公开(公告)号：US09721780B2

公开(公告)日：2017-08-01

申请号：US14847574

申请日：2015-09-08

申请人： Micromass UK Limited

发明人： Keith Richardson

IPC分类号： H01J49/26 ,  H01J49/40 ,  H01J49/00

CPC分类号： H01J49/401 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/40

摘要： A method of mass spectrometry is disclosed comprising separating ions according to one or more physico-chemical properties. Ions which are onwardly transmitted to a Time of Flight mass analyzer are controlled by attenuating ions which would otherwise be transmitted to the Time of Flight mass analyzer and cause saturation of an ion detector and which have been determined or which are predicted to have a relatively high intensity.

公开(公告)号：US09719970B2

公开(公告)日：2017-08-01

申请号：US14648197

申请日：2013-11-26

申请人： Waters Technologies Corporation

发明人： John Vukovic

IPC分类号： G01N30/34 ,  G01N30/02 ,  G01N1/18 ,  G01N33/82 ,  G01N30/88 ,  B01D15/40 ,  B01D11/02 ,  H01J49/00 ,  G01N30/72 ,  G01N33/68 ,  G01N33/538

CPC分类号： G01N30/34 ,  B01D11/0203 ,  B01D15/40 ,  C12N2500/38 ,  G01N30/02 ,  G01N30/72 ,  G01N30/7233 ,  G01N30/88 ,  G01N33/538 ,  G01N33/6848 ,  G01N33/82 ,  G01N2030/027 ,  G01N2030/8813 ,  H01J49/0027

摘要： The present disclosure relates to CO2-based chromatography for the efficient and precise separation of Vitamin D metabolites.

公开(公告)号：US09696325B2

公开(公告)日：2017-07-04

申请号：US14816586

申请日：2015-08-03

申请人： Quest Diagnostics Investments Incorporated

发明人： Scott M. Goldman ,  Julie A. Neidich

IPC分类号： G01N33/92 ,  G01N33/26 ,  G01N30/72 ,  G01N24/00 ,  H01J49/00 ,  H01J49/16 ,  H01J49/26 ,  H01J49/14

CPC分类号： G01N33/92 ,  G01N30/7266 ,  G01N33/26 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/145 ,  H01J49/165 ,  H01J49/168 ,  Y10T436/104165 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

摘要： The invention relates to the detection of DHA and EPA. In a particular aspect, the invention relates to methods for detecting DHA and EPA by mass spectrometry and kits for carrying out such methods.

公开(公告)号：US20170178880A1

公开(公告)日：2017-06-22

申请号：US15316309

申请日：2015-06-11

申请人： Micromass UK Limited

发明人： Jason Lee WILDGOOSE

IPC分类号： H01J49/00

CPC分类号： H01J49/0027 ,  H01J49/004 ,  H01J49/0045

摘要： A method of mass spectrometry is disclosed comprising performing a plurality of experimental runs, wherein each experimental run comprises: periodically mass analysing fragment or product ions at a plurality of time intervals, wherein a delay time is provided between the start of the experimental run and the first time interval at which the fragment or product ions are mass analysed. Different delay times are provided in different ones of the experimental runs and fragment or product ions that have been analysed in the same time interval in at least one of said experimental runs and that have been analysed in different time intervals in at least one other of said experimental runs are identified as fragment or product ions of interest. These fragment or product ions are thus determined to relate to different precursor ions and are used to identify their respective precursor ions.

公开(公告)号：US20170154761A1

公开(公告)日：2017-06-01

申请号：US15340355

申请日：2016-11-01

申请人： Purdue Research Foundation

发明人： Zheng Ouyang ,  Robert Graham Cooks ,  Sandilya Venkata Garimella ,  Jason David Harper ,  Nicholas Alan Charipar

IPC分类号： H01J49/04 ,  H01J49/26 ,  H01J49/10

CPC分类号： H01J49/0404 ,  G01N27/622 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0459 ,  H01J49/10 ,  H01J49/26 ,  H01J49/40 ,  H01J49/4215

摘要： The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.

公开(公告)号：US20170117129A1

公开(公告)日：2017-04-27

申请号：US15317017

申请日：2015-06-10

申请人： Micromass UK Limited

发明人： Steven Derek PRINGLE ,  Farnoush SALARZAEI ,  Nicholas TOMCZYK ,  Jason Lee WILDGOOSE

IPC分类号： H01J49/24 ,  G01N30/72 ,  G01N27/62 ,  H01J49/00

CPC分类号： H01J49/24 ,  G01N27/622 ,  G01N30/7233 ,  H01J49/0009 ,  H01J49/0027 ,  H01J49/004 ,  H01J49/0045

摘要： A mass spectrometer is disclosed comprising an ion mobility separator for separating ions according to their ion mobility, one or more first devices or stages arranged upstream of the ion mobility separator and a control system. The control system is arranged and adapted to monitor directly or indirectly the operating environment within the ion mobility separator, and to control the operating environment within the ion mobility separator based on the monitoring by controlling one or more gas flows to or within one or more of the one or more first devices or stages.

公开(公告)号：US09633827B2

公开(公告)日：2017-04-25

申请号：US15081459

申请日：2016-03-25

申请人： IONSENSE INC.

发明人： Brian D Musselman

IPC分类号： H01J49/10 ,  H01J49/00 ,  G01N27/62 ,  B01D59/44 ,  H01J49/04 ,  G01N1/22

CPC分类号： H01J49/10 ,  G01N1/2214 ,  G01N27/62 ,  H01J49/0027 ,  H01J49/0409

摘要： In various embodiments of the invention, a cargo container can be monitored at appropriate time intervals to determine that no controlled substances have been shipped with the cargo in the container. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present in the container which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules within the container whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the contents of the container.

公开(公告)号：US20170097320A1

公开(公告)日：2017-04-06

申请号：US15293775

申请日：2016-10-14

申请人： McMaster University

发明人： Philip Britz-McKibbin

IPC分类号： G01N27/447 ,  H01J49/04 ,  H01J49/16 ,  H01J49/00

CPC分类号： G01N27/44782 ,  G01N27/447 ,  G01N27/4473 ,  G01N27/44743 ,  G01N30/7266 ,  H01J49/0027 ,  H01J49/0404 ,  H01J49/165

摘要： Various embodiments illustrating a multiplexed method for high throughput screening of ions in biological samples within a single capillary when using capillary electrophoresis mass spectrometry (CE-MS) are illustrated. The method includes sequential injection of multiple sample segments in series within a single capillary, the sample segments being separated by a spacer plug of buffer, and multiplexed analysis of the sample segments simultaneously within a single capillary electrophoresis (CE) run. The method also includes application of voltage to the single capillary subsequent to sequential injection and zonal separation of polar metabolites within each sample segment by CE such that each analyte zone migrates within its characteristic electrophoretic mobility offset in time by the spacer. The incorporation of a quality control/reference sample and the use of dilution patterning with specific injection configurations also enables encoding of information temporally for enhanced data processing with quality assurance.

公开(公告)号：US09595430B2

公开(公告)日：2017-03-14

申请号：US14668485

申请日：2015-03-25

申请人： LI-COR, Inc.

发明人： Michael D. Furtaw ,  Jon P. Anderson ,  Mary J. Wirth ,  Robert E. Birdsall ,  Yimin Hua ,  Zhaorui Zhang

IPC分类号： H01J49/16 ,  H01J49/00

CPC分类号： H01J49/164 ,  H01J49/0027 ,  H01J49/0418

摘要： A self-assembled engineered lattice of nanometer-scale silica particles, or other suitable particles generally resembling regularly-sized spheres, is configured in a separation bed for electrophoresis, isoelectric focusing, chromatography, or other voltage-induced separation of analytes. After separation, the analytes are immobilized on the separation bed and then ionized using matrix-assisted laser desorption/ionization (MALDI) for use with a mass spectrometer. The nanoparticles can be coated with polymers that activate to immobilize the analytes or assist with MALDI. The separation can occur in two dimensions.

摘要翻译： 在电泳，等电聚焦，色谱法或其他电压分离分析物的分离床中配置纳米尺度二氧化硅颗粒或通常类似于规则尺寸的球体的其它合适颗粒的自组装工程晶格。 分离后，将分析物固定在分离床上，然后使用基质辅助激光解吸/电离（MALDI）离子化，用于质谱仪。 纳米颗粒可以用激活固定分析物或辅助MALDI的聚合物涂覆。 分离可以在两个维度上发生。

公开(公告)号：US09589776B2

公开(公告)日：2017-03-07

申请号：US15070433

申请日：2016-03-15

申请人： SRI INTERNATIONAL

发明人： Ashish Chaudhary ,  Friso Van Amerom ,  R. Timothy Short

IPC分类号： H01J49/00 ,  H01J49/24

CPC分类号： H01J49/0027 ,  H01J49/0013 ,  H01J49/004 ,  H01J49/0054 ,  H01J49/0059 ,  H01J49/107 ,  H01J49/24

摘要： A dual-ionization mass spectrometer includes a first mass spectrometer module forming a hard ionization mass spectrometer, a second mass spectrometer forming a soft ionization mass spectrometer, a vacuum ultraviolet light source positioned between the first and second modules, a housing encompassing the first and second sets of plates and the light source, and an inlet positioned to receive a sample of an analyte and provide it to at least one of the sets of plates. A method of detecting a substance includes receiving a sample of an analyte into a housing through an inlet, performing soft ionization mass spectrometry on the sample with a soft ionization mass spectrometer in the housing, performing hard ionization spectrometry on the sample with a hard ionization spectrometer in the housing if needed, and generating a detection result from at least one of the soft ionization spectrometry and the hard ionization spectrometry.

摘要翻译： 双电离质谱仪包括形成硬电离质谱仪的第一质谱模块，形成软电离质谱仪的第二质谱仪，位于第一和第二模块之间的真空紫外光源，包含第一和第二 一组板和光源，以及定位成接收分析物样品并将其提供给至少一组板的入口。 检测物质的方法包括通过入口将分析物的样品接收到壳体中，通过壳体中的软质电离质谱仪对样品进行软质电离质谱分析，用硬质电离光谱仪对样品进行硬质离子化分光光度法 如果需要，在壳体中，并且从至少一种软电离光谱法和硬质电离光谱法产生检测结果。