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    Adeno-associated virus vector
    31.
    发明授权
    Adeno-associated virus vector 有权

    公开(公告)号：US11845952B2

    公开(公告)日：2023-12-19

    申请号：US16968397

    申请日：2019-01-16

    申请人： NIPPON MEDICAL SCHOOL FOUNDATION ,  TEIKA PHARMACEUTICAL CO., LTD.

    发明人： Takashi Okada ,  Tsutomu Igarashi ,  Asaka Shiozawa

    IPC分类号： C12N15/861 ,  A61P27/02 ,  A61K35/761 ,  A61K38/18 ,  A61K39/235

    CPC分类号： C12N15/861 ,  A61K35/761 ,  A61K38/1833 ,  A61K39/235 ,  A61P27/02

    摘要： One disadvantage of adeno-associated virus (AAV) is low gene expression efficiency due to delayed expression of the inserted gene. Provided is a vector plasmid for producing a vector genome to be inserted into an adeno-associated virus (AAV). The vector plasmid is provided with a vector genome cassette as a template of the vector genome, and the vector genome cassette is provided with: (1) an expression cassette including a nucleic acid molecule encoding a target gene and (b) a nucleic acid molecule encoding an expression regulatory region that allows expression of the target gene; and (2) two nucleic acid molecules positioned on both sides of the expression cassette and encoding inverted terminal repeats (ITRs). Also provided is a pharmaceutical composition containing the AVV vector, for treating or preventing an eye disease or disease associated with same. Further provided is a method for treating or preventing the eye disease or disease associated with same, comprising administering a therapeutically effective amount of the pharmaceutical composition for treating or preventing the eye disease or disease associated with same to a subject suffering from the eye disease or disease associated with same.

    IMMUNOGENIC COMBINATIONS
    32.
    发明公开
    IMMUNOGENIC COMBINATIONS 审中-公开

    公开(公告)号：US20230390381A1

    公开(公告)日：2023-12-07

    申请号：US18082456

    申请日：2022-12-15

    申请人： GLAXOSMITHKLINE BIOLOGICALS SA

    发明人： Ann-Muriel STEFF ,  Jean-Francois TOUSSAINT ,  Alessandra VITELLI

    IPC分类号： A61K39/155 ,  A61K39/235 ,  A61K39/12

    CPC分类号： A61K39/155 ,  A61K39/235 ,  A61K39/12 ,  A61K2039/5256

    摘要： This disclosure provides immunogenic combinations that include a) an immunogenic component containing a peptide or polypeptide antigen of a respiratory pathogen; and b) an immunogenic component containing a nucleic acid encoding an antigen of the same respiratory pathogen, wherein the immunogenic components are formulated for concurrent, e.g., co-localized, administration. More specifically, the respiratory pathogen is respiratory syncytial virus (RSV). This disclosure also concerns provides the use of such immunogenic combinations, and methods for administering such immunogenic combinations to elicit an immune response specific for the respiratory pathogen.