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公开(公告)号:US12064540B2
公开(公告)日:2024-08-20
申请号:US18452516
申请日:2023-08-18
CPC分类号: A61M1/1601 , A61M1/154 , A61M1/155 , A61M1/15625 , A61M1/1565 , A61M1/16 , A61M1/1621 , A61M1/1654 , A61M1/1694 , A61M1/267 , A61M1/3401 , A61M1/341 , A61M1/3413 , A61M1/3424 , A61M1/3609 , A61M1/3621 , A61M1/36224 , A61M1/36225 , A61M1/362263 , A61M1/362265 , A61M1/362266 , A61M1/3623 , A61M1/3638 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M1/3672 , A61M1/1561 , A61M1/362261 , A61M2205/07 , A61M2205/12 , A61M2205/123 , A61M2205/125 , A61M2205/128 , A61M2205/15 , A61M2205/16 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/36 , A61M2205/505 , A61M2205/82 , A61M2205/8218 , A61M2205/8225 , Y10T137/87893
摘要: The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second compartments.
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公开(公告)号:US12044229B2
公开(公告)日:2024-07-23
申请号:US18357076
申请日:2023-07-21
发明人: Brian D. Tracey , Larry B. Gray , Jason A. Demers , James D. Dale , N. Christopher Perry , Michael J. Wilt , Scott A. Leonard
IPC分类号: F04B43/073 , A61M1/16 , A61M1/28 , A61M1/36 , F04B7/02 , F04B23/06 , F04B39/12 , F04B39/14 , F04B43/00 , F04B53/16 , F04B53/22
CPC分类号: F04B43/073 , A61M1/16 , A61M1/1605 , A61M1/1656 , A61M1/287 , A61M1/362227 , A61M1/36225 , A61M1/362265 , F04B7/02 , F04B23/06 , F04B39/12 , F04B39/123 , F04B39/14 , F04B43/0081 , F04B43/0736 , F04B53/16 , F04B53/22 , A61M1/362263 , A61M2205/12 , A61M2205/128 , A61M2205/3317 , A61M2205/3324 , A61M2205/3368
摘要: Embodiments of the present invention relate generally to certain types of reciprocating positive-displacement pumps (which may be referred to hereinafter as “pods,” “pump pods,” or “pod pumps”) used to pump fluids, such as a biological fluid (e.g., blood or peritoneal fluid), a therapeutic fluid (e.g., a medication solution), or a surfactant fluid. The pumps may be configured specifically to impart low shear forces and low turbulence on the fluid as the fluid is pumped from an inlet to an outlet. Such pumps may be particularly useful in pumping fluids that may be damaged by such shear forces (e.g., blood, and particularly heated blood, which is prone to hemolysis) or turbulence (e.g., surfactants or other fluids that may foam or otherwise be damaged or become unstable in the presence of turbulence).
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公开(公告)号:US20240238496A1
公开(公告)日:2024-07-18
申请号:US18621419
申请日:2024-03-29
申请人: NextKidney SA
发明人: Didier VECTEN , Ricardo ALLENDES , Paul VESCOVO
CPC分类号: A61M1/3644 , A61M1/1524 , A61M1/154 , A61M1/155 , A61M1/1561 , A61M1/1565 , A61M1/1603 , A61M1/1621 , A61M1/267 , A61M1/362227 , A61M1/36224 , A61M1/36225 , A61M1/362261 , A61M1/362265 , A61M1/3627 , A61M39/10 , A61M39/22 , A61M1/1566 , A61M1/362266 , A61M1/3646 , A61M2205/3337 , A61M2205/50
摘要: A dialysis system may include a blood circuit, a cassette, a subsystem having a processor, a sensor, and a blood pumping mechanism, a housing in which the subsystem is arranged, a movable support arranged in the housing and configured to hold the sensor and/or the blood pumping mechanism of the subsystem, a cassette holder configured to removably receive the cassette, and a loading system. The loading system may be configured to move the movable support, e.g. by an axial movement, to a first position and to a second position relatively to the housing while the cassette holder is fixedly arranged in the housing. The loading system may have an electric motor controlled by the processor, a drive assembly coupled to the electric motor, and a guiding assembly configured to cooperate with the drive assembly.
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公开(公告)号:US11986582B2
公开(公告)日:2024-05-21
申请号:US17511348
申请日:2021-10-26
发明人: Goetz Friederichs , William K. Weigel , Dennis M. Treu , Jeffrey H. Burbank , James M. Brugger , Keith David J. Wheeler , Scott W. Newell
IPC分类号: A61M1/16 , A61K31/191 , A61M1/14 , A61M1/36 , B01F21/20 , C02F9/00 , F15B1/04 , C02F1/20 , C02F1/28 , C02F1/42 , C02F1/44 , C02F103/02 , C02F103/04
CPC分类号: A61M1/1666 , A61K31/191 , A61M1/1524 , A61M1/154 , A61M1/155 , A61M1/1561 , A61M1/1562 , A61M1/1565 , A61M1/1658 , A61M1/166 , A61M1/362227 , A61M1/36224 , A61M1/36225 , A61M1/362261 , A61M1/362262 , A61M1/362265 , B01F21/20 , C02F9/00 , F15B1/04 , A61M1/1563 , A61M1/362263 , A61M2205/3317 , A61M2205/3368 , A61M2205/502 , A61M2205/6054 , A61M2205/6072 , C02F1/20 , C02F1/283 , C02F1/42 , C02F2001/425 , C02F2001/427 , C02F1/44 , C02F2103/026 , C02F2103/04 , C02F2209/05 , C02F2209/445 , F15B2201/315 , Y02A50/30
摘要: A medicament preparation system includes a water purification module and a medicament proportioning module that is interoperable with a replaceable fluid circuit. The fluid circuit includes a purified water inlet, a product medicament outlet, and a plurality of pumping tube segments. At least a first concentrate container is connected by at least a portion of the fluid circuit to the product medicament output and a first concentration measurement sensor station is positioned in a flow path. A controller is programmed to calculate iteratively a concentration of a first concentrate from the first concentrate container and the purified water from a signal generated by the first concentration measurement sensor station and to regulate one or both of a first pumping actuator engaged with the first pumping tube segment and a second pumping actuator engaged with the second pumping tube segment, responsively to the concentration of the first concentrate and water.
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公开(公告)号:US11969536B2
公开(公告)日:2024-04-30
申请号:US17117203
申请日:2020-12-10
申请人: Fenwal, Inc.
发明人: Benjamin E Kusters , Kyungyoon Min
IPC分类号: A61M1/36
CPC分类号: A61M1/3693 , A61M1/3607 , A61M1/3621 , A61M1/362227 , A61M1/36224 , A61M1/36225 , A61M1/362261 , A61M1/362265 , A61M1/362266 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429
摘要: Systems and methods are provided for therapeutic red blood cell exchange and/or therapeutic plasma exchange. A blood separation device includes a centrifugal separator, a spinning membrane separator drive unit, a pump system, and a controller. Blood is conveyed through a fluid flow circuit into either the centrifugal separator or the spinning membrane separator, which separates out the target blood component (red blood cells, in the case of therapeutic red blood cell exchange, or plasma, in the case of therapeutic plasma exchange). The target blood component is retained in the circuit as a waste product, while a replacement fluid is added to the remaining blood component(s), which is then conveyed to a recipient. In addition to allowing for execution of an exchange procedure using either a centrifugal separator or a spinning membrane separator drive unit, the blood separation device also allows for the use of differently sized spinning membrane separators.
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公开(公告)号:US20240131243A1
公开(公告)日:2024-04-25
申请号:US18381948
申请日:2023-10-18
发明人: Tom Bozzay
IPC分类号: A61M1/36
CPC分类号: A61M1/3639 , A61M1/36225 , A61M1/362263 , A61M1/362265 , A61M1/362266 , A61M1/3623 , A61M1/3624 , A61M1/365
摘要: A system for performing extracorporeal blood treatment of recovered blood can include a reservoir to receive a first portion of the recovered blood from a subject, an inline pump coupled the reservoir to regulate a flow rate of at least the first portion of the recovered blood, and an extracorporeal blood conditioner including at least one of an oxygenator to reoxygenate hemoglobin included in the recovered blood for at least intravenous delivery back to the subject or a temperature regulator configured to selectively control a temperature of the recovered blood.
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公开(公告)号:US20240123132A1
公开(公告)日:2024-04-18
申请号:US18394189
申请日:2023-12-22
发明人: Kevin L. Grant , Michael J. Wilt , Brian D. Tracey , Brett A. Rudolf , David E. Collins , Lisa A. Gustin , James D. Dale , Jesse T. Bodwell
CPC分类号: A61M1/3653 , A61M1/14 , A61M1/1658 , A61M1/1682 , A61M1/1686 , A61M1/362227 , A61M1/36225 , A61M1/362261 , A61M1/362265 , A61M1/3643 , A61M1/3644 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M1/3656 , A61M1/367 , A61M1/3672 , A61M1/168 , A61M1/36224 , A61M1/362266 , A61M2205/12 , A61M2205/121 , A61M2205/128
摘要: A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly.
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48.
公开(公告)号:US11938259B2
公开(公告)日:2024-03-26
申请号:US16529901
申请日:2019-08-02
申请人: Fenwal, Inc.
IPC分类号: A61M1/36
CPC分类号: A61M1/362 , A61M1/362227 , A61M1/36224 , A61M1/36225 , A61M1/362261 , A61M1/362265 , A61M1/3639 , A61M1/3663 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M1/362266
摘要: Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system.
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公开(公告)号:US11918717B2
公开(公告)日:2024-03-05
申请号:US17269856
申请日:2019-08-27
申请人: NIKKISO CO., LTD.
CPC分类号: A61M1/1629 , A61M1/152 , A61M1/153 , A61M1/155 , A61M1/1562 , A61M1/15632 , A61M1/36222 , A61M1/36223 , A61M1/36225 , A61M1/362262
摘要: A blood purification device includes a device body and a cassette. The cassette includes: a casing that accommodates a removal water receptacle; and pump tube. The device body includes fingers, a driving unit, and a housing. The cassette can be attached to and removed from the housing of the device body so that the pump tubes are positioned between the plurality of fingers and the outer surfaces of the casing.
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公开(公告)号:US11890403B2
公开(公告)日:2024-02-06
申请号:US17026804
申请日:2020-09-21
发明人: Kevin L. Grant , Michael J. Wilt , Brian D. Tracey , Brett A. Rudolf , David E. Collins , Lisa A. Gustin , James D. Dale , Jesse T. Bodwell
CPC分类号: A61M1/3653 , A61M1/14 , A61M1/1658 , A61M1/1682 , A61M1/1686 , A61M1/365 , A61M1/367 , A61M1/3643 , A61M1/3644 , A61M1/3647 , A61M1/3649 , A61M1/3652 , A61M1/3656 , A61M1/3672 , A61M1/36225 , A61M1/362227 , A61M1/362261 , A61M1/362265 , A61M1/168 , A61M1/36224 , A61M1/362266 , A61M2205/12 , A61M2205/121 , A61M2205/128
摘要: A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly.
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