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公开(公告)号：US08246826B2
公开(公告)日：2012-08-21
申请号：US12072908
申请日：2008-02-27
CPC分类号： A61M1/3672 , A61M1/16 , A61M1/1601 , A61M1/1621 , A61M1/1654 , A61M1/1694 , A61M1/267 , A61M1/3413 , A61M1/3424 , A61M1/3609 , A61M1/3621 , A61M1/3638 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M2205/12 , A61M2205/123 , A61M2205/128 , A61M2205/15 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/36 , A61M2205/505 , Y10T137/87893
摘要： The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second compartments.
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42.发明授权公开(公告)号：US08105265B2
公开(公告)日：2012-01-31
申请号：US12249668
申请日：2008-10-10
IPC分类号： A61M37/00
CPC分类号： A61M1/3621 , A61M1/1006 , A61M1/1037 , A61M1/106 , A61M1/1062 , A61M1/1086 , A61M1/3666 , A61M1/3667 , A61M2205/127 , Y10T137/86035
摘要： A cardiopulmonary bypass system utilizing membrane-based reciprocating positive displacement blood pumps (“pod pumps”). In one aspect, the pod pumps are constructed to provide reduced shear forces on the blood being pumped. In another aspect blood flow through the pod pumps can be controlled by a controller using information from pressure sensors in the control chamber of the pod pumps. In another aspect, the pod pumps are included on a disposable unit that can be received and held by a receptacle means on a base unit, the base unit also providing pressurized control fluid to the pod pumps on the disposable unit through the receptacle means.
摘要翻译： 一种使用膜式往复式正位移血液泵（“荚式泵”）的体外循环系统。 在一个方面，荚果泵构造成在被泵送的血液上提供减小的剪切力。 在另一方面，通过容器泵的血液流动可以由控制器使用来自荚果泵的控制室中的压力传感器的信息来控制。 在另一方面，所述荚式泵包括在一次性单元中，所述一次性单元可以由基座单元上的容器装置接收和保持，所述基座单元还通过所述容器装置向所述一次性单元上的所述容器泵提供加压控制流体。
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公开(公告)号：US20110218600A1
公开(公告)日：2011-09-08
申请号：US13018054
申请日：2011-01-31
申请人： Dean Kamen , Jason A. Demers , David E. Altobelli , Larry B. Gray , N. Christopher Perry , Brian Tracey , James D. Dale , Dirk A. van der Merwe , Kingston Owens
发明人： Dean Kamen , Jason A. Demers , David E. Altobelli , Larry B. Gray , N. Christopher Perry , Brian Tracey , James D. Dale , Dirk A. van der Merwe , Kingston Owens
IPC分类号： A61F7/00
CPC分类号： A61M1/106 , A61F7/12 , A61F2007/0069 , A61F2007/126 , A61M1/1006 , A61M1/1012 , A61M1/1037 , A61M1/1062 , A61M1/1086 , A61M1/1087 , A61M1/1096 , A61M1/3626 , A61M1/369 , A61M2205/12 , A61M2205/127 , A61M2205/27 , A61M2205/3334 , A61M2205/3368 , A61M2205/3606 , A61M2205/3653 , A61M2205/502 , F04B43/0054 , F04B43/06 , F04B43/0736 , G01K1/08 , G01K1/16 , G01M3/188
摘要： Embodiments of the present invention relate generally to heat-exchanger systems that can be used to heat or cool a fluid such as blood. Pod pumps that provide low shear and low turbulence may be used in such systems, particularly for systems that pump blood. A certain heat-exchanger system used to heat blood or other fluids may be used to provide whole-body hyperthermic treatments or regional hyperthermic chemotherapy treatments. A disposable unit may be used to separate the fluid path from the fluid control systems. The disposable unit typically includes a heat-exchanger component that is received by a corresponding heat exchanger in a base unit. Fluid pumped through the heat-exchanger component is heated by the heat exchanger.
摘要翻译： 本发明的实施例一般涉及可用于加热或冷却诸如血液的流体的热交换器系统。 可以在这种系统中使用提供低剪切和低湍流的杓式泵，特别是用于泵送血液的系统。 用于加热血液或其他液体的某种热交换器系统可用于提供全身热疗治疗或局部高热化疗治疗。 可以使用一次性单元来将流体路径与流体控制系统分离。 一次性单元通常包括由基本单元中的相应热交换器接收的热交换器部件。 泵送通过热交换器部件的流体被热交换器加热。
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公开(公告)号：US07874718B2
公开(公告)日：2011-01-25
申请号：US11926992
申请日：2007-10-29
申请人： Jason A. Demers , David W. McGill , Larry B. Gray
发明人： Jason A. Demers , David W. McGill , Larry B. Gray
CPC分类号： F04B53/16 , A61L2/0088 , A61L2/24 , A61M1/0213 , A61M1/0272 , A61M1/0281 , A61M1/3687 , A61M2205/125 , B01F3/0865 , B01F3/088 , B01F5/0077 , B01F5/12 , B01F13/1013 , B01F13/1016 , B01F15/0202 , B01F15/0475 , B01F2015/0221 , F04B43/0009 , F04B43/06 , F04B49/22 , F04B53/22 , G05D11/132 , Y10T29/53 , Y10T137/0329 , Y10T137/0352 , Y10T137/86131 , Y10T137/87652 , Y10T292/0911 , Y10T292/212 , Y10T292/438
摘要： A system, device, and method for mixing liquids involves pumping a first liquid into a first pump chamber of a pumping apparatus through a channel of the pumping apparatus and pumping a second liquid from a second pump chamber of the pumping apparatus into either the channel or the first pump chamber, preferably while the first liquid is being pumped into the first pump chamber, so that the two liquids are mixed within the pumping apparatus. The second liquid is preferably pumped in a pulsatile mode in which small quantities of the second liquid are pumped at intervals. The quantity and/or the interval can be dynamically adjusted to result in a predetermined concentration of the two liquids. The contents of the first pump chamber are pumped to a receptacle.
摘要翻译： 用于混合液体的系统，装置和方法涉及通过泵送装置的通道将第一液体泵送到泵送装置的第一泵室中，并将来自泵送装置的第二泵室的第二液体泵入通道或 第一泵室，优选地当第一液体被泵入第一泵室时，使得两种液体在泵送装置内混合。 第二液体优选以脉动模式泵送，其中少量的第二液体被间隔地泵送。 可以动态地调整数量和/或间隔以产生两种液体的预定浓度。 将第一泵室的内容物泵入容器。
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公开(公告)号：US07726362B2
公开(公告)日：2010-06-01
申请号：US11927101
申请日：2007-10-29
申请人： Jason A. Demers , James D. Dale , Brian Tracey , David W. McGill , Larry B. Gray
发明人： Jason A. Demers , James D. Dale , Brian Tracey , David W. McGill , Larry B. Gray
IPC分类号： B65B1/04
CPC分类号： B01F13/1013 , A61M1/0281 , A61M1/3687 , A61M2205/12 , B01F13/1016 , B01F15/0202 , B01F2015/0221
摘要： A system, device, and method for mixing a substance with a liquid pumps the liquid into a container of the substance to produce a solution. The container may be part of a container assembly including a port assembly for coupling with the container to produce an inlet and/or and outlet port for the container. The container assembly may be received within a receiving chamber for causing the coupling. The solution may be permitted to flow out of the outlet port when the solution rises within the container to a level of the outlet port so that the substance is partially diluted before flowing out of the outlet port.
摘要翻译： 用于将物质与液体混合的系统，装置和方法将液体泵送到物质的容器中以产生溶液。 容器可以是容器组件的一部分，其包括用于与容器联接以产生用于容器的入口和/或出口的端口组件。 容器组件可以被容纳在接收室内以引起联接。 当溶液在容器内升高到出口端口的水平面时，溶液可能被允许流出出口，使得物质在流出出口之前被部分地稀释。
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公开(公告)号：US07662139B2
公开(公告)日：2010-02-16
申请号：US10697862
申请日：2003-10-30
申请人： Jason A. Demers , David W. McGill , Brian Tracey , James D. Dale , Larry B. Gray
发明人： Jason A. Demers , David W. McGill , Brian Tracey , James D. Dale , Larry B. Gray
IPC分类号： A61M19/00
CPC分类号： A61M5/162 , A61M1/0281 , A61M5/1626 , A61M2205/12
摘要： An apparatus for use in a fluid processing system having a pump. The apparatus includes a pump cassette for use with the pump. The pump cassette includes at least one pump chamber and a first port in selective fluid communication with the at least one pump chamber. A spiking assembly includes at least one hollow spike having a piercing end for piercing a first container. The at least one hollow spike includes a first spike in fluid communication with the first port of the pump cassette.
摘要翻译： 一种用于具有泵的流体处理系统的装置。 该装置包括与泵一起使用的泵盒。 所述泵盒包括至少一个泵室和与所述至少一个泵室选择性流体连通的第一端口。 尖峰组件包括至少一个具有穿刺端部以刺穿第一容器的中空尖钉。 所述至少一个中空尖钉包括与所述泵盒的所述第一端口流体连通的第一尖峰。
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公开(公告)号：US07597784B2
公开(公告)日：2009-10-06
申请号：US10713617
申请日：2003-11-13
申请人： David F. Bednarek , Jason A. Demers , Timothy P. Duggan , James L. Jackson , Scott A. Leonard , David W. McGill , Kingston Owens
发明人： David F. Bednarek , Jason A. Demers , Timothy P. Duggan , James L. Jackson , Scott A. Leonard , David W. McGill , Kingston Owens
CPC分类号： B01D1/2887 , B01D1/221 , B01D1/28 , B01D1/289 , B01D1/2893 , B01D3/00 , B01D3/007 , B01D3/42 , B01D5/0003 , B01D5/0015 , B01D5/0039 , B01D5/006 , B01D29/01 , B01D29/52 , B01D29/66 , B01D29/96 , B01D35/12 , B01D45/08 , C02F1/041 , C02F1/048 , C02F1/16 , F04C19/002 , F04C19/004 , F04C19/008 , F04C2270/86 , F28D9/005 , Y10S203/08 , Y10S203/21 , Y10T137/7764 , Y10T137/7848 , Y10T137/7903
摘要： Embodiments of the invention are directed toward a novel pressurized vapor cycle for distilling liquids. In some embodiments of the invention, a liquid purification system is revealed, including the elements of an input for receiving untreated liquid, a vaporizer coupled to the input for transforming the liquid to vapor, a head chamber for collecting the vapor, a vapor pump with an internal drive shaft and an eccentric rotor with a rotatable housing for compressing vapor, and a condenser in communication with the vapor pump for transforming the compressed vapor into a distilled product. Other embodiments of the invention are directed toward heat management, and other process enhancements for making the system especially efficient.
摘要翻译： 本发明的实施例涉及一种用于蒸馏液体的新型加压蒸气循环。 在本发明的一些实施例中，揭示了一种液体净化系统，包括用于接收未处理液体的输入元件，耦合到输入端的用于将液体转化为蒸气的蒸发器，用于收集蒸汽的头部腔室，具有 内部驱动轴和具有用于压缩蒸气的可旋转壳体的偏心转子，以及与蒸气泵连通的冷凝器，用于将压缩蒸汽转化成蒸馏产物。 本发明的其它实施例涉及热管理和用于使系统特别有效的其它过程增强。
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48.发明申请公开(公告)号：US20090099498A1
公开(公告)日：2009-04-16
申请号：US12249668
申请日：2008-10-10
CPC分类号： A61M1/3621 , A61M1/1006 , A61M1/1037 , A61M1/106 , A61M1/1062 , A61M1/1086 , A61M1/3666 , A61M1/3667 , A61M2205/127 , Y10T137/86035
摘要： A cardiopulmonary bypass system utilizing membrane-based reciprocating positive displacement blood pumps (“pod pumps”). In one aspect, the pod pumps are constructed to provide reduced shear forces on the blood being pumped. In another aspect blood flow through the pod pumps can be controlled by a controller using information from pressure sensors in the control chamber of the pod pumps. In another aspect, the pod pumps are included on a disposable unit that can be received and held by a receptacle means on a base unit, the base unit also providing pressurized control fluid to the pod pumps on the disposable unit through the receptacle means.
摘要翻译： 一种使用膜式往复式正位移血液泵（“荚式泵”）的体外循环系统。 在一个方面，荚果泵构造成在被泵送的血液上提供减小的剪切力。 在另一方面，通过容器泵的血液流动可以由控制器使用来自荚果泵的控制室中的压力传感器的信息来控制。 在另一方面，所述荚式泵包括在一次性单元中，所述一次性单元可以由基座单元上的容器装置接收和保持，所述基座单元还通过所述容器装置向所述一次性单元上的所述容器泵提供加压控制流体。
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公开(公告)号：US20090095679A1
公开(公告)日：2009-04-16
申请号：US12199452
申请日：2008-08-27
CPC分类号： A61M1/1601 , A61M1/16 , A61M1/1613 , A61M1/1635 , A61M1/341 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3465 , A61M1/3609 , A61M1/3646 , A61M1/365 , A61M1/3652 , A61M2202/0413 , A61M2205/12 , A61M2205/18 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/502 , F04B45/0536 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： Hemodialysis dialysis systems are disclosed. Hemodialysis systems of the invention may include a dialysate flow path including a balancing circuit, a mixing circuit, and/or a directing circuit. The circuits may be defined within one or more cassettes. The fluid circuits may be at least partially isolated, spatially and/or thermally, from electrical components of the system. A gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer to urge dialysate through the dialyzer and blood back to the patient. The hemodialysis systems may include fluid handling devices, actuated using a control fluid, optionally delivered using a detachable pump. Fluid handling devices may be generally rigid and of a spheroid shape, optionally with a diaphragm dividing the device into compartments.
摘要翻译： 公开了血液透析透析系统。 本发明的血液透析系统可以包括透析液流路，其包括平衡电路，混合电路和/或定向电路。 电路可以被定义在一个或多个盒中。 流体回路可以与系统的电气部件至少部分隔离，空间和/或热。 可以提供气体供应，其与透析液流动路径和/或透析器流体连通，以促使通过透析器的透析液和血液返回给患者。 血液透析系统可以包括使用控制流体致动的流体处理装置，可选择地使用可拆卸的泵输送。 流体处理装置通常可以是刚性的并且具有球形形状，任选地具有将装置分隔成隔室的隔膜。
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公开(公告)号：US07214210B2
公开(公告)日：2007-05-08
申请号：US10803049
申请日：2004-03-16
申请人： Dean Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Lee Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard J. Lanigan
发明人： Dean Kamen , Charles M. Grinnell , Marc A. Mandro , Dennis Gilbreath , Kevin Lee Grant , Jason A. Demers , William T. Larkins , Robert Manning , Richard J. Lanigan
IPC分类号： A61M37/00
CPC分类号： A61M5/142 , A61M5/1409 , A61M5/1413 , A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/365 , A61M5/5086 , A61M39/24 , A61M2005/1402 , A61M2005/1403 , A61M2005/14208 , A61M2205/123 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , A61M2206/22 , F16K5/0414 , F16K5/0478
摘要： A disposable cassette for mixing an intravenous drug in a vial to a patient includes a liquid inlet for connection to a liquid supply, a first vial spike, a second vial spike and a chamber. The chamber, the first and second vial spikes, and the liquid inlet are in fluid communication with each other. A valve mechanism may be actuated to control flow between the chamber, the vial receptacles and the liquid inlet.
摘要翻译： 用于将小瓶中的静脉内药物混合到患者的一次性盒包括用于连接到液体供应源的液体入口，第一小瓶尖峰，第二小瓶尖峰和室。 腔室，第一和第二小瓶尖头和液体入口彼此流体连通。 可以致动阀机构以控制腔室，药瓶容器和液体入口之间的流动。
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