公开(公告)号：US20180038801A1

公开(公告)日：2018-02-08

申请号：US15787747

申请日：2017-10-19

Applicant: WALLAC OY

Inventor： Ville LAITALA

IPC: G01N21/75 ,  G01D18/00 ,  G01N21/64

CPC classification number: G01N21/75 ,  G01D18/00 ,  G01N1/286 ,  G01N21/253 ,  G01N21/474 ,  G01N21/6452 ,  G01N21/6486 ,  G01N2001/2873 ,  G01N2201/0407 ,  G01N2201/101 ,  G01N2201/103

Abstract: A measurement device includes mechanical support elements (101-104) for supporting a sample well, other mechanical support elements (105-109) for supporting a measurement head (112) suitable for optical measurements, and a control system (111) configured to control the measurement head to carry out at least two optical measurements from at least two different measurement locations inside the sample well, where each measurement location is a center point of a capture range from which radiation is captured in the respective optical measurement. The final measurement result is formed from the results of the at least two optical measurements in accordance with a pre-determined rule. The use of the at least two optical measurements from different measurement locations reduces measurement variation in situations where the sample well (153) contains a piece (158) of sample carrier.

公开(公告)号：US20170191933A1

公开(公告)日：2017-07-06

申请号：US15389897

申请日：2016-12-23

Applicant: Gen-Probe Incorporated

Inventor： David OPALSKY ,  Srajan RAGHUWANSHI ,  James BUI

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N21/0332 ,  G01N21/276 ,  G01N21/75 ,  G01N35/00732 ,  G01N35/025 ,  G01N2021/6441 ,  G01N2035/00356 ,  G01N2035/0455 ,  G01N2035/0475 ,  G01N2035/0484 ,  G01N2201/0407 ,  G01N2201/0415 ,  G01N2201/12723

Abstract: A system for measuring optical signal detector performance includes an optical signal detector comprising a first detection channel having a first light source and a first sensor. The first detection channel is configured to emit and focus light generated by the first light source at a first detection zone, and to receive and focus light on the first sensor. The system also includes a controller operatively coupled to the optical signal detector and configured to determine an operational performance status of the optical signal detector based on at least one of (i) a first measured characteristic of light focused on the sensor while a first non-fluorescent surface portion is in the first detection zone and (ii) a second measured characteristic of light focused on the sensor while a void is in the first detection zone. The optical signal detector can be a fluorometer.

公开(公告)号：US20160299070A1

公开(公告)日：2016-10-13

申请号：US15070211

申请日：2016-03-15

Applicant: Bio-Rad Laboratories Inc.

Inventor： Yochanan URI ,  Boaz RAN ,  Ariel G. NOTCOVICH ,  Shay NIMRI

IPC: G01N21/552 ,  G01N33/543

CPC classification number: G01N21/553 ,  G01N21/253 ,  G01N21/658 ,  G01N33/54373 ,  G01N2021/0328 ,  G01N2201/0407 ,  G01N2201/0484 ,  G01N2201/062

Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

公开(公告)号：US09354179B2

公开(公告)日：2016-05-31

申请号：US13911115

申请日：2013-06-06

Applicant: Bio-Rad Laboratories Inc.

Inventor： Yochanan Uri ,  Boaz Ran ,  Ariel G. Notcovich ,  Shay Nimri

IPC: G01N21/01 ,  G01N30/60 ,  G01N30/88 ,  G01N21/65 ,  G01N21/552 ,  G01N21/25 ,  G01N21/03

CPC classification number: G01N21/553 ,  G01N21/253 ,  G01N21/658 ,  G01N33/54373 ,  G01N2021/0328 ,  G01N2201/0407 ,  G01N2201/0484 ,  G01N2201/062

Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

Abstract translation: 一种用于光学检测系统的尖端，用于使用从分析物结合到所述尖端内部的检测表面反射的光来分析吸入所述尖端的流体样品中的分析物，所述检测表面包括第一检测表面和位于 相同的流动路径，没有可分离它们的可控阀，其中第一和第二检测表面具有不同的表面化学性质。

公开(公告)号：US20150219554A1

公开(公告)日：2015-08-06

申请号：US14170558

申请日：2014-01-31

Applicant: The Boeing Company

Inventor： Daniel E. Hedges ,  Mark J. Holland ,  Scott S. Rhodes ,  Jennifer D. Klemisch ,  Jessica C. Pavia ,  Thomas Michael Henry ,  Clay J. Anderson ,  Bruce W. McCaul ,  Thomas Mac Winsemius ,  Eric K. Thorson

IPC: G01N21/39 ,  B64D37/32 ,  B64D37/02

CPC classification number: G01N21/39 ,  B64D37/32 ,  G01N2021/399 ,  G01N2201/0214 ,  G01N2201/0407

Abstract: An oxygen analysis system (OAS) for measuring, monitoring and recording oxygen concentration in aircraft fuel tanks. The OAS has a rack support structure installed in an aircraft cabin with a plurality of oxygen analyzer devices mounted in the rack support structure. Each oxygen analyzer device has an oxygen sensor to measure oxygen concentration in gas samples continuously drawn from sample locations in aircraft fuel tanks and at an aircraft NGS ASM exit. The OAS further has a plurality of valves, a supply of calibration gases, a supply of purge and operating gases, and a power distribution assembly, all coupled to the rack support structure. The OAS further has a transport tubing assembly, a plurality of fuel tank gas sampling ports, an NGS ASM exit gas sampling port, a drain manifold assembly, and a data acquisition and recording system having a user interface software to monitor and control the OAS.

Abstract translation: 用于测量，监测和记录飞机燃料箱中氧气浓度的氧分析系统（OAS）。 OAS具有安装在飞机机舱中的机架支撑结构，其具有安装在机架支撑结构中的多个氧分析仪装置。 每个氧气分析仪装置都有一个氧传感器来测量在飞机燃料箱和飞机NGS ASM出口处连续抽取的气体样品中的氧气浓度。 OAS还具有多个阀，校准气体的供应，吹扫和操作气体的供应以及全部联接到齿条支撑结构的动力分配组件。 OAS还具有运输管道组件，多个燃料箱气体采样端口，NGS ASM出口采气口，排水歧管组件以及具有用于监测和控制OAS的用户界面软件的数据采集和记录系统。

公开(公告)号：US20090189089A1

公开(公告)日：2009-07-30

申请号：US12419008

申请日：2009-04-06

Applicant: William Bedingham ,  Peter D. Ludowise ,  Barry W. Robole

Inventor： William Bedingham ,  Peter D. Ludowise ,  Barry W. Robole

IPC: G01N21/64 ,  G01B11/00 ,  A61N5/00 ,  G01N21/85

CPC classification number: F16K99/003 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/025 ,  B01L2300/021 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/004 ,  F16K2099/0084 ,  G01N21/0332 ,  G01N21/07 ,  G01N21/359 ,  G01N21/6428 ,  G01N21/6452 ,  G01N35/00069 ,  G01N35/1097 ,  G01N2021/0325 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2035/00267 ,  G01N2035/00415 ,  G01N2035/0474 ,  G01N2201/0407 ,  G01N2201/0415 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0833 ,  Y10T436/11 ,  Y10T436/111666

Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.

Abstract translation: 描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。 例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。 检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。 该装置还包括多个可移除的光学模块，其被光学配置为激发物种并捕获由不同波长的物质发射的荧光。 耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。 此外，该装置可以通过利用激光加热阀来定位和选择性地打开阀分离腔来控制盘中的流体流动。

公开(公告)号：US07567346B2

公开(公告)日：2009-07-28

申请号：US11363938

申请日：2006-03-01

Applicant: Pavel A. Fomitchov ,  Eugene Barash ,  Ahmad Yetka ,  Joseph Masino, III

Inventor： Pavel A. Fomitchov ,  Eugene Barash ,  Ahmad Yetka ,  Joseph Masino, III

IPC: G01N21/25

CPC classification number: G01N21/6458 ,  G01N21/47 ,  G01N2201/0407 ,  G01N2201/1042 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/367

Abstract: A system and method for multimode imaging of at least one sample is disclosed. The system includes at least one light source; an optical system selected responsive to a mode of operation of the imaging system; and a detector capable of selective reading of pixels. The at least one sample is moved elative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving. The method includes the steps of (1) selecting a mode of operation for the imaging system; (2) transmitting light from at least one light source through an optical system selected in response to the mode of operation for the imaging system; (3) moving the at least one sample relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving; and (4) selectively reading pixels with a detector.

Abstract translation: 公开了一种用于至少一个样品的多模成像的系统和方法。 该系统包括至少一个光源; 响应于成像系统的操作模式选择的光学系统; 以及能够选择性地读取像素的检测器。 使用选自步骤样品移动和连续样品移动的样品移动技术将至少一个样品移动到光学系统。 该方法包括以下步骤：（1）选择成像系统的操作模式; （2）从至少一个光源透射通过响应于成像系统的操作模式选择的光学系统的光; （3）使用选自步骤样品移动和连续样品移动的样本移动技术来移动所述至少一个样品相对于所述光学系统; 和（4）用检测器选择性地读取像素。

公开(公告)号：US20060290345A1

公开(公告)日：2006-12-28

申请号：US11475091

申请日：2006-06-27

Applicant: Yoshiyuki Kunuki

Inventor： Yoshiyuki Kunuki

IPC: G01R31/28

CPC classification number: G01N21/553 ,  G01N21/05 ,  G01N2201/0407

Abstract: A measuring cell holding mechanism, comprising a measuring cell which is configured to include a dielectric block in which a flat face on which a ligand to be attached is formed, and a flow path member which constitutes a flow path between it and this flat face; a dielectric block pressing member which presses the dielectric block from the flow path member side; and a flow path member pressing member which presses the flow path member from the side opposite from the side on which the dielectric block is disposed, with a pressing force smaller than that by the dielectric block pressing member.

Abstract translation: 一种测量单元保持机构，包括测量单元，该测量单元被构造成包括其上形成有待附接的配体的平坦面的介质块和构成其与该平坦面之间的流路的流路构件; 介质块挤压构件，其从所述流路构件侧按压所述介质块; 以及流路构件按压构件，其以比所述介质块按压构件的按压力小的方式将所述流路构件从与设置有所述介质块的一侧相反的一侧挤压。

公开(公告)号：US5428696A

公开(公告)日：1995-06-27

申请号：US92162

申请日：1993-07-15

Applicant: Jerry E. Cahill ,  David H. Tracy

Inventor： Jerry E. Cahill ,  David H. Tracy

IPC: G01N21/25 ,  G02B6/32 ,  G02B6/36 ,  G02B6/42 ,  G02B6/26

CPC classification number: G02B6/3604 ,  G01N21/253 ,  G01N2201/0407 ,  G01N2201/084 ,  G02B6/32 ,  G02B6/4214

Abstract: In a spectrophotometer, each of a plurality of source optical fibers is selectively receptive of source radiation and carries the radiation to a corresponding selected liquid sample cell. A corresponding return optical fiber returns transmitted radiation from the sample to a polychromator. For selecting a sample, a switching member holds exposed ends of the optical fibers on a circle coaxial with an axle for rotating to selected positions. Respective optical trains in the instrument direct radiation into and out of the selected pair of fibers. The diameter of a source aperture, the spacing of the aperture from the radiation source, and the source area define a source etendue. The optical fibers have a fiber etendue substantially the same as the source etendue.

Abstract translation: 在分光光度计中，多个源光纤中的每一个选择性地接受源辐射，并将辐射传送到相应的选定液体样品池。 相应的返回光纤将来自样品的透射辐射返回到多色分光器。 为了选择样品，切换构件将光纤的露出端保持在与轴同轴的圆上，以旋转到选定位置。 仪器中的各种光学列车直接辐射进出所选择的一对光纤。 源孔径的直径，孔径与辐射源的距离以及源区域定义了源极化程度。 光纤具有基本上等于光源渗透率的纤维光密度。

公开(公告)号：US5345395A

公开(公告)日：1994-09-06

申请号：US785800

申请日：1991-10-31

Applicant: Christopher D. Griner

Inventor： Christopher D. Griner

IPC: G01N21/17 ,  G01N21/25 ,  G01N21/27 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N21/253 ,  G01N21/274 ,  G01N35/028 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/08 ,  G01N2201/1283

Abstract: A system uses a photometer that establishes an optical channel between a light emitter and a light detector. The photometer analyses a specimen while it occupies a well in a tray. A movable platform transports the tray to the optical channel for analysis and removes the tray from the optical channel after analysis. The system calibrates the movable platform to assure proper alignment between the specimen and the photometric apparatus used to analyzed the specimen. The system also calibrates the optical channel without use of an external reference.

Abstract translation: 系统使用在光发射器和光检测器之间建立光通道的光度计。 光度计分析样品时，它在托盘中占有很好的位置。 可移动平台将托盘运送到光通道进行分析，并在分析后从光通道中移除托盘。 系统校准可移动平台，以确保样品与用于分析样品的光度测量仪器之间的正确对准。 该系统还可以校准光通道而不使用外部参考。