abstract translation: 提供了具有蛋白质二硫键异构酶（PDI）活性的高度热稳定的多肽，编码多肽的基因和产生多肽的方法。 具有PDI活性的多肽的特征在于：A）具有催化蛋白质中二硫键交换的能力，B）主要以核糖核酸酶A为底物，C）具有20〜70℃的合适的活性温度，D）为 在pH值为6〜9的条件下稳定，E）分子量约为60,000〜62,000。 由于与常规PDI相比，具有较高的热稳定性并且在更宽的二硫苏糖醇浓度范围内表现出稳定的活性，因此可以提供可有利地用于某些蛋白质的重折叠反应的新型酶活性蛋白质。 此外，还提供了能够使用Humicola insolens或使用含有上述基因的表达载体转化的转化体有效地产生具有PDI活性的多肽的方法。

公开(公告)号：US5073823A

公开(公告)日：1991-12-17

申请号：US583595

申请日：1990-09-17

Applicant: Yukio Yamada ,  Akio Furukawa ,  Kazuki Isono

Inventor： Yukio Yamada ,  Akio Furukawa ,  Kazuki Isono

IPC: G03B15/03 ,  H04N5/225 ,  H04N5/232

CPC classification number: H04N5/232 ,  H04N5/2256 ,  Y10S358/906

Abstract: A video camera apparatus for use in a video camera or a video tape recorder having a built-in type camera in which a video light apparatus is detachably mounted to the body of the video camera, includes a circuit whereby the video light apparatus is automatically turned ON or OFF when the video camera apparatus is in a standby mode in response to a remote control signal, so that the video camera apparatus is easy to use and the video light apparatus can be operated for a longer period of time.

公开(公告)号：US4959279A

公开(公告)日：1990-09-25

申请号：US297949

申请日：1989-01-17

Applicant: Yasuzo Tanaka ,  Kaname Matsumoto ,  Yukio Yamada

Inventor： Yasuzo Tanaka ,  Kaname Matsumoto ,  Yukio Yamada

IPC: H01L39/24

CPC classification number: H01L39/2406 ,  Y10S148/901 ,  Y10S428/93 ,  Y10T29/49014 ,  Y10T428/12486 ,  Y10T428/12806

Abstract: A superconducting wire containing a multifilamentary superconducting alloy, comprising at least one composite containing a first matrix in which a plurality of superconducting alloy filaments have been arranged and a second matrix in which at least one composite is embedded; wherein said first matrix consists essentially of a metal or an alloy which does not form any intermetallic compound with the superconducting alloy filament. As the superconducting alloy filament, a Nb-Ti alloy filament may preferably be selected; the first matrix may preferably consist of one selected from the group of Nb, Ta and a Nb-Ta alloy; and the second matrix may preferably consist of Cu, A Cu-Ni alloy, Al, or an Al alloy.

Abstract translation: 一种含有多丝超导合金的超导线，包括至少一种复合材料，所述复合材料含有其中布置有多种超导合金细丝的第一基体和至少一种复合材料嵌入其中的第二基体; 其中所述第一基质基本上由不与所述超导合金细丝形成任何金属间化合物的金属或合金组成。 作为超导合金丝，优选选择Nb-Ti合金丝; 第一基体优选由选自Nb，Ta和Nb-Ta合金中的一种构成; 并且第二基体可以优选由Cu，A Cu-Ni合金，Al或Al合金组成。