公开(公告)号：US20020009015A1

公开(公告)日：2002-01-24

申请号：US09812723

申请日：2001-03-20

Inventor： James A. Laugharn JR. ,  Brevard S. Garrison

IPC: B01F011/00

CPC classification number: B01J19/0046 ,  B01F3/08 ,  B01F11/02 ,  B01F11/0283 ,  B01F13/0001 ,  B01F13/0059 ,  B01F13/02 ,  B01F13/0222 ,  B01F15/00123 ,  B01F15/00285 ,  B01F15/0201 ,  B01F2215/0037 ,  B01F2215/0073 ,  B01F2215/0427 ,  B01F2215/0431 ,  B01F2215/045 ,  B01F2215/0454 ,  B01F2215/0468 ,  B01F2215/0477 ,  B01J19/008 ,  B01J19/0093 ,  B01J19/10 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00486 ,  B01J2219/00495 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00783 ,  B01J2219/00889 ,  B01L3/50273 ,  B01L3/5085 ,  B01L7/52 ,  B01L2400/0433 ,  B01L2400/0436 ,  C40B60/14 ,  G10K15/00

Abstract: Acoustic energy is used to control motion in a fluid. According to one embodiment, the invention directs acoustic energy at selected naturally occurring nucleation features to control motion in the fluid. In another embodiment, the invention provides focussed or unfocussed acoustic energy to selectively placed nucleation features to control fluid motion. According to one embodiment, the invention includes an acoustic source, a controller for controlling operation of the acoustic source, and one or more nucleation features located proximate to or in the fluid to be controlled.

Abstract translation: 声能用于控制流体中的运动。 根据一个实施例，本发明将选定的天然存在的成核特征的声能引导以控制流体中的运动。 在另一个实施例中，本发明提供聚焦或未聚焦的声能以选择性地放置成核特征以控制流体运动。 根据一个实施例，本发明包括声源，用于控制声源的操作的控制器和位于要被控制的流体附近或之中的一个或多个成核特征。

公开(公告)号：US5779985A

公开(公告)日：1998-07-14

申请号：US762887

申请日：1996-12-07

Applicant: Irving Sucholeiki

Inventor： Irving Sucholeiki

IPC: B01F11/02 ,  B01F13/08 ,  B01J19/00 ,  B06B3/02 ,  C07K1/04 ,  C40B40/10 ,  C40B50/14 ,  C40B60/14 ,  B06B1/00

CPC classification number: B06B3/02 ,  B01F11/0283 ,  B01F13/0809 ,  B01J19/0046 ,  C07K1/042 ,  C07K1/045 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00328 ,  B01J2219/00351 ,  B01J2219/00414 ,  B01J2219/00454 ,  B01J2219/00459 ,  B01J2219/00486 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00686 ,  B01J2219/00691 ,  B01J2219/0072 ,  B01J2219/00725 ,  C40B40/10 ,  C40B50/14 ,  C40B60/14 ,  Y10S436/809 ,  Y10T436/25375

Abstract: An apparatus for facilitating the running of multiple simultaneous solid phase reactions for mounting on a temperature controllable water bath and a method of using this apparatus in the presence or absence of paramagnetic beads to perform chemical syntheses resulting in separation and recovery of a final desired reaction product is provided. The apparatus comprises a reaction plate, a reaction vessel for mounting in the reaction plate, a reaction plate holder, a screw-like rod, a mounting block attached to the reaction plate holder for operably receiving the screw-like rod, a motor, a sonication region in the water bath and a magnetic separation region in the water bath. Paramagnetic beads having reaction sites are introduced into the reaction vessels along with the appropriate solvent and one or more reactants. The contents of the reaction vessel are sonicated, then moved to the magnetic separation region where the paramagnetic beads are tightly held against the reaction vessel while the solvent is aspirated off. Once the desired reaction product is attained, the reaction product is cleaved off the paramagnetic bead. In an alternative embodiment, chemical synthesis is performed in a similar manner in the absence of the paramagnetic beads.

Abstract translation: 用于促进多个同步固相反应运行以安装在温度可控的水浴上的装置以及在存在或不存在顺磁珠的情况下使用该装置的方法进行化学合成，导致最终所需反应产物的分离和回收 被提供。 该装置包括反应板，用于安装在反应板中的反应容器，反应板保持器，螺杆状杆，安装在反作用板保持器上用于可操作地接收螺杆状杆的安装块，马达， 水浴中的超声处理区域和水浴中的磁分离区域。 具有反应位点的顺磁珠与合适的溶剂和一种或多种反应物一起引入反应容器中。 将反应容器的内容物进行超声处理，然后移动到磁性分离区域，其中顺磁珠紧紧地保持在反应容器上，同时吸出溶剂。 一旦达到所需的反应产物，反应产物就从顺磁珠上分离出来。 在替代实施方案中，在不存在顺磁珠的情况下以类似的方式进行化学合成。

公开(公告)号：US3867269A

公开(公告)日：1975-02-18

申请号：US44823774

申请日：1974-03-05

Applicant: UNIV OSAKA

Inventor： SHIMONISHI YASUTSUGU ,  TAKAHASHI SATOMI

IPC: B01J19/00 ,  B01J19/10 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07K1/04 ,  C07K14/575 ,  C40B40/10 ,  C40B60/14 ,  B01J1/12

CPC classification number: B01J19/10 ,  B01J19/0046 ,  B01J2219/00486 ,  B01J2219/00596 ,  B01J2219/00725 ,  C07K1/045 ,  C40B40/10 ,  C40B60/14

Abstract: In producing a peptide by coupling an amino acid or oligomer thereof with an amino acid or its oligomer bound to a resin to form a peptide on the resin, cleaving the peptide from the resin and thereafter extracting the peptide, a process which is characterized in that said peptide forming reaction is conducted under the irradiation of ultrasonic waves.

Abstract translation: 通过将氨基酸或其低聚物与与树脂结合的氨基酸或其低聚物偶联制备肽，以在树脂上形成肽，从树脂中切割肽，然后提取肽，其特征在于， 所述肽形成反应在超声波的照射下进行。

公开(公告)号：US20240025736A1

公开(公告)日：2024-01-25

申请号：US18254940

申请日：2021-11-19

Applicant: INSTYTUT NISKICH TEMPERATUR I BADAN STRUKTURALNYCH PAN IM.W.TRZEBIATOWSKIEGO

Inventor： Wieslaw STREK ,  Przemyslaw WIEWIORSKI ,  Robert TOMALA ,  Wlodzimierz MISTA ,  Pawel GLUCHOWSKI

IPC: C01B3/06 ,  B01J8/16 ,  B01J19/10 ,  B01J19/12

CPC classification number: C01B3/06 ,  B01J8/16 ,  B01J19/10 ,  B01J19/123 ,  B01J19/128 ,  B01J19/127 ,  B01J2219/00486 ,  B01J2208/00805 ,  B01J2219/00819 ,  B01J2219/0877 ,  B01J2219/00936 ,  B01J2219/00943 ,  B01J2219/00945 ,  C01B2203/1205

Abstract: The invention relates to a method for producing hydrogen in a liquid and to a device for implementing the method characterized in that suspension 1.2 of graphene particles in the liquid is provided to reaction tank 1.1, and then the contents of the reaction tank are exposed to an electromagnetic radiation beam with a wavelength in the UV-VIS-FIR light wave range, which radiation is generated by emitter 1.5, after which the hydrogen liberated from the liquid is transferred through vent 7 outside the reaction tank.

公开(公告)号：US20190033185A1

公开(公告)日：2019-01-31

申请号：US16042378

申请日：2018-07-23

Applicant: AbbVie Inc.

Inventor： Amanda Dombrowski ,  Noah P. Tu ,  Ying Wang

IPC: G01N1/38 ,  G01N1/28 ,  G01N35/10

CPC classification number: G01N1/38 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00459 ,  B01J2219/00461 ,  B01J2219/00479 ,  B01J2219/00486 ,  B01J2219/00596 ,  B01J2219/0072 ,  B01J2219/00747 ,  C40B50/18 ,  G01N1/286 ,  G01N35/1002 ,  G01N35/1016 ,  G01N2001/002 ,  G01N2001/386 ,  G01N2035/00237 ,  G01N2035/00574

Abstract: Systems, methods, and compositions for high throughput screening of micro-scale chemical reactions are disclosed. In particular, systems, methods, and compositions for handling small amounts of solid reagent are disclosed. For example, mechanical mixing is employed to obtain reagent-coated bulking agents that can be used, inter alia, in high throughput methods for screening micro-scale chemical reactions.

公开(公告)号：US07981368B2

公开(公告)日：2011-07-19

申请号：US12693121

申请日：2010-01-25

Applicant: James A. Laugharn, Jr. ,  Brevard S. Garrison

Inventor： James A. Laugharn, Jr. ,  Brevard S. Garrison

IPC: B01J19/00 ,  B01F11/02

CPC classification number: B01F11/02 ,  B01F3/08 ,  B01F11/0283 ,  B01F13/0001 ,  B01F13/0059 ,  B01F13/02 ,  B01F13/0222 ,  B01F15/00123 ,  B01F15/00285 ,  B01F15/0201 ,  B01F2215/0037 ,  B01F2215/0073 ,  B01F2215/0427 ,  B01F2215/0431 ,  B01F2215/045 ,  B01F2215/0454 ,  B01F2215/0468 ,  B01F2215/0477 ,  B01J19/0046 ,  B01J19/008 ,  B01J19/0093 ,  B01J19/10 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00486 ,  B01J2219/00495 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00783 ,  B01J2219/00889 ,  B01L3/50273 ,  B01L3/5085 ,  B01L7/52 ,  B01L2400/0433 ,  B01L2400/0436 ,  C40B60/14 ,  G10K15/00

Abstract: Acoustic energy is used to control motion in a fluid. According to one embodiment, the invention directs acoustic energy at selected naturally occurring nucleation features to control motion in the fluid. In another embodiment, the invention provides focussed or unfocussed acoustic energy to selectively placed nucleation features to control fluid motion. According to one embodiment, the invention includes an acoustic source, a controller for controlling operation of the acoustic source, and one or more nucleation features located proximate to or in the fluid to be controlled.

Abstract translation: 声能用于控制流体中的运动。 根据一个实施例，本发明将选定的天然存在的成核特征的声能引导以控制流体中的运动。 在另一个实施例中，本发明提供聚焦或未聚焦的声能以选择性地放置成核特征以控制流体运动。 根据一个实施例，本发明包括声源，用于控制声源的操作的控制器和位于要被控制的流体附近或之中的一个或多个成核特征。

公开(公告)号：US20100124142A1

公开(公告)日：2010-05-20

申请号：US12693121

申请日：2010-01-25

Applicant: James A. Laugharn, JR. ,  Brevard S. Garrison

Inventor： James A. Laugharn, JR. ,  Brevard S. Garrison

IPC: B01F11/02

CPC classification number: B01F11/02 ,  B01F3/08 ,  B01F11/0283 ,  B01F13/0001 ,  B01F13/0059 ,  B01F13/02 ,  B01F13/0222 ,  B01F15/00123 ,  B01F15/00285 ,  B01F15/0201 ,  B01F2215/0037 ,  B01F2215/0073 ,  B01F2215/0427 ,  B01F2215/0431 ,  B01F2215/045 ,  B01F2215/0454 ,  B01F2215/0468 ,  B01F2215/0477 ,  B01J19/0046 ,  B01J19/008 ,  B01J19/0093 ,  B01J19/10 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00486 ,  B01J2219/00495 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00783 ,  B01J2219/00889 ,  B01L3/50273 ,  B01L3/5085 ,  B01L7/52 ,  B01L2400/0433 ,  B01L2400/0436 ,  C40B60/14 ,  G10K15/00

Abstract: Acoustic energy is used to control motion in a fluid. According to one embodiment, the invention directs acoustic energy at selected naturally occurring nucleation features to control motion in the fluid. In another embodiment, the invention provides focussed or unfocussed acoustic energy to selectively placed nucleation features to control fluid motion. According to one embodiment, the invention includes an acoustic source, a controller for controlling operation of the acoustic source, and one or more nucleation features located proximate to or in the fluid to be controlled.

Abstract translation: 声能用于控制流体中的运动。 根据一个实施例，本发明将选定的天然存在的成核特征的声能引导以控制流体中的运动。 在另一个实施例中，本发明提供聚焦或未聚焦的声能以选择性地放置成核特征以控制流体运动。 根据一个实施例，本发明包括声源，用于控制声源的操作的控制器和位于要被控制的流体附近或之中的一个或多个成核特征。

公开(公告)号：US07687026B2

公开(公告)日：2010-03-30

申请号：US11894655

申请日：2007-08-20

Applicant: James A. Laugharn, Jr. ,  Brevard S. Garrison

Inventor： James A. Laugharn, Jr. ,  Brevard S. Garrison

IPC: A61L2/24 ,  B06B1/00 ,  B01F11/02

CPC classification number: B01F13/0277 ,  B01F11/02 ,  B01F11/0283 ,  B01F13/0059 ,  B01F13/0222 ,  B01F15/00175 ,  B01F15/00285 ,  B01F2215/0427 ,  B01F2215/0431 ,  B01F2215/045 ,  B01F2215/0454 ,  B01F2215/0468 ,  B01F2215/0477 ,  B01J2219/00317 ,  B01J2219/00486 ,  B01J2219/00659 ,  C12M35/04 ,  C40B60/14 ,  G01N2035/00554 ,  G01N2291/02836 ,  G01N2291/02872 ,  G01N2291/02881

Abstract: Apparatus and methods are disclosed for treating a sample by selectively controlling sonic energy and/or selectively controlling the location of the sample relative to the sonic energy.

Abstract translation: 公开了用于通过选择性地控制声能和/或选择性地控制样品相对于声能的位置来处理样品的装置和方法。

公开(公告)号：US20090317884A1

公开(公告)日：2009-12-24

申请号：US12489693

申请日：2009-06-23

Applicant: James A. Laugharn, JR.

Inventor： James A. Laugharn, JR.

IPC: C12N13/00 ,  C12M1/33

CPC classification number: G01N1/286 ,  B01F11/0283 ,  B01J2219/00308 ,  B01J2219/00344 ,  B01J2219/00486 ,  B01J2219/00722 ,  B01J2219/0074 ,  G01N2035/00554

Abstract: Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using an energy director positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.

Abstract translation: 用于控制包括液体的样品的声学处理的方法和装置。 可以例如通过定位合适的元件以减少和/或消除样品/气体界面处的顶部空间来控制其中声学处理样品的处理体积。 可以例如通过使用至少部分地定位在样品中的能量导向器来控制声能和样品之间的相互作用，这有助于减少否则将发生的飞溅或其它样品喷射。

公开(公告)号：US07468280B2

公开(公告)日：2008-12-23

申请号：US12072364

申请日：2008-02-26

Applicant: Robert H. Wollenberg ,  Thomas J. Balk

Inventor： Robert H. Wollenberg ,  Thomas J. Balk

IPC: G01N33/26 ,  C40B50/00 ,  C40B60/14

CPC classification number: B01J19/0046 ,  B01J2219/0036 ,  B01J2219/00364 ,  B01J2219/00481 ,  B01J2219/00486 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00704 ,  B01J2219/00756 ,  G01N33/30 ,  Y10T436/12 ,  Y10T436/25

Abstract: A high throughput preparation of a plurality of different lubricating oil compositions for combinatorial libraries and subsequent high throughput screening for lubricant performance is provided. The methods can advantageously be optimized using combinatorial chemistry, in which a database of combinations of lubricating oil compositions are generated. As market conditions vary and/or product requirements or customer specifications change, conditions suitable for forming desired products can be identified with little or no downtime.

Abstract translation: 提供了用于组合文库的多种不同润滑油组合物的高通量制备和随后的用于润滑剂性能的高通量筛选。 可以使用组合化学方法有利地优化这些方法，其中产生润滑油组合物的组合数据库。 随着市场条件的变化和/或产品要求或客户规格的变化，适合于形成所需产品的条件可以很少或没有停机时间被识别。