公开(公告)号：US20070092400A1

公开(公告)日：2007-04-26

申请号：US11617795

申请日：2006-12-29

申请人： Steven Sundberg ,  J. Parce ,  Calvin Chow

发明人： Steven Sundberg ,  J. Parce ,  Calvin Chow

IPC分类号： G01N21/00

CPC分类号： G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

公开(公告)号：US20070032091A1

公开(公告)日：2007-02-08

申请号：US11495188

申请日：2006-07-28

申请人： David Heald ,  Karen Cruden ,  Xiangfeng Duan ,  Chao Liu ,  J. Parce

发明人： David Heald ,  Karen Cruden ,  Xiangfeng Duan ,  Chao Liu ,  J. Parce

IPC分类号： H01L21/31

CPC分类号： H01L21/28008 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  H01L21/28229 ,  H01L21/28273 ,  H01L21/3105 ,  Y10S977/774 ,  Y10S977/782 ,  Y10S977/845 ,  Y10S977/855 ,  Y10S977/89 ,  Y10S977/891

摘要： Methods for forming or patterning nanostructure arrays are provided. The methods involve formation of arrays on coatings comprising nanostructure association groups, formation of arrays in spin-on-dielectrics, solvent annealing after nanostructure deposition, patterning using resist, and/or use of devices that facilitate array formation. Related devices for forming nanostructure arrays are also provided, as are devices including nanostructure arrays (e.g., memory devices).

摘要翻译： 提供了形成或构图纳米结构阵列的方法。 所述方法包括在包含纳米结构缔合基团，自旋电介质中阵列形成，纳米结构沉积后的溶剂退火，使用抗蚀剂图案化和/或使用促进阵列形成的器件的涂层上形成阵列。 还提供了用于形成纳米结构阵列的相关器件，以及包括纳米结构阵列（例如，存储器件）的器件。

公开(公告)号：US20050238545A1

公开(公告)日：2005-10-27

申请号：US11165749

申请日：2005-06-23

申请人： J. Parce ,  Yung-mae Yao ,  Donald Morrissey

发明人： J. Parce ,  Yung-mae Yao ,  Donald Morrissey

IPC分类号： B01L3/00 ,  B81B1/00 ,  G01N27/27 ,  G01N27/447 ,  G01N35/00 ,  G01N35/08 ,  G01N35/10

CPC分类号： B01L3/502784 ,  B01L3/5027 ,  B01L3/502746 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/105 ,  B01L2300/14 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/084 ,  G01N27/44791 ,  G01N35/08 ,  G01N2035/00237 ,  G01N2035/1034 ,  Y10T137/0324 ,  Y10T137/0391 ,  Y10T436/2575

摘要： Methods of controlling environmental conditions within a fluidic system, where such environmental conditions can affect the operation of the system in its desired function, and fluidic channels, devices and systems that are used in practicing these methods. Such methods are generally directed to environmental control fluids, the movement of such fluids through these systems, and the interaction of these fluids with other components of the system, e.g., other fluids or solid components of the system.

摘要翻译： 控制流体系统内的环境条件的方法，其中这种环境条件可影响系统在其期望功能中的操作，以及用于实施这些方法的流体通道，装置和系统。 这种方法通常涉及环境控制流体，这些流体通过这些系统的运动，以及这些流体与系统的其它部件（例如系统的其它流体或固体组分）的相互作用。

公开(公告)号：US20050005684A1

公开(公告)日：2005-01-13

申请号：US10916270

申请日：2004-08-11

申请人： Ring-Ling Chien ,  J. Parce ,  Andrea Chow ,  Anne Kopf-Sill

发明人： Ring-Ling Chien ,  J. Parce ,  Andrea Chow ,  Anne Kopf-Sill

IPC分类号： G01N11/04 ,  B01L3/00 ,  B01L9/00 ,  G01N11/08 ,  G01N27/06 ,  G01N27/447 ,  G01N35/08 ,  G01N35/10 ,  G01N37/00 ,  G05D7/06 ,  G01N27/26

CPC分类号： B01L9/527 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/146 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/082 ,  G01N11/08 ,  G01N27/44791 ,  G01N2035/1044 ,  G05D7/0694 ,  Y10T137/2076 ,  Y10T137/218 ,  Y10T137/86131

摘要： Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a series of nodes connected together by channel segments and determining the flow resistance characteristics of the channel segments may allow calculation of fluid flows through the channel segments resulting from a given pressure configuration at the reservoirs. To effect a desired flow within a particular channel or series of channels, reservoir pressures may be identified using the network model. Viscometers or other flow sensors may measure flow characteristics within the channels, and the measured flow characteristics can be used to calculate pressures to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems can optionally be used in conjunction with electrokinetic or other fluid transport mechanisms.

摘要翻译： 改进的微流体装置，系统和方法允许通过在多个储存器处施加，控制和改变压力来选择性地输送微流体网络的微流体通道内的流体。 将微流体网络建模为通过通道段连接在一起的一系列节点并且确定通道段的流动阻力特性可以允许计算通过在储存器处的给定压力构造导致的通道段的流体流动。 为了在特定通道或一系列通道内实现期望的流量，可以使用网络模型来识别储层压力。 粘度计或其他流量传感器可以测量通道内的流量特性，并且可以使用测量的流量特性来计算产生期望流量的压力。 多储层压力调节器和压力控制器系统可以可选地与电动或其它流体输送机构结合使用。

公开(公告)号：US20070151852A1

公开(公告)日：2007-07-05

申请号：US11594705

申请日：2006-11-07

申请人： Ring-Ling Chien ,  J. Parce ,  Michael Spaid

发明人： Ring-Ling Chien ,  J. Parce ,  Michael Spaid

IPC分类号： C07K1/26 ,  G01N27/00

CPC分类号： B01F13/0076 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084 ,  F04B19/006 ,  G01N27/44791 ,  H02N11/006

摘要： Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated by altering the applied pressure and electric fields in the various channel segments of the channel networks.

摘要翻译： 采用混合流体流动分布的方法和系统，通过通道网络优化材料的运动。 这些系统采用基于混合压力和电动的流动系统，用于通过互连的通道网络移动材料，同时保持各个通道段之间的互连。 特别地，本发明通常涉及通道网络，其中第一通道段中的流动由具有随后的抛物线流动分布的压力流驱动，而在互连的通道段中的流动由其动力流以及随之而来的塞流动分布主导。 本发明还提供了通道网络，其中通道段中的流体流动由压力和电场驱动，并且通过改变通道网络的各个通道段中施加的压力和电场来分离流体塞中包含的多个物质。

公开(公告)号：US20070102297A1

公开(公告)日：2007-05-10

申请号：US11617800

申请日：2006-12-29

申请人： Steven Sundberg ,  J. Parce ,  Calvin Chow

发明人： Steven Sundberg ,  J. Parce ,  Calvin Chow

IPC分类号： G01N27/00

CPC分类号： G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

公开(公告)号：US20070102296A1

公开(公告)日：2007-05-10

申请号：US11617799

申请日：2006-12-29

申请人： Steven Sundberg ,  J. Parce ,  Calvin Chow

发明人： Steven Sundberg ,  J. Parce ,  Calvin Chow

IPC分类号： G01N27/00

CPC分类号： G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

摘要翻译： 通过使用完全延伸通过微流体衬底的端口来促进流体引入。 可以使用毛细管力将流体保持在端口内，并且可以通过单个端口引入一系列样品或其它流体，通过依次将流体通过基底吹出并用替代流体代替去除的流体，或通过置换 流体部分附加流体。 在另一方面，微流体衬底具有在横截面尺寸上变化的通道，使得毛细管作用仅在通道网络的有限部分内扩散流体。 在另一方面，引入端口可以包括从端口引导到流体通道的多个非常小的通道，以便过滤除了通道和引入端口之间的连接处可能阻挡通道的颗粒或其它污染物 。

公开(公告)号：US20070099200A1

公开(公告)日：2007-05-03

申请号：US11412055

申请日：2006-04-25

申请人： Andrea Chow ,  John Owicki ,  J. Parce

发明人： Andrea Chow ,  John Owicki ,  J. Parce

IPC分类号： C12Q1/68 ,  C12M3/00 ,  G01N33/557

CPC分类号： G01N33/557 ,  B01L3/50273 ,  B01L3/502753 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/1822 ,  B01L2300/1833 ,  B01L2400/0415 ,  B01L2400/0421 ,  B01L2400/0487 ,  G01N27/44791 ,  G01N33/5306

摘要： The present invention provides novel microfluidic devices and methods for performing pulsed field mobility shift assays in microfluidic devices. In particular the devices and methods of the invention utilize differences between electrophoretic mobilities (e.g., as between reactants and products, especially in non-fluorogenic reactions) in order to separate the species and thus analyze the reaction.

摘要翻译： 本发明提供了用于在微流体装置中进行脉冲场迁移率变动测定的新型微流体装置和方法。 特别地，本发明的装置和方法利用电泳迁移率之间的差异（例如，在反应物和产物之间，特别是在非荧光反应中），以便分离物种并因此分析反应。

公开(公告)号：US20060286000A1

公开(公告)日：2006-12-21

申请号：US11493996

申请日：2006-07-27

申请人： Steven Sundberg ,  J. Parce ,  Calvin Chow

发明人： Steven Sundberg ,  J. Parce ,  Calvin Chow

IPC分类号： B01L3/02

CPC分类号： G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.

公开(公告)号：US20060000722A1

公开(公告)日：2006-01-05

申请号：US11050900

申请日：2005-02-03

申请人： J. Parce ,  Anne Kopf-Sill ,  Luc Bousse

发明人： J. Parce ,  Anne Kopf-Sill ,  Luc Bousse

IPC分类号： G01N27/26

CPC分类号： C12Q1/00 ,  B01J19/0093 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00853 ,  B01L3/50273 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0415

摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.