利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

213 条记录 (耗时 0.035 秒)

    Streamline-based microfluidic device
    41.
    发明授权
    Streamline-based microfluidic device 有权
    流线型微流控器件

    公开(公告)号：US08354075B1

    公开(公告)日：2013-01-15

    申请号：US11408514

    申请日：2006-04-20

    申请人： Yu-Chong Tai ,  Siyang Zheng ,  Harvey Kasdan

    发明人： Yu-Chong Tai ,  Siyang Zheng ,  Harvey Kasdan

    IPC分类号： B01L3/00 ,  G01N1/00

    CPC分类号： B01L3/502761 ,  B01L3/502746 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2400/0487 ,  B01L2400/0688 ,  Y10T436/2575

    摘要： The present invention provides a streamline-based device and a method for using the device for continuous separation of particles including cells in biological fluids. The device includes a main microchannel and an array of side microchannels disposed on a substrate. The main microchannel has a plurality of stagnation points with a predetermined geometric design, for example, each of the stagnation points has a predetermined distance from the upstream edge of each of the side microchannels. The particles are separated and collected in the side microchannels.

    摘要翻译： 本发明提供了一种基于流线的装置和使用该装置用于连续分离包括生物流体中的细胞的颗粒的方法。 该器件包括主微通道和设置在衬底上的侧面微通道阵列。 主微通道具有多个具有预定几何设计的停滞点，例如，每个停滞点距离每个侧面微通道的上游边缘具有预定距离。 将颗粒分离并收集在侧面微通道中。

    Implantable Intraocular Pressure Drain
    42.
    发明申请
    Implantable Intraocular Pressure Drain 失效
    植入式眼内压排水

    公开(公告)号：US20120289883A1

    公开(公告)日：2012-11-15

    申请号：US13555329

    申请日：2012-07-23

    申请人： Ellis Fan-chuin Meng ,  Po-Jui Chen ,  Damien Rodger ,  Yu-Chong Tai ,  Mark Humayun

    发明人： Ellis Fan-chuin Meng ,  Po-Jui Chen ,  Damien Rodger ,  Yu-Chong Tai ,  Mark Humayun

    IPC分类号： A61F9/00 ,  A61M1/00

    CPC分类号： A61F9/00781 ,  A61B3/16 ,  A61B5/4836 ,  A61B5/6821 ,  A61B2562/0247 ,  A61B2562/028 ,  A61B2562/12 ,  F16K99/0009 ,  F16K99/0057 ,  F16K2099/0086

    摘要： An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical valve, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.

    摘要翻译： 植入的聚对二甲苯管分流器可减轻眼内压力。 该装置在眼睛的前房中植入开放端，允许多余的液体通过管排出眼睛。 在一个实施例中，仅植入眼睛前房的管的第一端是开放的。 然后监测眼内压（IOP），例如利用植入的传感器。 当IOP超过临界阀时，从业者介入，用激光穿刺位于眼睛外部的管的薄的区域，从而引起流体排出并释放压力。 根据替代实施例，管的两端是开放的，并且管包括被配置为允许IOP超过临界值的排水的单向阀。 管可以包括突出的倒钩以将管锚定在眼睛中而不需要缝线。

    Microfluidic Check Valves With Enhanced Cracking Pressures and Methods of Making the Same
    44.
    发明申请
    Microfluidic Check Valves With Enhanced Cracking Pressures and Methods of Making the Same 审中-公开
    具有增强裂纹压力的微流控止回阀及其制作方法

    公开(公告)号：US20120241017A1

    公开(公告)日：2012-09-27

    申请号：US13427282

    申请日：2012-03-22

    申请人： Jeffrey Chun-Hui Lin ,  Feiqiao Yu ,  Yu-Chong Tai

    发明人： Jeffrey Chun-Hui Lin ,  Feiqiao Yu ,  Yu-Chong Tai

    IPC分类号： F16K21/04 ,  F16K51/00

    CPC分类号： F16K99/0009 ,  F16K99/0057 ,  Y10T137/0491 ,  Y10T137/7837

    摘要： Microfluidic normally closed check valves and methods of making and using the same are provided. The check valves include an orifice, an occluding portion, and one or more attachment members which urge the occluding portion into a position occluding the orifice. In various embodiments, the attachment member or members are pre-stressed by thermal annealing to introduce tensile stress of at least 800 PSI therewithin, thereby increasing the cracking pressure of the valve

    摘要翻译： 提供微流体常闭止回阀及其制作及使用方法。 止回阀包括孔口，闭塞部分和一个或多个附着构件，其将阻塞部分推入封闭孔口的位置。 在各种实施例中，通过热退火对附接构件进行预应力，以在其中引入至少800PSI的拉伸应力，从而增加阀的开启压力

    Integrated capacitive microfluidic sensors method and apparatus
    47.
    发明授权
    Integrated capacitive microfluidic sensors method and apparatus 有权
    集成电容微流体传感器的方法和装置

    公开(公告)号：US07796371B2

    公开(公告)日：2010-09-14

    申请号：US11830581

    申请日：2007-07-30

    申请人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

    发明人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

    IPC分类号： H01G7/00

    CPC分类号： G01N27/226 ,  B81B7/02 ,  B81B2201/0292 ,  B81B2201/058 ,  G01L9/0042 ,  G01L9/0072

    摘要： A micro fluidic device and method for capacitive sensing. The device includes a fluid channel including an inlet at a first end and an outlet at a second end, a cavity region coupled to the fluid channel, and a polymer based membrane coupled between the fluid channel and the cavity region. Additionally, the device includes a first capacitor electrode coupled to the membrane, a second capacitor electrode coupled to the cavity region and physically separated from the first capacitor electrode by at least the cavity region, and an electrical power source coupled between the first capacitor electrode and the second capacitor electrode and causing an electric field at least within the cavity region. The polymer based membrane includes a polymer.

    摘要翻译： 一种用于电容式感测的微流体装置和方法。 该装置包括流体通道，其包括在第一端处的入口和在第二端处的出口，耦合到流体通道的空腔区域以及耦合在流体通道和腔区域之间的基于聚合物的膜。 另外，该器件包括耦合到膜的第一电容器电极，耦合到空腔区域的第二电容器电极，并且至少通过腔区域与第一电容器电极物理分离;以及电源，耦合在第一电容器电极和 所述第二电容器电极至少在所述腔区域内引起电场。 基于聚合物的膜包括聚合物。

    MICROFLUIDIC VALVE HAVING FREE-FLOATING MEMBER AND METHOD OF FABRICATION
    49.
    发明申请
    MICROFLUIDIC VALVE HAVING FREE-FLOATING MEMBER AND METHOD OF FABRICATION 有权
    具有自由浮动构件的微流控阀和制造方法

    公开(公告)号：US20100025613A1

    公开(公告)日：2010-02-04

    申请号：US12565636

    申请日：2009-09-23

    申请人： Yu-Chong Tai ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark S. Humayun

    发明人： Yu-Chong Tai ,  Po-Jui Chen ,  Damien C. Rodger ,  Mark S. Humayun

    IPC分类号： F16K17/02 ,  B21D53/10

    CPC分类号： F16K99/0005 ,  F16K99/0015 ,  F16K99/0057 ,  Y10T29/49409 ,  Y10T137/0497 ,  Y10T137/7866 ,  Y10T137/7895 ,  Y10T137/7904 ,  Y10T137/7914

    摘要： Micro check valves having a free-floating member for controlling flow of fluid in microfluidic and biomedical applications and methods of fabrication. A micro check valve includes a valve seat, a valve cap that contacts the valve seat and an untethered floating member that can move between the valve seat and the valve cap. Certain micro check valves have zero cracking pressure and no reverse leakage. Certain other valves may be configured to permit flow of fluid within a pressure range. The floating member can be solid or define an orifice, and the valve seat can have one or two levels. Valves can be configured to allow fluid to flow when the floating member is pushed by fluid against the valve cap or against the valve seat. The valve seat may be silicon or another material that is compatible with micromachining processes, and the valve cap and the floating member may be a polymer such as Parylene.

    摘要翻译： 微型止回阀具有用于控制微流体和生物医学应用中的流体流动的自由浮动部件和制造方法。 微型止回阀包括阀座，接触阀座的阀盖和可在阀座与阀盖之间移动的无阻力浮动件。 某些微型止回阀具有零开裂压力，无反向泄漏。 某些其它阀可以被配置为允许流体在压力范围内流动。 浮动构件可以是固定的或限定孔口，并且阀座可以具有一个或两个水平面。 阀可以被配置为当浮动构件被流体压靠在阀盖或阀座上时流体流动。 阀座可以是硅或与微加工过程相容的另一种材料，阀帽和浮动元件可以是聚合物，例如聚对二甲苯。

    Resonance-induced sensitivity enhancement method for conductivity sensors
    50.
    发明授权
    Resonance-induced sensitivity enhancement method for conductivity sensors 失效
    电导率传感器的共振诱导灵敏度增强方法

    公开(公告)号：US07629797B2

    公开(公告)日：2009-12-08

    申请号：US11697060

    申请日：2007-04-05

    申请人： Yu-Chong Tai ,  Chi-yuan Shih ,  Wei Li ,  Siyang Zheng

    发明人： Yu-Chong Tai ,  Chi-yuan Shih ,  Wei Li ,  Siyang Zheng

    IPC分类号： G01R27/26

    CPC分类号： G01N27/023 ,  G01N15/1056 ,  G01N15/12 ,  G01N27/4473 ,  G01N2030/645 ,  G01R27/22

    摘要： Methods and systems for improving the sensitivity of a variety of conductivity sensing devices, in particular capacitively-coupled contactless conductivity detectors. A parallel inductor is added to the conductivity sensor. The sensor with the parallel inductor is operated at a resonant frequency of the equivalent circuit model. At the resonant frequency, parasitic capacitances that are either in series or in parallel with the conductance (and possibly a series resistance) is substantially removed from the equivalent circuit, leaving a purely resistive impedance. An appreciably higher sensor sensitivity results. Experimental verification shows that sensitivity improvements of the order of 10,000-fold are possible. Examples of detecting particulates with high precision by application of the apparatus and methods of operation are described.

    摘要翻译： 用于提高各种电导率传感装置的灵敏度的方法和系统，特别是电容耦合的非接触电导检测器。 并联电感器被添加到电导率传感器。 具有并联电感器的传感器以等效电路模型的谐振频率工作。 在谐振频率下，与电导串联或并联的寄生电容（和可能的串联电阻）基本上从等效电路中去除，留下纯电阻阻抗。 传感器敏感度会更高。 实验验证表明灵敏度提高可达10,000倍。 描述了通过应用该装置和操作方法检测高精度的微粒的实例。