GERANYLGERANYL PYROPHOSPHATE SYNTHASES
    49.
    发明公开

    公开(公告)号:US20240067938A1

    公开(公告)日:2024-02-29

    申请号:US18455969

    申请日:2023-08-25

    CPC classification number: C12P19/56 C12N9/1085 C12Y205/01001

    Abstract: The present invention relates a variant polypeptide having geranylgeranyl pyrophosphate synthase activity, which variant polypeptide comprises an amino acid sequence which, when aligned with a geranylgeranyl pyrophosphate synthase comprising the sequence set out in SEQ ID NO: 1, comprises at least one substitution of an amino acid residue corresponding to any of amino acids at positions 92, 100 or 235 said positions being defined with reference to SEQ ID NO: 1 and wherein the variant has one or more modified properties as compared with a reference polypeptide having geranylgeranyl pyrophosphate synthase activity. A variant polypeptide of the invention may be used in a recombinant host for the production of steviol or a steviol glycoside.

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