公开(公告)号：US20170127947A1

公开(公告)日：2017-05-11

申请号：US15243207

申请日：2016-08-22

Applicant: ROBERT R. ALFANO

Inventor： ROBERT ALFANO ,  LINGYAN SHI ,  YURY BUDANSKY

IPC: A61B5/00 ,  G01N21/65

CPC classification number: A61B5/0075 ,  A61B5/0068 ,  G01N21/65 ,  G01N2021/655 ,  G01N2201/0612

Abstract: There is a need for a compact instrument and microscope that maps the vibration fingerprints of biomolecules and chemicals in a sample such as brain, breast, cervix, and arteries. One can use spontaneous Raman scattering to accomplish this; however, the problem is low scattering efficiency to 10−5. With the availability of continuous wave diode laser at numerous wavelengths from 375 nm-1800 nm for parametric nonlinear difference vibrational mixing to enhance Stimulated Raman process within materials. A seed beam at Raman frequency is used with pump laser beam. In this way one can map in 2D and 3D images of the vibrations associate with disease changes. Scanning a pair of laser beams can map the location of vibrations within cells, smears, membranes, arteries, and tissues of animal and human.

公开(公告)号：US09625377B2

公开(公告)日：2017-04-18

申请号：US15056907

申请日：2016-02-29

Applicant: KLEIN MEDICAL LIMITED

Inventor： Bryan James Smith ,  Donal Paul Krouse ,  Raymond Andrew Simpkin

IPC: G01N33/48 ,  G01N21/359 ,  G01J3/10 ,  G01J3/42 ,  G01N21/3577 ,  G01J3/28 ,  G01N21/84 ,  G01J3/12 ,  G01N21/35

CPC classification number: G01N21/3577 ,  G01J3/10 ,  G01J3/28 ,  G01J3/42 ,  G01J2003/1286 ,  G01N21/359 ,  G01N21/84 ,  G01N2021/3595 ,  G01N2201/0612 ,  G01N2201/0691

Abstract: An analyser and related methods for characterising a sample. The analyser includes an integrated laser for emitting electromagnetic radiation in at least one beam at a sample. The electromagnetic radiation can include at least two different wavelengths. A sample detector detects affected electromagnetic radiation resulting from the emitted electromagnetic radiation affected by the sample and provides output representing the detected affected radiation. The analyser also includes a processor for characterising the sample from the detector output representing the detected affected electromagnetic radiation.

公开(公告)号：US20170097601A1

公开(公告)日：2017-04-06

申请号：US15373112

申请日：2016-12-08

Applicant: Noriaki TAKENAGA ,  Tohru MATSUMOTO ,  Tetsuya OFUCHI ,  Takayuki NISHIMURA ,  Yukifumi KOBAYASHI ,  Hideyo MAKINO ,  Satoshi NAKAYAMA

Inventor： Noriaki TAKENAGA ,  Tohru MATSUMOTO ,  Tetsuya OFUCHI ,  Takayuki NISHIMURA ,  Yukifumi KOBAYASHI ,  Hideyo MAKINO ,  Satoshi NAKAYAMA

IPC: G03G15/00

CPC classification number: G03G15/5062 ,  G01B5/0023 ,  G01B5/24 ,  G01N21/21 ,  G01N21/474 ,  G01N21/55 ,  G01N21/59 ,  G01N2021/556 ,  G01N2021/558 ,  G01N2201/0612 ,  G01N2201/0683 ,  G03G15/5029 ,  G03G2215/00738 ,  G03G2215/00751

Abstract: A sheet discriminator, which can be included in an image forming apparatus, includes an optical information detector, a sheet distinguisher, and a sheet thickness detector. The optical information detector includes a light emitter to emit light to a recording medium and a light receiver to receive the light and detects information of the recording medium. The sheet distinguisher distinguishes a type of the recording medium based on the information detected by the optical information detector. The sheet thickness detector includes a displacement gauge to sandwich the recording medium with an opposing member disposed facing the displacement gauge and to move from an initial position thereof and a displacement detector to detect an amount of displacement of the displacement gauge. The sheet thickness detector detects a thickness of the recording medium based on detection results obtained by the displacement detector.

公开(公告)号：US20170059486A1

公开(公告)日：2017-03-02

申请号：US15250168

申请日：2016-08-29

Applicant: Sysmex Corporation

Inventor： Yuhgi SUZUKI ,  Munehisa IZUKA ,  Konobu KIMURA

IPC: G01N21/64 ,  G01N15/06 ,  G01N21/47 ,  G01N1/30

CPC classification number: G01N21/6428 ,  G01N1/30 ,  G01N15/06 ,  G01N15/147 ,  G01N21/47 ,  G01N33/4915 ,  G01N33/5091 ,  G01N33/5094 ,  G01N33/582 ,  G01N2001/302 ,  G01N2015/0065 ,  G01N2015/0073 ,  G01N2015/0693 ,  G01N2015/1037 ,  G01N2015/1402 ,  G01N2015/1477 ,  G01N2015/1486 ,  G01N2015/1488 ,  G01N2015/1493 ,  G01N2021/4707 ,  G01N2021/6439 ,  G01N2201/0612 ,  G01N2201/12 ,  G01N2333/445

Abstract: A blood analyzer comprises a sample preparing part configured to prepare a measurement sample from a blood sample, an staining dye and diluent, a detecting part configured to detect the fluorescent light intensity and the scattered light intensity, an output part, and an analyzing part configured to identify the population including red blood cells infected by ring-form malaria parasite based on the fluorescent light intensity and the scattered light intensity, and output to the output part the information relating to infection of Plasmodium falciparum based on the scattered light distribution of particles associated with the identified population that includes red blood cells infected by the ring-form malaria parasite.

Abstract translation: 一种血液分析装置，其特征在于，包括：样本制备部，其构成为从血液样品，染色染料和稀释剂制备测定样品，被配置为检测荧光强度和散射光强度的检测部，输出部，以及分析部 基于荧光强度和散射光强度鉴定包括由环状疟原虫感染的红细胞的群体，并且基于与颗粒相关的散射光分布将与恶性疟原虫感染相关的信息输出到输出部分 识别的人群包括被环状疟原虫感染的红细胞。

公开(公告)号：US20170045459A1

公开(公告)日：2017-02-16

申请号：US15235170

申请日：2016-08-12

Applicant: Sean Xiaolu Wang ,  Qun Li

Inventor： Sean Xiaolu Wang ,  Qun Li

IPC: G01N21/71

CPC classification number: G01N21/718 ,  G01J3/0208 ,  G01J3/10 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/443 ,  G01N2201/0612 ,  G01N2201/129

Abstract: This invention discloses a laser induced breakdown spectroscopy (LIBS) apparatus based on high repetition rate pulsed laser. The laser produces a train of laser pulses at a high repetition rate in the kHz (or even higher) range. When the laser beam hits the biological sample, it generates several thousands of micro-plasmas per second. Synchronized miniature CCD array optical spectrometer modules collect the LIBS signal from these micro-plasmas. By adjusting the integration time of the spectrometer to cover a plurality of periods of the laser pulse train, the spectrometer integrates the LIBS signal produced by this plurality of laser pulses. Hence the intensity of the obtained LIBS spectrum can be greatly improved to increase the signal-to-noise ratio (SNR) and lower the level of detection (LOD).

Abstract translation: 本发明公开了一种基于高重复率脉冲激光的激光诱导击穿光谱（LIBS）装置。 激光器在kHz（或甚至更高）的范围内以高重复率产生一串激光脉冲。 当激光束撞击生物样品时，它每秒产生数千个微等离子体。 同步微型CCD阵列光谱仪模块从这些微等离子体收集LIBS信号。 通过调整光谱仪的积分时间来覆盖激光脉冲串的多个周期，光谱仪将由多个激光脉冲产生的LIBS信号进行积分。 因此，可以大大提高获得的LIBS频谱的强度，以增加信噪比（SNR）并降低检测电平（LOD）。

公开(公告)号：US20170023481A1

公开(公告)日：2017-01-26

申请号：US15194059

申请日：2016-06-27

Applicant: Panasonic Intellecutal Property Management Co., Ltd.

Inventor： YOSHIHISA NAGASAKI ,  NOBUYASU SUZUKI ,  YUKIHIKO SUGIO

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01M3/38 ,  G01N33/005 ,  G01N2201/0612

Abstract: A hydrogen gas inspection method includes: converting first light having a first wavelength to second light having a second wavelength longer than the first wavelength by using a phosphor, the first light being emitted from a semiconductor light emitting device; irradiating a space to be inspected with the second light; and determining whether hydrogen gas is present in the space utilizing Raman scattered light generated by the hydrogen gas irradiated with the second light.

Abstract translation: 氢气检查方法包括：通过使用荧光体将具有第一波长的第一光转换成具有比第一波长长的第二波长的第二光，第一光从半导体发光器件发射; 用第二光照射要检查的空间; 以及利用由所述第二光照射的氢气产生的拉曼散射光来确定在所述空间中是否存在氢气。

公开(公告)号：US09546902B2

公开(公告)日：2017-01-17

申请号：US14662307

申请日：2015-03-19

Applicant: Servomex Group Limited

Inventor： Richard P. Kovacich ,  Bahram Alizadeh ,  Ian C. Gaskin ,  James D. Hobby ,  Martin Lopez

IPC: G01N21/00 ,  G01J3/02 ,  G01J3/10 ,  G01J3/433 ,  G01N21/39 ,  G01N21/27 ,  G01J3/42

CPC classification number: G01J3/027 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/433 ,  G01J2003/423 ,  G01N21/274 ,  G01N21/39 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/121 ,  G01N2201/1215

Abstract: A method and system for correcting the effect of intensity fluctuations of the transmitted light in an absorption spectroscopy system used for the detection or measurement of chemical species in a medium, whereby one or more modulation bursts are imposed onto a light beam that passes through the medium. This burst signal may be obtained by modulating the bias current of a tunable diode laser, and the modulation burst signal may be optimally at the second harmonic of the modulation frequency of a wavelength modulated beam to allow usage of the same signal path processing used for the spectroscopic detection of the measurand for a second harmonic detection system. The burst signal can be controlled using a smooth window function to minimise the effects of non-linear perturbations that are inherent in tunable diode laser wavelength modulation spectroscopy systems, of optical interference fringes (etalons) and of the residual light absorption by background chemical species or the measurand at the wavelength coinciding with the modulation burst.

Abstract translation: 一种用于校正用于检测或测量介质中的化学物质的吸收光谱系统中的透射光的强度波动的影响的方法和系统，由此一个或多个调制脉冲串被施加到通过介质的光束 。 可以通过调制可调二极管激光器的偏置电流来获得该脉冲串信号，并且调制脉冲串信号可以在波长调制波束的调制频率的二次谐波处最佳地进行，以允许使用与 用于二次谐波检测系统的被测量的光谱检测。 可以使用平滑窗函数来控制突发信号，以最小化可调谐二极管激光波长调制光谱系统固有的非线性扰动，光学干涉条纹（标准具）和背景化学物质的残余光吸收的影响， 在波长上的被测量与调制脉冲串一致。

公开(公告)号：US20170010222A1

公开(公告)日：2017-01-12

申请号：US15265805

申请日：2016-09-14

Applicant: KLA-Tencor Corporation

Inventor： Richard E. Bills ,  Neil Judell ,  Klaus R. Freischlad ,  James P. McNiven

IPC: G01N21/95 ,  G01N21/47 ,  G06T7/00 ,  G01N21/21

CPC classification number: G01N21/9501 ,  G01N21/21 ,  G01N21/47 ,  G01N21/4738 ,  G01N21/474 ,  G01N21/55 ,  G01N21/88 ,  G01N21/8806 ,  G01N21/95 ,  G01N21/956 ,  G01N2021/4707 ,  G01N2021/4711 ,  G01N2021/4792 ,  G01N2021/556 ,  G01N2021/8809 ,  G01N2021/8848 ,  G01N2021/8864 ,  G01N2021/8877 ,  G01N2021/8896 ,  G01N2201/0612 ,  G01N2201/105 ,  G06T7/0004 ,  G06T2207/30148 ,  Y10T29/49826

Abstract: A surface inspection system, as well as related components and methods, are provided. The surface inspection system includes a beam source subsystem, a beam scanning subsystem, a workpiece movement subsystem, an optical collection and detection subsystem, and a processing subsystem. The optical collection and detection system features, in the front quartersphere, a light channel assembly for collecting light reflected from the surface of the workpiece, and a front collector and wing collectors for collecting light scattered from the surface, to greatly improve the measurement capabilities of the system. The light channel assembly has a switchable edge exclusion mask and a reflected light detection system for improved detection of the reflected light.

Abstract translation: 提供了表面检查系统，以及相关的部件和方法。 表面检查系统包括光束源子系统，光束扫描子系统，工件运动子系统，光学收集和检测子系统以及处理子系统。 光学收集和检测系统在前四分之一区域中具有用于收集从工件表面反射的光的光通道组件，以及用于收集从表面散射的光的前收集器和翼收集器，以大大提高测量能力 系统。 光通道组件具有可切换的边缘排除掩模和用于改进反射光检测的反射光检测系统。

公开(公告)号：US09541493B2

公开(公告)日：2017-01-10

申请号：US14724932

申请日：2015-05-29

Applicant: YOKOGAWA ELECTRIC CORPORATION

Inventor： Yoshinori Matsumoto ,  Takashi Tsubota ,  Toyoaki Hamaguchi ,  Akishige Ito

IPC: G01N21/21 ,  G01N21/84 ,  G01N21/89 ,  G01N21/88

CPC classification number: G01N21/21 ,  G01N21/8422 ,  G01N21/8851 ,  G01N21/8901 ,  G01N2021/8848 ,  G01N2201/0612 ,  G01N2201/062

Abstract: An inspection apparatus using polarized lights according to one aspect of the present invention includes an irradiator configured to irradiate an inspection target with a first plurality of lights. The first plurality of lights have different polarization states and different wavelengths from each other. The inspection apparatus further includes a light receiver configured to perform a wavelength demultiplexing of a second plurality of lights obtained from the inspection target to generate a third plurality of lights, to separately receive the third plurality of lights, and to output at least one light-receiving signal associated with the third plurality of lights and a processor configured to calculate at least one of an ellipse azimuth, a degree of polarization, and a polarization component intensity using the light-receiving signal and to determine whether the inspection target is defective or non-defective.

Abstract translation: 根据本发明的一个方面的使用偏振光的检查装置包括被配置为用第一多个光照射检查对象的照射器。 第一组多个光具有彼此不同的偏振态和不同的波长。 检查装置还包括：受光器，被配置为对从检查对象获得的第二多个光进行波长解复用以产生第三多个光，以分别接收第三多个光，并且输出至少一个发光元件， 接收与所述第三多个灯相关联的信号;以及处理器，其被配置为使用所述光接收信号来计算椭圆方位角，偏振度和偏振分量强度中的至少一个，并且确定所述检查对象是否有缺陷 有效的

公开(公告)号：US20170003202A1

公开(公告)日：2017-01-05

申请号：US15198314

申请日：2016-06-30

Applicant: AVALUN

Inventor： Patrick Pouteau ,  Vincent Poher ,  Paul Laurens

IPC: G01N1/10 ,  G01N21/49 ,  G01N33/487 ,  G01N21/78 ,  B01L9/00 ,  B01L3/00

CPC classification number: G01N1/10 ,  B01L3/508 ,  B01L9/50 ,  B01L2200/025 ,  B01L2300/0654 ,  B01L2300/0848 ,  B01L2300/18 ,  G01N21/49 ,  G01N21/78 ,  G01N33/48785 ,  G01N2201/0612 ,  G01N2201/062

Abstract: The invention relates to a system for analyzing a liquid sample, including an analysis device comprising a casing including a through-opening leading into a housing adapted to receive a portion of a collecting device and extending longitudinally from the opening along an axis of insertion of the collecting device. The analysis system further includes a collecting device comprising a main body extending along a longitudinal axis and including a fluid chamber adapted to be inserted in the housing along the insertion axis and a receiving surface intended to receive the liquid sample extending substantially orthogonally relative to the axis of the main body.

Abstract translation: 本发明涉及一种用于分析液体样品的系统，包括分析装置，该分析装置包括壳体，该壳体包括通向壳体的通孔，所述通孔适于容纳收集装置的一部分并且沿着插入的轴线从开口纵向延伸 收集装置。 分析系统还包括收集装置，该收集装置包括主体，其沿着纵向轴线延伸并且包括适于沿着插入轴线插入壳体中的流体室，以及用于接收基本上相对于轴线正交延伸的液体样本的接收表面 的主体。