Patent search ap:("Acucela Page Inc.") AND inv:"Ryo Kubota"

41.

发明授权
Optical coherence tomography patient alignment system for home based ophthalmic applications 有权

公开(公告)号：US11730363B2

公开(公告)日：2023-08-22

申请号：US17757748

申请日：2020-09-02

Applicant: ACUCELA INC.

Inventor： Ryo Kubota , Philip M. Buscemi

IPC: A61B3/10 , A61B3/00 , A61B3/12

CPC classification number: A61B3/102 , A61B3/0075 , A61B3/0091 , A61B3/1005 , A61B3/12

Abstract: Improved optical coherence tomography systems and methods to measure retinal data are presented. The systems may be compact, provide in-home monitoring, and have automation to allow the patient to measure himself or herself.

$Stick on devices using peripheral defocus to treat progressive refractive error$

42.

发明授权
Stick on devices using peripheral defocus to treat progressive refractive error 有权

公开(公告)号：US11467426B2

公开(公告)日：2022-10-11

申请号：US17655496

申请日：2022-03-18

Applicant: ACUCELA INC.

Inventor： Ryo Kubota , Philip M. Buscemi , Amitava Gupta , Stefan Bauer , Benjamin Crook , Julien Sauvet

IPC: G02C7/08 , G02C7/06 , G02C7/14 , G02C7/10 , G02C7/02

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

$Methods for the treatment of refractive error using active stimulation$

43.

发明授权
Methods for the treatment of refractive error using active stimulation 有权

公开(公告)号：US11467423B2

公开(公告)日：2022-10-11

申请号：US17650266

申请日：2022-02-08

Applicant: ACUCELA INC.

Inventor： Philip M. Buscemi , Ryo Kubota

IPC: G02C7/02 , G02C7/04 , G02B27/01 , G02C7/14

Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.

44.

发明授权
Scan pattern and signal processing for optical coherence tomography 有权

公开(公告)号：US11369266B2

公开(公告)日：2022-06-28

申请号：US17248870

申请日：2021-02-11

Applicant: ACUCELA INC.

Inventor： Ryo Kubota , Stephan Wyder , Philip M. Buscemi , Matthias Pfister , Alexander Holzer

IPC: A61B3/10 , G01B9/02 , A61B3/12 , G01B9/02004 , G01B9/02091

Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.

45.

发明授权
Electro-switchable spectacles for myopia treatment 有权

公开(公告)号：US11320674B2

公开(公告)日：2022-05-03

申请号：US17302827

申请日：2021-05-13

Applicant: ACUCELA INC.

Inventor： Ryo Kubota , Amitava Gupta

IPC: G02C7/08 , G02F1/29

Abstract: An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.

$Apparatus and methods for the treatment of refractive error using active stimulation$

46.

发明授权
Apparatus and methods for the treatment of refractive error using active stimulation 有权

公开(公告)号：US11281022B2

公开(公告)日：2022-03-22

申请号：US17303889

申请日：2021-06-09

Applicant: ACUCELA INC.

Inventor： Philip M. Buscemi , Ryo Kubota

IPC: G02B27/01 , G02C7/04 , G02C7/14

Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.

47.

发明申请
SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS 审中-公开
Title translation: 用于治疗眼科疾病和疾病的替代3-苯丙氨酸衍生物

公开(公告)号：US20170022180A1

公开(公告)日：2017-01-26

申请号：US14849857

申请日：2015-09-10

Applicant: Acucela Inc.

Inventor： Vladimir A. Kuksa , Mark W. Orme , Feng Hong , Ryo Kubota

IPC: C07D335/02 , C07D213/30 , C07D211/22 , C07D307/80 , C07D307/12 , C07D239/26 , C07D311/58 , C07D207/08 , C07D309/04 , C07D211/76 , C07D333/16 , C07D279/02 , C07D209/08 , C07D211/96 , C07D233/64 , C07D309/06

CPC classification number: C07D335/02 , A61K31/341 , A61K31/343 , A61K31/351 , A61K31/382 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/4465 , A61K31/505 , C07D207/08 , C07D207/09 , C07D207/26 , C07D209/08 , C07D209/14 , C07D211/22 , C07D211/26 , C07D211/60 , C07D211/76 , C07D211/96 , C07D213/30 , C07D213/38 , C07D233/64 , C07D233/96 , C07D239/26 , C07D279/02 , C07D307/12 , C07D307/14 , C07D307/80 , C07D307/81 , C07D309/04 , C07D309/06 , C07D311/04 , C07D311/58 , C07D333/12 , C07D333/16 , C07D333/20

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。本文提供了取代的3-苯基丙胺衍生物化合物和包含所述化合物的药物组合物。主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。

48.

发明授权
Substituted heterocyclic compounds for disease treatment 有权
Title translation: 用于疾病治疗的取代的杂环化合物

公开(公告)号：US09447078B2

公开(公告)日：2016-09-20

申请号：US13745675

申请日：2013-01-18

Applicant: Acucela Inc.

Inventor： Vladimir A. Kuksa , Mark W. Orme , Feng Hong , Ryo Kubota

IPC: C07D213/36 , C07D213/42 , C07D405/12 , C07D207/36 , C07D213/38 , C07D213/64 , C07D213/71 , C07D239/34 , C07D249/04 , C07D277/28 , C07D307/52 , C07D307/58 , C07D307/66 , C07D333/20 , C07D333/32 , C07D333/36 , C07D401/12 , C07D213/74 , C07D333/16 , C07D333/34 , C07D213/30 , C07D213/65 , C07D213/68 , C07D213/70 , C07D307/42

CPC classification number: C07D405/12 , C07D207/36 , C07D213/30 , C07D213/38 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/70 , C07D213/71 , C07D213/74 , C07D239/34 , C07D249/04 , C07D277/28 , C07D307/42 , C07D307/52 , C07D307/58 , C07D307/66 , C07D333/16 , C07D333/20 , C07D333/32 , C07D333/34 , C07D333/36 , C07D401/12

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted heterocyclic amine derivative compound and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。本文提供了取代的杂环胺衍生物化合物和包含这些化合物的药物组合物。主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。